Richard van Breemen

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL 60612 7231, USA
    Drug Metab Dispos 32:272-9. 2004
  2. ncbi request reprint Absorption and subcellular localization of lycopene in human prostate cancer cells
    Ang Liu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 South Wood Street, M C 781, Chicago, IL 60612 7231
    Mol Cancer Ther 5:2879-85. 2006
  3. pmc Effects of lycopene on protein expression in human primary prostatic epithelial cells
    Xi Qiu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Cancer Prev Res (Phila) 6:419-27. 2013
  4. ncbi request reprint Ensuring the safety of botanical dietary supplements
    Richard B van Breemen
    University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, L 60612, USA
    Am J Clin Nutr 87:509S-13S. 2008
  5. ncbi request reprint Caco-2 cell permeability assays to measure drug absorption
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Expert Opin Drug Metab Toxicol 1:175-85. 2005
  6. pmc The role of quality assurance and standardization in the safety of botanical dietary supplements
    Richard B van Breemen
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    Chem Res Toxicol 20:577-82. 2007
  7. pmc Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh
    R B van Breemen
    UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, Chicago, Illinois, USA
    Clin Pharmacol Ther 87:219-25. 2010
  8. pmc Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Fitoterapia 82:38-43. 2011
  9. pmc Multitargeted therapy of cancer by lycopene
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Cancer Lett 269:339-51. 2008
  10. ncbi request reprint How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, 60612, USA
    J Nutr 135:2062S-4S. 2005

Research Grants

  1. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
  2. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
  3. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
  4. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
  5. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004

Detail Information

Publications92

  1. ncbi request reprint Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL 60612 7231, USA
    Drug Metab Dispos 32:272-9. 2004
    ..An unusual hydroxy quinone product formed by ipso hydroxylation of the B ring of 8-prenylnaringenin was also detected. This product was probably an intermediate for the B ring cleavage product, 8-prenylchromone...
  2. ncbi request reprint Absorption and subcellular localization of lycopene in human prostate cancer cells
    Ang Liu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 South Wood Street, M C 781, Chicago, IL 60612 7231
    Mol Cancer Ther 5:2879-85. 2006
    ..No lycopene was detected in the cytosol. These data suggest that the rapid uptake of lycopene by LNCaP cells might be facilitated by a receptor or binding protein and that lycopene is stored selectively in the nucleus of LNCaP cells...
  3. pmc Effects of lycopene on protein expression in human primary prostatic epithelial cells
    Xi Qiu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Cancer Prev Res (Phila) 6:419-27. 2013
    ..These data are consistent with previous studies suggesting that lycopene can prevent cancer in human prostatic epithelial cells at the stages of cancer initiation, promotion, and/or progression...
  4. ncbi request reprint Ensuring the safety of botanical dietary supplements
    Richard B van Breemen
    University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, L 60612, USA
    Am J Clin Nutr 87:509S-13S. 2008
    ....
  5. ncbi request reprint Caco-2 cell permeability assays to measure drug absorption
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Expert Opin Drug Metab Toxicol 1:175-85. 2005
    ..Furthermore, LC-MS and LC-MS-MS add another dimension to Caco-2 assays by facilitating the investigation of the metabolism of compounds by Caco-2 cells...
  6. pmc The role of quality assurance and standardization in the safety of botanical dietary supplements
    Richard B van Breemen
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    Chem Res Toxicol 20:577-82. 2007
  7. pmc Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh
    R B van Breemen
    UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, Chicago, Illinois, USA
    Clin Pharmacol Ther 87:219-25. 2010
    ..Less than 0.01% of the 23-epi-26-deoxyactein was recovered in urine 24 h after administration. No phase I or phase II metabolites were observed either in clinical specimens or in vitro...
  8. pmc Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Fitoterapia 82:38-43. 2011
    ..5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger...
  9. pmc Multitargeted therapy of cancer by lycopene
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612, USA
    Cancer Lett 269:339-51. 2008
    ....
  10. ncbi request reprint How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, 60612, USA
    J Nutr 135:2062S-4S. 2005
  11. ncbi request reprint Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:2214-9. 2002
    ....
  12. pmc Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial
    Richard B van Breemen
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Cancer Prev Res (Phila) 4:711-8. 2011
    ..005). No significant changes in the DNA oxidation product 8-oxo-deoxyguanosine and the lipid peroxidation product malondialdehyde were observed in prostate tissue and plasma, respectively, as a result of lycopene administration...
  13. ncbi request reprint Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis
    Phyllis Bowen
    Department of Human Nutrition and Dietetics, m c 517, University of Illinois, 1919 West Taylor Street, Chicago, IL 60612, USA
    Exp Biol Med (Maywood) 227:886-93. 2002
    ..Whether reduction in DNA damage to prostate cancer cells is beneficial awaits further research, although reduction in serum PSA concentrations is promising...
  14. ncbi request reprint Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1
    Guowen Liu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Anal Chem 77:6407-14. 2005
    ..Therefore, this new mass spectrometric screening assay was demonstrated to facilitate the discovery of chemoprevention agents in complex natural product mixtures...
  15. ncbi request reprint Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase
    Birgit M Dietz
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 18:1296-305. 2005
    ..This suggests that XH induces QR by covalently modifying the Keap1 protein. Therefore, XH and hops dietary supplements might function as chemopreventive agents, through induction of detoxification enzymes such as QR...
  16. pmc Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS
    Yongsoo Choi
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Comb Chem High Throughput Screen 11:1-6. 2008
    ..These screening results are consistent with those obtained using previous screening approaches...
  17. ncbi request reprint Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation
    Hong Liu
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 18:162-73. 2005
    ..In microsomal incubations of 4'-F-DMA in the presence of GSH, no GSH adducts were detected. These data suggest that 4'-F-DMA might be a promising SERM with similar activity to DMA and raloxifene and less toxicity...
  18. ncbi request reprint A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C
    Tomoyoshi Kobayashi
    Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue M C 901, Chicago, IL 60612, USA
    J Mol Cell Cardiol 38:213-8. 2005
    ..Using mass spectrometry analysis of Tn and thin filaments, we identified Ser-23 and Ser-24 (normally considered to be PKA-dependent sites) as substrates for phosphorylation by PKC-beta and PKC-epsilon...
  19. ncbi request reprint p-Hydroxybenzoic acid alkyl esters in Andrographis paniculata herbs, commercial extracts, and formulated products
    Wenkui Li
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA
    J Agric Food Chem 51:524-9. 2003
    ..The levels of these p-hydroxybenzoic acid esters measured in the commercial products of A. paniculata suggest that they were introduced inadvertently during processing or as artificial additives...
  20. ncbi request reprint Retinoic acid receptors and retinoids are up-regulated in the developing and adult rat prostate by neonatal estrogen exposure
    Gail S Prins
    Department of Urology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    Endocrinology 143:3628-40. 2002
    ..Thus, we hypothesize that alterations in morphogenesis as well as dysplasia in the adult prostate may be mediated in part through augmentation of transcriptional signals in the retinoid pathway...
  21. pmc Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial
    Stacie E Geller
    Department of Obstetrics and Gynecology, Center for Research on Women and Gender, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Menopause 16:1156-66. 2009
    ..The aim of this study was to evaluate the safety and efficacy of black cohosh and red clover compared with placebo for the relief of menopausal vasomotor symptoms...
  22. pmc Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1
    Birgit M Dietz
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 21:1939-48. 2008
    ..These observations suggest that A. sinensis dietary supplements standardized to ligustilide have potential as chemopreventive agents through induction of detoxification enzymes...
  23. pmc The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use
    Norman R Farnsworth
    University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Am J Clin Nutr 87:504S-8S. 2008
    ..We conclude that this type of research can only be successful with the use of a multidisciplinary approach...
  24. ncbi request reprint Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry
    Wenkui Li
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    Rapid Commun Mass Spectrom 17:978-82. 2003
    ..Dehydrocimicifugic acid A and dehydrocimicifugic acid B have not been reported previously to be constituents of black cohosh...
  25. ncbi request reprint Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides
    Ju Liu
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 18:174-82. 2005
    ..Acolbifene could also induce DNA damage in the S30 breast cancer cell line. These data imply that the classical electrophilic acolbifene quinone methide might contribute to the potential toxicity of acolbifene...
  26. ncbi request reprint Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Agric Food Chem 50:7022-8. 2002
    ..These data suggest that black cohosh can protect against cellular DNA damage caused by reactive oxygen species by acting as antioxidants...
  27. pmc The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract
    Nancy L Booth
    UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA
    J Altern Complement Med 12:133-9. 2006
    ..extract by identifying and measuring the major and minor components visible in the high-performance liquid chromatography-ultraviolet (HPLC-UV) chromatogram and evaluating each compound for estrogenic and antioxidant activity...
  28. ncbi request reprint In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh)
    Benjamin M Johnson
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 16:838-46. 2003
    ..Therefore, for moderate doses of a dietary supplement containing black cohosh, this study found no cause for safety concerns over the formation of quinoid metabolites in women...
  29. pmc Chlorination diversifies Cimicifuga racemosa triterpene glycosides
    Shao Nong Chen
    UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 70:1016-23. 2007
    ....
  30. ncbi request reprint Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical and Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Agric Food Chem 51:5661-70. 2003
    ..This study identifies other possible biological targets of black cohosh that could account for reported biological effects...
  31. ncbi request reprint Quantitative analysis of lycopene isomers in human plasma using high-performance liquid chromatography-tandem mass spectrometry
    Liqiong Fang
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    Anal Chem 75:812-7. 2003
    ..The limit of detection was 11.2 fmol injected on-column, and the limit of quantitation was 22.8 fmol...
  32. ncbi request reprint Secondary metabolites from Andrographis paniculata
    Wenkui Li
    Department of Medicinal Chemistry and Pharmacognosy M C 781, University of Illinois at Chicago, IL 60612, USA
    Chem Pharm Bull (Tokyo) 55:455-8. 2007
    ..paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 microg/ml, respectively...
  33. ncbi request reprint Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives
    Laura Marler
    College of Pharmacy, University of Hawaii, Hilo, Hawaii 96720, USA
    Anticancer Res 30:4873-82. 2010
    ..In sum, the in vivo activity of these compounds appears to be diminished by low bioavailability, but this experimental approach indicates the importance of systematic biomarker investigation...
  34. pmc In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin
    Cassia R Overk
    UIC NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences PCRPS, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, M C 781, Chicago, IL 60612, USA
    Chem Biol Interact 176:30-9. 2008
    ..The lack of a safe and reliable alternative to hormone therapy (HT) for treating menopausal symptoms underscores the need for alternative therapies...
  35. pmc Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)
    Cassia R Overk
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, M C 781, University of Illinois, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Agric Food Chem 53:6246-53. 2005
    ..9 microg/mL, respectively, in the alkaline phosphatase induction assay. On the basis of these data, hops and red clover could be attractive for the development as herbal dietary supplements to alleviate menopause-associated symptoms...
  36. pmc Sites of alkylation of human Keap1 by natural chemoprevention agents
    Yan Luo
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, Illinois, USA
    J Am Soc Mass Spectrom 18:2226-32. 2007
    ..These in vitro results agree with evidence from in vivo experiments, and indicate that C151 is the most important site of alkylation on Keap1 by chemoprevention agents that function by activating the ARE through Nrf2...
  37. ncbi request reprint Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats
    Joanna E Burdette
    Department of Medicinal Chemistry and Pharmacognosy and UIC National Institutes of Health Center for Botanical and Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Nutr 132:27-30. 2002
    ..Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model...
  38. ncbi request reprint Binding of the hop (Humulus lupulus L.) chalcone xanthohumol to cytosolic proteins in Caco-2 intestinal epithelial cells
    Yan Pang
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Mol Nutr Food Res 51:872-9. 2007
    ..These data suggest that specific binding of xanthohumol to cytosolic proteins in intestinal epithelial cells contributes to the poor oral bioavailability observed previously in vivo...
  39. ncbi request reprint Quantitative analyses of beta-carotene and retinol in serum and feces in support of clinical bioavailability studies
    Dongwei Zhu
    College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Rapid Commun Mass Spectrom 20:2427-32. 2006
    ....
  40. pmc Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators
    Zhihui Qin
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Drug Metab Dispos 37:161-9. 2009
    ..The predicted extensive metabolism of DMA was confirmed in vivo and compared with the relatively stable arzoxifene and F-DMA...
  41. pmc Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba
    Yongkai Sun
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA
    J Mass Spectrom 40:373-9. 2005
    ..Therefore, this LC/MS/MS assay facilitated the rapid quantitative analysis of ginkgolides A, B, C and J and bilobalide in ginkgo dietary supplements with excellent recovery, reproducibity, accuracy and sensitivity...
  42. ncbi request reprint Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism
    Yongmei Li
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612, USA
    Comb Chem High Throughput Screen 6:757-67. 2003
    ..Although these data indicate that resveratrol diffuses rapidly across the intestinal epithelium, extensive phase II metabolism during absorption might reduce resveratrol bioavailability...
  43. ncbi request reprint Activity-guided isolation of novel norwithanolides from depreasubtriflora with potential cancer chemopreventive activity
    Bao Ning Su
    Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Org Chem 68:2350-61. 2003
    ..Compounds 1-10 were evaluated for their cancer chemopreventive activity in terms of their ability to induce quinone reductase activity with cultured murine hepatoma cells, and compounds 1 and 6 were found to be highly effective...
  44. ncbi request reprint Identification of novel electrophilic metabolites of piper methysticum Forst (Kava)
    Benjamin M Johnson
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 16:733-40. 2003
    ..g., because of a drug interaction, genetic difference in enzyme expression, etc.) or if conjugation pathways become saturated...
  45. ncbi request reprint Enhanced ionization of phosphorylated peptides during MALDI TOF mass spectrometry
    Xiaofeng Yang
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Anal Chem 76:1532-6. 2004
    ..Finally, tryptic digestion followed by analysis using MALDI TOF mass spectrometry with THAP as the matrix facilitated the identification of a unique phosphorylation site in PKC-treated troponin I...
  46. ncbi request reprint Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612 7231, USA
    J Mass Spectrom 40:289-99. 2005
    ..Since XN can be converted to IX through acid-catalyzed cyclization in the stomach, XN might contribute to the in vivo levels of estrogenic 8-PN following consumption of hops extracts...
  47. pmc Axonopathy is a compounding factor in the pathogenesis of Krabbe disease
    Ludovico Cantuti Castelvetri
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois, MC512, Chicago, IL 60612, USA
    Acta Neuropathol 122:35-48. 2011
    ..Neuronal damage occurred at later stages, when mutant mice were moribund and demyelinated. Altogether, these findings suggest a progressive dying-back neuronal dysfunction in Twitcher mutants...
  48. pmc Coumaroyl iridoids and a depside from cranberry (Vaccinium macrocarpon)
    Allison Turner
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy MC 781 and PCRPS, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612, USA
    J Nat Prod 70:253-8. 2007
    ....
  49. pmc Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors
    Bai He
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Med Chem 52:7003-13. 2009
    ..The data also suggest that an "upside-down" pose with the surface binding group of the probe bound in an alternative pocket near the catalytic site may contribute to the binding...
  50. ncbi request reprint Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin
    Xuemei Liu
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street M C 877, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 16:741-9. 2003
    ..These data suggest that the 4-fluoroequilenin derivatives have promise as alternatives to traditional estrogen replacement therapy due to their similar estrogenic properties with less overall toxicity...
  51. pmc Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases
    Jian Guo
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood St, Chicago, IL 60612 7231, USA
    Drug Metab Dispos 36:2104-12. 2008
    ..4 ml/min/kg. These studies indicate that isoliquiritigenin will be conjugated rapidly in the liver to form up to five monoglucuronides...
  52. ncbi request reprint Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate
    Chongwoo Yu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Rapid Commun Mass Spectrom 17:307-13. 2003
    ..Our results indicate that trans-resveratrol is a marginal inhibitor of CYP3A4 and a weak inhibitor of CYP2C19, but its major metabolite trans-resveratrol-3-sulfate is not an inhibitor of any of the cytochrome P450 isozymes investigated...
  53. pmc Rapid quantitative analysis of 8-iso-prostaglandin-F(2alpha) using liquid chromatography-tandem mass spectrometry and comparison with an enzyme immunoassay method
    Jeffrey H Dahl
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Anal Biochem 404:211-6. 2010
    ..Our method was optimized for rapid measurement of 8-iso-PGF(2alpha) in urine, and it is ideally suited for clinical sample analysis...
  54. pmc In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent
    SHARLA L POWELL
    Department of Medicinal Chemistry and Pharmacognosy and UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, 833 South Wood Street, M C 781, University of Illinois at Chicago, Chicago, Illinois 60612 7231, USA
    J Agric Food Chem 56:11718-26. 2008
    ..These data suggest N(omega)-methylserotonin may be responsible for the serotonergic activity of black cohosh...
  55. pmc Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts
    Tanja Gödecke
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy and PCRPS, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Phytochem Anal 20:120-33. 2009
    ..The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in the extract...
  56. pmc Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus
    Zhican Wang
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois, Chicago, Illinois 60612 7231, USA
    J Biol Chem 284:8633-42. 2009
    ..The Trojan horse mechanism may be of general importance beyond estrogen genotoxins...
  57. pmc Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa)
    Tanja Gödecke
    UIC NIH Center for Botanical Dietary Supplements Research and Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612
    J Nat Prod 72:433-7. 2009
    ..These strongly basic and frequently zwitterionic nitrogenous metabolites contribute considerable chemical diversity to the polar serotonergic fraction of black cohosh...
  58. pmc Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry
    Yi Tao
    Bioanlytical Research, Bristol Myers Squibb, Chicago, Illinois, USA
    J Agric Food Chem 57:10014-21. 2009
    ..This assay showed excellent sensitivity, accuracy, and precision and may be used to address the need for quality control and standardization of ginger dietary supplements...
  59. ncbi request reprint Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry
    Wenkui Li
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    Chem Res Toxicol 15:1174-8. 2002
    ....
  60. ncbi request reprint An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine
    Yan Wang
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Agric Food Chem 50:431-5. 2002
    ..56 to 1042 nmol/g in Concord grape products, and from 8.63 to 24.84 micromol/L in Italian red wine. The concentrations of resveratrol were silmilar in cranberry and grape juice at 1.07 and 1.56 nmol/g, respectively...
  61. pmc Screening antioxidants using LC-MS: case study with cocoa
    Angela I Calderón
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, Illinois 60612, USA
    J Agric Food Chem 57:5693-9. 2009
    ..This new LC-MS assay facilitates the rapid identification and then the determination of the relative antioxidant activities of individual antioxidant species in complex natural product samples and food products such as cocoa...
  62. ncbi request reprint Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora
    Bao Ning Su
    Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 66:1089-93. 2003
    ..The potential cancer chemopreventive activities of all isolates in terms of their ability to induce QR activity with cultured Hepa 1c1c7 mouse hepatoma cells were evaluated...
  63. ncbi request reprint Estrogens and congeners from spent hops (Humulus lupulus)
    Lucas R Chadwick
    UIC NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 67:2024-32. 2004
    ..The principle estrogen 8-prenylnaringenin (15) from hops is an artifact formed along with its positional isomer 6-prenylnaringenin (16) through the spontaneous isomerization of the pro-estrogenic chalcone DMX (7)...
  64. pmc In vitro studies of intestinal permeability and hepatic and intestinal metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus L.)
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, Illinois 60612 7231, USA
    Pharm Res 23:864-72. 2006
    ..The absorption potential and metabolism of 8-prenylnaringenin (8-PN) from hops (Humulus lupulus L.) were investigated. 8-PN is a potent estrogen with the potential to be used for the relief of menopausal symptoms in women...
  65. ncbi request reprint New metabolic pathways for flavanones catalyzed by rat liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL 60612 7231, USA
    Drug Metab Dispos 32:387-97. 2004
    ..However, little is known about the pharmacological activities of the other types of flavonone metabolites...
  66. ncbi request reprint Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones
    Linning Yu
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 17:879-88. 2004
    ..These results suggest that raloxifene could be metabolized to electrophilic and redox active quinoids, which have the potential to cause toxicity in vivo...
  67. ncbi request reprint GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels
    Shixin Deng
    UIC NIH Center for Botanical Dietary Supplements Research and Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, M C 781, Chicago, IL 60612, USA
    Phytochem Anal 17:398-405. 2006
    ..Both dimers 1 and 2 were found to be active in an in vitro GABAa receptor-binding assay with IC50 values of 29 and 24 microM, respectively...
  68. ncbi request reprint Confusion regarding anticoagulant coumarins in dietary supplements
    Nancy L Booth
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, USA
    Clin Pharmacol Ther 76:511-6. 2004
  69. ncbi request reprint Minor withanolides from Physalis philadelphica: structures, quinone reductase induction activities, and liquid chromatography (LC)-MS-MS investigation as artifacts
    Jian Qiao Gu
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 60612, USA
    Chem Pharm Bull (Tokyo) 51:530-9. 2003
    ..Ixocarpalactone A was detected in the fresh fruits (tomatillos) of P. philadelphica by LC-MS-MS analysis at a concentration of 143+/-4.53 ppb...
  70. ncbi request reprint Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry
    Xun Cheng
    College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Rapid Commun Mass Spectrom 17:2089-92. 2003
    ..At 15 and 25 microg/mL in mouse, rat or dog plasma, betulinic acid was 99.99% bound to serum proteins, and, at 5 microg/mL, betulinic acid was > or =99.97% bound...
  71. pmc Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2
    Rui Yu
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL 60612 7231, USA
    J Pharmacol Exp Ther 339:716-25. 2011
    ....
  72. pmc Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    Aimee L Eggler
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 102:10070-5. 2005
    ..Based on these results, a model is proposed that should aid in the understanding of Keap1-Nrf2 signaling mechanisms...
  73. pmc Technologies and experimental approaches at the National Institutes of Health Botanical Research Centers
    Stephen Barnes
    Botanical Center for Age Related Disease, Purdue University University of Alabama at Birmingham, West Lafayette, IN, USA
    Am J Clin Nutr 87:476S-80S. 2008
    ..In summary, the skills needed to carry out botanical centers' research are extensive and may exceed those practiced by most NIH investigators...
  74. ncbi request reprint Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent
    Aimee L Eggler
    The Center for Pharmaceutical Biotechnology, and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 60607, USA
    Chem Res Toxicol 20:1878-84. 2007
    ..Notably, C151 was no longer detected as modified by BIA. We therefore recommend our method of Keap1 protein preparation for the detection of modified cysteines in proteomic studies...
  75. ncbi request reprint Extraction of carotenoids from feces, enabling the bioavailability of beta-carotene to be studied in Indonesian children
    Machteld van Lieshout
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Agric Food Chem 51:5123-30. 2003
    ..8 times (interval, 0.6, 5.5) greater than that from spinach (n = 8), based on data from feces compared with 1.7 times (interval, 0.9, 3.1) based on data from serum...
  76. ncbi request reprint A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses
    Alida Melse-Boonstra
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am J Clin Nutr 84:1128-33. 2006
    ..Previous studies comparing the bioavailabilities of polyglutamyl and monoglutamyl folic acid had inconsistent results...
  77. ncbi request reprint Applications of pulsed ultrafiltration-mass spectrometry
    Benjamin M Johnson
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Mass Spectrom Rev 21:76-86. 2002
    ....
  78. ncbi request reprint Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase
    Yan Li
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, University of Illinois at Chicago, 833 South Wood St, Chicago, IL 60612 7231, USA
    Chem Biol Interact 152:151-63. 2005
    ....
  79. ncbi request reprint Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha
    Xuemei Liu
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA
    Chem Res Toxicol 15:512-9. 2002
    ..These data suggest that the mechanism of DNA damage induced by equine estrogen metabolites could involve oxidative stress and that the estrogen receptor may play a role in this process...
  80. ncbi request reprint Quantitative determination of N7-methyldeoxyguanosine and O6-methyldeoxyguanosine in DNA by LC-UV-MS-MS
    Yanan Yang
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA
    Anal Chem 74:5376-82. 2002
    ..2 N7-MedG/105 dG and 14.8 O6-MedG/105 dG. This LC-UV-MS-MS assay provides the sensitivity and speed required to evaluate the extent of methylated DNA lesions in animal models of cancer induced by the methylating agent MNU...
  81. ncbi request reprint Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa
    Daniel S Fabricant
    Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 68:1266-70. 2005
    ..racemosa...
  82. ncbi request reprint Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.)
    Jian Guo
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, University of Illinois at Chicago National Institutes of Health Center for Botanical Dietary Supplements Research, IL 60612 7231, USA
    Drug Metab Dispos 34:1152-9. 2006
    ..8 +/- 3.7 microM. These results suggest that the estrogenicity of hop constituents in vivo will depend in part on metabolic conversion that may show individual variation...
  83. pmc An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids
    Hongmei Cao
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Anal Biochem 372:41-51. 2008
    ....
  84. ncbi request reprint NF-kappaB-inducing kinase regulates cyclooxygenase 2 gene expression in macrophages by phosphorylation of PU.1
    Anser C Azim
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 179:7868-75. 2007
    ..1 to the COX-2 promoter in response to treatment with endotoxin. These findings suggest a novel role for NIK in mediating COX-2 gene expression in endotoxin-treated macrophages by a mechanism that involves phosphorylation of PU.1...
  85. ncbi request reprint Identification of photocatalytic degradation products of diazinon in TiO2 aqueous suspensions using GC/MS/MS and LC/MS with quadrupole time-of-flight mass spectrometry
    Vasilis N Kouloumbos
    General Chemical State Laboratory, Athens, Greece
    J Am Soc Mass Spectrom 14:803-17. 2003
    ..Exact mass measurements of the derivatives allowed the elemental formula of the molecules to be determined confidently. Similarities to the metabolic pathways occurring in living organisms were observed...
  86. ncbi request reprint Inhibition of rat mammary tumorigenesis by concord grape juice constituents
    Keith W Singletary
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801
    J Agric Food Chem 51:7280-6. 2003
    ..These studies thus indicate that Concord grape juice constituents can inhibit the promotion stage of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis, in part by suppressing cell proliferation...
  87. ncbi request reprint Resveratrol in raw and baked blueberries and bilberries
    Mary M Lyons
    Food and Nutritional Science Division, California State University Long Beach, Long Beach, CA 90840, USA
    J Agric Food Chem 51:5867-70. 2003
    ..Furthermore, cooking or heat processing of these berries will contribute to the degradation of resveratrol...
  88. ncbi request reprint Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification
    Yaoqiu Zhu
    Department of Chemistry, Drug Discovery Program, Northwestern University, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 127:858-68. 2005
    ..This appears to be the first example of a compound that causes irreversible inactivation of an enzyme without itself becoming modified in any way...
  89. pmc (+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway
    Zhiyong Wang
    Department of Chemistry, Center for Drug Discovery and Chemical Biology, Northwestern University, Evanston, Illinois 60208 3113, USA
    Biochemistry 45:14513-22. 2006
    ..An elimination-aromatization mechanism is proposed to account for these results...
  90. ncbi request reprint Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly beta-carotene, in humans: a review
    Machteld van Lieshout
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 77:12-28. 2003
    ..A step-by-step discussion of aspects related to these techniques is provided, including study design, choice of isotopic tracers, dosing regimen, collection of samples, chemical analysis of samples, and data analysis...
  91. ncbi request reprint Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages
    Anser C Azim
    Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 293:L668-73. 2007
    ..1. We show that both NF-kappaB pathway and PU.1 are involved in normal macrophage function and play a role in macrophage COX-2 expression. In summary, these data indicate that Rac2 regulates COX-2 expression in BMDM...
  92. ncbi request reprint The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours
    Andreas I Constantinou
    Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    Eur J Cancer 41:647-54. 2005
    ....

Research Grants10

  1. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..
  2. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
    ..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. ..
  3. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
    ..capacity to provide accurate mass measurements to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs ..
  4. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
    ..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
  5. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004
    ..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..