Vitaly Vasilevko

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    J Neuroinflammation 5:42. 2008
  2. pmc Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
    Vitaly Vasilevko
    The Institute for Memory Impairments and Neurological Disorders, University of California, Irvine 92697 4540, USA
    Neurobiol Dis 39:301-10. 2010
  3. doi request reprint A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:3555-66. 2008
  4. pmc Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model
    Masashi Kitazawa
    Department of Neurobiology and Behavior and Neurology, University of California, Irvine, California 92697 4545, USA
    J Neurosci 29:6132-41. 2009
  5. doi request reprint Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:12163-75. 2008
  6. doi request reprint Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
    Masashi Kitazawa
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:6539-49. 2011
  7. pmc An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
    Kwang Mook Jung
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697 4625, USA
    Neurobiol Aging 33:1522-32. 2012
  8. doi request reprint Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
    Anna Parachikova
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697 4545, USA
    J Alzheimers Dis 21:527-42. 2010
  9. ncbi request reprint Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Vaccine 24:2824-34. 2006
  10. ncbi request reprint Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle
    Vitaly Vasilevko
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    CNS Neurol Disord Drug Targets 8:98-113. 2009

Detail Information

Publications14

  1. pmc Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    J Neuroinflammation 5:42. 2008
    ..In the current study, we tested the efficacy of this vaccine configuration in amyloid precursor protein (APP) transgenic mice (Tg2576)...
  2. pmc Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
    Vitaly Vasilevko
    The Institute for Memory Impairments and Neurological Disorders, University of California, Irvine 92697 4540, USA
    Neurobiol Dis 39:301-10. 2010
    ..Our findings indicate that prolonged immunization results in distinctive temporal changes in antibody profiles, which may be important for other experimental and clinical settings...
  3. doi request reprint A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:3555-66. 2008
    ..Alternatively, clearing preexisting Abeta from the brain in a treatment study may be more efficacious for cognition if combined with a second intervention that restores neuron health...
  4. pmc Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model
    Masashi Kitazawa
    Department of Neurobiology and Behavior and Neurology, University of California, Irvine, California 92697 4545, USA
    J Neurosci 29:6132-41. 2009
    ..These findings provide support for the hypothesis that Abeta is one of the key pathogenic components in IBM pathology and subsequent skeletal muscle degeneration...
  5. doi request reprint Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:12163-75. 2008
    ..These data highlight the critical role CHIP plays as a link between Abeta and tau and identify CHIP as a new potential target not only for AD but for other neurodegenerative disorders characterized by tau accumulation...
  6. doi request reprint Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model
    Masashi Kitazawa
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:6539-49. 2011
    ..Taken together, our results suggest that the IL-1 signaling cascade may be involved in one of the key disease mechanisms for AD...
  7. pmc An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
    Kwang Mook Jung
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697 4625, USA
    Neurobiol Aging 33:1522-32. 2012
    ..The results suggest that an Aβ(42)-dependent impairment in brain anandamide mobilization contributes to cognitive dysfunction in AD...
  8. doi request reprint Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
    Anna Parachikova
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697 4545, USA
    J Alzheimers Dis 21:527-42. 2010
    ....
  9. ncbi request reprint Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Vaccine 24:2824-34. 2006
    ..A nonsignificant increase in CSF Abeta(1-40) and decrease in Abeta(1-40/1-42) in cortex was detected. Canines may be a useful system for testing an Abeta vaccine...
  10. ncbi request reprint Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle
    Vitaly Vasilevko
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    CNS Neurol Disord Drug Targets 8:98-113. 2009
    ..We propose that the canine model complements existing animal models and will be helpful in developing new vaccine approaches to slowing or preventing Abeta pathology that can be translated to human clinical trials...
  11. pmc Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy
    Vitaly Vasilevko
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1207:58-70. 2010
    ..Thus, there is a critical need for new strategies that improve BBB function and limit the development of β-amyloidosis in the cerebral vasculature...
  12. pmc The Bradykinin B1 Receptor Regulates Aβ Deposition and Neuroinflammation in Tg-SwDI Mice
    Giselle F Passos
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California Electronic address
    Am J Pathol 182:1740-9. 2013
    ..Therefore, the modulation of the receptor may represent a novel therapeutic approach for AD...
  13. ncbi request reprint Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice
    Vitaly Vasilevko
    The Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 27:13376-83. 2007
    ..Thus, approaches that deliver immunotherapy to the brain may be more effective at clearing Abeta than immunization strategies in which the majority of the antibodies are in the periphery...
  14. ncbi request reprint Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    Salvatore Oddo
    Departments of Neurobiology and Behavior and Neurology, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697, USA
    J Biol Chem 281:39413-23. 2006
    ..Notably, reducing soluble Abeta alone did not improve the cognitive phenotype in mice with plaques and NFTs. Our results show that Abeta immunotherapy reduces soluble tau and ameliorates behavioral deficit in old transgenic mice...