Dimitrios N Vatakis

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection
    Sohn G Kim
    1 David Geffen School of Medicine, 615 Charles E Young Dr S, BSRB 173, Mail Code 736322, Los Angeles, CA 90095, USA Twitter https twitter com vatakisd
    J Leukoc Biol 94:835-43. 2013
  2. pmc Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    Mol Ther 21:1055-63. 2013
  3. pmc Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA
    Proc Natl Acad Sci U S A 108:E1408-16. 2011
  4. pmc Viral complementation allows HIV-1 replication without integration
    Huub C Gelderblom
    Department of Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA
    Retrovirology 5:60. 2008
  5. pmc The signal peptide sequence impacts the immune response elicited by a DNA epitope vaccine
    Dimitrios Vatakis
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Vaccine Immunol 18:1776-80. 2011
  6. pmc Quiescent T cells and HIV: an unresolved relationship
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Immunol Res 48:110-21. 2010
  7. ncbi request reprint CD4+ T cell epitope affinity to MHC II influences the magnitude of CTL responses elicited by DNA epitope vaccines
    Dimitrios N Vatakis
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Vaccine 23:2639-46. 2005
  8. pmc Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents
    Dimitrios N Vatakis
    David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology Oncology, Los Angeles, California 90095, USA
    J Virol 83:3374-8. 2009
  9. pmc Primary cell model for activation-inducible human immunodeficiency virus
    Bryan Burke
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1678, USA
    J Virol 81:7424-34. 2007
  10. pmc Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 83:6222-33. 2009

Collaborators

Detail Information

Publications13

  1. pmc Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection
    Sohn G Kim
    1 David Geffen School of Medicine, 615 Charles E Young Dr S, BSRB 173, Mail Code 736322, Los Angeles, CA 90095, USA Twitter https twitter com vatakisd
    J Leukoc Biol 94:835-43. 2013
    ..The latter underscores the impact that stimulants have on HIV-seropositive individuals and the challenges posed for treatment. ..
  2. pmc Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    Mol Ther 21:1055-63. 2013
    ..This suggests that this stem cell based approach can provide a potentially safer approach for anticancer immunotherapy due to the involvement of thymic selection...
  3. pmc Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at the University of California, Los Angeles CA 90095, USA
    Proc Natl Acad Sci U S A 108:E1408-16. 2011
    ..These studies present a potential therapeutic approach and an important tool to understand better and to optimize the human immune response to melanoma and, potentially, to other types of cancer...
  4. pmc Viral complementation allows HIV-1 replication without integration
    Huub C Gelderblom
    Department of Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA
    Retrovirology 5:60. 2008
    ..Here we examine the influence of an integrated provirus on unintegrated HIV-1 DNA (uDNA)...
  5. pmc The signal peptide sequence impacts the immune response elicited by a DNA epitope vaccine
    Dimitrios Vatakis
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Clin Vaccine Immunol 18:1776-80. 2011
    ..The chemokine leader enhanced vaccine immunogenicity, thus underscoring the importance of the leader sequence in DNA epitope vaccine design...
  6. pmc Quiescent T cells and HIV: an unresolved relationship
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Immunol Res 48:110-21. 2010
    ..Therefore, a better understanding of the relationship between HIV and quiescent T cells may lead to further advances in the field of HIV...
  7. ncbi request reprint CD4+ T cell epitope affinity to MHC II influences the magnitude of CTL responses elicited by DNA epitope vaccines
    Dimitrios N Vatakis
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA
    Vaccine 23:2639-46. 2005
    ..Thus, the immunogenicity of a DNA epitope vaccine can be modulated by altering the affinity of the T(H) epitope...
  8. pmc Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents
    Dimitrios N Vatakis
    David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology Oncology, Los Angeles, California 90095, USA
    J Virol 83:3374-8. 2009
    ..These studies increase our understanding of how T cells support viral replication and provide insight regarding the efficiency of antiretroviral therapy in lymphoid compartments...
  9. pmc Primary cell model for activation-inducible human immunodeficiency virus
    Bryan Burke
    Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1678, USA
    J Virol 81:7424-34. 2007
    ..This model can therefore be used to study intricate molecular aspects of activation-inducible HIV infection in primary cells...
  10. pmc Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells
    Dimitrios N Vatakis
    Department of Medicine, Division of Hematology Oncology, UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 83:6222-33. 2009
    ..While site selections are similar, the integration process in quiescent cells is plagued by the formation of high levels of incorrectly processed viral ends and abortive two-long-terminal-repeat circles...
  11. pmc HIV restriction in quiescent CD4⁺ T cells
    Jerome A Zack
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Retrovirology 10:37. 2013
    ..In this review, we will present the progress made, other avenues of investigation and the potential impact these studies have in the development of more effective therapies against HIV...
  12. pmc Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells
    Dimitrios N Vatakis
    David Geffen School of Medicine at UCLA, 650 Charles Young Dr South, Box 951678, 11 934 Factor, Los Angeles, CA 90095 1678, USA
    J Virol 81:3574-82. 2007
    ..Together, these data demonstrate that the early stages of the HIV life cycle are inefficient in these poststimulated cells and that efficient replication cannot be induced by subsequent activation...