Research Topics
| Annelies Van RieSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Point-of-care Xpert® MTB/RIF for smear-negative tuberculosis suspects at a primary care clinic in South AfricaA van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Int J Tuberc Lung Dis 17:368-72. 2013..To assess the clinical utility and cost of point-of-care Xpert® MTB/RIF for the diagnosis of smear-negative tuberculosis (TB)...- False-positive rifampicin resistance on Xpert® MTB/RIF: case report and clinical implicationsA van Rie
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Int J Tuberc Lung Dis 16:206-8. 2012..When decentralising Xpert, test performance characteristics need to be understood by health care workers and methods of confirmation of RMP resistance need to be accessible... 
Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort studyIan M Sanne
Clinical HIV Research Unit, Dept of Medicine, University of the Witwatersrand, Johannesburg, South Africa
J Int AIDS Soc 12:38. 2009..We aimed to prospectively evaluate long-term treatment outcomes at a large scale HIV/AIDS care clinic in South Africa...- Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS)David M Murdoch
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
AIDS Res Ther 6:16. 2009..CONCLUSION: CD4+ and CD8+ T cell subset maturational phenotypes were heterogeneous among IRIS cases and controls. However, IRIS cases demonstrated significant increases in activation of CD8+ T cell effector subpopulations... - Multi-analyte profiling of ten cytokines in South African HIV-infected patients with Immune Reconstitution Inflammatory Syndrome (IRIS)Catherine M Worsley
Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Services, Johannesburg, South Africa
AIDS Res Ther 7:36. 2010..The immune system's role in HIV infected patients is complex with cytokine expression strongly influencing HIV infection and replication... - Tuberculosis in patients receiving antiretroviral treatment: incidence, risk factors, and prevention strategiesAnnelies Van Rie
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
J Acquir Immune Defic Syndr 56:349-55. 2011..To determine tuberculosis (TB) incidence rates and risk factors among individuals receiving antiretroviral treatment (ART)... 
Patient and provider perspectives on implementation models of HIV counseling and testing for patients with TBA Corneli
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Int J Tuberc Lung Dis 12:79-84. 2008..TB clinics in Kinshasa, Democratic Republic of Congo...- Counseling and testing TB patients for HIV: evaluation of three implementation models in Kinshasa, CongoA van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
Int J Tuberc Lung Dis 12:73-8. 2008..Kinshasa, Democratic Republic of Congo... - Measuring stigma associated with tuberculosis and HIV/AIDS in southern Thailand: exploratory and confirmatory factor analyses of two new scalesAnnelies Van Rie
The University of North Carolina, Chapel Hill, NC, USA
Trop Med Int Health 13:21-30. 2008..To develop scales to measure tuberculosis and HIV/AIDS stigma in a developing world context... - Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the CongoAnnelies Van Rie
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Pediatrics 122:e123-8. 2008.... - Training health care workers to promote HIV services for patients with tuberculosis in the Democratic Republic of CongoKoen Vanden Driessche
School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Hum Resour Health 7:23. 2009..CONCLUSION: Many HCWs did not possess the knowledge or skills necessary to integrate HIV activities into routine care for patients with TB. A participatory approach resulted in training materials that fulfilled local needs... - XDR tuberculosis: an indicator of public-health negligenceAnnelies Van Rie
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599-7435, USA
Lancet 368:1554-6. 2006 - Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspectiveAnnelies Van Rie
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, 2104F Mc Gavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Eur J Paediatr Neurol 11:1-9. 2007..Neurotropic HIV-1 likely develops distinct genotypic characteristics in response to this unique environment. We reviewed the literature on pediatric neuroAIDS and identified gaps in the current knowledge... - Adolescent and adult pertussis vaccination: computer simulations of five new strategiesAnnelies Van Rie
Department of Epidemiology, University of North Carolina, 2104F McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Vaccine 22:3154-65. 2004.... - Gamma interferon production in response to Mycobacterium bovis BCG and Mycobacterium tuberculosis antigens in infants born to human immunodeficiency virus-infected mothersAnnelies Van Rie
Department of Epidemiology, The University of North Carolina at Chapel Hill, 2104F McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Clin Vaccine Immunol 13:246-52. 2006..Further studies will be important to help determine optimal vaccination and disease prevention strategies for this vulnerable population group... - Neurodevelopmental trajectory of HIV-infected children accessing care in Kinshasa, Democratic Republic of CongoAnnelies Van Rie
Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
J Acquir Immune Defic Syndr 52:636-42. 2009..To assess the effect of HIV care (including highly active antiretroviral therapy if eligible) on neurodevelopment... - Xpert(®) MTB/RIF for point-of-care diagnosis of TB in high-HIV burden, resource-limited countries: hype or hope?Annelies Van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599 7435, USA
Expert Rev Mol Diagn 10:937-46. 2010..We also discuss key research questions that need to be addressed prior to possible large-scale implementation of the assay... - TB and HIV in St Petersburg, Russia: a looming catastrophe?A van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Int J Tuberc Lung Dis 9:740-5. 2005..After decades of improved tuberculosis (TB) control in Russia, notification rates started to rise in 1992. Russia also faces a fast growing human immunodeficiency virus (HIV) epidemic... - Effect of pulmonary tuberculosis on mortality in patients receiving HAARTDaniel Westreich
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
AIDS 23:707-15. 2009..To estimate the effect of ongoing treatment for pulmonary tuberculosis (PTB) at time of initiation of HAART on subsequent risk of death... - Anti-retroviral therapy reduces incident tuberculosis in HIV-infected childrenAndrew Edmonds
The University of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, NC, USA
Int J Epidemiol 38:1612-21. 2009..We aimed to estimate the effect of anti-retroviral therapy (ART) on incident tuberculosis (TB) in a cohort of HIV-infected children... - A visual dosing aid for first-line pediatric antiretroviral treatment in resource-poor settingsSteven F J Callens
School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
J Trop Pediatr 55:135-7. 2009..Results did not differ between sites. The VDA enables accurate dosing of pediatric ART in distinct populations and could facilitate roll-out of pediatric ART in resource-poor settings... - Quantification of CD4 responses to combined antiretroviral therapy over 5 years among HIV-infected children in Kinshasa, Democratic Republic of CongoAndrew Edmonds
Department of Epidemiology, The University of North Carolina at Chapel Hill, McGavran Greenberg Hall, CB 7435, Chapel Hill, NC 27599 7435, USA
J Acquir Immune Defic Syndr 61:90-8. 2012..We sought to describe this relationship... - Mortality and associated factors after initiation of pediatric antiretroviral treatment in the Democratic Republic of the CongoSteven F J Callens
School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Pediatr Infect Dis J 28:35-40. 2009..We aimed to describe factors associated with mortality among children receiving antiretroviral treatment (ART) at a pediatric hospital in Kinshasa, Democratic Republic of the Congo... - The effect of highly active antiretroviral therapy on the survival of HIV-infected children in a resource-deprived setting: a cohort studyAndrew Edmonds
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Med 8:e1001044. 2011..Because most pediatric HIV occurs in low- and middle-income countries, our objective was to provide a first estimate of this effect among children living in a resource-deprived setting... - Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African childrenMarcel Yotebieng
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
AIDS 24:139-46. 2010..Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses... - Socio-demographic and AIDS-related factors associated with tuberculosis stigma in southern Thailand: a quantitative, cross-sectional study of stigma among patients with TB and healthy community membersAaron M Kipp
University of North Carolina, Department of Epidemiology, Chapel Hill, North Carolina, USA
BMC Public Health 11:675. 2011..The purpose of this study was to measure TB stigma and identify factors associated with TB stigma among patients and healthy community members... - Baseline assessment of collaborative tuberculosis/HIV activities in Kinshasa, the Democratic Republic of CongoAmanda Martinot
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
Trop Doct 38:137-41. 2008..Shortcomings in human resources, infrastructure and quality of services were revealed. Strengthening those clinics already implementing HIV activities could be prioritized to achieve the goals set forward by the Global Plan to Stop TB... - Computed CD4 percentage as a low-cost method for determining pediatric antiretroviral treatment eligibilitySteven F J Callens
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA
BMC Infect Dis 8:31. 2008..The performance of the WHO recommendations for pediatric antiretroviral treatment (ART) in resource poor settings is insufficiently documented in routine care... - Effect on mortality and virological response of delaying antiretroviral therapy initiation in children receiving tuberculosis treatmentMarcel Yotebieng
Department of Epidemiology, University of North Carolina at Chapel Hill, USA
AIDS 24:1341-9. 2010..To estimate the effect of delaying antiretroviral treatment (ART) for 15, 30, or 60 days after tuberculosis (TB) treatment initiation on mortality and virological suppression... - Pulmonary cystic disease in HIV positive individuals in the Democratic Republic of Congo: three case reportsSteven Fj Callens
School of Public Health, University of North Carolina at Chapel Hill, USA
J Med Case Reports 1:101. 2007..In this report, we describe three HIV-infected individuals (one woman and two children) presenting with extensive pulmonary cystic disease... - Tuberculosis treatment and risk of stavudine substitution in first-line antiretroviral therapyDaniel J Westreich
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Clin Infect Dis 48:1617-23. 2009..We estimated the effect of TB treatment on risk of stavudine substitution among individuals receiving first-line HAART... - Role of maternal pertussis antibodies in infantsAnnelies Van Rie
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Pediatr Infect Dis J 24:S62-5. 2005..The limited data on neonatal and maternal pertussis immunization are promising and call for further research to reduce the vulnerability of young infants to pertussis disease... - Effect of baseline immune suppression on growth recovery in HIV positive South African children receiving antiretroviral treatmentLydia Feinstein
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 61:235-42. 2012..Growth failure is common among children infected with HIV. The degree of growth recovery and its determinants in children initiating combination antiretroviral therapy (cART) are not well understood... - NeuroAIDS in AfricaKevin Robertson
Department of Neurology, University of North Carolina, Chapel Hill, North Carolina 27599 7025, USA
J Neurovirol 16:189-202. 2010.... - Survival in women exposed to single-dose nevirapine for prevention of mother-to-child transmission of HIV: a stochastic modelDaniel Westreich
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Infect Dis 195:837-46. 2007..The impact that sdNVP has on survival in the era of increasing access to HAART is unknown... - Second assessment of NeuroAIDS in AfricaKevin Robertson
Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
J Neurovirol 14:87-101. 2008..The conference presentations summarized here highlight the need for further research on neuroAIDS in Africa and methods for assessing HIV-related neurological disorders... - Implementation of Xpert MTB/RIF for routine point-of-care diagnosis of tuberculosis at the primary care levelKate Clouse
Clinical HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
S Afr Med J 102:805-7. 2012..POC use of Xpert is feasible at the primary healthcare level but must be accompanied by financial, operational and logistical support... - Prevalent tuberculosis and mortality among HAART initiatorsDaniel Westreich
Department of Obstetrics and Gynecology, Duke Global Health Institute, Duke University, Durham, North Carolina, USA
AIDS 26:770-3. 2012..In reanalysis, treatment for tuberculosis at time of HAART initiation remained unassociated with increased risks of all-cause mortality, with adjusted hazard ratios ranging from 1.00 to 1.09... - Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective studyDavid M Murdoch
Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina NC 27710, USA
AIDS 22:601-10. 2008..To determine the incidence, clinical manifestations, risk factors and outcome of immune reconstitution inflammatory syndrome (IRIS) in South Africa... - Pulmonary Sporothrix schenckii infection in a HIV positive childSteven F J Callens
Pediatric Hospital Kalembe Lembe, Kinshasa, Democratic Republic of the Congo
J Trop Pediatr 52:144-6. 2006..schenckii in Sub-Saharan Africa is not well known. We report a case of invasive pulmonary sporotrichosis in an eleven year old HIV-infected boy in Kinshasa, Democratic Republic of the Congo, successfully treated with oral fluconazole... - Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South AfricaKate Clouse
Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Trop Med Int Health 18:451-60. 2013..HIV-positive pregnant women are at heightened risk of becoming lost to follow-up (LTFU) from HIV care. We examined LTFU before and after delivery among pregnant women newly diagnosed with HIV... - Effects of cotrimoxazole prophylactic treatment on adverse health outcomes among HIV-exposed, uninfected infantsAnna Dow
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27599 7435, USA
Pediatr Infect Dis J 31:842-7. 2012.... - "They have already thrown away their chicken": barriers affecting participation by HIV-infected women in care and treatment programs for their infants in Blantyre, MalawiMarie Collins Donahue
Department of Health Education and Behavior, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA
AIDS Care 24:1233-9. 2012..For optimal impact of EID and infant ART, reasons for poor uptake should be better understood and addressed in a culturally sensitive manner... - Effect of cotrimoxazole on mortality in HIV-infected adults on antiretroviral therapy: a systematic review and meta-analysisAmitabh B Suthar
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Bull World Health Organ 90:128C-138C. 2012..To determine whether cotrimoxazole reduces mortality in adults receiving antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in low- and middle-income countries through a systematic review and meta-analysis... - Extrapulmonary tuberculosis, human immunodeficiency virus, and foreign birth in North Carolina, 1993 - 2006Aaron M Kipp
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
BMC Public Health 8:107. 2008..HIV infection and foreign birth are increasingly associated with tuberculosis and understanding their effect on the clinical presentation of tuberculosis is important... - Preventing vertical transmission of HIV in Kinshasa, Democratic Republic of the Congo: a baseline survey of 18 antenatal clinicsFrieda Mtf Behets
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel, NC, USA
Bull World Health Organ 84:969-75. 2006..To assess the content and delivery of essential antenatal services before implementation of programmes for prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV)... - Reinfection and mixed infection cause changing Mycobacterium tuberculosis drug-resistance patternsAnnelies Van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Respir Crit Care Med 172:636-42. 2005..We conclude that treatment and adherence determines which strain is dominant. We hypothesize that treatment with second-line drugs may lead to reemergence of the drug-susceptible strain in patients with mixed infection... - Transmission of Bordetella pertussis to young infantsAaron M Wendelboe
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7435, USA
Pediatr Infect Dis J 26:293-9. 2007..This proportion, however, remains unclear, because studies have not been able to determine the source case for 47%-60% of infant cases... - Is HIV infection a risk factor for multi-drug resistant tuberculosis? A systematic reviewSujit Suchindran
School of Medicine, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 4:e5561. 2009..The association between MDR-TB and HIV infection has not yet been fully investigated. We conducted a systematic review and meta-analysis to summarize the evidence on the association between HIV infection and MDR-TB... - Duration of immunity against pertussis after natural infection or vaccinationAaron M Wendelboe
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Pediatr Infect Dis J 24:S58-61. 2005..Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control... - Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young childrenChrista Buckheit Sturdevant
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS Pathog 8:e1003094. 2012..5 months, and becoming fully apparent in the CSF by age 18 months. Overall, compartmentalized viral replication in the CNS occurred in half of children by year three... - [Prenatal care in Kinshasa: Knowledge, beliefs, and barriers to timely care]Maria Khan
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Sante 15:93-7. 2005..Educating women on the importance of timely antenatal care and improving its financial accessibility should be priorities for maternal and child health programs in the DRC... - Pertussis in adolescents and adults: should we accept the results?Jaime Caro
Pediatrics 116:1263; author reply 1263-4. 2005 - HIV immune reconstitution syndrome in sub-Saharan AfricaDavid M Murdoch
AIDS 22:1689-90. 2008 - Diagnosis of pertussis: a historical review and recent developmentsAaron Mark Wendelboe
AMW, 1190 St Francis Dr, Suite N1320, Santa Fe, NM 87505, USA
Expert Rev Mol Diagn 6:857-64. 2006..This article reviews the strengths and limitations, including the sensitivity and specificity, of each of these diagnostic tools... - Comparison of serological and real-time PCR assays to diagnose Bordetella pertussis infection in 2007Philippe Andre
Sanofi Pasteur, 2 avenue Pont Pasteur, 69367 Lyon Cedex 07, France
J Clin Microbiol 46:1672-7. 2008..The most specific tests for diagnosis of pertussis were single serology and ptxA-Pr PCR, and the most sensitive diagnostic tool was the combination of IS481 PCR with single serology... - Unveiling the burden of pertussisMichiel van Boven
Animal Sciences Group, Wageningen University and Research Centre, P.O. Box 65, 8200 AB Lelystad, The Netherlands
Trends Microbiol 12:116-9. 2004
Research Grants
- Pediatric HIV-encephalopathy in DRC: effect of ART & role of compartmentalizationAnnelies Van Rie; Fiscal Year: 2007....
- Neurodevelopment and HIV/AIDSAnnelies Van Rie; Fiscal Year: 2005....
- Impact of malnutrition on TB-IRIS and pharmacokinetics of TB and ARV co-treatmentAnnelies Van Rie; Fiscal Year: 2009..In these children, we will also study the use of rifabutin, a drug used in U.S. adults with TB and HIV. The results of the research have the potential to substantially improve the management of children with TB and HIV. ..
- Pediatric HIV-encephalopathy in DRC: effect of ART & role of compartmentalizationAnnelies Van Rie; Fiscal Year: 2010....
- Impact of malnutrition on TB-IRIS and pharmacokinetics of TB and ARV co-treatmentAnnelies Van Rie; Fiscal Year: 2010..In these children, we will also study the use of rifabutin, a drug used in U.S. adults with TB and HIV. The results of the research have the potential to substantially improve the management of children with TB and HIV. ..