Annelies Van Rie

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Linkage to care and treatment for TB and HIV among people newly diagnosed with TB or HIV-associated TB at a large, inner city South African hospital
    Yara Voss De Lima
    Clinical HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 8:e49140. 2013
  2. doi request reprint Diagnostic accuracy and effectiveness of the Xpert MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, 2104F McGavran Greenberg Hall, Chapel Hill, NC, 27514 7435, USA
    Eur J Clin Microbiol Infect Dis 32:1409-15. 2013
  3. doi request reprint Point-of-care Xpert® MTB/RIF for smear-negative tuberculosis suspects at a primary care clinic in South Africa
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 17:368-72. 2013
  4. pmc False-positive rifampicin resistance on Xpert® MTB/RIF: case report and clinical implications
    A van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 16:206-8. 2012
  5. pmc Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
    David M Murdoch
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    AIDS Res Ther 6:16. 2009
  6. pmc Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)
    Catherine M Worsley
    Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
    AIDS Res Ther 7:36. 2010
  7. ncbi request reprint Counseling and testing TB patients for HIV: evaluation of three implementation models in Kinshasa, Congo
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
    Int J Tuberc Lung Dis 12:73-8. 2008
  8. ncbi request reprint Patient and provider perspectives on implementation models of HIV counseling and testing for patients with TB
    A Corneli
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 12:79-84. 2008
  9. doi request reprint Measuring stigma associated with tuberculosis and HIV/AIDS in southern Thailand: exploratory and confirmatory factor analyses of two new scales
    Annelies Van Rie
    The University of North Carolina, Chapel Hill, NC, USA
    Trop Med Int Health 13:21-30. 2008
  10. pmc Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Pediatrics 122:e123-8. 2008

Research Grants

Detail Information

Publications80

  1. pmc Linkage to care and treatment for TB and HIV among people newly diagnosed with TB or HIV-associated TB at a large, inner city South African hospital
    Yara Voss De Lima
    Clinical HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    PLoS ONE 8:e49140. 2013
    ..To assess the outcomes of linkage to TB and HIV care and identify risk factors for poor referral outcomes...
  2. doi request reprint Diagnostic accuracy and effectiveness of the Xpert MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, 2104F McGavran Greenberg Hall, Chapel Hill, NC, 27514 7435, USA
    Eur J Clin Microbiol Infect Dis 32:1409-15. 2013
    ..Xpert is accurate and effective and could be endorsed as the initial diagnostic for HIV-associated LNTB...
  3. doi request reprint Point-of-care Xpert® MTB/RIF for smear-negative tuberculosis suspects at a primary care clinic in South Africa
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 17:368-72. 2013
    ..To assess the clinical utility and cost of point-of-care Xpert® MTB/RIF for the diagnosis of smear-negative tuberculosis (TB)...
  4. pmc False-positive rifampicin resistance on Xpert® MTB/RIF: case report and clinical implications
    A van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 16:206-8. 2012
    ..When decentralising Xpert, test performance characteristics need to be understood by health care workers and methods of confirmation of RMP resistance need to be accessible...
  5. pmc Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)
    David M Murdoch
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    AIDS Res Ther 6:16. 2009
    ..CONCLUSION: CD4+ and CD8+ T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8+ T cell effector subpopulations...
  6. pmc Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)
    Catherine M Worsley
    Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
    AIDS Res Ther 7:36. 2010
    ..The immune system's role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication...
  7. ncbi request reprint Counseling and testing TB patients for HIV: evaluation of three implementation models in Kinshasa, Congo
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
    Int J Tuberc Lung Dis 12:73-8. 2008
    ..Kinshasa, Democratic Republic of Congo...
  8. ncbi request reprint Patient and provider perspectives on implementation models of HIV counseling and testing for patients with TB
    A Corneli
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 12:79-84. 2008
    ..TB clinics in Kinshasa, Democratic Republic of Congo...
  9. doi request reprint Measuring stigma associated with tuberculosis and HIV/AIDS in southern Thailand: exploratory and confirmatory factor analyses of two new scales
    Annelies Van Rie
    The University of North Carolina, Chapel Hill, NC, USA
    Trop Med Int Health 13:21-30. 2008
    ..To develop scales to measure tuberculosis and HIV/AIDS stigma in a developing world context...
  10. pmc Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Pediatrics 122:e123-8. 2008
    ....
  11. pmc Training health care workers to promote HIV services for patients with tuberculosis in the Democratic Republic of Congo
    Koen Vanden Driessche
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Hum Resour Health 7:23. 2009
    ..CONCLUSION: Many HCWs did not possess the knowledge or skills necessary to integrate HIV activities into routine care for patients with TB. A participatory approach resulted in training materials that fulfilled local needs...
  12. pmc Neurodevelopmental trajectory of HIV-infected children accessing care in Kinshasa, Democratic Republic of Congo
    Annelies Van Rie
    Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    J Acquir Immune Defic Syndr 52:636-42. 2009
    ..To assess the effect of HIV care (including highly active antiretroviral therapy if eligible) on neurodevelopment...
  13. pmc Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategies
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    J Acquir Immune Defic Syndr 56:349-55. 2011
    ..To determine tuberculosis (TB) incidence rates and risk factors among individuals receiving antiretroviral treatment (ART)...
  14. doi request reprint Xpert(®) MTB/RIF for point-of-care diagnosis of TB in high-HIV burden, resource-limited countries: hype or hope?
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599 7435, USA
    Expert Rev Mol Diagn 10:937-46. 2010
    ..We also discuss key research questions that need to be addressed prior to possible large-scale implementation of the assay...
  15. ncbi request reprint TB and HIV in St Petersburg, Russia: a looming catastrophe?
    A van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Int J Tuberc Lung Dis 9:740-5. 2005
    ..After decades of improved tuberculosis (TB) control in Russia, notification rates started to rise in 1992. Russia also faces a fast growing human immunodeficiency virus (HIV) epidemic...
  16. pmc Gamma interferon production in response to Mycobacterium bovis BCG and Mycobacterium tuberculosis antigens in infants born to human immunodeficiency virus-infected mothers
    Annelies Van Rie
    Department of Epidemiology, The University of North Carolina at Chapel Hill, 2104F McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
    Clin Vaccine Immunol 13:246-52. 2006
    ..Further studies will be important to help determine optimal vaccination and disease prevention strategies for this vulnerable population group...
  17. ncbi request reprint Adolescent and adult pertussis vaccination: computer simulations of five new strategies
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina, 2104F McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
    Vaccine 22:3154-65. 2004
    ....
  18. ncbi request reprint Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective
    Annelies Van Rie
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 2104F Mc Gavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
    Eur J Paediatr Neurol 11:1-9. 2007
    ..Neurotropic HIV-1 likely develops distinct genotypic characteristics in response to this unique environment. We reviewed the literature on pediatric neuroAIDS and identified gaps in the current knowledge...
  19. ncbi request reprint XDR tuberculosis: an indicator of public-health negligence
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Lancet 368:1554-6. 2006
  20. pmc Effect of pulmonary tuberculosis on mortality in patients receiving HAART
    Daniel Westreich
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    AIDS 23:707-15. 2009
    ..To estimate the effect of ongoing treatment for pulmonary tuberculosis (PTB) at time of initiation of HAART on subsequent risk of death...
  21. pmc Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South Africa
    Kate Clouse
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 18:451-60. 2013
    ..HIV-positive pregnant women are at heightened risk of becoming lost to follow-up (LTFU) from HIV care. We examined LTFU before and after delivery among pregnant women newly diagnosed with HIV...
  22. pmc Initiating antiretroviral therapy when presenting with higher CD4 cell counts results in reduced loss to follow-up in a resource-limited setting
    Kate Clouse
    Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa
    AIDS 27:645-50. 2013
    ..Mortality and morbidity are known to be reduced when initiating at higher CD4 levels; we explored the impact on patient loss to follow-up...
  23. pmc Patient retention from HIV diagnosis through one year on antiretroviral therapy at a primary health care clinic in Johannesburg, South Africa
    Kate Clouse
    Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 62:e39-46. 2013
    ..To compare patient retention at 3 stages of pre-antiretroviral (ART) care and 2 stages of post-ART care to identify when greatest attrition occurs...
  24. pmc Anti-retroviral therapy reduces incident tuberculosis in HIV-infected children
    Andrew Edmonds
    The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC, USA
    Int J Epidemiol 38:1612-21. 2009
    ..We aimed to estimate the effect of anti-retroviral therapy (ART) on incident tuberculosis (TB) in a cohort of HIV-infected children...
  25. pmc Xpert MTB/RIF as a measure of sputum bacillary burden. Variation by HIV status and immunosuppression
    Colleen F Hanrahan
    1 Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina
    Am J Respir Crit Care Med 189:1426-34. 2014
    ..Xpert MTB/RIF cycle threshold values are a measure of sputum mycobacterial burden. Data on the impact of HIV infection and immunosuppression on this measure are limited...
  26. pmc The effect of cotrimoxazole prophylactic treatment on malaria, birth outcomes, and postpartum CD4 count in HIV-infected women
    Anna Dow
    University of North Carolina Gillings School of Global Public Health, 2104 McGavran Greenberg Hall, 135 Dauer Drive, CB 7435, Chapel Hill, NC 27599 7435, USA
    Infect Dis Obstet Gynecol 2013:340702. 2013
    ..Limited data exist on cotrimoxazole prophylactic treatment (CPT) in pregnant women, including protection against malaria versus standard intermittent preventive therapy with sulfadoxine-pyrimethamine (IPTp)...
  27. doi request reprint A visual dosing aid for first-line pediatric antiretroviral treatment in resource-poor settings
    Steven F J Callens
    School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    J Trop Pediatr 55:135-7. 2009
    ..Results did not differ between sites. The VDA enables accurate dosing of pediatric ART in distinct populations and could facilitate roll-out of pediatric ART in resource-poor settings...
  28. doi request reprint Integration and task shifting for TB/HIV care and treatment in highly resource-scarce settings: one size may not fit all
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC and School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
    J Acquir Immune Defic Syndr 65:e110-7. 2014
    ..The effectiveness of CD4-stratified ART initiation in a nurse-centered, integrated TB/HIV program at primary care in Kinshasa, Democratic Republic of Congo, was assessed...
  29. doi request reprint Quantification of CD4 responses to combined antiretroviral therapy over 5 years among HIV-infected children in Kinshasa, Democratic Republic of Congo
    Andrew Edmonds
    Department of Epidemiology, The University of North Carolina at Chapel Hill, McGavran Greenberg Hall, CB 7435, Chapel Hill, NC 27599 7435, USA
    J Acquir Immune Defic Syndr 61:90-8. 2012
    ..We sought to describe this relationship...
  30. pmc Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children
    Marcel Yotebieng
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 24:139-46. 2010
    ..Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses...
  31. pmc The effect of highly active antiretroviral therapy on the survival of HIV-infected children in a resource-deprived setting: a cohort study
    Andrew Edmonds
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Med 8:e1001044. 2011
    ..Because most pediatric HIV occurs in low- and middle-income countries, our objective was to provide a first estimate of this effect among children living in a resource-deprived setting...
  32. doi request reprint Mortality and associated factors after initiation of pediatric antiretroviral treatment in the Democratic Republic of the Congo
    Steven F J Callens
    School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
    Pediatr Infect Dis J 28:35-40. 2009
    ..We aimed to describe factors associated with mortality among children receiving antiretroviral treatment (ART) at a pediatric hospital in Kinshasa, Democratic Republic of the Congo...
  33. pmc Time to treatment and patient outcomes among TB suspects screened by a single point-of-care xpert MTB/RIF at a primary care clinic in Johannesburg, South Africa
    Colleen F Hanrahan
    University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e65421. 2013
    ..We describe the diagnostic follow-up, clinical characteristics and outcomes of a cohort of tuberculosis suspects screened using a single point-of-care Xpert...
  34. pmc Socio-demographic and AIDS-related factors associated with tuberculosis stigma in southern Thailand: a quantitative, cross-sectional study of stigma among patients with TB and healthy community members
    Aaron M Kipp
    University of North Carolina, Department of Epidemiology, Chapel Hill, North Carolina, USA
    BMC Public Health 11:675. 2011
    ..The purpose of this study was to measure TB stigma and identify factors associated with TB stigma among patients and healthy community members...
  35. doi request reprint Baseline assessment of collaborative tuberculosis/HIV activities in Kinshasa, the Democratic Republic of Congo
    Amanda Martinot
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Trop Doct 38:137-41. 2008
    ..Shortcomings in human resources, infrastructure and quality of services were revealed. Strengthening those clinics already implementing HIV activities could be prioritized to achieve the goals set forward by the Global Plan to Stop TB...
  36. doi request reprint Implementation of Xpert MTB/RIF for routine point-of-care diagnosis of tuberculosis at the primary care level
    Kate Clouse
    Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
    S Afr Med J 102:805-7. 2012
    ..POC use of Xpert is feasible at the primary healthcare level but must be accompanied by financial, operational and logistical support...
  37. pmc Comparison of Xpert MTB/RIF with other nucleic acid technologies for diagnosing pulmonary tuberculosis in a high HIV prevalence setting: a prospective study
    Lesley E Scott
    Department of Molecular Medicine and Hematology, University of the Witwatersrand, Johannesburg, South Africa
    PLoS Med 8:e1001061. 2011
    ....
  38. pmc Computed CD4 percentage as a low-cost method for determining pediatric antiretroviral treatment eligibility
    Steven F J Callens
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA
    BMC Infect Dis 8:31. 2008
    ..The performance of the WHO recommendations for pediatric antiretroviral treatment (ART) in resource poor settings is insufficiently documented in routine care...
  39. doi request reprint Effect on mortality and virological response of delaying antiretroviral therapy initiation in children receiving tuberculosis treatment
    Marcel Yotebieng
    Department of Epidemiology, University of North Carolina at Chapel Hill, USA
    AIDS 24:1341-9. 2010
    ..To estimate the effect of delaying antiretroviral treatment (ART) for 15, 30, or 60 days after tuberculosis (TB) treatment initiation on mortality and virological suppression...
  40. pmc Postpartum depression and HIV infection among women in Malawi
    Anna Dow
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC and Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi
    J Acquir Immune Defic Syndr 65:359-65. 2014
    ..We aimed to describe the prevalence and cumulative incidence of PPD in the low-income setting of Malawi and to determine the association between maternal and infant HIV and PPD...
  41. pmc Comparison of pharmacy-based measures of adherence to antiretroviral therapy as predictors of virological failure
    Cassidy E Henegar
    Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    AIDS Behav 19:612-8. 2015
    ..Pharmacy based measures alone, however, are inadequate for identifying most cases of nonadherence. ..
  42. pmc Pulmonary cystic disease in HIV positive individuals in the Democratic Republic of Congo: three case reports
    Steven Fj Callens
    School of Public Health, University of North Carolina at Chapel Hill, USA
    J Med Case Reports 1:101. 2007
    ..In this report, we describe three HIV-infected individuals (one woman and two children) presenting with extensive pulmonary cystic disease...
  43. ncbi request reprint Role of maternal pertussis antibodies in infants
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Pediatr Infect Dis J 24:S62-5. 2005
    ..The limited data on neonatal and maternal pertussis immunization are promising and call for further research to reduce the vulnerability of young infants to pertussis disease...
  44. pmc Tuberculosis treatment and risk of stavudine substitution in first-line antiretroviral therapy
    Daniel J Westreich
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Clin Infect Dis 48:1617-23. 2009
    ..We estimated the effect of TB treatment on risk of stavudine substitution among individuals receiving first-line HAART...
  45. doi request reprint Impact of systematic HIV testing on case finding and retention in care at a primary care clinic in South Africa
    Kate Clouse
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA
    Trop Med Int Health 19:1411-9. 2014
    ..We explored LTFU and patient clinical outcomes under two different HIV testing strategies...
  46. doi request reprint Barriers to successful early infant diagnosis of HIV infection at primary care level in Malawi
    Elizabeth A Cromwell
    From the Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi Department of Pediatrics and Child Health, Queen Elizabeth Central Hospital, Blantyre, Malawi and School of Medicine, University of Washington, Seattle, Washington
    Pediatr Infect Dis J 34:273-5. 2015
    ..Infants of mothers receiving antiretroviral treatment were less likely to drop out (adjusted risk ratio 0.51), suggesting that EID completion may improve in programs providing antiretroviral treatment to all pregnant women. ..
  47. doi request reprint Temporal changes in the outcomes of HIV-exposed infants in Kinshasa, Democratic Republic of Congo during a period of rapidly evolving guidelines for care (2007-2013)
    Lydia Feinstein
    aThe University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA bKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo cThe University of North Carolina at Chapel Hill, School of Medicine, Department of Obstetrics and Gynecology, Chapel Hill, North Carolina, USA
    AIDS 28:S301-11. 2014
    ..We describe HIV-exposed infant outcomes in Kinshasa, Democratic Republic of Congo, between 2007 and 2013...
  48. ncbi request reprint Effect of baseline immune suppression on growth recovery in HIV positive South African children receiving antiretroviral treatment
    Lydia Feinstein
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Acquir Immune Defic Syndr 61:235-42. 2012
    ..Growth failure is common among children infected with HIV. The degree of growth recovery and its determinants in children initiating combination antiretroviral therapy (cART) are not well understood...
  49. pmc NeuroAIDS in Africa
    Kevin Robertson
    Department of Neurology, University of North Carolina, Chapel Hill, North Carolina 27599 7025, USA
    J Neurovirol 16:189-202. 2010
    ....
  50. ncbi request reprint Survival in women exposed to single-dose nevirapine for prevention of mother-to-child transmission of HIV: a stochastic model
    Daniel Westreich
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Infect Dis 195:837-46. 2007
    ..The impact that sdNVP has on survival in the era of increasing access to HAART is unknown...
  51. pmc Second assessment of NeuroAIDS in Africa
    Kevin Robertson
    Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
    J Neurovirol 14:87-101. 2008
    ..The conference presentations summarized here highlight the need for further research on neuroAIDS in Africa and methods for assessing HIV-related neurological disorders...
  52. pmc High uptake of systematic HIV counseling and testing and TB symptom screening at a primary care clinic in South Africa
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 9:e105428. 2014
    ..Timely diagnosis and treatment of tuberculosis (TB) and HIV is important to reduce morbidity and mortality, and break the cycle of ongoing transmission...
  53. ncbi request reprint Transmission of Bordetella pertussis to young infants
    Aaron M Wendelboe
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
    Pediatr Infect Dis J 26:293-9. 2007
    ..This proportion, however, remains unclear, because studies have not been able to determine the source case for 47%-60% of infant cases...
  54. pmc Extrapulmonary tuberculosis, human immunodeficiency virus, and foreign birth in North Carolina, 1993 - 2006
    Aaron M Kipp
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Public Health 8:107. 2008
    ..HIV infection and foreign birth are increasingly associated with tuberculosis and understanding their effect on the clinical presentation of tuberculosis is important...
  55. pmc Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patterns
    Annelies Van Rie
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Respir Crit Care Med 172:636-42. 2005
    ..Multiple infections with different strains of Mycobacterium tuberculosis may occur in settings where the infection pressure is high. The relevance of mixed infections for the patient, clinician, and control program remains unclear...
  56. pmc Prevalent tuberculosis and mortality among HAART initiators
    Daniel Westreich
    Department of Obstetrics and Gynecology, Duke Global Health Institute, Duke University, Durham, North Carolina, USA
    AIDS 26:770-3. 2012
    ..In reanalysis, treatment for tuberculosis at time of HAART initiation remained unassociated with increased risks of all-cause mortality, with adjusted hazard ratios ranging from 1.00 to 1.09...
  57. ncbi request reprint Pulmonary Sporothrix schenckii infection in a HIV positive child
    Steven F J Callens
    Pediatric Hospital Kalembe Lembe, Kinshasa, Democratic Republic of the Congo
    J Trop Pediatr 52:144-6. 2006
    ..schenckii in Sub-Saharan Africa is not well known. We report a case of invasive pulmonary sporotrichosis in an eleven year old HIV-infected boy in Kinshasa, Democratic Republic of the Congo, successfully treated with oral fluconazole...
  58. doi request reprint Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective study
    David M Murdoch
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina NC 27710, USA
    AIDS 22:601-10. 2008
    ..To determine the incidence, clinical manifestations, risk factors and outcome of immune reconstitution inflammatory syndrome (IRIS) in South Africa...
  59. doi request reprint "What they wanted was to give birth; nothing else": barriers to retention in option B+ HIV care among postpartum women in South Africa
    Kate Clouse
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC and Witkoppen Health and Welfare Centre, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 67:e12-8. 2014
    ..We aimed to identify challenges to postpartum retention in care under Option B+, which expands antiretroviral therapy access to all HIV-positive pregnant women regardless of CD4 count...
  60. pmc Validity of US norms for the Bayley Scales of Infant Development-III in Malawian children
    Elizabeth A Cromwell
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, USA Electronic address
    Eur J Paediatr Neurol 18:223-30. 2014
    ..We assessed the validity of United States (US)-based norms for the Bayley Scales of Infant and Toddler Development-III (BSID-III), a neurodevelopmental tool developed for and commonly used in the US, in Malawian children...
  61. doi request reprint The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral therapy: a systematic review
    Heidi M Soeters
    aDepartment of Epidemiology bDivision of Infectious Diseases cCenter for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 28:245-55. 2014
    ..To determine the impact of tuberculosis (TB) treatment at the time of combination antiretroviral therapy (cART) initiation on virologic and CD4 cell count response to cART...
  62. pmc Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children
    Christa Buckheit Sturdevant
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1003094. 2012
    ..5 months, and becoming fully apparent in the CSF by age 18 months. Overall, compartmentalized viral replication in the CNS occurred in half of children by year three...
  63. pmc Effects of cotrimoxazole prophylactic treatment on adverse health outcomes among HIV-exposed, uninfected infants
    Anna Dow
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27599 7435, USA
    Pediatr Infect Dis J 31:842-7. 2012
    ....
  64. pmc "They have already thrown away their chicken": barriers affecting participation by HIV-infected women in care and treatment programs for their infants in Blantyre, Malawi
    Marie Collins Donahue
    Department of Health Education and Behavior, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA
    AIDS Care 24:1233-9. 2012
    ..For optimal impact of EID and infant ART, reasons for poor uptake should be better understood and addressed in a culturally sensitive manner...
  65. pmc Effect of cotrimoxazole on mortality in HIV-infected adults on antiretroviral therapy: a systematic review and meta-analysis
    Amitabh B Suthar
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Bull World Health Organ 90:128C-138C. 2012
    ..To determine whether cotrimoxazole reduces mortality in adults receiving antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in low- and middle-income countries through a systematic review and meta-analysis...
  66. pmc Preventing vertical transmission of HIV in Kinshasa, Democratic Republic of the Congo: a baseline survey of 18 antenatal clinics
    Frieda Mtf Behets
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel, NC, USA
    Bull World Health Organ 84:969-75. 2006
    ..To assess the content and delivery of essential antenatal services before implementation of programmes for prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV)...
  67. pmc Age-specific and sex-specific weight gain norms to monitor antiretroviral therapy in children in low-income and middle-income countries
    Marcel Yotebieng
    aDivision of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio bDepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA cDepartment of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa dSchool of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA eSchool of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa fInstitute of Social and Preventive Medicine, University of Bern, Switzerland gTumbi Regional Referral Hospital, Kibaha hMorogoro Regional Hospital, Morogoro, Tanzania iUniversity of New South Wales, The Kirby Institute for Infection and Immunity in Society, Darlinghurst, New South Wales, Australia jChiangrai Prachanukroh Hospital, Chiangrai, Thailand kInstitut de Santé Publique Epidemiologie et Développement, Université Bordeaux lInserm, Centre Inserm U897 Épidémiologie et Biostatistique, Bordeaux, France mCentre National Hospitalier, Universitaire Hubert K Maga, Cotonou, Bénin nRTI International, Biostatistics and Epidemiology, Research Triangle Park, North Carolina, USA
    AIDS 29:101-9. 2015
    ..We aimed to construct normative curves for weight gain at 6, 12, 18, and 24 months following initiation of ART in children, and to assess the association between poor weight gain and subsequent responses to ART...
  68. pmc Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment
    Cassidy E Henegar
    Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa and Division of Infectious Diseases, Department of Medicine, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC
    J Acquir Immune Defic Syndr 68:477-80. 2015
    ..46, 95% confidence interval: 1.17 to 1.82) but not during pregnancy itself (weighted risk ratio: 0.95, 95% confidence interval: 0.78 to 1.17). ..
  69. pmc Is HIV infection a risk factor for multi-drug resistant tuberculosis? A systematic review
    Sujit Suchindran
    School of Medicine, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5561. 2009
    ..The association between MDR-TB and HIV infection has not yet been fully investigated. We conducted a systematic review and meta-analysis to summarize the evidence on the association between HIV infection and MDR-TB...
  70. doi request reprint Implementation of a safer conception service for HIV-affected couples in South Africa
    Sheree R Schwartz
    aDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA bWitkoppen Health and Welfare Centre cClinical HIV Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa dRight to Care, Johannesburg, South Africa eDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    AIDS 28:S277-85. 2014
    ..To describe the development and implementation of a safer conception service in a resource-limited setting...
  71. pmc The effect of tuberculosis treatment at combination antiretroviral therapy initiation on subsequent mortality: a systematic review and meta-analysis
    Heidi M Soeters
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e78073. 2013
    ..We aimed to perform a systematic review and meta-analysis examining the impact of TB treatment at the time of combination antiretroviral therapy (cART) initiation on subsequent mortality...
  72. pmc Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study
    Ian M Sanne
    Clinical HIV Research Unit, Dept of Medicine, University of the Witwatersrand, Johannesburg, South Africa
    J Int AIDS Soc 12:38. 2009
    ..We aimed to prospectively evaluate long-term treatment outcomes at a large scale HIV/AIDS care clinic in South Africa...
  73. ncbi request reprint Duration of immunity against pertussis after natural infection or vaccination
    Aaron M Wendelboe
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Pediatr Infect Dis J 24:S58-61. 2005
    ..Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control...
  74. pmc Tuberculosis Immune Reconstitution Inflammatory Syndrome in Children Initiating Antiretroviral Therapy for HIV Infection: A Systematic Literature Review
    Ruth Link-Gelles
    From the Department of Epidemiology, University of North Carolina, Chapel Hill, NC Wits Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa and Duke University Medical Center, Durham, NC
    Pediatr Infect Dis J 33:499-503. 2014
    ..While this syndrome has been well researched in adults, little is known about the incidence, case fatality, underlying immunopathology and treatment approaches in children...
  75. ncbi request reprint [Prenatal care in Kinshasa: Knowledge, beliefs, and barriers to timely care]
    Maria Khan
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Sante 15:93-7. 2005
    ..Educating women on the importance of timely antenatal care and improving its financial accessibility should be priorities for maternal and child health programs in the DRC...
  76. pmc HIV immune reconstitution syndrome in sub-Saharan Africa
    David M Murdoch
    AIDS 22:1689-90. 2008
  77. ncbi request reprint Pertussis in adolescents and adults: should we accept the results?
    Jaime Caro
    Pediatrics 116:1263; author reply 1263-4. 2005
  78. pmc Comparison of serological and real-time PCR assays to diagnose Bordetella pertussis infection in 2007
    Philippe Andre
    Sanofi Pasteur, 2 avenue Pont Pasteur, 69367 Lyon Cedex 07, France
    J Clin Microbiol 46:1672-7. 2008
    ..The most specific tests for diagnosis of pertussis were single serology and ptxA-Pr PCR, and the most sensitive diagnostic tool was the combination of IS481 PCR with single serology...
  79. ncbi request reprint Unveiling the burden of pertussis
    Michiel van Boven
    Animal Sciences Group, Wageningen University and Research Centre, P O Box 65, 8200 AB Lelystad, The Netherlands
    Trends Microbiol 12:116-9. 2004
  80. ncbi request reprint Diagnosis of pertussis: a historical review and recent developments
    Aaron Mark Wendelboe
    AMW, 1190 St Francis Dr, Suite N1320, Santa Fe, NM 87505, USA
    Expert Rev Mol Diagn 6:857-64. 2006
    ..This article reviews the strengths and limitations, including the sensitivity and specificity, of each of these diagnostic tools...

Research Grants2

  1. Neurodevelopment and HIV/AIDS
    Annelies Van Rie; Fiscal Year: 2005
    ....
  2. Pediatric HIV-encephalopathy in DRC: effect of ART & role of compartmentalization
    Annelies Van Rie; Fiscal Year: 2010
    ....