Carin K Vanderpool

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. pmc The novel transcription factor SgrR coordinates the response to glucose-phosphate stress
    Carin K Vanderpool
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Bacteriol 189:2238-48. 2007
  2. ncbi request reprint Physiological consequences of small RNA-mediated regulation of glucose-phosphate stress
    Carin K Vanderpool
    Department of Microbiology, University of Illinois at Urbana Champaign B213, Chemical and Life Sciences Laboratories CLSL, MC 110 Urbana, IL 61801, USA
    Curr Opin Microbiol 10:146-51. 2007
  3. ncbi request reprint Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system
    Carin K Vanderpool
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Microbiol 54:1076-89. 2004
  4. pmc Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA
    Jennifer B Rice
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 109:E2691-8. 2012
  5. pmc The small RNA SgrS controls sugar-phosphate accumulation by regulating multiple PTS genes
    Jennifer B Rice
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 39:3806-19. 2011
  6. pmc Characterization of homologs of the small RNA SgrS reveals diversity in function
    Caryn S Wadler
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 37:5477-85. 2009
  7. pmc A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptide
    Caryn S Wadler
    Department of Microbiology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:20454-9. 2007
  8. pmc Induction of the Pho regulon suppresses the growth defect of an Escherichia coli sgrS mutant, connecting phosphate metabolism to the glucose-phosphate stress response
    Gregory R Richards
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    J Bacteriol 194:2520-30. 2012
  9. pmc Homologs of the small RNA SgrS are broadly distributed in enteric bacteria but have diverged in size and sequence
    Richard S P Horler
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 37:5465-76. 2009
  10. pmc Effect of RyhB small RNA on global iron use in Escherichia coli
    Eric Massé
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 187:6962-71. 2005

Collaborators

Detail Information

Publications18

  1. pmc The novel transcription factor SgrR coordinates the response to glucose-phosphate stress
    Carin K Vanderpool
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Bacteriol 189:2238-48. 2007
    ..Clones containing mlc, which encodes a glucose-specific repressor protein, also downregulate P(sgrS)-lacZ. The mlc clones do not appear to titrate the SgrR protein, indicating that Mlc affects sgrS expression by an alternative mechanism...
  2. ncbi request reprint Physiological consequences of small RNA-mediated regulation of glucose-phosphate stress
    Carin K Vanderpool
    Department of Microbiology, University of Illinois at Urbana Champaign B213, Chemical and Life Sciences Laboratories CLSL, MC 110 Urbana, IL 61801, USA
    Curr Opin Microbiol 10:146-51. 2007
    ..The current model is that SgrS promotes recovery by stopping the synthesis of glucose transport proteins, which in turn limits the accumulation of toxic sugar-phosphates...
  3. ncbi request reprint Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system
    Carin K Vanderpool
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Microbiol 54:1076-89. 2004
    ..Decreased ptsG mRNA results in decreased production of glucose transport machinery, thus limiting further accumulation of glucose phosphate...
  4. pmc Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNA
    Jennifer B Rice
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 109:E2691-8. 2012
    ..Moreover, use of multiple binding sites may be particularly important for coordinating regulation of multiple genes encoded in operons...
  5. pmc The small RNA SgrS controls sugar-phosphate accumulation by regulating multiple PTS genes
    Jennifer B Rice
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 39:3806-19. 2011
    ..A ptsG manXYZ double mutant is resistant to the stress, indicating that PTS transporters encoded by both SgrS targets are involved in taking up substrates that cause stress...
  6. pmc Characterization of homologs of the small RNA SgrS reveals diversity in function
    Caryn S Wadler
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 37:5477-85. 2009
    ..Genetic evidence suggests that a secondary structure in the E. coli SgrS 5' region inhibits sgrT translation. This structure is not present in S. typhimurium SgrS, which explains its higher level of SgrT production...
  7. pmc A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptide
    Caryn S Wadler
    Department of Microbiology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:20454-9. 2007
    ....
  8. pmc Induction of the Pho regulon suppresses the growth defect of an Escherichia coli sgrS mutant, connecting phosphate metabolism to the glucose-phosphate stress response
    Gregory R Richards
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    J Bacteriol 194:2520-30. 2012
    ..Altogether, this work describes one of the first studies of glucose-phosphate stress physiology and suggests a novel connection of carbon and phosphate metabolism...
  9. pmc Homologs of the small RNA SgrS are broadly distributed in enteric bacteria but have diverged in size and sequence
    Richard S P Horler
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nucleic Acids Res 37:5465-76. 2009
    ..The identification of this set of homologous sRNAs and their targets sets the stage for future studies to further elucidate the molecular requirements for regulation by SgrS...
  10. pmc Effect of RyhB small RNA on global iron use in Escherichia coli
    Eric Massé
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Bacteriol 187:6962-71. 2005
    ..Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis...
  11. doi request reprint Combined experimental and computational strategies define an expansive regulon for GcvB small RNA
    Carin K Vanderpool
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Microbiol 81:1129-32. 2011
    ..Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date...
  12. pmc Heme transport contributes to in vivo fitness of Bordetella pertussis during primary infection in mice
    Timothy J Brickman
    Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
    Infect Immun 74:1741-4. 2006
    ..pertussis in the mouse infection model and indicate that heme utilization may be most important for adaptation to host conditions existing during the later stages of infection...
  13. pmc Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stress
    Yan Sun
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Bacteriol 193:143-53. 2011
    ....
  14. ncbi request reprint Bacterial small RNA regulators
    Nadim Majdalani
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Crit Rev Biochem Mol Biol 40:93-113. 2005
    ..Homologs of CsrA and related regulatory RNAs have been implicated in the regulation of gluconeogenesis, biofilm formation,and virulence factor expression in plant and human pathogens...
  15. pmc Dual-function RNA regulators in bacteria
    Carin K Vanderpool
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Biochimie 93:1943-9. 2011
    ....
  16. pmc Molecular call and response: the physiology of bacterial small RNAs
    Gregory R Richards
    Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
    Biochim Biophys Acta 1809:525-31. 2011
    ..We highlight sRNAs involved in regulation of the processes of iron homeostasis (RyhB, PrrF, and FsrA) and carbon metabolism (Spot 42, CyaR, and SgrS)...
  17. pmc Integration of environmental signals controls expression of Bordetella heme utilization genes
    Carin K Vanderpool
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 0312, USA
    J Bacteriol 186:938-48. 2004
    ....
  18. ncbi request reprint Noncoding RNAs at the membrane
    Carin K Vanderpool
    Nat Struct Mol Biol 12:285-6. 2005

Research Grants1

  1. Analysis of the Molecular Determinants of Regulatory Hierarchy of a Bacterial Sma
    Carin K Vanderpool; Fiscal Year: 2010
    ..Studies of SgrS in particular are important since SgrS is the first member of a novel class of bifunctional sRNA regulators and therefore serves as a model for other similar sRNAs that will be identified in the future. ..