M M Vanyukov

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Drug Alcohol Depend 123:S3-17. 2012
  2. pmc Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability
    Michael M Vanyukov
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA 15261, USA
    Behav Genet 39:233-44. 2009
  3. ncbi The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
  4. ncbi Haplotypes of the monoamine oxidase genes and the risk for substance use disorders
    Michael M Vanyukov
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 125:120-5. 2004
  5. ncbi Liability to substance use disorders: 2. A measurement approach
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Neurosci Biobehav Rev 27:517-26. 2003
  6. ncbi Liability to substance use disorders: 1. Common mechanisms and manifestations
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Neurosci Biobehav Rev 27:507-15. 2003
  7. ncbi Antisociality, substance dependence, and the DRD5 gene: a preliminary study
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet 96:654-8. 2000
  8. ncbi An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, Pennsylvania 15213, USA
    Behav Genet 28:75-82. 1998
  9. ncbi Mating assortment and the liability to substance abuse
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh School of Medicine, PA 15213, USA
    Drug Alcohol Depend 42:1-10. 1996
  10. ncbi Genetic studies of substance abuse
    M M Vanyukov
    Center for Education and Drug Abuse Research, University of Pittsburgh, 3811 O Hara Street, PA 15213, USA
    Drug Alcohol Depend 59:101-23. 2000

Research Grants

  1. Substance Use Disorder Liability: Candidate Gene System
    Michael Vanyukov; Fiscal Year: 2007
  2. Phenogenetics of Liability to Substance Use Disorders
    Michael Vanyukov; Fiscal Year: 2007
  3. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2004

Collaborators

Detail Information

Publications19

  1. pmc Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Drug Alcohol Depend 123:S3-17. 2012
    ..Two competing concepts address the development of involvement with psychoactive substances: the "gateway hypothesis" (GH) and common liability to addiction (CLA)...
  2. pmc Measurement of the risk for substance use disorders: phenotypic and genetic analysis of an index of common liability
    Michael M Vanyukov
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 711 Salk Hall, Pittsburgh, PA 15261, USA
    Behav Genet 39:233-44. 2009
    ..The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk...
  3. ncbi The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene-environment interaction
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 17:323-32. 2007
    ....
  4. ncbi Haplotypes of the monoamine oxidase genes and the risk for substance use disorders
    Michael M Vanyukov
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet B Neuropsychiatr Genet 125:120-5. 2004
    ..Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems...
  5. ncbi Liability to substance use disorders: 2. A measurement approach
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Neurosci Biobehav Rev 27:517-26. 2003
    ..This method is also applicable to measuring liabilities to other complex disorders, especially those with relatively late onset...
  6. ncbi Liability to substance use disorders: 1. Common mechanisms and manifestations
    Michael M Vanyukov
    Department of Pharmaceutical Sciences, Center for Education and Drug Abuse Research, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Neurosci Biobehav Rev 27:507-15. 2003
    ..An accompanying paper describes an approach to the quantitative estimation of this trait...
  7. ncbi Antisociality, substance dependence, and the DRD5 gene: a preliminary study
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet 96:654-8. 2000
    ..The data suggest involvement of the DRD5 locus in the variation and sexual dimorphism of SD liability and antisociality and in the developmental continuity of antisociality...
  8. ncbi An association between a microsatellite polymorphism at the DRD5 gene and the liability to substance abuse: pilot study
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, Pennsylvania 15213, USA
    Behav Genet 28:75-82. 1998
    ..The data suggest that the DRD5 locus is involved in the variation and sex dimorphism of substance abuse liability...
  9. ncbi Mating assortment and the liability to substance abuse
    M M Vanyukov
    Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh School of Medicine, PA 15213, USA
    Drug Alcohol Depend 42:1-10. 1996
    ..This paper reviews the theoretical and empirical literature on mechanisms related to mate resemblance for the liability to substance abuse, sources and consequences of such resemblance, and suggests directions for further research...
  10. ncbi Genetic studies of substance abuse
    M M Vanyukov
    Center for Education and Drug Abuse Research, University of Pittsburgh, 3811 O Hara Street, PA 15213, USA
    Drug Alcohol Depend 59:101-23. 2000
    ..This paper reviews the concepts, methods and results pertaining to genetic investigation of substance abuse...
  11. ncbi Preadolescent children of substance-dependent fathers with antisocial personality disorder: psychiatric disorders and problem behaviors
    H B Moss
    Department of Psychiatry, Temple University School of Medicine, Philadelphia, PA, USA
    Am J Addict 10:269-78. 2001
    ..The results suggest that SD+/ASP+ children are at significant risk for internalizing and externalizing psychopathology...
  12. ncbi A dinucleotide repeat polymorphism at the gene for monoamine oxidase A and measures of aggressiveness
    M M Vanyukov
    Pittsburgh Adolescent Alcohol Research Center PAARC, PA 15213 2593, USA
    Psychiatry Res 59:35-41. 1995
    ..Alternative explanations of this trend are discussed. The data obtained suggest that the polymorphism studied is not associated with the variation in aggressiveness...
  13. pmc Dopamine receptors in human lymphocytes: radioligand binding and quantitative RT-PCR assays
    Galina P Kirillova
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Neurosci Methods 174:272-80. 2008
    ..The expression levels were comparable with those in the brain for DRD3 and DRD4, and were significantly lower for DRD2 and DRD5...
  14. ncbi Social dominance mediates the association of testosterone and neurobehavioral disinhibition with risk for substance use disorder
    Ralph E Tarter
    Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15261, USA
    Psychol Addict Behav 21:462-8. 2007
    ..In addition, SD/NVB mediated the association between ND and SUD. These findings suggest that development of SUD is influenced by androgen-dependent and neurobehavioral processes via a social motivational style characterized by SD/NVB...
  15. ncbi Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis
    Brion S Maher
    Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Psychiatr Genet 12:207-15. 2002
    ..Overall, the meta-analyses support the involvement of the dopamine system genes in ADHD liability variation and suggest the need for studies examining interactions between these genes...
  16. pmc Physical maturation, peer environment, and the ontogenesis of substance use disorders
    Galina P Kirillova
    Center for Education and Drug Abuse Research, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    Psychiatry Res 158:43-53. 2008
    ..The data support the hypothesis that parental SUD liability influences the rate of physiological maturation in offspring, which in turn is related to affiliation with deviant peers and an elevated rate of the development of CD and SUD...
  17. ncbi Pittsburgh Registry of Infant Multiplets (PRIM): an update
    Elizabeth A Jenkins
    Department of Human Genetics, University of Pittsburgh, 707 Salk Hall, Pittsburgh, PA 15261, USA
    Twin Res Hum Genet 9:1006-8. 2006
    ..Pilot data on the heritability of minor physical anomalies and neuropsychological characteristics (Continuous Performance Test) are reported...
  18. ncbi Quantitative trait linkage analysis of the liability underlying a common oligogenic disease
    B S Maher
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    Genet Epidemiol 21:S720-5. 2001
    ....
  19. ncbi Does adverse family environment or sex matter in the salivary cortisol responses to anticipatory stress?
    Thomas L Hardie
    University of Delaware, Department of Nursing, Room 361, McDowell Hall, Newark 19716, USA
    Psychiatry Res 112:121-31. 2002
    ..These results suggest that there may be a sex difference in salivary cortisol dynamics in preadolescent children; however, the functional status of the current family environment does not appear to be related to cortisol reactivity...

Research Grants15

  1. Substance Use Disorder Liability: Candidate Gene System
    Michael Vanyukov; Fiscal Year: 2007
    ..abstract_text> ..
  2. Phenogenetics of Liability to Substance Use Disorders
    Michael Vanyukov; Fiscal Year: 2007
    ..The applicant is the Center's Co-Pi and Scientific Director as well as PI of the CGS project. ..
  3. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2004
    ..The results will allow for more accurate estimation of the risk for SUD and suggest approaches for prevention. ..