STEVEN VARGA

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection
    Stacey M Hartwig
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 9:e90720. 2014
  2. pmc The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 8:e1003054. 2012
  3. doi request reprint The adaptive immune response to respiratory syncytial virus
    Steven M Varga
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA
    Curr Top Microbiol Immunol 372:155-71. 2013
  4. pmc Lung tissue bioenergetics and caspase activity in rodents
    Ahmed R Alsuwaidi
    Department of Pediatrics, United Arab Emirates University, Al Ain, UAE
    BMC Res Notes 6:12. 2013
  5. pmc Bioenergetics of murine lungs infected with respiratory syncytial virus
    Ahmed R Alsuwaidi
    Departments of Pediatrics, College of Medicine and Health Sciences, UAE University, P, O, Box 17666, Al Ain, United Arab Emirates
    Virol J 10:22. 2013
  6. pmc Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:2196-207. 2008
  7. pmc The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:7958-68. 2008
  8. pmc Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:6692-6. 2008
  9. ncbi request reprint IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2376-84. 2008
  10. ncbi request reprint Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 532 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Immunol Res 39:225-39. 2007

Research Grants

Collaborators

Detail Information

Publications29

  1. pmc Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection
    Stacey M Hartwig
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 9:e90720. 2014
    ..Our results indicate that AM play a critical role in modulating MHV-1-induced morbidity and mortality. ..
  2. pmc The initial draining lymph node primes the bulk of the CD8 T cell response and influences memory T cell trafficking after a systemic viral infection
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS Pathog 8:e1003054. 2012
    ..Our results indicate that CD62L(-) effector memory CD8 T cells are granted preferential access into the draining lymph nodes for an extended time following resolution of an infection...
  3. doi request reprint The adaptive immune response to respiratory syncytial virus
    Steven M Varga
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA
    Curr Top Microbiol Immunol 372:155-71. 2013
    ..In this review, we summarize our current understanding of the adaptive immune response to RSV and its contribution to disease. ..
  4. pmc Lung tissue bioenergetics and caspase activity in rodents
    Ahmed R Alsuwaidi
    Department of Pediatrics, United Arab Emirates University, Al Ain, UAE
    BMC Res Notes 6:12. 2013
    ..Lung histology and immunostaining with anti-cleaved caspase-3 antibody were also performed...
  5. pmc Bioenergetics of murine lungs infected with respiratory syncytial virus
    Ahmed R Alsuwaidi
    Departments of Pediatrics, College of Medicine and Health Sciences, UAE University, P, O, Box 17666, Al Ain, United Arab Emirates
    Virol J 10:22. 2013
    ..The status of cellular mitochondrial O(2) consumption of the lung in pulmonary RSV infection is unknown...
  6. pmc Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:2196-207. 2008
    ..These data demonstrate that IFN-gamma can have both beneficial and detrimental effects during a secondary RSV infection...
  7. pmc The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:7958-68. 2008
    ..Taken together, these results indicate that RSV-specific memory CD8 T cells may alter the trafficking of Th2 cells and eosinophils into the lung...
  8. pmc Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 181:6692-6. 2008
    ..Our results have important implications for future RSV vaccine design, suggesting that enhancing a Th1 response may exacerbate disease...
  9. ncbi request reprint IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2376-84. 2008
    ....
  10. ncbi request reprint Understanding respiratory syncytial virus (RSV) vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 3 532 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
    Immunol Res 39:225-39. 2007
    ..Information gained from the animal models will provide important information and novel approaches for the rational design of a safe and efficacious RSV vaccine...
  11. ncbi request reprint CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease
    Matthew R Olson
    Department of Microbiology, University of Iowa, IA 52242, USA
    J Immunol 179:5415-24. 2007
    ..Our results suggest that the failure of the FI-RSV vaccine to induce a CD8 T cell response may have contributed to the development of pulmonary eosinophilia and augmented disease that occurred in vaccinated individuals...
  12. pmc Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
    Ross B Fulton
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:2382-92. 2010
    ....
  13. pmc Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced disease
    Matthew R Olson
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 182:3024-31. 2009
    ..Taken together, these data identify a previously undefined role for FasL in the accumulation of secondary effector CD4 T cells and the development of RSV vaccine-enhanced disease...
  14. pmc Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J, Iowa City, IA 52242, USA
    J Biol Chem 285:24023-31. 2010
    ..The result is limited phosphorylation of eIF2alpha and continued translation of cellular and viral proteins...
  15. pmc Comparison of histochemical methods for murine eosinophil detection in an RSV vaccine-enhanced inflammation model
    David K Meyerholz
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Toxicol Pathol 37:249-55. 2009
    ..For multiple parameters such as eosinophil detection, specificity, and contrast with background tissues, the Sirius Red followed by Congo Red and Modified Hematoxylin and Eosin methods were useful, each with their own staining qualities...
  16. pmc Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, 100 EMRB, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 41:189-98. 2009
    ..Cigarette smoke causes necrosis rather than apoptosis in viral infection, resulting in increased inflammation and enhanced viral replication...
  17. pmc Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17
    Martha M Monick
    Department of Internal Medicine, University of Iowa Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    J Immunol 179:1648-58. 2007
    ..These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung...
  18. ncbi request reprint Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells
    Dayna J Groskreutz
    Division of Pulmonary, Critical Care, and Occupational Medicine, Department of Pharmacology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 179:2741-7. 2007
    ..These findings reveal that RSV decreases p53 by enhancing Akt/Mdm2-mediated p53 degradation, thereby delaying apoptosis and prolonging survival of airway epithelial cells...
  19. pmc Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus
    Matthew R Olson
    Department of Microbiology, Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3 532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    Expert Rev Vaccines 7:1239-55. 2008
    ..Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design...
  20. pmc Regulation of cytokine production by virus-specific CD8 T cells in the lungs
    Ross B Fulton
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:7799-811. 2008
    ..Our results suggest that the regulation of T-cell cytokine production by peripheral tissues may serve as an important mechanism to prevent immunopathology and preserve normal tissue function...
  21. pmc T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 185:1132-41. 2010
    ..Thus, identification of novel CD4 and CD8 T cell epitopes for MHV-1 permitted high-resolution analyses of pulmonary T cell responses in a mouse model of SARS...
  22. ncbi request reprint Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction
    Murali Ramaswamy
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Virology 344:328-39. 2006
    ..Taken together, our results indicate that NS2 regulates Stat2 levels during RSV infection, thereby modulating viral effects on interferon-dependent gene expression...
  23. ncbi request reprint In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor
    Jodie S Haring
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Immunol 175:3117-22. 2005
    ..Thus, both chains of the IFN-gammaR are dispensable for the generation of Th1 Ag-specific CD4 T cells after infection in vivo...
  24. pmc Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, Iowa City, 52242, USA
    J Virol 83:9258-72. 2009
    ..Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease...
  25. pmc Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice
    Aaruni Khanolkar
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 83:8946-56. 2009
    ..C3H/HeJ mice exhibit enhanced morbidity and mortality following i.n. MHV-1 infection compared to wild-type C3H/HeN mice. Our results indicate that TLR4 plays an important role in respiratory CoV pathogenesis...
  26. pmc Proliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection
    Erika L Wissinger
    The Carter Immunology Center, Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908, USA
    J Immunol 180:2957-66. 2008
    ....
  27. pmc Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV
    Teresa R Johnson
    Vaccine Research Center, NIAID, NIH, Bldg 40, Room 2614, 40 Convent Dr, MSC 3017, Bethesda, MD 20892 3017, USA
    J Virol 78:8753-60. 2004
    ....
  28. ncbi request reprint RSV-induced immunopathology: dynamic interplay between the virus and host immune response
    Steven M Varga
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Virology 295:203-7. 2002
  29. ncbi request reprint Sensitive detection and quantitation of mouse eosinophils in tissues using an enzymatic eosinophil peroxidase assay: its use to rapidly measure pulmonary eosinophilia during experimental respiratory syncytial virus infection of mice
    Steven M Varga
    Beirne B Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Immunol Methods 262:111-20. 2002
    ....

Research Grants5

  1. Immunopathology mediated by RSV-specific CD4 T cells
    STEVEN VARGA; Fiscal Year: 2007
    ..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..
  2. Immunopathology mediated by RSV-specific CD4 T cells
    STEVEN VARGA; Fiscal Year: 2009
    ..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..
  3. Immunopathology mediated by RSV-specific CD4 T cells
    Steven M Varga; Fiscal Year: 2010
    ..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..
  4. Immunopathology mediated by RSV-specific CD4 T cells
    STEVEN VARGA; Fiscal Year: 2009
    ..The studies in this proposal are designed to determine the role of RSV-specific memory CD8 T cells in decreasing the severity of CD4 T cell-mediated immunopathology in a model system with direct relevance to human disease. ..