V Vasiliou

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacology 61:192-8. 2000
  2. ncbi request reprint Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, 80262, USA
    Drug Metab Dispos 33:649-56. 2005
  3. ncbi request reprint Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, School of Pharmacy, Denver, Colorado 80262, USA
    Drug Metab Rev 36:279-99. 2004
  4. ncbi request reprint Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Chem Biol Interact 129:1-19. 2000
  5. ncbi request reprint Role of CYP1B1 in glaucoma
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Annu Rev Pharmacol Toxicol 48:333-58. 2008
  6. ncbi request reprint Involvement of p65 in the regulation of NF-kappaB in rat hepatic stellate cells during cirrhosis
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochem Biophys Res Commun 273:546-50. 2000
  7. pmc Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Genomics 2:329-35. 2006
  8. ncbi request reprint CYP2E1 and catalase influence ethanol sensitivity in the central nervous system
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pharmacogenet Genomics 16:51-8. 2006
  9. ncbi request reprint Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression
    V Vasiliou
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio, USA
    Pharmacogenetics 9:569-80. 1999
  10. pmc Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hum Genomics 2:138-43. 2005

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacology 61:192-8. 2000
    ..Allelic variants of the ALDH1A1, ALDH1B1, ALDH3A1 and ALDH9A1 genes have also been observed but not yet characterized. This review describes consequences of ALDH polymorphisms with respect to drug metabolism and disease...
  2. ncbi request reprint Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, 80262, USA
    Drug Metab Dispos 33:649-56. 2005
    ..These results are the first reported on the cloning, expression, and characterization of a zebrafish ALDH, and indicate that zebrafish is a suitable model for studying ethanol metabolism and, therefore, toxicity...
  3. ncbi request reprint Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, School of Pharmacy, Denver, Colorado 80262, USA
    Drug Metab Rev 36:279-99. 2004
    ..Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases...
  4. ncbi request reprint Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Chem Biol Interact 129:1-19. 2000
    ..This review summarizes the ALDHs with an emphasis on catalytic properties and xenobiotic substrates of these enzymes...
  5. ncbi request reprint Role of CYP1B1 in glaucoma
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Annu Rev Pharmacol Toxicol 48:333-58. 2008
    ..The exact role of CYP1B1 in the pathogenesis of glaucoma and other ASD disorders remains to be elucidated...
  6. ncbi request reprint Involvement of p65 in the regulation of NF-kappaB in rat hepatic stellate cells during cirrhosis
    V Vasiliou
    Molecular Toxicology and Environmental Health Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Biochem Biophys Res Commun 273:546-50. 2000
    ..It is likely that this regulation affects IL-6 expression and may represent a mechanism regulating hepatocyte death during fibrogenesis...
  7. pmc Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Genomics 2:329-35. 2006
    ....
  8. ncbi request reprint CYP2E1 and catalase influence ethanol sensitivity in the central nervous system
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pharmacogenet Genomics 16:51-8. 2006
    ..Ethanol is metabolized to acetaldehyde mainly by the alcohol dehydrogenase pathway (ADHs) and, to a lesser extent, by microsomal oxidization (CYP2E1) and the catalase-H2O2 system...
  9. ncbi request reprint Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression
    V Vasiliou
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio, USA
    Pharmacogenetics 9:569-80. 1999
    ..The dioxin-mediated upregulation of Aldh3a1 expression in mouse hepatoma Hepa-1c1c7 cell cultures was shown to depend exclusively on the aromatic hydrocarbon receptor...
  10. pmc Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hum Genomics 2:138-43. 2005
    ..The ALDH gene products appear to be multifunctional proteins, possessing both catalytic and non-catalytic properties...
  11. ncbi request reprint Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, P O Box C238, Denver, CO 80262, USA
    Arch Biochem Biophys 413:164-71. 2003
    ..This resistance may be a part of the activation process of the hepatic stellate cells and could contribute to their increased proliferation and production of extracellular matrix...
  12. ncbi request reprint Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice
    V Vasiliou
    Center for Environmental Genetics, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    Biochem Biophys Res Commun 233:631-6. 1997
    ..Our results show a wide variation in extrahepatic tissue-specific expression of all four transcripts and indicate that numerous differences exist in the extrahepatic expression of these genes between 14CoS/14CoS and ch/ch mice...
  13. ncbi request reprint Corneal and stomach expression of aldehyde dehydrogenases: from fish to mammals
    A Pappa
    Molecular Toxicology and Environmental Health Sciences, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 80262, Denver, CO, USA
    Chem Biol Interact 130:181-91. 2001
    ..It can, therefore, be concluded that corneal expression of ALDH3A1 or ALDH1A1/ALDH2 occurs in a taxon-specific manner, supporting the protective role of these ALDHs in cornea against the UV-induced oxidative damage...
  14. ncbi request reprint Characterization of 4-hydroxy-2-nonenal metabolism in stellate cell lines derived from normal and cirrhotic rat liver
    J F Reichard
    School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochim Biophys Acta 1487:222-32. 2000
    ....
  15. ncbi request reprint Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines
    V Vasiliou
    Department of Environmental Health and Center for Ecogenetics and Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 59:703-12. 2000
    ..It is therefore likely that differences in the oxidative stress responses between the 14CoS/14CoS newborn liver and the immortalized hepatocyte cell line might be explained by the presence of large T antigen in the established cell line...
  16. ncbi request reprint Aldehyde dehydrogenase gene superfamily: the 2000 update
    N A Sophos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 80262, Denver, CO, USA
    Chem Biol Interact 130:323-37. 2001
    ..Thus far, the eukaryotic ALDHs comprise 20 gene families. A complete list of all ALDH sequences known to date is presented here along with the evolution analysis of the eukaryotic ALDHs...
  17. ncbi request reprint Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, University Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 280:27998-8006. 2005
    ..In conclusion, these results suggest that ALDH3A1 may protect corneal epithelial cells against oxidative damage not only through its metabolic function but also by prolonging the cell cycle...
  18. ncbi request reprint Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light
    T Shiao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Centre, Denver 80262, USA
    Pharmacogenetics 9:145-53. 1999
    ..It is likely that structural changes associated with these amino acid changes are responsible for the loss of ALDH3A1 enzymatic activity in SWR/J mice...
  19. ncbi request reprint Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Biochem Pharmacol 50:2057-68. 1995
    ..To our knowledge, this is among the first reports of the same transcription factor operating at two different response elements upstream of a single gene...
  20. ncbi request reprint Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping
    V Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Centre, Denver, USA
    Pharmacogenetics 9:421-34. 1999
    ..uchsc.edu/sp./sp./alcdbase/a ldhcov.html) and will serve as a medium for interaction amongst colleagues in this field...
  21. pmc Glutathione defense mechanism in liver injury: insights from animal models
    Y Chen
    Department of Pharmaceutical Sciences, University of Colorado, School of Pharmacy, Aurora, CO 80045, United States Electronic address
    Food Chem Toxicol 60:38-44. 2013
    ..Collectively, these transgenic mouse models provide interesting new insights regarding pathophysiological functions of GSH in the liver...
  22. ncbi request reprint Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 41:1459-69. 2006
    ..g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant...
  23. ncbi request reprint Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    DNA Cell Biol 15:235-45. 1996
    ..These data indicate that, although inducible by dioxin, the Ahd3 gene does not qualify as a member of the aromatic hydrocarbon [Ah] gene battery...
  24. pmc Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization
    Dimitrios Stagos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    Brain Res Bull 81:211-8. 2010
    ..We recently have identified ALDH3A1 as a nuclear protein in corneal epithelium. Herein, we show that ALDH3A1 is also found in the nucleus of rabbit keratocytes. The nuclear presence of ALDH3A1 may be involved in cell cycle regulation...
  25. pmc Evolutionary divergence and functions of the ADAM and ADAMTS gene families
    Chad N Brocker
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:43-55. 2009
    ....
  26. ncbi request reprint Aldehyde dehydrogenase gene superfamily: the 2002 update
    Nickolas A Sophos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, P O Box C 238, Denver, CO 80262, USA
    Chem Biol Interact 143:5-22. 2003
    ..Thus far, the eukaryotic ALDHs comprise 20 gene families. Detailed information on ALDH gene superfamily is also available at http://www.uchsc.edu/sp/sp/alcdbase/aldhcov.html...
  27. ncbi request reprint Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1
    Tia Estey
    Center for Pharmaceutical Biotechnology and Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:4382-92. 2007
    ..This study provides for the first time mechanistic evidence supporting the structural role of the corneal crystallin ALDH3A1 as a UV-absorbing constituent of the cornea...
  28. ncbi request reprint Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver 80262, USA
    Free Radic Biol Med 34:1178-89. 2003
    ..Taken together, these data suggest that ALDH3A1 is a regulatory element of the cellular defense system that protects corneal epithelium against UV- and 4-HNE-induced oxidative damage...
  29. ncbi request reprint Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA
    Rizwan Manzer
    Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    DNA Cell Biol 22:329-38. 2003
    ..These data suggest that ALDH1A1 may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation...
  30. pmc Expression and initial characterization of human ALDH3B1
    Satori A Marchitti
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Biochem Biophys Res Commun 356:792-8. 2007
    ..This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress...
  31. ncbi request reprint The role of corneal crystallins in the cellular defense mechanisms against oxidative stress
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Semin Cell Dev Biol 19:100-12. 2008
    ..In this review, we extend the discussion of the antioxidant defenses of the cornea to include these highly expressed corneal crystallins and address their specific capacities to minimize oxidative damage...
  32. pmc 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells
    Dimitrios Stagos
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, 12700 E 19th Avenue, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 379:654-8. 2009
    ..This inhibition occurs at least in part via 4-HNE-induced CHM-I protein expression...
  33. pmc Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase
    Satori A Marchitti
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Pharmacol Rev 59:125-50. 2007
    ....
  34. pmc Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature
    William J Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    Pharmacogenet Genomics 19:893-902. 2009
    ..The aim of this nomenclature update was to identify splice transcriptional variants principally for the human ALDH genes...
  35. pmc Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress
    Chad Brocker
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:18452-63. 2010
    ..In conclusion, ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes...
  36. pmc Analysis of the glutathione S-transferase (GST) gene family
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Hum Genomics 1:460-4. 2004
    ..It is concluded that the complete GST gene family comprises 16 genes in six subfamilies--alpha (GSTA), mu (GSTM), omega (GSTO), pi (GSTP), theta (GSTT) and zeta (GSTZ)...
  37. ncbi request reprint Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1
    Rizwan Manzer
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chem Biol Interact 143:45-53. 2003
    ..Such conformational changes may be associated with the function of ALDH3A1 as a chaperone-like molecule in the cornea...
  38. ncbi request reprint ALDH3A1: a corneal crystallin with diverse functions
    Tia Estey
    Center for Pharmaceutical Biotechnology, Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Exp Eye Res 84:3-12. 2007
    ....
  39. pmc Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
    Satori A Marchitti
    University of Colorado Health Sciences Center, Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, 4200 East Ninth Avenue, C238, Denver, Colorado 80262, USA
    Expert Opin Drug Metab Toxicol 4:697-720. 2008
    ..While several non-P450 enzyme systems participate in their metabolism, one of the most important is the aldehyde dehydrogenase (ALDH) superfamily, composed of NAD(P)+-dependent enzymes that catalyze aldehyde oxidation...
  40. pmc Human ATP-binding cassette (ABC) transporter family
    Vasilis Vasiliou
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 3:281-90. 2009
    ....
  41. pmc The aldehyde dehydrogenase gene superfamily resource center
    William Black
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:136-42. 2009
    ..Also included are a summary of substrates, inhibitors and enzyme kinetics. The site provides reference lists and is designed to facilitate data mining by interested investigators...
  42. pmc Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice
    Natalie Lassen
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, Rocky Mountain Lions Eye Institute, The Children s Hospital, University of Colorado, Denver, Colorado 80262, USA
    J Biol Chem 282:25668-76. 2007
    ..In conclusion, these findings support the hypothesis that corneal ALDH3A1 and lens ALDH1A1 protect the eye against cataract formation via nonenzymatic (light filtering) and enzymatic (detoxification) functions...
  43. pmc Update of human and mouse matrix metalloproteinase families
    Brian C Jackson
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Hum Genomics 4:194-201. 2010
    ..Although there has been much clinical interest in MMP inhibitors (MMPIs), few trials have been successful - often due to the broad nature of inhibition and the complex role of different MMPs in a given disease state...
  44. pmc Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea
    Aglaia Pappa
    Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem J 376:615-23. 2003
    ..Both recombinant human ALDH3A1 and the highly specific monoclonal antibodies described in the present paper may prove to be useful in probing biological functions of this protein in ocular tissue...
  45. ncbi request reprint Removal of acetaldehyde from the body
    Richard A Deitrich
    Department of Pharmacology, University of Colorado School of Medicine, University of Colorado, HSC, PO Box 6511, Mail Stop 8303, Aurora, CO 80045, USA
    Novartis Found Symp 285:23-40; discussion 40-51, 198-9. 2007
    ..However, these enzymes account for only a small fraction of the total activity...
  46. ncbi request reprint Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice
    Sanjiv V Bhave
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045 0511, USA
    Alcohol Clin Exp Res 30:1659-69. 2006
    ..Differences in ethanol metabolizing enzymes expressed in brain have been suggested to contribute to the significant differences in ethanol (alcohol) preference between inbred C57BL/6 and DBA/2 mouse strains...
  47. ncbi request reprint Enzymatic mechanisms of ethanol oxidation in the brain
    Sergey M Zimatkin
    Grodno State Medical University, Grodno, Belarus
    Alcohol Clin Exp Res 30:1500-5. 2006
    ..The objective of the study was to determine the contribution of the different enzymatic pathways to ethanol oxidation in brain homogenates from mice and rats...
  48. ncbi request reprint Arachidonic acid suppresses growth of human lung tumor A549 cells through down-regulation of ALDH3A1 expression
    Giuliana Muzio
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy
    Free Radic Biol Med 40:1929-38. 2006
    ..In conclusion, our data show that the arachidonic acid-induced suppression of A549 cell growth is associated with increased lipid peroxidation and decreased ALDH3A1 expression, which may be due to activation of PPARgamma...
  49. ncbi request reprint Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder
    M Cristina Kenney
    Department of Ophthalmology, University of California Irvine, Medical Center, 101 The City Drive, Orange, CA 92868, USA
    Invest Ophthalmol Vis Sci 46:823-32. 2005
    ..Protein levels or enzyme activities were analyzed when RNA levels were different...
  50. ncbi request reprint Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin
    Sujuan Jia
    Laboratory of Molecular and Development Biology, National Eye Institute, National Institutes of Health, 7 Memorial Dr, Bldg 7, Rm 100, Bethesda, MD 20892, USA
    FASEB J 21:3318-28. 2007
    ..Our data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin gene and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin...
  51. pmc Cyclophilin nomenclature problems, or, 'a visit from the sequence police'
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA dan nerbert uc edu
    Hum Genomics 1:381-8. 2004
    ....
  52. ncbi request reprint Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family
    Douglas G Mashek
    Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Lipid Res 45:1958-61. 2004
    ..Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made...
  53. ncbi request reprint Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance
    Jon DiFabio
    Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen s University, Kingston, ON, Canada K7L 3N6
    Mol Pharmacol 64:1109-16. 2003
    ....

Research Grants2

  1. Novel Role of Corneal Crystallins as Modulators of Cell Growth and Transparency
    Vasilis Vasiliou; Fiscal Year: 2007
    ....
  2. Molec. Mechanisms & Role of Corneal Aldehyde Dehydrogen.
    Vasilis Vasiliou; Fiscal Year: 2007
    ..abstract_text> ..