CRAIG VANDER KOOI

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition
    Matthew W Parker
    Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e49177. 2012
  2. doi Megaprimer method for mutagenesis of DNA
    Craig W Vander Kooi
    Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, KY, USA Electronic address
    Methods Enzymol 529:259-69. 2013
  3. pmc The Prp19 WD40 domain contains a conserved protein interaction region essential for its function
    Craig W Vander Kooi
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Structure 18:584-93. 2010
  4. pmc Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19
    Liping Ren
    Howard Hughes Medical Institute, Vanderbilt University, Nashville, Tennessee, corrected United States of America
    PLoS ONE 6:e16719. 2011
  5. pmc Structural and functional analysis of essential pre-mRNA splicing factor Prp19p
    Melanie D Ohi
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 25:451-60. 2005
  6. ncbi Structural insights into the U-box, a domain associated with multi-ubiquitination
    Melanie D Ohi
    Howard Hughes Medical Institute School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Nat Struct Biol 10:250-5. 2003
  7. pmc The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases
    Craig W Vander Kooi
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:121-30. 2006

Research Grants

  1. Mechanism of Neuropilin Dependent Angiogenesis
    CRAIG VANDER KOOI; Fiscal Year: 2010

Collaborators

  • Walter Chazin
  • Ping Xu
  • Tony R Hazbun
  • Melanie D Ohi
  • Liping Ren
  • Kathleen L Gould
  • Matthew W Parker
  • Joshua A Rosenberg
  • Hou Fu Guo
  • Stanley Fields
  • Janel R McLean
  • Justin P Hirsch
  • Thomas Walz

Detail Information

Publications7

  1. pmc Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition
    Matthew W Parker
    Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e49177. 2012
    ..This establishes that unique mechanisms are used by Nrp receptors to mediate specific ligand binding and that these differences can be exploited to engineer soluble Nrp receptors with specificity for Sema3...
  2. doi Megaprimer method for mutagenesis of DNA
    Craig W Vander Kooi
    Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, KY, USA Electronic address
    Methods Enzymol 529:259-69. 2013
    ..To create mutations in a gene of interest, including point mutations, short insertions, or deletions. ..
  3. pmc The Prp19 WD40 domain contains a conserved protein interaction region essential for its function
    Craig W Vander Kooi
    Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA
    Structure 18:584-93. 2010
    ..Experiments in vitro and in vivo demonstrate that two molecules of Cwc2 bind to the Prp19 tetramer. These coupled structural and functional studies provide a model for the functional architecture of Prp19...
  4. pmc Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19
    Liping Ren
    Howard Hughes Medical Institute, Vanderbilt University, Nashville, Tennessee, corrected United States of America
    PLoS ONE 6:e16719. 2011
    ..Our multi-faceted approach has revealed new low abundance splicing factors connected to NTC function, provides evidence for distinct Prp19 containing complexes, and underscores the role of the Prp19 WD40 domain as a splicing scaffold...
  5. pmc Structural and functional analysis of essential pre-mRNA splicing factor Prp19p
    Melanie D Ohi
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 25:451-60. 2005
    ..These structural and functional data provide a basis for understanding the role of Prp19p as a key architectural component of the NTC...
  6. ncbi Structural insights into the U-box, a domain associated with multi-ubiquitination
    Melanie D Ohi
    Howard Hughes Medical Institute School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Nat Struct Biol 10:250-5. 2003
    ..These comparative structural and functional analyses imply that the U-box and its associated ubiquitin ligase activity are critical for Prp19p function in vivo...
  7. pmc The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases
    Craig W Vander Kooi
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:121-30. 2006
    ....

Research Grants1

  1. Mechanism of Neuropilin Dependent Angiogenesis
    CRAIG VANDER KOOI; Fiscal Year: 2010
    ..Understanding how neuropilin works in the formation of new blood vessels will help us understand how this pathway normally functions and how we can block its activity in tumors and related diseases. ..