MARQUIS VAWTER

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA 92697-1675, USA
    Biol Psychiatry 55:346-52. 2004
  2. ncbi Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
  3. ncbi Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007
  4. ncbi Application of cDNA microarrays to examine gene expression differences in schizophrenia
    M P Vawter
    Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Brain Res Bull 55:641-50. 2001
  5. ncbi Shared gene expression alterations in schizophrenia and bipolar disorder
    Ling Shao
    Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, School of Medicine, University of California, Irvine, California 92697 4260, USA
    Biol Psychiatry 64:89-97. 2008
  6. ncbi Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition
    Marquis P Vawter
    Department of Psychiatry, University of California, Irvine, California, USA
    Am J Med Genet B Neuropsychiatr Genet 144:728-34. 2007
  7. ncbi Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
    M P Vawter
    Department of Psychiatry, University of California, Irvine, USA
    Mol Psychiatry 11:615, 663-79. 2006
  8. ncbi Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, College of Medicine, University of California, Irvine, CA 92697, USA
    Hum Genet 119:558-70. 2006
  9. ncbi Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
    Neurochem Res 29:1245-55. 2004
  10. ncbi Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
    Schizophr Res 67:41-52. 2004

Research Grants

  1. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
  2. Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder
    MARQUIS PHILIP VAWTER; Fiscal Year: 2010

Detail Information

Publications26

  1. ncbi Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
    Hiroaki Tomita
    Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA 92697-1675, USA
    Biol Psychiatry 55:346-52. 2004
    ..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
  2. ncbi Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation
    Maureen V Martin
    Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
    BMC Med Genomics 2:62. 2009
    ..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
  3. ncbi Sample matching by inferred agonal stress in gene expression analyses of the brain
    Jun Z Li
    Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
    BMC Genomics 8:336. 2007
    ..This problem is analogous to the one encountered in genetic association studies, where self-reported race and ethnicity are often imprecise proxies for an individual's actual genetic ancestry...
  4. ncbi Application of cDNA microarrays to examine gene expression differences in schizophrenia
    M P Vawter
    Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Brain Res Bull 55:641-50. 2001
    ..Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders...
  5. ncbi Shared gene expression alterations in schizophrenia and bipolar disorder
    Ling Shao
    Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, School of Medicine, University of California, Irvine, California 92697 4260, USA
    Biol Psychiatry 64:89-97. 2008
    ..5% of the world population, and their etiologies are thought to involve multiple genetic variants and environmental influences. The analysis of gene expression patterns in brain may provide a characteristic signature for each disorder...
  6. ncbi Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition
    Marquis P Vawter
    Department of Psychiatry, University of California, Irvine, California, USA
    Am J Med Genet B Neuropsychiatr Genet 144:728-34. 2007
    ..A screen of candidate genes may serve as biomarkers of KS for early diagnosis...
  7. ncbi Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
    M P Vawter
    Department of Psychiatry, University of California, Irvine, USA
    Mol Psychiatry 11:615, 663-79. 2006
    ..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
  8. ncbi Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, College of Medicine, University of California, Irvine, CA 92697, USA
    Hum Genet 119:558-70. 2006
    ..Moreover, they also replicate recent findings of complex trans- and cis- regulation of genes...
  9. ncbi Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophrenia
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
    Neurochem Res 29:1245-55. 2004
    ..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia...
  10. ncbi Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
    Marquis P Vawter
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
    Schizophr Res 67:41-52. 2004
    ..The present study offers support for examination of gene expression patterns using lymphocytic RNA for complex neuropsychiatric disorders from large cohorts of patients...
  11. ncbi An integrative functional genomics approach for discovering biomarkers in schizophrenia
    Marquis P Vawter
    Functional Genomics Laboratory, Department of Psychiatry, University of California, Irvine, USA
    Brief Funct Genomics 10:387-99. 2011
    ..This method has general application to many complex disorders...
  12. ncbi Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes
    Marquis P Vawter
    Department of Psychiatry, University of California, Irvine CA, USA
    Neuropsychopharmacology 29:373-84. 2004
    ..Studies of the protein expression of these sex-chromosome-linked genes in brain tissue are required to address the functional consequences of the observed gene expression differences...
  13. ncbi Methodological considerations for gene expression profiling of human brain
    Mary Atz
    Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA
    J Neurosci Methods 163:295-309. 2007
    ..We find that clinical, tissue, RNA, and microarray quality are all useful variables for collection and consideration in study design, analysis, and interpretation of gene expression results in human postmortem studies...
  14. ncbi NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences
    Mary E Atz
    Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
    Psychiatr Genet 17:55-67. 2007
    ..Bipolar disorder and schizophrenia may share common vulnerability or susceptibility risk factors for shared features in each disorder...
  15. ncbi Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders
    William E Bunney
    Department of Psychiatry, University of California, Irvine 92697, USA
    Am J Psychiatry 160:657-66. 2003
    ..Instead of studying one gene at a time, microarrays provide the opportunity to analyze thousands of genes at once...
  16. ncbi Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
  17. ncbi Analysis of whole genome biomarker expression in blood and brain
    Brandi Rollins
    Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, California 92697 4260, USA
    Am J Med Genet B Neuropsychiatr Genet 153:919-36. 2010
    ..This study demonstrates over 4,100 brain transcripts co-expressed in blood samples can be further examined by in vitro and in vivo experimental studies of blood and cell lines from patients with psychiatric disorders...
  18. ncbi Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder
    Brandi Rollins
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4913. 2009
    ..Several mutations in mitochondrial DNA (mtDNA) sequence have been reported in SZ and BD patients...
  19. ncbi Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study
    Marquis P Vawter
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Schizophr Res 58:11-20. 2002
    ..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques...
  20. ncbi Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissue
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Pediatr Res 53:762-9. 2003
    ..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...
  21. ncbi Mitochondrial involvement in psychiatric disorders
    Ling Shao
    Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine CA, USA
    Ann Med 40:281-95. 2008
    ....
  22. ncbi AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression
    M E Truckenmiller
    Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Exp Neurol 175:318-37. 2002
    ..These data suggest that the AF5 cell line may be useful as an in vitro model system for studies of neural differentiation...
  23. ncbi Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa Rica
    Hilary Bertisch
    Department of Psychiatry, New York University School of Medicine, New York 10016, USA
    Psychiatr Genet 19:45-52. 2009
    ....
  24. ncbi Application of z-score transformation to Affymetrix data
    Chris Cheadle
    Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Appl Bioinformatics 2:209-17. 2003
    ..Z-score transformation provides a useful tool for comparisons between experiments and between laboratories that use the Affymetrix platform...
  25. ncbi Analysis of microarray data using Z score transformation
    Chris Cheadle
    DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
    J Mol Diagn 5:73-81. 2003
    ..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs...
  26. ncbi SNAP-25 reduction in the hippocampus of patients with schizophrenia
    Peter M Thompson
    Mood and Anxiety Disorders Division, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, TX 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:411-7. 2003
    ..These data add to evidence suggesting that in schizophrenia the molecular pathology of the hippocampus involves presynaptic components...

Research Grants3

  1. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
    ..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
  2. Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder
    MARQUIS PHILIP VAWTER; Fiscal Year: 2010
    ..By understanding the accumulation of mitochondrial DNA defects in brain, it will advance mitochondrial medicine for earlier diagnosis and treatment of brain related disorders. ..