Vasilis Vasiliou

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Reviewer acknowledgement 2014
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 8:2. 2014
  2. pmc Genetic tests obtainable through pharmacies: the good, the bad, and the ugly
    George P Patrinos
    Department of Pharmacy, School of Health Sciences, University of Patras, University Campus, Rion, Patras, 26504, Greece
    Hum Genomics 7:17. 2013
  3. pmc Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures
    Yu Ting Saw
    Department of Obstetrics Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Cancer 12:329. 2012
  4. pmc ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA
    Chem Biol Interact 202:22-31. 2013
  5. doi request reprint Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80445, USA
    Chem Biol Interact 202:2-10. 2013
  6. ncbi request reprint Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:27998-8006. 2005
  7. pmc Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity
    Chad Brocker
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Chem Biol Interact 191:269-77. 2011
  8. pmc Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal
    William Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado AMC, Aurora, CO 80045, USA
    Free Radic Biol Med 52:1937-44. 2012
  9. ncbi request reprint Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
  10. ncbi request reprint Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA
    Rizwan Manzer
    Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    DNA Cell Biol 22:329-38. 2003

Collaborators

Detail Information

Publications58

  1. doi request reprint Reviewer acknowledgement 2014
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 8:2. 2014
    ..The Editors of Human Genomics would like to thank all our reviewers who have contributed to the journal in volume 7 (2013)...
  2. pmc Genetic tests obtainable through pharmacies: the good, the bad, and the ugly
    George P Patrinos
    Department of Pharmacy, School of Health Sciences, University of Patras, University Campus, Rion, Patras, 26504, Greece
    Hum Genomics 7:17. 2013
    ....
  3. pmc Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures
    Yu Ting Saw
    Department of Obstetrics Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    BMC Cancer 12:329. 2012
    ..The purpose of the present study was to determine if the expression and activities of other major ALDH isozymes are associated with human ovarian cancer and ovarian cancer sphere cultures...
  4. pmc ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA
    Chem Biol Interact 202:22-31. 2013
    ....
  5. doi request reprint Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80445, USA
    Chem Biol Interact 202:2-10. 2013
    ..This article serves as a comprehensive review of the current state of knowledge regarding the ALDH superfamily and the contribution of ALDHs to various physiological and pathophysiological processes...
  6. ncbi request reprint Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:27998-8006. 2005
    ..In conclusion, these results suggest that ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle...
  7. pmc Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity
    Chad Brocker
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Chem Biol Interact 191:269-77. 2011
    ..In conclusion, ALDH7A1 mechanistically appears to provide cells protection through multiple pathways including the removal of toxic LPO-derived aldehydes in addition to osmolyte generation...
  8. pmc Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal
    William Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado AMC, Aurora, CO 80045, USA
    Free Radic Biol Med 52:1937-44. 2012
    ..Based on the present results, it is apparent that ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress...
  9. ncbi request reprint Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
    ..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant...
  10. ncbi request reprint Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA
    Rizwan Manzer
    Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    DNA Cell Biol 22:329-38. 2003
    ..These data suggest that ALDH1A1 may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation...
  11. pmc Structural and functional modifications of corneal crystallin ALDH3A1 by UVB light
    Tia Estey
    Center for Pharmaceutical Biotechnology, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 5:e15218. 2010
    ..Collectively, our data suggest that the UV-induced inactivation of ALDH3A1 is a result of non-native aggregation and associated structural changes rather than specific damage to the active site Cys...
  12. ncbi request reprint Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  13. pmc Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2
    Brian C Jackson
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 80045, USA
    Chem Biol Interact 202:11-21. 2013
    ....
  14. pmc Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress
    Chad Brocker
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:18452-63. 2010
    ..In conclusion, ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes...
  15. pmc Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme
    Dimitrios Stagos
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    Drug Metab Dispos 38:1679-87. 2010
    ..The current study is the first report on the expression, purification, and biochemical characterization of human ALDH1B1 protein...
  16. pmc Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress
    Satori A Marchitti
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado at Denver, Aurora, CO 80045, USA
    Free Radic Biol Med 49:1432-43. 2010
    ..In addition, ALDH3B1 protein expression was up-regulated by 4HNE in ARPE-19 cells. The results detailed in this study support a pathophysiological role for ALDH3B1 in protecting cells from the damaging effects of oxidative stress...
  17. ncbi request reprint Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, 80262, USA
    Drug Metab Dispos 33:649-56. 2005
    ..These results are the first reported on the cloning, expression, and characterization of a zebrafish ALDH, and indicate that zebrafish is a suitable model for studying ethanol metabolism and, therefore, toxicity...
  18. ncbi request reprint ALDH3A1: a corneal crystallin with diverse functions
    Tia Estey
    Center for Pharmaceutical Biotechnology, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Exp Eye Res 84:3-12. 2007
    ....
  19. pmc Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem J 376:615-23. 2003
    ..Both recombinant human ALDH3A1 and the highly specific monoclonal antibodies described in the present paper may prove to be useful in probing biological functions of this protein in ocular tissue...
  20. pmc Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes
    Satori A Marchitti
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Eye Contact Lens 37:206-13. 2011
    ....
  21. pmc Update on the aldehyde dehydrogenase gene (ALDH) superfamily
    Brian Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Center, Aurora, USA
    Hum Genomics 5:283-303. 2011
    ..This information should be useful to future studies that might wish to compare the role of ALDH members among species and how the gene superfamily as a whole has changed throughout evolution...
  22. ncbi request reprint The role of corneal crystallins in the cellular defense mechanisms against oxidative stress
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Semin Cell Dev Biol 19:100-12. 2008
    ..In this review, we extend the discussion of the antioxidant defenses of the cornea to include these highly expressed corneal crystallins and address their specific capacities to minimize oxidative damage...
  23. pmc Ocular aldehyde dehydrogenases: protection against ultraviolet damage and maintenance of transparency for vision
    Ying Chen
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Prog Retin Eye Res 33:28-39. 2013
    ..A putative regulatory function of ALDH3A1 on corneal cell proliferation has also been proposed. Finally, the three retinaldehyde dehydrogenases cooperatively mediate retinoic acid signaling during the eye development...
  24. pmc Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application
    Vindhya Koppaka
    Department of Pharmaceutical Sciences, University of Colorado Denver, 12850 East Montview Blvd, Aurora, CO 80045, USA
    Pharmacol Rev 64:520-39. 2012
    ....
  25. pmc Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature
    William J Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacogenet Genomics 19:893-902. 2009
    ..The aim of this nomenclature update was to identify splice transcriptional variants principally for the human ALDH genes...
  26. pmc Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress
    Surendra Singh
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Free Radic Biol Med 56:89-101. 2013
    ..Mutations in various ALDHs are associated with a variety of pathological conditions in humans, highlighting the fundamental importance of these enzymes in physiological and pathological processes...
  27. pmc Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer
    Ying Chen
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 405:173-9. 2011
    ....
  28. pmc Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues
    Satori A Marchitti
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    J Histochem Cytochem 58:765-83. 2010
    ..The specificity of ALDH3B1 distribution may prove to be directly related to the functional role of this enzyme in human tissues...
  29. pmc Update of the human and mouse SERPIN gene superfamily
    Claire Heit
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 7:22. 2013
    ..Further characterization of these proteins will likely reveal potential biomarkers and therapeutic targets for disease. ..
  30. pmc ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets
    Yuchun Luo
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    Stem Cells 30:2100-13. 2012
    ..Further investigation of these isozymes and genes will enhance our understanding of the molecular mechanisms governing CSCs and reveal new molecular targets for therapeutic intervention of cancer...
  31. pmc Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
    Satori A Marchitti
    University of Colorado Health Sciences Center, Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, 4200 East Ninth Avenue, C238, Denver, Colorado 80262, USA
    Expert Opin Drug Metab Toxicol 4:697-720. 2008
    ..While several non-P450 enzyme systems participate in their metabolism, one of the most important is the aldehyde dehydrogenase (ALDH) superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation...
  32. pmc Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization
    Dimitrios Stagos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    Brain Res Bull 81:211-8. 2010
    ..We recently have identified ALDH3A1 as a nuclear protein in corneal epithelium. Herein, we show that ALDH3A1 is also found in the nucleus of rabbit keratocytes. The nuclear presence of ALDH3A1 may be involved in cell cycle regulation...
  33. pmc Update of human and mouse forkhead box (FOX) gene families
    Brian C Jackson
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, 80045, USA
    Hum Genomics 4:345-52. 2010
    ....
  34. pmc Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hum Genomics 2:138-43. 2005
    ..The ALDH gene products appear to be multifunctional proteins, possessing both catalytic and non-catalytic properties...
  35. ncbi request reprint Antioxidant defenses in the ocular surface
    Ying Chen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Ocul Surf 7:176-85. 2009
    ..Herein, we review the properties and functions of key constituent antioxidants of the ocular surface...
  36. pmc Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics
    Chad Brocker
    Department of Pharmaceutical Sciences, Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Planta 237:189-210. 2013
    ....
  37. ncbi request reprint Removal of acetaldehyde from the body
    Richard A Deitrich
    Department of Pharmacology, University of Colorado School of Medicine, University of Colorado, HSC, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA
    Novartis Found Symp 285:23-40; discussion 40-51, 198-9. 2007
    ..However, these enzymes account for only a small fraction of the total activity...
  38. ncbi request reprint Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, P O Box C238, Denver, CO 80262, USA
    Arch Biochem Biophys 413:164-71. 2003
    ..This resistance may be a part of the activation process of the hepatic stellate cells and could contribute to their increased proliferation and production of extracellular matrix...
  39. ncbi request reprint Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver 80262, USA
    Free Radic Biol Med 34:1178-89. 2003
    ..Taken together, these data suggest that ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV- and 4-HNE-induced oxidative damage...
  40. pmc Evolutionary divergence and functions of the ADAM and ADAMTS gene families
    Chad N Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:43-55. 2009
    ....
  41. ncbi request reprint Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, School of Pharmacy, Denver, Colorado 80262, USA
    Drug Metab Rev 36:279-99. 2004
    ..Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases...
  42. pmc Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family
    Chad Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:411-20. 2010
    ....
  43. pmc The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1
    Gunter Scharer
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Inherit Metab Dis 33:571-81. 2010
    ..There is evidence from patients with similar genotypes for nongenetic factors contributing to the phenotypic spectrum...
  44. pmc Expression and initial characterization of human ALDH3B1
    Satori A Marchitti
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Biochem Biophys Res Commun 356:792-8. 2007
    ..This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress...
  45. pmc Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, Rocky Mountain Lions Eye Institute, The Children s Hospital, University of Colorado, Denver, Colorado 80262, USA
    J Biol Chem 282:25668-76. 2007
    ..In conclusion, these findings support the hypothesis that corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions...
  46. pmc 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells
    Dimitrios Stagos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 379:654-8. 2009
    ..This inhibition occurs at least in part via 4-HNE-induced CHM-I protein expression...
  47. pmc Evolutionary divergence and functions of the human interleukin (IL) gene family
    Chad Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 5:30-55. 2010
    ..This suggests that the gene family organisation may be subject to further change in the near future...
  48. pmc Human ATP-binding cassette (ABC) transporter family
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 3:281-90. 2009
    ....
  49. ncbi request reprint CYP2E1 and catalase influence ethanol sensitivity in the central nervous system
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pharmacogenet Genomics 16:51-8. 2006
    ..Ethanol is metabolized to acetaldehyde mainly by the alcohol dehydrogenase pathway (ADHs) and, to a lesser extent, by microsomal oxidization (CYP2E1) and the catalase-H2O2 system...
  50. pmc Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA
    Hum Genomics 5:691-702. 2011
    ..Such information is predicted to reveal valuable novel drug targets for the treatment of inflammation, as well as designing biomarkers that might identify tissue damage or cancer...
  51. pmc Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Genomics 2:329-35. 2006
    ....
  52. pmc Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
    Satori A Marchitti
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacol Rev 59:125-50. 2007
    ....
  53. pmc The aldehyde dehydrogenase gene superfamily resource center
    William Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:136-42. 2009
    ..Also included are a summary of substrates, inhibitors and enzyme kinetics. The site provides reference lists and is designed to facilitate data mining by interested investigators...
  54. pmc Update of human and mouse matrix metalloproteinase families
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:194-201. 2010
    ..Although there has been much clinical interest in MMP inhibitors (MMPIs), few trials have been successful - often due to the broad nature of inhibition and the complex role of different MMPs in a given disease state...
  55. ncbi request reprint Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1
    Tia Estey
    Center for Pharmaceutical Biotechnology and Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:4382-92. 2007
    ..This study provides for the first time mechanistic evidence supporting the structural role of the corneal crystallin ALDH3A1 as a UV-absorbing constituent of the cornea...
  56. ncbi request reprint Aldehyde dehydrogenase gene superfamily: the 2002 update
    Nickolas A Sophos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, P O Box C 238, Denver, CO 80262, USA
    Chem Biol Interact 143:5-22. 2003
    ..Thus far, the eukaryotic ALDHs comprise 20 gene families. Detailed information on ALDH gene superfamily is also available at http://www.uchsc.edu/sp/sp/alcdbase/aldhcov.html...
  57. ncbi request reprint Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1
    Rizwan Manzer
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chem Biol Interact 143:45-53. 2003
    ..Such conformational changes may be associated with the function of ALDH3A1 as a chaperone-like molecule in the cornea...
  58. ncbi request reprint Role of CYP1B1 in glaucoma
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Annu Rev Pharmacol Toxicol 48:333-58. 2008
    ..The exact role of CYP1B1 in the pathogenesis of glaucoma and other ASD disorders remains to be elucidated...

Research Grants17

  1. Role and Molecular Mechanisms of Corneal Aldehyde Dehydrogenase
    Vasilis Vasiliou; Fiscal Year: 2010
    ..The proposed research will characterize the role and the molecular mechanisms of ocular ALDH1A1 and ALDH3A1 in protecting the eye from UVR-induced damage, and will serve as a foundation for future drug development. ..
  2. Molec. Mechanisms & Role of Corneal Aldehyde Dehydrogen.
    Vasilis Vasiliou; Fiscal Year: 2007
    ..abstract_text> ..
  3. Novel Role of Corneal Crystallins as Modulators of Cell Growth and Transparency
    Vasilis Vasiliou; Fiscal Year: 2007
    ....
  4. Molec. Mechanisms & Role of Corneal Aldehyde Dehydrogenase
    Vasilis Vasiliou; Fiscal Year: 2007
    ....
  5. GENETIC MODELS TO STUDY ALCOHOL TOXICITY
    Vasilis Vasiliou; Fiscal Year: 2003
    ..These studies will greatly enhance our understanding of genetic factors involved in alcohol toxicity. ..
  6. Novel Role of Corneal Crystallins as Modulators of Cell Growth and Transparency
    Vasilis Vasiliou; Fiscal Year: 2010
    ....