Research Topics
| STEVEN VARGASummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
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Detail Information
Publications
Bioenergetics of murine lungs infected with respiratory syncytial virusAhmed R Alsuwaidi
Departments of Pediatrics, College of Medicine and Health Sciences, UAE University, P, O, Box 17666, Al Ain, United Arab Emirates
Virol J 10:22. 2013..The status of cellular mitochondrial O2 consumption of the lung in pulmonary RSV infection is unknown...
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virusElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
J Virol 82:2196-207. 2008..These data demonstrate that IFN-gamma can have both beneficial and detrimental effects during a secondary RSV infection...- The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophiliaMatthew R Olson
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 181:7958-68. 2008..Taken together, these results indicate that RSV-specific memory CD8 T cells may alter the trafficking of Th2 cells and eosinophils into the lung... - Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced diseaseElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 181:6692-6. 2008..Our results have important implications for future RSV vaccine design, suggesting that enhancing a Th1 response may exacerbate disease... 
IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced diseaseElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
J Immunol 180:2376-84. 2008....- Understanding respiratory syncytial virus (RSV) vaccine-enhanced diseaseElaine M Castilow
Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 532 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
Immunol Res 39:225-39. 2007..Information gained from the animal models will provide important information and novel approaches for the rational design of a safe and efficacious RSV vaccine... - CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced diseaseMatthew R Olson
Department of Microbiology, University of Iowa, IA 52242, USA
J Immunol 179:5415-24. 2007..Our results suggest that the failure of the FI-RSV vaccine to induce a CD8 T cell response may have contributed to the development of pulmonary eosinophilia and augmented disease that occurred in vaccinated individuals... - Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infectionRoss B Fulton
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 185:2382-92. 2010.... - Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced diseaseMatthew R Olson
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 182:3024-31. 2009..Taken together, these data identify a previously undefined role for FasL in the accumulation of secondary effector CD4 T cells and the development of RSV vaccine-enhanced disease... - Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replicationDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J, Iowa City, IA 52242, USA
J Biol Chem 285:24023-31. 2010..The result is limited phosphorylation of eIF2alpha and continued translation of cellular and viral proteins... - Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replicationDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 41:189-98. 2009..Cigarette smoke causes necrosis rather than apoptosis in viral infection, resulting in increased inflammation and enhanced viral replication... - Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation modelDavid K Meyerholz
Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
Toxicol Pathol 37:249-55. 2009..For multiple parameters such as eosinophil detection, specificity, and contrast with background tissues, the Sirius Red followed by Congo Red and Modified Hematoxylin and Eosin methods were useful, each with their own staining qualities... - Pulmonary immunity and immunopathology: lessons from respiratory syncytial virusMatthew R Olson
Department of Microbiology, Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3 532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
Expert Rev Vaccines 7:1239-55. 2008..Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design... - Regulation of cytokine production by virus-specific CD8 T cells in the lungsRoss B Fulton
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Virol 82:7799-811. 2008..Our results suggest that the regulation of T-cell cytokine production by peripheral tissues may serve as an important mechanism to prevent immunopathology and preserve normal tissue function... - Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cellsDayna J Groskreutz
Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Pharmacology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
J Immunol 179:2741-7. 2007..These findings reveal that RSV decreases p53 by enhancing Akt/Mdm2-mediated p53 degradation, thereby delaying apoptosis and prolonging survival of airway epithelial cells... - Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17Martha M Monick
Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
J Immunol 179:1648-58. 2007..These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung... - T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hostsAaruni Khanolkar
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Immunol 185:1132-41. 2010..Thus, identification of novel CD4 and CD8 T cell epitopes for MHV-1 permitted high-resolution analyses of pulmonary T cell responses in a mouse model of SARS... - Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transductionMurali Ramaswamy
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Virology 344:328-39. 2006..Taken together, our results indicate that NS2 regulates Stat2 levels during RSV infection, thereby modulating viral effects on interferon-dependent gene expression... - Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndromeAaruni Khanolkar
Department of Microbiology, University of Iowa, Iowa City, 52242, USA
J Virol 83:9258-72. 2009..Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease... - Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H miceAaruni Khanolkar
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
J Virol 83:8946-56. 2009..C3H/HeJ mice exhibit enhanced morbidity and mortality following i.n. MHV-1 infection compared to wild-type C3H/HeN mice. Our results indicate that TLR4 plays an important role in respiratory CoV pathogenesis... - In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptorJodie S Haring
Department of Microbiology, University of Iowa, Iowa City 52242, USA
J Immunol 175:3117-22. 2005..Thus, both chains of the IFN-gammaR are dispensable for the generation of Th1 Ag-specific CD4 T cells after infection in vivo... - Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSVTeresa R Johnson
Vaccine Research Center, NIAID, NIH, Bldg 40, Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
J Virol 78:8753-60. 2004.... - Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infectionErika L Wissinger
The Carter Immunology Center, Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
J Immunol 180:2957-66. 2008.... - RSV-induced immunopathology: dynamic interplay between the virus and host immune responseSteven M Varga
Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
Virology 295:203-7. 2002 - Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of miceSteven M Varga
Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Immunol Methods 262:111-20. 2002....
Research Grants
- Immunopathology mediated by RSV-specific CD4 T cellsSteven M Varga; Fiscal Year: 2010..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..
- Immunopathology mediated by RSV-specific CD4 T cellsSTEVEN VARGA; Fiscal Year: 2009..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..