Kenneth L van Golen

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Breast Cancer Res 5:174-9. 2003
  2. pmc Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0948, USA
    Neoplasia 4:373-9. 2002
  3. ncbi request reprint Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    Kenneth L van Golen
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
    Clin Exp Metastasis 19:301-11. 2002
  4. ncbi request reprint WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Oncogene 21:3172-80. 2002
  5. ncbi request reprint Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
  6. ncbi request reprint Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cancer Ther 1:575-83. 2002
  7. pmc Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1
    Min Lin
    Division of Hematology Oncology, Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Mol Cancer 4:21. 2005
  8. ncbi request reprint Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone
    Cynthia M van Golen
    Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Cancer Res 66:6570-8. 2006
  9. ncbi request reprint Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Cancer Res 66:8648-54. 2006
  10. pmc Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Neoplasia 10:797-803. 2008

Collaborators

Detail Information

Publications25

  1. pmc Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology Oncology, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Breast Cancer Res 5:174-9. 2003
    ..Therefore, the importance of the Rho GTPases in the progression of aggressive cancers, is becoming more appreciated...
  2. pmc Suppression of tumor recurrence and metastasis by a combination of the PHSCN sequence and the antiangiogenic compound tetrathiomolybdate in prostate carcinoma
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0948, USA
    Neoplasia 4:373-9. 2002
    ..Improved survival, fewer metastatic lesions, and excellent tolerability were observed with the combination therapy...
  3. ncbi request reprint Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    Kenneth L van Golen
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0948, USA
    Clin Exp Metastasis 19:301-11. 2002
    ..We found that activation of the MAPK pathway was responsible for motility, invasion and production of angiogenic factors. In contrast, growth under anchorage independent conditions was dependent on the PI3K pathway...
  4. ncbi request reprint WISP3 is a novel tumor suppressor gene of inflammatory breast cancer
    Celina G Kleer
    Department of Pathology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Oncogene 21:3172-80. 2002
    ..Our data demonstrate that WISP3 acts as a tumor suppressor gene in the breast. Loss of WISP3 expression contributes to the phenotype of IBC by regulating tumor cell growth, invasion and angiogenesis...
  5. ncbi request reprint Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
    Quintin Pan
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 62:4854-9. 2002
    ..Our study suggests that a major mechanism of the antiangiogenic effect of copper deficiency induced by TM is suppression of NFkappaB, contributing to a global inhibition of NFkappaB-mediated transcription of proangiogenic factors...
  6. ncbi request reprint Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor
    Kenneth L van Golen
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cancer Ther 1:575-83. 2002
    ..These data provide direct evidence that FTIs may find use in the clinic when directed against RhoC-overexpressing tumors and suggest appropriate biological markers to evaluate during FTI treatment...
  7. pmc Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1
    Min Lin
    Division of Hematology Oncology, Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Mol Cancer 4:21. 2005
    ..RhoC GTPase is overexpressed in aggressive cancers that metastasize and is the predominant GTPase in PC. Like several GTPases, RhoC contains a putative cav-1 binding motif...
  8. ncbi request reprint Insulin-like growth factor-I receptor expression regulates neuroblastoma metastasis to bone
    Cynthia M van Golen
    Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Cancer Res 66:6570-8. 2006
    ..These results support the hypothesis that IGF-IR expression in neuroblastoma cells increases tumor cell interaction with the bone microenvironment, resulting in greater formation of metastases...
  9. ncbi request reprint Type I collagen receptor (alpha 2 beta 1) signaling promotes the growth of human prostate cancer cells within the bone
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Cancer Res 66:8648-54. 2006
    ..We conclude that collagen I attachment mediated by alpha(2)beta(1) initiates motility programs through RhoC and suggest a mechanism for prostate cancer metastasis to the bone...
  10. pmc Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, MI 48109 0940, USA
    Neoplasia 10:797-803. 2008
    ..We conclude that the ligation of alpha(2)beta(1) by collagen I activates RhoC guanosine triphosphatase, which mediates PCa invasion, and suggests a mechanism for the preferential metastasis of PCa cells within the bone...
  11. ncbi request reprint Rho-regulatory proteins in breast cancer cell motility and invasion
    Min Lin
    Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0948, USA
    Breast Cancer Res Treat 84:49-60. 2004
    ..The importance of the Rho-GTPases in cancer progression, particularly in the area of metastasis, is becoming increasingly evident. This review will provide an overview of the role of the Rho-regulatory proteins in breast cancer metastatis...
  12. ncbi request reprint The current understanding of the molecular determinants of inflammatory breast cancer metastasis
    Galina S Radunsky
    Department of Internal Medicine, Division of Hematology and Oncology, Ann Arbor, MI 48109, USA
    Clin Exp Metastasis 22:615-20. 2005
    ..The goal of this review is to introduce IBC to the reader and provide a brief overview of what is known about the metastatic mechanisms of the disease...
  13. pmc Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability
    Celina G Kleer
    Department of Pathology, Division of Hematology and Oncology, 2G332 University Hospital, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Am J Pathol 160:579-84. 2002
    ..RhoC is specifically expressed in invasive breast carcinomas capable of metastasizing, and it may be clinically useful in patients with tumors smaller than 1 cm to guide treatment...
  14. pmc Integrin expression regulates neuroblastoma attachment and migration
    Amy Meyer
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 6:332-42. 2004
    ..These data suggest that specific classes of integrins in concert with IGF-IR regulate NBL attachment and migration...
  15. ncbi request reprint RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast
    Celina G Kleer
    Department of Pathology and Internal Medicine, University of Michigan, Ann Arbour, MI 48109 0054, USA
    Breast Cancer Res Treat 93:101-10. 2005
    ..We hypothesized that RhoC expression would identify aggressive, non-IBC tumors breast cancer patients at any stage with worse outcomes defined as recurrence and/or metastasis...
  16. ncbi request reprint Detection of Epstein-Barr virus in rapidly growing fibroadenomas of the breast in immunosuppressed hosts
    Celina G Kleer
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Mod Pathol 15:759-64. 2002
    ..This is the first study suggesting a role for EBV in the pathogenesis of fibroadenomas...
  17. ncbi request reprint Is caveolin-1 a viable therapeutic target to reduce cancer metastasis?
    Kenneth L van Golen
    The University of Michigan Comprehensive Cancer Center, Division of Hematology Oncology, Department of Internal Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0575 0548, USA
    Expert Opin Ther Targets 10:709-21. 2006
    ..The purpose of this review is twofold: firstly, to survey the current knowledge of the contribution of caveolin-1 in promoting a metastasis, and secondly, to explore the viability of targeting caveolin-1 with novel therapeutics...
  18. ncbi request reprint Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling
    Steven J Van Laere
    Translational Cancer Research Group, Lab Pathology University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Breast Cancer Res Treat 95:243-55. 2006
    ....
  19. ncbi request reprint N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells
    Daniel Noujaim
    Department of Neurology, University of Michigan, Ann Arbor 48109, USA
    Oncogene 21:4549-57. 2002
    ..These data imply that N-Myc and Bcl-2 cooperate to increase the expression, secretion, and activation of MMP-2, which likely leads to a more tumorigenic phenotype due to increased MMP-2 mediated invasion...
  20. ncbi request reprint Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
    Gert G Van den Eynden
    Translational Cancer Research Group Antwerp, Lab Pathology, University of Antwerp University Hospital Antwerp, Edegem, Belgium
    Breast Cancer Res Treat 95:219-28. 2006
    ..In this study we sought to investigate the role of caveolin-1 and -2 in IBC cell lines and in human IBC samples...
  21. ncbi request reprint Stepping out of the flow: capillary extravasation in cancer metastasis
    Fayth L Miles
    Department of Biological Sciences, Center for Translational Cancer Research, University of Delaware, Newark, DE 19716, USA
    Clin Exp Metastasis 25:305-24. 2008
    ..As the mechanisms of cancer TEM are elucidated, new approaches to study and target metastasis may be utilized and developed...
  22. doi request reprint Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis
    Linda Sequeira
    The Laboratory of Cytoskeletal Physiology, The University of Delaware, Newark, DE 19716, USA
    Clin Exp Metastasis 25:569-79. 2008
    ..In the current study we analyze the individual roles of RhoA, RhoC and Rac1 GTPases in PC-3 cell directed migration, invasion and tumor cell diapedesis across a human bone marrow endothelial cell layer in vitro...
  23. doi request reprint CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac
    Kenneth L van Golen
    Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware, USA
    J Cell Biochem 104:1587-97. 2008
    ..These data suggest a role for HBME-secreted CCL2 in promoting PCa cell extravasation into the bone microenvironment...
  24. ncbi request reprint Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration
    Xihong Zhang
    Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN, 55455, USA
    Breast Cancer Res Treat 93:159-68. 2005
    ..Defining the key molecules downstream of the type I IGF receptor may provide a basis for optimizing therapies directed at this target...
  25. doi request reprint Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-alpha
    Carlton R Cooper
    Center for Translational Cancer Research and Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Cell Biochem 104:2298-309. 2008
    ..Taken together, we show cell surface localization of RCN1 that has not been described previously for either PCa or BMEC and that the surface expression on BMEC is regulated by pro-inflammatory TNF-alpha...