Affiliation: University of California
- Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brainHiroaki Tomita
Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA 92697-1675, USA
Biol Psychiatry 55:346-52. 2004..Reducing the variance due to agonal factors is critical in investigating small but validated gene expression differences in messenger RNA levels between psychiatric patients and control subjects...
- Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivationMaureen V Martin
Department of Psychiatry and Human Behavior, Univ of California, Irvine, CA, USA
BMC Med Genomics 2:62. 2009..The purpose of this study was to examine the effects of glucose reduction stress on lymphoblastic cell line (LCL) gene expression in subjects with schizophrenia compared to non-psychotic relatives...
- Sample matching by inferred agonal stress in gene expression analyses of the brainJun Z Li
Stanford Human Genome Center, Stanford University, Palo Alto, CA, USA
BMC Genomics 8:336. 2007..This problem is analogous to the one encountered in genetic association studies, where self-reported race and ethnicity are often imprecise proxies for an individual's actual genetic ancestry...
- Application of cDNA microarrays to examine gene expression differences in schizophreniaM P Vawter
Section on Plasticity and Development, Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Brain Res Bull 55:641-50. 2001..Identification of patterns of changes in gene expression may lead to a better understanding of the pathophysiology of schizophrenia disorders...
- Shared gene expression alterations in schizophrenia and bipolar disorderLing Shao
Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, School of Medicine, University of California, Irvine, California 92697 4260, USA
Biol Psychiatry 64:89-97. 2008..5% of the world population, and their etiologies are thought to involve multiple genetic variants and environmental influences. The analysis of gene expression patterns in brain may provide a characteristic signature for each disorder...
- Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognitionMarquis P Vawter
Department of Psychiatry, University of California, Irvine, California, USA
Am J Med Genet B Neuropsychiatr Genet 144:728-34. 2007..A screen of candidate genes may serve as biomarkers of KS for early diagnosis...
- Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disordersM P Vawter
Department of Psychiatry, University of California, Irvine, USA
Mol Psychiatry 11:615, 663-79. 2006..Genes with the least sensitivity to agonal-pH could present a starting point for candidate gene search in neuropsychiatric disorders...
- Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophreniaMarquis P Vawter
Department of Psychiatry and Human Behavior, Functional Genomics Laboratory, College of Medicine, University of California, Irvine, CA 92697, USA
Hum Genet 119:558-70. 2006..Moreover, they also replicate recent findings of complex trans- and cis- regulation of genes...
- Gene expression of metabolic enzymes and a protease inhibitor in the prefrontal cortex are decreased in schizophreniaMarquis P Vawter
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, California 92697 1675, USA
Neurochem Res 29:1245-55. 2004..These results confirm earlier reports and suggest abnormalities of specific genes related to metabolic and protease activities in the DLPFC might be considered as part of a molecular pathway in male patients with schizophrenia...
- Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigreeMarquis P Vawter
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA 92697 1675, USA
Schizophr Res 67:41-52. 2004..The present study offers support for examination of gene expression patterns using lymphocytic RNA for complex neuropsychiatric disorders from large cohorts of patients...
- An integrative functional genomics approach for discovering biomarkers in schizophreniaMarquis P Vawter
Functional Genomics Laboratory, Department of Psychiatry, University of California, Irvine, USA
Brief Funct Genomics 10:387-99. 2011..This method has general application to many complex disorders...
- Gender-specific gene expression in post-mortem human brain: localization to sex chromosomesMarquis P Vawter
Department of Psychiatry, University of California, Irvine CA, USA
Neuropsychopharmacology 29:373-84. 2004..Studies of the protein expression of these sex-chromosome-linked genes in brain tissue are required to address the functional consequences of the observed gene expression differences...
- Methodological considerations for gene expression profiling of human brainMary Atz
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, CA, USA
J Neurosci Methods 163:295-309. 2007..We find that clinical, tissue, RNA, and microarray quality are all useful variables for collection and consideration in study design, analysis, and interpretation of gene expression results in human postmortem studies...
- NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differencesMary E Atz
Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
Psychiatr Genet 17:55-67. 2007..Bipolar disorder and schizophrenia may share common vulnerability or susceptibility risk factors for shared features in each disorder...
- Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disordersWilliam E Bunney
Department of Psychiatry, University of California, Irvine 92697, USA
Am J Psychiatry 160:657-66. 2003..Instead of studying one gene at a time, microarrays provide the opportunity to analyze thousands of genes at once...
- Identifying gene regulatory networks in schizophreniaSteven G Potkin
Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
Neuroimage 53:839-47. 2010..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
- Analysis of whole genome biomarker expression in blood and brainBrandi Rollins
Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, California 92697 4260, USA
Am J Med Genet B Neuropsychiatr Genet 153:919-36. 2010..This study demonstrates over 4,100 brain transcripts co-expressed in blood samples can be further examined by in vitro and in vivo experimental studies of blood and cell lines from patients with psychiatric disorders...
- Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorderBrandi Rollins
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
PLoS ONE 4:e4913. 2009..Several mutations in mitochondrial DNA (mtDNA) sequence have been reported in SZ and BD patients...
- Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary studyMarquis P Vawter
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Schizophr Res 58:11-20. 2002..These results are subject to limitations based on variations inherent to human subjects and tissue samples, possible effects of neuroleptic treatment, and the requirement for verification using independent techniques...
- Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissueAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Pediatr Res 53:762-9. 2003..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...
- Mitochondrial involvement in psychiatric disordersLing Shao
Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine CA, USA
Ann Med 40:281-95. 2008....
- AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expressionM E Truckenmiller
Cellular Neurobiology Research Branch, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
Exp Neurol 175:318-37. 2002..These data suggest that the AF5 cell line may be useful as an in vitro model system for studies of neural differentiation...
- Neuropsychological performance as endophenotypes in extended schizophrenia families from the Central Valley of Costa RicaHilary Bertisch
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
Psychiatr Genet 19:45-52. 2009....
- Application of z-score transformation to Affymetrix dataChris Cheadle
Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Appl Bioinformatics 2:209-17. 2003..Z-score transformation provides a useful tool for comparisons between experiments and between laboratories that use the Affymetrix platform...
- Analysis of microarray data using Z score transformationChris Cheadle
DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
J Mol Diagn 5:73-81. 2003..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs...
- SNAP-25 reduction in the hippocampus of patients with schizophreniaPeter M Thompson
Mood and Anxiety Disorders Division, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, TX 78229 3900, USA
Prog Neuropsychopharmacol Biol Psychiatry 27:411-7. 2003..These data add to evidence suggesting that in schizophrenia the molecular pathology of the hippocampus involves presynaptic components...
- Biomarker Genes in Mood Disorder: Lymphocyte and BrainMARQUIS VAWTER; Fiscal Year: 2006..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
- Mitochondrial Abnormalities in Schizophrenia and Bipolar DisorderMARQUIS PHILIP VAWTER; Fiscal Year: 2010..By understanding the accumulation of mitochondrial DNA defects in brain, it will advance mitochondrial medicine for earlier diagnosis and treatment of brain related disorders. ..