G T Vatassery

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Oxidative stress and inhibition of oxidative phosphorylation induced by peroxynitrite and nitrite in rat brain subcellular fractions
    Govind T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, MN 55417, USA
    Neurochem Int 45:963-70. 2004
  2. ncbi request reprint High doses of vitamin E in the treatment of disorders of the central nervous system in the aged
    G T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, MN, USA
    Am J Clin Nutr 70:793-801. 1999
  3. ncbi request reprint Impairment of brain mitochondrial oxidative phosphorylation accompanying vitamin E oxidation induced by iron or reactive nitrogen species: a selective review
    Govind T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Neurochem Res 29:1951-9. 2004
  4. ncbi request reprint Oxidation of vitamin E and vitamin C and inhibition of brain mitochondrial oxidative phosphorylation by peroxynitrite
    Govind T Vatassery
    Research Service and GRECC, V A Medical Center, Minneapolis, Minnesota 55417, USA
    J Neurosci Res 75:845-53. 2004
  5. ncbi request reprint Iron uncouples oxidative phosphorylation in brain mitochondria isolated from vitamin E-deficient rats
    Govind T Vatassery
    Reserch Service and GRECC, VA Medical Center, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1688:265-73. 2004
  6. ncbi request reprint Alpha and gamma tocopherols in cerebrospinal fluid and serum from older, male, human subjects
    Govind T Vatassery
    Research Service, Veterans Administration Medical Center, and Department of Psychiatry, Graduate Program in Neuroscience, University of Minnesota, Minneapolis, 55417, USA
    J Am Coll Nutr 23:233-8. 2004
  7. ncbi request reprint Oxidation of cholesterol in synaptosomes and mitochondria isolated from rat brains
    G T Vatassery
    Research Service, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Lipids 32:879-86. 1997
  8. ncbi request reprint Aging is associated with a decrease in synaptosomal glutamate uptake and an increase in the susceptibility of synaptosomal vitamin E to oxidative stress
    G T Vatassery
    Department of Psychiatry, GRECC, VA Medical Center, University of Minnesota, Minneapolis 55455, USA
    Neurochem Res 23:121-5. 1998
  9. ncbi request reprint Relationship between nutrition and dementia in the elderly
    G T Vatassery
    Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, Minnesota
    Psychiatr Med 1:429-43. 1983
  10. ncbi request reprint Effect of vitamin E deficiency on the growth and secretory function of the rat prostatic complex
    Michael J Wilson
    Research Service, VA Medical Center, Minneapolis, MN 55417, USA
    Exp Mol Pathol 74:267-75. 2003

Detail Information

Publications16

  1. ncbi request reprint Oxidative stress and inhibition of oxidative phosphorylation induced by peroxynitrite and nitrite in rat brain subcellular fractions
    Govind T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, MN 55417, USA
    Neurochem Int 45:963-70. 2004
    ..It is possible that nitrite may impair oxidative phosphorylation through modulating levels of nitric oxide, changing the activity of heme proteins or a mild uncoupling of mitochondria...
  2. ncbi request reprint High doses of vitamin E in the treatment of disorders of the central nervous system in the aged
    G T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, MN, USA
    Am J Clin Nutr 70:793-801. 1999
    ..However, the safety and efficacy of supplemental vitamin E over periods of many years in the prevention of neurologic diseases has not been adequately explored...
  3. ncbi request reprint Impairment of brain mitochondrial oxidative phosphorylation accompanying vitamin E oxidation induced by iron or reactive nitrogen species: a selective review
    Govind T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Neurochem Res 29:1951-9. 2004
    ..4) Finally, iron is a strong uncoupler of oxidative phosphorylation in brain mitochondria from vitamin E deficient animals and not from controls...
  4. ncbi request reprint Oxidation of vitamin E and vitamin C and inhibition of brain mitochondrial oxidative phosphorylation by peroxynitrite
    Govind T Vatassery
    Research Service and GRECC, V A Medical Center, Minneapolis, Minnesota 55417, USA
    J Neurosci Res 75:845-53. 2004
    ....
  5. ncbi request reprint Iron uncouples oxidative phosphorylation in brain mitochondria isolated from vitamin E-deficient rats
    Govind T Vatassery
    Reserch Service and GRECC, VA Medical Center, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1688:265-73. 2004
    ..The results are important for understanding the pathogenesis of human brain disorders known to be associated with abnormalities in mitochondrial function as well as iron homeostasis (e.g., Parkinson's disease)...
  6. ncbi request reprint Alpha and gamma tocopherols in cerebrospinal fluid and serum from older, male, human subjects
    Govind T Vatassery
    Research Service, Veterans Administration Medical Center, and Department of Psychiatry, Graduate Program in Neuroscience, University of Minnesota, Minneapolis, 55417, USA
    J Am Coll Nutr 23:233-8. 2004
    ..The goal of this study was to obtain indirect information about the transport of tocopherols across the blood/spinal fluid barrier by comparing the concentrations of alpha and gamma tocopherols in serum and cerebrospinal fluid (CSF)...
  7. ncbi request reprint Oxidation of cholesterol in synaptosomes and mitochondria isolated from rat brains
    G T Vatassery
    Research Service, VA Medical Center, Minneapolis, Minnesota 55417, USA
    Lipids 32:879-86. 1997
    ..The 7-oxysterols produced are known to be inhibitors of membrane enzymes and also can modify membrane permeability. Hence, oxysterols may plan an important role in brain tissue damage during oxidative stress...
  8. ncbi request reprint Aging is associated with a decrease in synaptosomal glutamate uptake and an increase in the susceptibility of synaptosomal vitamin E to oxidative stress
    G T Vatassery
    Department of Psychiatry, GRECC, VA Medical Center, University of Minnesota, Minneapolis 55455, USA
    Neurochem Res 23:121-5. 1998
    ....
  9. ncbi request reprint Relationship between nutrition and dementia in the elderly
    G T Vatassery
    Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, Minnesota
    Psychiatr Med 1:429-43. 1983
    ..Hopefully, the future will see an increase in research activity, resulting in answers to many of the questions posed in this paper...
  10. ncbi request reprint Effect of vitamin E deficiency on the growth and secretory function of the rat prostatic complex
    Michael J Wilson
    Research Service, VA Medical Center, Minneapolis, MN 55417, USA
    Exp Mol Pathol 74:267-75. 2003
    ..Thus, the effects of vitamin E in the prostate of the rat appear to be selective...
  11. ncbi request reprint Moderate hyperoxia (40%) increases antioxidant levels in mouse tissue
    Eugene S Lee
    Department of Surgery, University of California Davis, Sacramento, California 95817, USA
    J Surg Res 127:80-4. 2005
    ..In this study, we examined whether the breathing of 40% oxygen causes beneficial effects upon tissue levels of antioxidants such as vitamin E, vitamin C, and glutathione...
  12. ncbi request reprint Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain
    Govind T Vatassery
    Research Service and GRECC, VA Medical Center, Minneapolis, Minnesota 55417, USA
    J Neurosci Res 84:1335-42. 2006
    ..ApoE may be an important protein controlling vitamin E levels in specific brain regions. Further understanding of the interactions between apoE and vitamin E could be important in the appropriate use of vitamin E in AD...
  13. ncbi request reprint Effect of oxidative stress induced by L-dopa on endogenous antioxidants in PC-12 cells
    Govind T Vatassery
    Research Service 151, VA Medical Center, Minneapolis, MN 55417, USA
    Ann N Y Acad Sci 1074:330-6. 2006
    ..Thus L-dopa modulates the cellular dynamics of ascorbate and tocopherol altering cellular antioxidant protection...
  14. ncbi request reprint Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles
    Govind T Vatassery
    Research Service, VA Medical Center, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1772:797-803. 2007
    ..Overall, the current data reinforce the hypothesis that apoE is a key protein involved with the transport and/or retention of alpha tocopherol in brain...
  15. pmc Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system
    Kishorchandra Gohil
    Department of Internal Medicine, Genome and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    Brain Res 1201:167-76. 2008
    ..Interestingly, functional abnormality (ataxia) develops only very late in alpha-TTP-KO mice in spite of the severe alpha-tocopherol deficiency in the brain starting at an early age...
  16. doi request reprint Deletion of apolipoprotein E gene modifies the rate of depletion of alpha tocopherol (vitamin E) from mice brains
    Govind T Vatassery
    Research Service, V A Medical Center, Minneapolis, MN 55417, USA
    Biochim Biophys Acta 1782:414-20. 2008
    ..Our current and previous observations strongly suggest that apoE has an important role in modulating tocopherol concentrations in brain, probably acting in concert with other proteins as well...