Genomes and Genes
Ambro van Hoof
Affiliation: University of Arizona
- Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeastA van Hoof
Department of Molecular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA
EMBO J 19:1357-65. 2000....
- Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNAA van Hoof
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, Arizona 85721, USA
Mol Cell Biol 20:8230-43. 2000..These data indicate that the distinct functions of the exosome can be separated genetically and suggest that the RNA binding domain of Csl4p may have a specific function in mRNA degradation...
- Exosome-mediated recognition and degradation of mRNAs lacking a termination codonAmbro van Hoof
Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
Science 295:2262-4. 2002..This system efficiently degrades mRNAs that are prematurely polyadenylated within the coding region and prevents their expression...
- Messenger RNA degradation: beginning at the endAmbro van Hoof
Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
Curr Biol 12:R285-7. 2002..Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA...
- Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tailStacie Meaux
Department of Microbiology and Molecular Genetics, University of Texas Health Science Center Houston, Houston, TX 77030, USA
Mol Cell 29:134-40. 2008..These results establish that neither the poly(A) tail nor PAB1 is required in yeast for discrimination of nonsense-codon-containing mRNA from normal by NMD...
- A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolismMarenda A Wilson
Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, Texas 77030, USA
Genetics 177:773-84. 2007..Further, we show that the proteasome and Ski7p affected expression of nonstop reporter genes independently of each other. In addition, our results implicate inositol 1,3,4,5,6-pentakisphosphate as an inhibitor of nonstop mRNA decay...
- RNase II structure completes group portrait of 3' exoribonucleasesDaneen Grossman
Nat Struct Mol Biol 13:760-1. 2006
- Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decayStacie Meaux
Deparment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, TX 77030, USA
RNA 12:1323-37. 2006....
- Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variationMarenda A Wilson
Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, 6431 Fannin Street, MSB 1 212, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 102:10244-9. 2005..Such a process would allow periodic sampling of the 3' UTR, which can diverge rapidly, for novel and beneficial protein extensions...
- An mRNA surveillance mechanism that eliminates transcripts lacking termination codonsPamela A Frischmeyer
Institute for Genetic Medicine, Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 295:2258-61. 2002..This process regulates the stability and expression of mRNAs that fail to signal translational termination...
- Diverse aberrancies target yeast mRNAs to cytoplasmic mRNA surveillance pathwaysMarenda A Wilson
University of Texas Health Science Center Houston, Department of Microbiology and Molecular Genetics, 6431 Fannin Street MSB 1 212, Houston, TX 77030, USA
Biochim Biophys Acta 1779:550-7. 2008..Here, we review how cytoplasmic mRNA surveillance mechanisms selectively recognize and degrade a surprisingly wide variety of aberrant mRNAs that are exported from the nucleus into the cytoplasm...
- Conserved functions of yeast genes support the duplication, degeneration and complementation model for gene duplicationAmbro van Hoof
University of Texas Health Science Center, Microbiology and Molecular Genetics, Houston, TX 77030, USA
Genetics 171:1455-61. 2005..Therefore, the results are not consistent with the classical model, but instead fit the duplication, divergence, and complementation model...
- Making and breaking the messageDavid A Mangus
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Genome Biol 4:346. 2003
- Messenger RNA regulation: to translate or to degradeAnn Bin Shyu
Department of Biochemistry and Molecular Biology, The University of Texas, Medical School, Houston, TX 77030, USA
EMBO J 27:471-81. 2008..In addition, both are linked to RNA processing bodies. Possible modes involving 3' untranslated region and its associated factors, which appear to play key roles in both processes, are discussed...