Research Topics
| Carin K VanderpoolSummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
The novel transcription factor SgrR coordinates the response to glucose-phosphate stressCarin K Vanderpool
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
J Bacteriol 189:2238-48. 2007..Clones containing mlc, which encodes a glucose-specific repressor protein, also downregulate P(sgrS)-lacZ. The mlc clones do not appear to titrate the SgrR protein, indicating that Mlc affects sgrS expression by an alternative mechanism...
Physiological consequences of small RNA-mediated regulation of glucose-phosphate stressCarin K Vanderpool
Department of Microbiology, University of Illinois at Urbana Champaign B213, Chemical and Life Sciences Laboratories CLSL, MC 110 Urbana, IL 61801, USA
Curr Opin Microbiol 10:146-51. 2007..The current model is that SgrS promotes recovery by stopping the synthesis of glucose transport proteins, which in turn limits the accumulation of toxic sugar-phosphates...- Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase systemCarin K Vanderpool
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Mol Microbiol 54:1076-89. 2004..Decreased ptsG mRNA results in decreased production of glucose transport machinery, thus limiting further accumulation of glucose phosphate... - The small RNA SgrS controls sugar-phosphate accumulation by regulating multiple PTS genesJennifer B Rice
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Nucleic Acids Res 39:3806-19. 2011..A ptsG manXYZ double mutant is resistant to the stress, indicating that PTS transporters encoded by both SgrS targets are involved in taking up substrates that cause stress... - Characterization of homologs of the small RNA SgrS reveals diversity in functionCaryn S Wadler
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Nucleic Acids Res 37:5477-85. 2009..Genetic evidence suggests that a secondary structure in the E. coli SgrS 5' region inhibits sgrT translation. This structure is not present in S. typhimurium SgrS, which explains its higher level of SgrT production... - A dual function for a bacterial small RNA: SgrS performs base pairing-dependent regulation and encodes a functional polypeptideCaryn S Wadler
Department of Microbiology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 104:20454-9. 2007.... - Small RNA binding-site multiplicity involved in translational regulation of a polycistronic mRNAJennifer B Rice
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 109:E2691-8. 2012..Moreover, use of multiple binding sites may be particularly important for coordinating regulation of multiple genes encoded in operons... - Induction of the Pho regulon suppresses the growth defect of an Escherichia coli sgrS mutant, connecting phosphate metabolism to the glucose-phosphate stress responseGregory R Richards
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
J Bacteriol 194:2520-30. 2012..Altogether, this work describes one of the first studies of glucose-phosphate stress physiology and suggests a novel connection of carbon and phosphate metabolism... - Homologs of the small RNA SgrS are broadly distributed in enteric bacteria but have diverged in size and sequenceRichard S P Horler
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Nucleic Acids Res 37:5465-76. 2009..The identification of this set of homologous sRNAs and their targets sets the stage for future studies to further elucidate the molecular requirements for regulation by SgrS... - Effect of RyhB small RNA on global iron use in Escherichia coliEric Massé
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Bacteriol 187:6962-71. 2005..Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis... 
Combined experimental and computational strategies define an expansive regulon for GcvB small RNACarin K Vanderpool
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Mol Microbiol 81:1129-32. 2011..Using a unique combination of experimental and biocomputational approaches, the authors triple the size of the GcvB regulon, making it the largest sRNA regulon defined to date...- Heme transport contributes to in vivo fitness of Bordetella pertussis during primary infection in miceTimothy J Brickman
Department of Microbiology, University of Minnesota, MMC 196, 420 Delaware Street S E, Minneapolis, MN 55455 0312, USA
Infect Immun 74:1741-4. 2006..pertussis in the mouse infection model and indicate that heme utilization may be most important for adaptation to host conditions existing during the later stages of infection... - Regulation and function of Escherichia coli sugar efflux transporter A (SetA) during glucose-phosphate stressYan Sun
Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Bacteriol 193:143-53. 2011.... - Bacterial small RNA regulatorsNadim Majdalani
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA
Crit Rev Biochem Mol Biol 40:93-113. 2005..Homologs of CsrA and related regulatory RNAs have been implicated in the regulation of gluconeogenesis, biofilm formation,and virulence factor expression in plant and human pathogens... - Dual-function RNA regulators in bacteriaCarin K Vanderpool
Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
Biochimie 93:1943-9. 2011.... - Molecular call and response: the physiology of bacterial small RNAsGregory R Richards
Department of Microbiology, University of Illinois, Urbana, IL 61801, USA
Biochim Biophys Acta 1809:525-31. 2011..We highlight sRNAs involved in regulation of the processes of iron homeostasis (RyhB, PrrF, and FsrA) and carbon metabolism (Spot 42, CyaR, and SgrS)... - Integration of environmental signals controls expression of Bordetella heme utilization genesCarin K Vanderpool
Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455-0312, USA
J Bacteriol 186:938-48. 2004.... - Noncoding RNAs at the membraneCarin K Vanderpool
Nat Struct Mol Biol 12:285-6. 2005
Research Grants
- Analysis of the Molecular Determinants of Regulatory Hierarchy of a Bacterial SmaCarin K Vanderpool; Fiscal Year: 2010..Studies of SgrS in particular are important since SgrS is the first member of a novel class of bifunctional sRNA regulators and therefore serves as a model for other similar sRNAs that will be identified in the future. ..