Albert van Der Vliet

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Acrolein exposure suppresses antigen-induced pulmonary inflammation
    Page C Spiess
    Department of Pathology, College of Medicine, D205 Given Building, 89 Beaumont Ave, Burlington, VT 05405, USA
    Respir Res 14:107. 2013
  2. pmc NADPH oxidases in lung biology and pathology: host defense enzymes, and more
    Albert van Der Vliet
    Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, D205 Given Building, 89 Beaumont Ave, Burlington, VT 05405, USA
    Free Radic Biol Med 44:938-55. 2008
  3. ncbi request reprint Tyrosine nitration: who did it, and how do we prove it? A commentary on "pH dependent nitration of para-hydroxyphenylacetic acid in the stomach"
    Albert van Der Vliet
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Free Radic Biol Med 41:869-71. 2006
  4. pmc Nox enzymes in allergic airway inflammation
    Albert van Der Vliet
    Department of Pathology, Vermont Lung Cancer, College of Medicine, Universitu of Vermont, Burlington, VT 05405, USA
    Biochim Biophys Acta 1810:1035-44. 2011
  5. doi request reprint Purinergic signaling in wound healing and airway remodeling
    Albert van Der Vliet
    Department of Pathology, University of Vermont, Burlington, VT, USA
    Subcell Biochem 55:139-57. 2011
  6. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010
  7. pmc Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 36:645-53. 2007
  8. pmc Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 51:1249-57. 2011
  9. pmc Modulation of NF-κB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice
    Nels Olson
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Cell Mol Biol 44:813-23. 2011
  10. pmc Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha
    Peter F Bove
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:17919-28. 2008

Research Grants

  1. NITRIC OXIDE SIGNALING IN ALLERGIC AIRWAY DISEASE
    Albert van Der Vliet; Fiscal Year: 2007
  2. TOXIC ALDEHYDES AS MODULATORS OF LUNG INFLAMMATION
    Albert van Der Vliet; Fiscal Year: 2007
  3. MODULATION OF EGF-RECEPTOR SIGNALING
    Albert van Der Vliet; Fiscal Year: 2001
  4. Dual Oxidase in Airway Epithelial Repair and Remodeling
    Albert van Der Vliet; Fiscal Year: 2010

Collaborators

Detail Information

Publications57

  1. pmc Acrolein exposure suppresses antigen-induced pulmonary inflammation
    Page C Spiess
    Department of Pathology, College of Medicine, D205 Given Building, 89 Beaumont Ave, Burlington, VT 05405, USA
    Respir Res 14:107. 2013
    ....
  2. pmc NADPH oxidases in lung biology and pathology: host defense enzymes, and more
    Albert van Der Vliet
    Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, D205 Given Building, 89 Beaumont Ave, Burlington, VT 05405, USA
    Free Radic Biol Med 44:938-55. 2008
    ..This review summarizes the current state of knowledge regarding the general functional properties of mammalian NOX enzymes, and their specific importance in respiratory tract physiology and pathology...
  3. ncbi request reprint Tyrosine nitration: who did it, and how do we prove it? A commentary on "pH dependent nitration of para-hydroxyphenylacetic acid in the stomach"
    Albert van Der Vliet
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Free Radic Biol Med 41:869-71. 2006
  4. pmc Nox enzymes in allergic airway inflammation
    Albert van Der Vliet
    Department of Pathology, Vermont Lung Cancer, College of Medicine, Universitu of Vermont, Burlington, VT 05405, USA
    Biochim Biophys Acta 1810:1035-44. 2011
    ..This article is part of a Special Issue entitled: Biochemistry of Asthma...
  5. doi request reprint Purinergic signaling in wound healing and airway remodeling
    Albert van Der Vliet
    Department of Pathology, University of Vermont, Burlington, VT, USA
    Subcell Biochem 55:139-57. 2011
    ..This chapter describes the crosstalk between these signaling cascades and discusses the impact of deregulated purinergic signaling in chronic lung diseases...
  6. pmc Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation
    John F Alcorn
    Department of Pathology, Univ of Vermont, HSRF Bldg, Rm 216A, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 298:L57-66. 2010
    ....
  7. pmc Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 36:645-53. 2007
    ....
  8. pmc Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling
    Scott W Aesif
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 51:1249-57. 2011
    ..Collectively, this study demonstrates that the Glrx1 gene is positively regulated by NF-κB and suggests a feed-forward mechanism to promote NF-κB signaling by decreasing S-glutathionylation...
  9. pmc Modulation of NF-κB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice
    Nels Olson
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Am J Respir Cell Mol Biol 44:813-23. 2011
    ....
  10. pmc Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha
    Peter F Bove
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:17919-28. 2008
    ....
  11. pmc Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:4255-64. 2008
    ..These results suggest that inhibition of arginase activity enhanced a variety of parameters relevant to allergic airways disease, possibly by altering NO homeostasis...
  12. pmc Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction
    Nels Olson
    Department of Pathology, College of Medicine, University of Vermont, Burlington, 05405 0068, USA
    Am J Physiol Lung Cell Mol Physiol 301:L993-L1002. 2011
    ..Together, our results suggest that loss of epithelial barrier integrity by oxidative stress is minimized by activation of HIF-1, in part by induction of sestrin-2...
  13. pmc Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability
    Nels Olson
    Department of Pathology, College of Medicine, University of Vermont, D205 Given Building, 89 Beaumont Avenue, Burlington VT 05405, USA
    Arch Biochem Biophys 484:205-13. 2009
    ..Overall, our results demonstrate that epithelial NOS2 is not responsible for epithelial barrier dysfunction during inflammation, but may contribute to restoration of epithelial integrity...
  14. pmc Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Am Thorac Soc 6:249-55. 2009
    ....
  15. pmc Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
    Niki L Reynaert
    Department of Pathology and Chemistry, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 103:13086-91. 2006
    ..Collectively, these findings demonstrate the physiological relevance of the S-glutathionylation-GRX redox module in controlling the magnitude of activation of the NF-kappaB pathway...
  16. pmc Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury
    Stefan H Gorissen
    Department of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 48:337-45. 2013
    ....
  17. ncbi request reprint In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Biochim Biophys Acta 1760:380-7. 2006
    ....
  18. ncbi request reprint Nitric oxide and redox signaling in allergic airway inflammation
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Antioxid Redox Signal 7:129-43. 2005
    ..Lastly, difficulties in studying NO signaling and possible therapeutic uses for NO will be highlighted...
  19. ncbi request reprint Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway
    Cristen Pantano
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Antioxid Redox Signal 8:1791-806. 2006
    ..The crosstalk of NF-kappaB with other signaling pathways is therefore critical for cellular fate, notably survival or cell death under oxidative conditions, and will also be reviewed...
  20. pmc The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase
    Milena Hristova
    Department of Pathology, College of Medicine, University of Vermont, Burlington, 05405, USA
    Am J Respir Cell Mol Biol 46:23-33. 2012
    ....
  21. pmc ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17
    Derek Sham
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont, USA
    PLoS ONE 8:e54391. 2013
    ....
  22. pmc Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch
    Sean M McCarthy
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    Biochemistry 47:5832-40. 2008
    ..Collectively, our results demonstrate that NO is incapable of directly activating proMMP-9 and that S-nitrosylation of MMP-9 propeptide by NO-donors is unrelated to their ability to regulate MMP-9 activity...
  23. pmc ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli
    Agnes W Boots
    Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 284:17858-67. 2009
    ....
  24. pmc Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure
    Sara A Paveglio
    Vermont Lung Center, and Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:11-23. 2011
    ....
  25. ncbi request reprint Airway epithelial cell migration and wound repair by ATP-mediated activation of dual oxidase 1
    Umadevi V Wesley
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 282:3213-20. 2007
    ....
  26. pmc Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia
    David Itiro Kasahara
    Department of Pathology, Vermont Lung Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 181:736-45. 2008
    ..Disruption of cytokine signaling by acrolein may represent a mechanism by which smoking contributes to chronic disease in chronic obstructive pulmonary disease and asthma...
  27. pmc Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9
    Peter F Bove
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 36:138-46. 2007
    ..Overall, our results demonstrate that NOS2-derived NO contributes to airway epithelial repair by both PKG-dependent and -independent mechanisms, and involves NO-dependent expression and activation of MMP-9...
  28. pmc Proteomic profiling of acrolein adducts in human lung epithelial cells
    Page C Spiess
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Proteomics 74:2380-94. 2011
    ..Our findings indicate that these approaches are useful in characterizing major protein targets for acrolein, and will enhance mechanistic understanding of the impact of acrolein on cell biology...
  29. pmc GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein
    Milena Hristova
    Department of Pathology, College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    FEBS Lett 581:361-7. 2007
    ..Our findings indicate that inhibition of caspase-8 by thiol-reactive agents such as acrolein is not due to GSH depletion but caused by direct protein thiol modifications...
  30. pmc Protein alkylation by the α,β-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?
    Matthew J Randall
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:3808-14. 2013
    ..Our findings indicate that acrolein-induced protein alkylation is not necessarily a feature of irreversible protein damage, but may reflect a reversible signaling mechanism that is regulated by GSH and Trx1. ..
  31. pmc Emerging mechanisms of glutathione-dependent chemistry in biology and disease
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 114:1962-8. 2013
    ..We will also cover newly developed methodology to detect S-glutathionylation in situ, which will enable further discovery into the role of S-glutathionylation in biology and disease...
  32. pmc Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease
    Nels Olson
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Nitric Oxide 25:125-37. 2011
    ....
  33. pmc Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 7:26. 2010
    ....
  34. ncbi request reprint Nitric oxide and reactive nitrogen species in airway epithelial signaling and inflammation
    Peter F Bove
    Department of Pathology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Free Radic Biol Med 41:515-27. 2006
    ..signaling pathways are needed to fully appreciate the contributions of NO(.-)/RNS to airway inflammation and to develop suitable therapeutic approaches based on regulating NO(.-) function...
  35. ncbi request reprint In situ detection and visualization of S-nitrosylated proteins following chemical derivatization: identification of Ran GTPase as a target for S-nitrosylation
    Karina Ckless
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Nitric Oxide 11:216-27. 2004
    ....
  36. pmc SOD inactivation in asthma: bad or no news?
    Yvonne Janssen-Heininger
    Department of Pathology, University of Vermont, Health Sciences Research Facility, 216A, 149 Beaumont Avenue, Burlington VT 05405, USA
    Am J Pathol 166:649-52. 2005
  37. pmc Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts
    Sherrill L Macura
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405 0068, USA
    BMC Cancer 13:400. 2013
    ..The systemic toxicities of these treatments emphasize the need for more effective, localized treatment regimens...
  38. pmc Redox-based regulation of signal transduction: principles, pitfalls, and promises
    Yvonne M W Janssen-Heininger
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Free Radic Biol Med 45:1-17. 2008
    ..We also attempt to highlight some of the current pitfalls and the approaches needed to advance this important area of biochemical and biomedical research...
  39. pmc Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery
    Timothy J Phalen
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Cell Biol 175:779-89. 2006
    ..We propose a model in which Prxs function as peroxide dosimeters in subcellular processes that involve redox cycling, with hyperoxidation controlling structural transitions that alert cells of perturbations in peroxide homeostasis...
  40. pmc Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis
    Vikas Anathy
    Department of Pathology, University of Vermont, Burlington, Vermont, USA
    Mol Cell Biol 32:3464-78. 2012
    ..Collectively, these findings illuminate a regulatory switch, a ligand-initiated oxidative processing of latent Fas, that controls the strength of apoptosis...
  41. ncbi request reprint Nitric oxide-evoked transient kinetics of cyclic GMP in vascular smooth muscle cells
    Sharon M Cawley
    Department of Pharmacology, University of Vermont, College of Medicine, Burlington, VT 05405, USA
    Cell Signal 19:1023-33. 2007
    ..These results demonstrate a continuous sensitivity of the NO/cGMP signaling system, inherent to the phasic nature of smooth muscle physiology...
  42. doi request reprint Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger?
    Albert van Der Vliet
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont, 05405
    J Cell Biochem 115:427-35. 2014
    ..J. Cell. Biochem. 115: 427-435, 2014. © 2013 Wiley Periodicals, Inc. ..
  43. ncbi request reprint Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal
    Erik I Finkelstein
    Dept of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1019-28. 2005
    ....
  44. ncbi request reprint Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice
    Astrid Haegens
    Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05404, USA
    Cancer Res 65:9670-7. 2005
    ..These results support the hypothesis that myeloperoxidase status modulates early asbestos-induced oxidative stress, epithelial cell proliferation, and inflammation...
  45. doi request reprint Venous valvular stasis-associated hypoxia and thrombosis: what is the link?
    Edwin G Bovill
    Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA
    Annu Rev Physiol 73:527-45. 2011
    ..Thus, the effects of blood flow stasis, hypercoagulability of blood, and the characteristics of the vessel wall within the venous valvular sinus are assessed in turn...
  46. pmc Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation
    Niki L Reynaert
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 101:8945-50. 2004
    ..Collectively, our findings demonstrate that IKKbeta is an important target for the redox regulation of NF-kappaB by endogenous or exogenous NO, providing an additional mechanism for its antiinflammatory properties...
  47. ncbi request reprint S-nitrosothiols inhibit cytokine-mediated induction of matrix metalloproteinase-9 in airway epithelial cells
    Tatsuya Okamoto
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of California Davis School of Medicine, USA
    Am J Respir Cell Mol Biol 27:463-73. 2002
    ....
  48. ncbi request reprint Ozone exposure activates oxidative stress responses in murine skin
    Giuseppe Valacchi
    Center for Comparative Respiratory Biology and Medicine, Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Toxicology 179:163-70. 2002
    ....
  49. ncbi request reprint Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice
    Nicholas J Kenyon
    Pulmonary Critical Care Medicine, School of Medicine, University of California, Davis, California 95616 8723, USA
    Am J Physiol Lung Cell Mol Physiol 282:L540-5. 2002
    ....
  50. ncbi request reprint Environmental oxidant pollutant effects on biologic systems: a focus on micronutrient antioxidant-oxidant interactions
    Carroll E Cross
    Division of Pulmonary and Critical Care Medicine, and Center for Comparative Lung Biology and Medicine, University of California School of Medicine, Davis, California 95817, USA
    Am J Respir Crit Care Med 166:S44-50. 2002
    ..Parallelisms among several living organisms, with regard to their protective strategies against environmental atmospheric oxidants, are presented...
  51. ncbi request reprint Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice
    Bettina C Schock
    Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California School of Medicine, Davis, CA 95616, USA
    Arch Biochem Biophys 423:162-9. 2004
    ..Taken together, these results demonstrate that alpha-tocopherol is important for proper modulation of inflammatory responses and that sub-optimal alpha-tocopherol concentrations may derange inflammatory-immune responses...
  52. ncbi request reprint Quantitation and localization of tyrosine nitration in proteins
    Patrick S Y Wong
    Department of Internal Medicine, University of California, Davis, California 95616, USA
    Methods Enzymol 359:399-410. 2002
  53. ncbi request reprint Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin
    Giuseppe Valacchi
    Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California Davis, Surge I Rm 1121, Davis, CA 95616, USA
    Biochem Biophys Res Commun 305:741-6. 2003
    ....
  54. ncbi request reprint Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice
    Tatsuya Okamoto
    Department of Internal Medicine, University of California, Davis, 95616, USA
    Am J Physiol Lung Cell Mol Physiol 286:L198-209. 2004
    ....
  55. ncbi request reprint Reactive nitrogen species in refractory asthma: markers or players?
    David A Kaminsky
    J Allergy Clin Immunol 121:338-40. 2008
  56. ncbi request reprint Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acrolein
    Giuseppe Valacchi
    Division of Pulmonary and Critical Care Medicine, UC Davis, Davis, CA 95616, USA
    Antioxid Redox Signal 7:25-31. 2005
    ..In summary, our results demonstrate that acrolein can suppress inflammatory processes in the airways by inhibiting epithelial IL-8 production through direct or indirect inhibitory effects on NFkappaB activation...
  57. ncbi request reprint Ascorbic acid in nasal and tracheobronchial airway lining fluids
    Bettina C Schock
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Center for Comparative Lung Biology and Medicine, School of Medicine, University of California, Davis, CA 95817, USA
    Free Radic Biol Med 37:1393-401. 2004
    ....

Research Grants17

  1. NITRIC OXIDE SIGNALING IN ALLERGIC AIRWAY DISEASE
    Albert van Der Vliet; Fiscal Year: 2007
    ..Collectively, we anticipate that these studies will provide causal links between NO" metabolism, NF-?B activation, and chronic airway inflammation. ..
  2. TOXIC ALDEHYDES AS MODULATORS OF LUNG INFLAMMATION
    Albert van Der Vliet; Fiscal Year: 2007
    ..We propose that thus identified cellular targets and its modifications could be used as mechanism-based biomarkers to explore a role of these aldehydes in the etiology of such diseases as COPD. ..
  3. MODULATION OF EGF-RECEPTOR SIGNALING
    Albert van Der Vliet; Fiscal Year: 2001
    ....
  4. Dual Oxidase in Airway Epithelial Repair and Remodeling
    Albert van Der Vliet; Fiscal Year: 2010
    ..Collectively, these studies will further our understanding of the biological roles of airway Duox1, and its potential importance in chronic airway diseases such as asthma. ..