Kevin Vaughan

Summary

Affiliation: University of Notre Dame
Country: USA

Publications

  1. ncbi request reprint Surfing, regulating and capturing: are all microtubule-tip-tracking proteins created equal?
    Kevin T Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Trends Cell Biol 14:491-6. 2004
  2. ncbi request reprint Microtubule plus ends, motors, and traffic of Golgi membranes
    Kevin T Vaughan
    Department of Biological Sciences, P O Box 369, University of Notre Dame, Notre Dame, IN 46556, USA
    Biochim Biophys Acta 1744:316-24. 2005
  3. pmc TIP maker and TIP marker; EB1 as a master controller of microtubule plus ends
    Kevin T Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 171:197-200. 2005
  4. pmc Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis
    Jacqueline Whyte
    Department of Biological Sciences and 2Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 183:819-34. 2008
  5. pmc Live-cell analysis of mitotic spindle formation in taxol-treated cells
    Jessica E Hornick
    Department of Biological Sciences and Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Cell Motil Cytoskeleton 65:595-613. 2008
  6. pmc A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport
    Patricia S Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 158:305-19. 2002
  7. pmc Dynein at the kinetochore: Timing, Interactions and Functions
    Jason R Bader
    Department of Biological Sciences, University of Notre Dame, Galvin Life Sciences Center, Notre Dame, IN 46556, United States
    Semin Cell Dev Biol 21:269-75. 2010
  8. pmc Transfection-induced defects in dynein-driven transport: evidence that ICs mediate cargo-binding
    William L Towns
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Cell Motil Cytoskeleton 66:80-9. 2009
  9. pmc Centrosome duplication proceeds during mimosine-induced G1 cell cycle arrest
    Thomas M Durcan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Cell Physiol 215:182-91. 2008
  10. ncbi request reprint The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain
    Stephen J Susalka
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:32939-46. 2002

Research Grants

  1. REGULATION OF CYTOPLASMIC DYNEIN TARGETING
    Kevin Vaughan; Fiscal Year: 2009

Collaborators

  • Edward H Hinchcliffe
  • KEVIN PFISTER
  • RICHARD BERT VALLEE
  • Stephen King
  • J Richard McIntosh
  • Ian R Gibbons
  • Patricia S Vaughan
  • Jason R Bader
  • William L Towns
  • Sinji B F Tauhata
  • Jessica E Hornick
  • Thomas M Durcan
  • Elizabeth S Halpin
  • Jacqueline Whyte
  • Sean W Deacon
  • Stephen J Susalka
  • J Scott Breunig
  • Luciana Casaletti
  • Jessica Hornick
  • Emily K Tribble
  • Gordon K Chan
  • Maggie R Pierson
  • Kayleigh Trimble
  • William S Lane
  • Shane Woods
  • Maurice Raycroft
  • Vladimir I Gelfand
  • Monica Lopez Fanarraga
  • Isabelle Vernos
  • Anna S Serpinskaya
  • Pedro Miura
  • Belinda Byrne
  • Karina Nikulina
  • Matthew Henderson
  • Mark W Salata

Detail Information

Publications12

  1. ncbi request reprint Surfing, regulating and capturing: are all microtubule-tip-tracking proteins created equal?
    Kevin T Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Trends Cell Biol 14:491-6. 2004
    ..Focusing on the shared ability of these proteins to undergo tip tracking, this article is intended to place the search-capture model in the context of other proposed functions and to stimulate discussion in this area...
  2. ncbi request reprint Microtubule plus ends, motors, and traffic of Golgi membranes
    Kevin T Vaughan
    Department of Biological Sciences, P O Box 369, University of Notre Dame, Notre Dame, IN 46556, USA
    Biochim Biophys Acta 1744:316-24. 2005
    ..An examination of dynactin's role in ER-Golgi transport suggests that plus end binding could be a reflection of fundamental membrane transport mechanisms...
  3. pmc TIP maker and TIP marker; EB1 as a master controller of microtubule plus ends
    Kevin T Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 171:197-200. 2005
    ..p. 229; Wu et al., p. 201). These results raise the possibility that EB1 is a central player in MT-based transport, and that the activity of MT-binding proteins depends on their ability or inability to interact with EB1...
  4. pmc Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis
    Jacqueline Whyte
    Department of Biological Sciences and 2Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 183:819-34. 2008
    ..Together, these results suggest a new model for localization of kinetochore dynein and the contribution of kinetochore dynactin...
  5. pmc Live-cell analysis of mitotic spindle formation in taxol-treated cells
    Jessica E Hornick
    Department of Biological Sciences and Notre Dame Integrated Imaging Facility, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Cell Motil Cytoskeleton 65:595-613. 2008
    ..Our results suggest that taxol prevents rapid transport of key components, such as NuMA, to the nascent spindle poles. The net result is loss of mitotic spindle pole cohesion, microtubule re-distribution, and cytaster formation...
  6. pmc A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport
    Patricia S Vaughan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Cell Biol 158:305-19. 2002
    ....
  7. pmc Dynein at the kinetochore: Timing, Interactions and Functions
    Jason R Bader
    Department of Biological Sciences, University of Notre Dame, Galvin Life Sciences Center, Notre Dame, IN 46556, United States
    Semin Cell Dev Biol 21:269-75. 2010
    ..Recent work clarifies the contribution of dynein to MT interactions and to events that drive anaphase onset. This review summarizes these studies and provides new models for dynein function...
  8. pmc Transfection-induced defects in dynein-driven transport: evidence that ICs mediate cargo-binding
    William L Towns
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Cell Motil Cytoskeleton 66:80-9. 2009
    ..Together these findings suggest that transfected ICs disrupt organelle transport by competing with native dynein for dynactin binding in a phosphorylation-sensitive manner...
  9. pmc Centrosome duplication proceeds during mimosine-induced G1 cell cycle arrest
    Thomas M Durcan
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Cell Physiol 215:182-91. 2008
    ....
  10. ncbi request reprint The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain
    Stephen J Susalka
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:32939-46. 2002
    ..In addition, this roadblock-binding domain is significantly downstream from both the Tctex1- and LC8-binding sites, supporting the hypothesis that multiple light chain family members can bind to the same intermediate chain...
  11. pmc Dynactin is required for bidirectional organelle transport
    Sean W Deacon
    Department of Cell and Structural Biology, University of Illinois Urbana Champaign, Urbana, IL 61801
    J Cell Biol 160:297-301. 2003
    ..These results reveal that dynactin is required for transport activity of microtubule motors of opposite polarity, cytoplasmic dynein and kinesin II, and may provide a new mechanism to coordinate their activities...
  12. pmc Cytoplasmic dynein nomenclature
    K Kevin Pfister
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 171:411-3. 2005
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms...

Research Grants6

  1. REGULATION OF CYTOPLASMIC DYNEIN TARGETING
    Kevin Vaughan; Fiscal Year: 2009
    ..Through identification of cargo binding subunits and regulatory pathways that control dynein function, this work will advance our understanding of molecular motors and provide new tools for future work. ..