Ambro van Hoof

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast
    A van Hoof
    Department of Molecular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA
    EMBO J 19:1357-65. 2000
  2. ncbi Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA
    A van Hoof
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, Arizona 85721, USA
    Mol Cell Biol 20:8230-43. 2000
  3. ncbi Exosome-mediated recognition and degradation of mRNAs lacking a termination codon
    Ambro van Hoof
    Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
    Science 295:2262-4. 2002
  4. ncbi Messenger RNA degradation: beginning at the end
    Ambro van Hoof
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Curr Biol 12:R285-7. 2002
  5. ncbi Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail
    Stacie Meaux
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Mol Cell 29:134-40. 2008
  6. ncbi A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism
    Marenda A Wilson
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 177:773-84. 2007
  7. ncbi RNase II structure completes group portrait of 3' exoribonucleases
    Daneen Grossman
    Nat Struct Mol Biol 13:760-1. 2006
  8. ncbi Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay
    Stacie Meaux
    Deparment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, TX 77030, USA
    RNA 12:1323-37. 2006
  9. ncbi Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation
    Marenda A Wilson
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, 6431 Fannin Street, MSB 1 212, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:10244-9. 2005
  10. ncbi An mRNA surveillance mechanism that eliminates transcripts lacking termination codons
    Pamela A Frischmeyer
    Institute for Genetic Medicine, Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 295:2258-61. 2002

Collaborators

Detail Information

Publications14

  1. ncbi Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast
    A van Hoof
    Department of Molecular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA
    EMBO J 19:1357-65. 2000
    ....
  2. ncbi Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA
    A van Hoof
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, Arizona 85721, USA
    Mol Cell Biol 20:8230-43. 2000
    ..These data indicate that the distinct functions of the exosome can be separated genetically and suggest that the RNA binding domain of Csl4p may have a specific function in mRNA degradation...
  3. ncbi Exosome-mediated recognition and degradation of mRNAs lacking a termination codon
    Ambro van Hoof
    Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
    Science 295:2262-4. 2002
    ..This system efficiently degrades mRNAs that are prematurely polyadenylated within the coding region and prevents their expression...
  4. ncbi Messenger RNA degradation: beginning at the end
    Ambro van Hoof
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
    Curr Biol 12:R285-7. 2002
    ..Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA...
  5. ncbi Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail
    Stacie Meaux
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Mol Cell 29:134-40. 2008
    ..These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense-codon-containing mRNA from normal by NMD...
  6. ncbi A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism
    Marenda A Wilson
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, Texas 77030, USA
    Genetics 177:773-84. 2007
    ..Further, we show that the proteasome and Ski7p affected expression of nonstop reporter genes independently of each other. In addition, our results implicate inositol 1,3,4,5,6-pentakisphosphate as an inhibitor of nonstop mRNA decay...
  7. ncbi RNase II structure completes group portrait of 3' exoribonucleases
    Daneen Grossman
    Nat Struct Mol Biol 13:760-1. 2006
  8. ncbi Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay
    Stacie Meaux
    Deparment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, TX 77030, USA
    RNA 12:1323-37. 2006
    ....
  9. ncbi Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation
    Marenda A Wilson
    Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, 6431 Fannin Street, MSB 1 212, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:10244-9. 2005
    ..Such a process would allow periodic sampling of the 3' UTR, which can diverge rapidly, for novel and beneficial protein extensions...
  10. ncbi An mRNA surveillance mechanism that eliminates transcripts lacking termination codons
    Pamela A Frischmeyer
    Institute for Genetic Medicine, Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 295:2258-61. 2002
    ..This process regulates the stability and expression of mRNAs that fail to signal translational termination...
  11. ncbi Diverse aberrancies target yeast mRNAs to cytoplasmic mRNA surveillance pathways
    Marenda A Wilson
    University of Texas Health Science Center Houston, Department of Microbiology and Molecular Genetics, 6431 Fannin Street MSB 1 212, Houston, TX 77030, USA
    Biochim Biophys Acta 1779:550-7. 2008
    ..Here, we review how cytoplasmic mRNA surveillance mechanisms selectively recognize and degrade a surprisingly wide variety of aberrant mRNAs that are exported from the nucleus into the cytoplasm...
  12. ncbi Conserved functions of yeast genes support the duplication, degeneration and complementation model for gene duplication
    Ambro van Hoof
    University of Texas Health Science Center, Microbiology and Molecular Genetics, Houston, TX 77030, USA
    Genetics 171:1455-61. 2005
    ..Therefore, the results are not consistent with the classical model, but instead fit the duplication, divergence, and complementation model...
  13. ncbi Making and breaking the message
    David A Mangus
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Genome Biol 4:346. 2003
  14. ncbi Messenger RNA regulation: to translate or to degrade
    Ann Bin Shyu
    Department of Biochemistry and Molecular Biology, The University of Texas, Medical School, Houston, TX 77030, USA
    EMBO J 27:471-81. 2008
    ..In addition, both are linked to RNA processing bodies. Possible modes involving 3' untranslated region and its associated factors, which appear to play key roles in both processes, are discussed...