SHAMBHU VARMA

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Inhibition of selenite-induced cataract by caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine Baltimore, 21201, USA
    Acta Ophthalmol 88:e245-9. 2010
  2. pmc Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma
    Peeyush Chandra
    Chandra Eye Research Institute, Allahabad, UP, India
    Clin Ophthalmol 5:1623-9. 2011
  3. pmc Prevention of cataract in diabetic mice by topical pyruvate
    Kr Hegde
    Ophthalmology and Visual Sciences
    Clin Ophthalmol 5:1141-5. 2011
  4. pmc Protective effect of caffeine against high sugar-induced transcription of microRNAs and consequent gene silencing: a study using lenses of galactosemic mice
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 19:493-500. 2013
  5. pmc Effect of high sugar levels on miRNA expression. Studies with galactosemic mice lenses
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Vis 18:1609-18. 2012
  6. pmc Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eye Contact Lens 37:233-45. 2011
  7. pmc Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 16:2626-33. 2010
  8. pmc Oxidative stress in lens in vivo: inhibitory effect of caffeine. A preliminary report
    S D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 16:501-5. 2010
  9. ncbi request reprint Kynurenine-induced photo oxidative damage to lens in vitro: protective effect of caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Biochem 340:49-54. 2010
  10. pmc Prevention of oxidative damage to lens by caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Ocul Pharmacol Ther 26:73-7. 2010

Research Grants

  1. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1993
  2. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2007
  3. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2001
  4. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2002
  5. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2003
  6. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2004
  7. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2005
  8. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2006
  9. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2009
  10. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1992

Collaborators

  • Kavita R Hegde
  • Peeyush Chandra
  • Kr Hegde
  • S Kovtun
  • Ajit Gaur
  • Svitlana Kovtun

Detail Information

Publications15

  1. pmc Inhibition of selenite-induced cataract by caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine Baltimore, 21201, USA
    Acta Ophthalmol 88:e245-9. 2010
    ..The objective of the investigation was to study possible inhibition of oxidative stress and cataract formation by caffeine in vivo...
  2. pmc Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma
    Peeyush Chandra
    Chandra Eye Research Institute, Allahabad, UP, India
    Clin Ophthalmol 5:1623-9. 2011
    ..The objective of this study was to determine if this represents a direct caffeine effect. This study was therefore done using pure caffeine applied directly to the eyes...
  3. pmc Prevention of cataract in diabetic mice by topical pyruvate
    Kr Hegde
    Ophthalmology and Visual Sciences
    Clin Ophthalmol 5:1141-5. 2011
    ..With a view to exploring the clinical usefulness of these findings, this study examined its preventive effect when administered topically as an eye drop...
  4. pmc Protective effect of caffeine against high sugar-induced transcription of microRNAs and consequent gene silencing: a study using lenses of galactosemic mice
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 19:493-500. 2013
    ..The objective of this study was to investigate if this protective effect is reflected in the attenuation of the transcription of microRNAs (miRNAs) known to induce apoptosis and cell death by gene silencing...
  5. pmc Effect of high sugar levels on miRNA expression. Studies with galactosemic mice lenses
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Vis 18:1609-18. 2012
    ..In addition, it was intended to investigate if such expression could be antagonized by reactive oxygen species (ROS) scavengers...
  6. pmc Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eye Contact Lens 37:233-45. 2011
    ....
  7. pmc Effectiveness of topical caffeine in cataract prevention: studies with galactose cataract
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 16:2626-33. 2010
    ..It was hypothesized that caffeine will do so by acting as scavenger of reactive oxygen species known to be generated under hyperglycemic conditions...
  8. pmc Oxidative stress in lens in vivo: inhibitory effect of caffeine. A preliminary report
    S D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Vis 16:501-5. 2010
    ..Experiments have been conducted to study the hypothesis that caffeine would inhibit reactive oxygen species induced oxidative stress in the lens in vivo, with implications of attenuating or preventing cataract formation...
  9. ncbi request reprint Kynurenine-induced photo oxidative damage to lens in vitro: protective effect of caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Biochem 340:49-54. 2010
    ..Further studies on the pharmacological significance of the findings are hence in progress...
  10. pmc Prevention of oxidative damage to lens by caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Ocul Pharmacol Ther 26:73-7. 2010
    ..The primary objective of this study was to examine the possibility of inhibiting oxidative damage to the lens in vitro by caffeine...
  11. pmc UV-B-induced damage to the lens in vitro: prevention by caffeine
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Ocul Pharmacol Ther 24:439-44. 2008
    ..The addition of caffeine to the medium prevented such deleterious effects. That caffeine and perhaps other xanthinoids have a protective effect against cataract formation induced by UV has hence been demonstrated for the first time...
  12. ncbi request reprint Induction of ultraviolet cataracts in vitro: prevention by pyruvate
    Kavita R Hegde
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Ocul Pharmacol Ther 23:492-502. 2007
    ..Hence, further studies on the possible protective effects of such alpha-keto acids against UV damage are in progress...
  13. ncbi request reprint Susceptibility of the ocular lens to nitric oxide: implications in cataractogenesis
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Ocul Pharmacol Ther 23:188-95. 2007
    ..The results, therefore, were highly suggestive of a contribution of the oxides of nitrogen in cataract formation associated with diabetes and other aging diseases...
  14. doi request reprint Prevention of oxidative stress to the retina by pyruvate. A preliminary report
    Kavita R Hegde
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ophthalmologica 222:194-8. 2008
    ....
  15. ncbi request reprint Lens thiol depletion by peroxynitrite. Protective effect of pyruvate
    Shambhu D Varma
    Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, MSTF, 5 00A, 10 South Pine Street, Baltimore, MD 21201, USA
    Mol Cell Biochem 298:199-204. 2007
    ..The findings therefore appear potentially useful to protect against nitrite induced damage to the lens and other tissues known to occur with aging and certain diseases such as diabetes...

Research Grants25

  1. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1993
    ..The monkey's aqueous humor will be analyzed for ascorbate and amino acid contents as a function of age...
  2. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2007
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  3. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2001
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  4. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2002
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  5. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2003
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  6. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2004
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  7. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2005
    ..Hypothesis #5 will be verified by the relative activity of the keto acids in scavenging ROS, and their effectiveness in preventing lens damage in culture, as indexed by the cation pump activity, and the above biochemical parameters. ..
  8. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2006
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  9. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 2009
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..
  10. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1992
    ..The monkey's aqueous humor will be analyzed for ascorbate and amino acid contents as a function of age...
  11. OXIDATIVE STRESS ON THE OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1991
    ..The monkey's aqueous humor will be analyzed for ascorbate and amino acid contents as a function of age...
  12. OXIDATIVE STRESS AND CATARACT FORMATION
    SHAMBHU VARMA; Fiscal Year: 1999
    ..5. Study the prevention of such glycation by these compounds in vivo in diabetic and galactosemic animals. ..
  13. OXIDATIVE STRESS ON OCULAR LENS
    SHAMBHU VARMA; Fiscal Year: 1990
    ..The monkey's aqueous humor will be analyzed for ascorbate and amino acid contents as a function of age...
  14. OXIDATIVE STRESS AND CATARACT FORMATION
    Shambhu D Varma; Fiscal Year: 2010
    ..Along with monitoring inhibition of lens opacification, mechanism of action of EP will be ascertained at the levels of morphology, histology, tissue metabolism and apoptotic changes. ..