Research Topics
Genomes and GenesSpecies | Kenneth L van GolenSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancersKenneth L van Golen
Department of Internal Medicine, Division of Hematology Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
Breast Cancer Res 5:174-9. 2003..Therefore, the importance of the Rho GTPases in the progression of aggressive cancers, is becoming more appreciated...- Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinomaKenneth L van Golen
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0948, USA
Neoplasia 4:373-9. 2002..Improved survival, fewer metastatic lesions, and excellent tolerability were observed with the combination therapy... 
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancerKenneth L van Golen
Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
Clin Exp Metastasis 19:301-11. 2002..We found that activation of the MAPK pathway was responsible for motility, invasion and production of angiogenic factors. In contrast, growth under anchorage independent conditions was dependent on the PI3K pathway...- WISP3 is a novel tumor suppressor gene of inflammatory breast cancerCelina G Kleer
Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Oncogene 21:3172-80. 2002..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis... - Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesisQuintin Pan
Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 62:4854-9. 2002..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors... - Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitorKenneth L van Golen
Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cancer Ther 1:575-83. 2002..These data provide direct evidence that FTIs may find use in the clinic when directed against RhoC-overexpressing tumors and suggest appropriate biological markers to evaluate during FTI treatment... - Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1Min Lin
Division of Hematology Oncology, Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
Mol Cancer 4:21. 2005..RhoC GTPase is overexpressed in aggressive cancers that metastasize and is the predominant GTPase in PC. Like several GTPases, RhoC contains a putative cav-1 binding motif... - Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to boneCynthia M van Golen
Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Cancer Res 66:6570-8. 2006..These results support the hypothesis that IGF-IR expression in neuroblastoma cells increases tumor cell interaction with the bone microenvironment, resulting in greater formation of metastases... - Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the boneChristopher L Hall
Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
Cancer Res 66:8648-54. 2006..We conclude that collagen I attachment mediated by alpha(2)beta(1) initiates motility programs through RhoC and suggest a mechanism for prostate cancer metastasis to the bone... - Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPaseChristopher L Hall
Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
Neoplasia 10:797-803. 2008..We conclude that the ligation of alpha(2)beta(1) by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone... - Rho-regulatory proteins in breast cancer cell motility and invasionMin Lin
Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0948, USA
Breast Cancer Res Treat 84:49-60. 2004..The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory proteins in breast cancer metastatis... - The current understanding of the molecular determinants of inflammatory breast cancer metastasisGalina S Radunsky
Department of Internal Medicine, Division of Hematology and Oncology, Ann Arbor, MI 48109, USA
Clin Exp Metastasis 22:615-20. 2005..The goal of this review is to introduce IBC to the reader and provide a brief overview of what is known about the metastatic mechanisms of the disease... - Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic abilityCelina G Kleer
Department of Pathology, Division of Hematology and Oncology, 2G332 University Hospital, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
Am J Pathol 160:579-84. 2002..RhoC is specifically expressed in invasive breast carcinomas capable of metastasizing, and it may be clinically useful in patients with tumors smaller than 1 cm to guide treatment... - Integrin expression regulates neuroblastoma attachment and migrationAmy Meyer
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neoplasia 6:332-42. 2004..These data suggest that specific classes of integrins in concert with IGF-IR regulate NBL attachment and migration... - RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breastCelina G Kleer
Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI 48109 0054, USA
Breast Cancer Res Treat 93:101-10. 2005..We hypothesized that RhoC expression would identify aggressive, non-IBC tumors breast cancer patients at any stage with worse outcomes defined as recurrence and/or metastasis... - Detection of Epstein-Barr virus in rapidly growing fibroadenomas of the breast in immunosuppressed hostsCelina G Kleer
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
Mod Pathol 15:759-64. 2002..This is the first study suggesting a role for EBV in the pathogenesis of fibroadenomas... - Is caveolin-1 a viable therapeutic target to reduce cancer metastasis?Kenneth L van Golen
The University of Michigan Comprehensive Cancer Center, Division of Hematology Oncology, Department of Internal Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0575 0548, USA
Expert Opin Ther Targets 10:709-21. 2006..The purpose of this review is twofold: firstly, to survey the current knowledge of the contribution of caveolin-1 in promoting a metastasis, and secondly, to explore the viability of targeting caveolin-1 with novel therapeutics... - Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profilingSteven J Van Laere
Translational Cancer Research Group, Lab Pathology University of Antwerp and Oncology Center, General Hospital Sint-Augustinus, Wilrijk, Belgium
Breast Cancer Res Treat 95:243-55. 2006.... - N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cellsDaniel Noujaim
Department of Neurology, University of Michigan, Ann Arbor 48109, USA
Oncogene 21:4549-57. 2002..These data imply that N-Myc and Bcl-2 cooperate to increase the expression, secretion, and activation of MMP-2, which likely leads to a more tumorigenic phenotype due to increased MMP-2 mediated invasion... - Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancerGert G Van den Eynden
Translational Cancer Research Group Antwerp, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
Breast Cancer Res Treat 95:219-28. 2006..In this study we sought to investigate the role of caveolin-1 and -2 in IBC cell lines and in human IBC samples... - Stepping out of the flow: capillary extravasation in cancer metastasisFayth L Miles
Department of Biological Sciences, Center for Translational Cancer Research, University of Delaware, Newark, DE 19716, USA
Clin Exp Metastasis 25:305-24. 2008..As the mechanisms of cancer TEM are elucidated, new approaches to study and target metastasis may be utilized and developed... 
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesisLinda Sequeira
The Laboratory of Cytoskeletal Physiology, The University of Delaware, Newark, DE 19716, USA
Clin Exp Metastasis 25:569-79. 2008..In the current study we analyze the individual roles of RhoA, RhoC and Rac1 GTPases in PC-3 cell directed migration, invasion and tumor cell diapedesis across a human bone marrow endothelial cell layer in vitro...- CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase RacKenneth L van Golen
Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware, USA
J Cell Biochem 104:1587-97. 2008..These data suggest a role for HBME-secreted CCL2 in promoting PCa cell extravasation into the bone microenvironment... - Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migrationXihong Zhang
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN, 55455, USA
Breast Cancer Res Treat 93:159-68. 2005..Defining the key molecules downstream of the type I IGF receptor may provide a basis for optimizing therapies directed at this target... - Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-alphaCarlton R Cooper
Center for Translational Cancer Research and Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
J Cell Biochem 104:2298-309. 2008..Taken together, we show cell surface localization of RCN1 that has not been described previously for either PCa or BMEC and that the surface expression on BMEC is regulated by pro-inflammatory TNF-alpha...