Abbe N Vallejo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A
    Abbe N Vallejo
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15201, USA
    Proc Natl Acad Sci U S A 106:11252-7. 2009
  2. pmc NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e26558. 2011
  3. pmc Immunological hurdles of ageing: indispensable research of the human model
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Ageing Res Rev 10:315-8. 2011
  4. pmc Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells
    Abbe N Vallejo
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Ageing Res Rev 10:354-61. 2011
  5. pmc Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis
    Jeffrey A Dvergsten
    Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Arthritis Rheum 65:2201-10. 2013
  6. ncbi request reprint Induction of CD56 and TCR-independent activation of T cells with aging
    Bonnie H Lemster
    Department of Pediatrics, University of Pittsburgh, PA 15213, USA
    J Immunol 180:1979-90. 2008
  7. ncbi request reprint CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis
    Joshua J Michel
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthritis Rheum 56:43-57. 2007
  8. ncbi request reprint Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly
    Sameem Abedin
    Division of Rheumatology, Children s Hospital of Pittsburgh, PA 15213, USA
    Exp Gerontol 40:537-48. 2005
  9. ncbi request reprint The ontogeny and fate of NK cells marked by permanent DNA rearrangements
    Kristy Pilbeam
    Department of Immunology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Immunol 180:1432-41. 2008
  10. pmc Integration of immunity with physical and cognitive function in definitions of successful aging
    Patricia Griffin
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    Aging Dis 3:34-50. 2012

Collaborators

  • Christine Milcarek
  • Tim Bongartz
  • Derek C Angus
  • Suzanne Lentzsch
  • Mary Chester Wasko
  • Jorg J Goronzy
  • Joshua J Michel
  • Patricia Griffin
  • Sameem Abedin
  • Jeffrey A Dvergsten
  • Kristin A Lowry
  • Lela Kardava
  • Sachin Kale
  • Stephanie A Studenski
  • Lisa Borghesi
  • Anne B Newman
  • Bonnie H Lemster
  • Kristy Pilbeam
  • Bonnie Lemster
  • Andrea Braun
  • Allyson Pishko
  • Robert G Mueller
  • Daniel A Kietz
  • Margalit E Rosenkranz
  • Ann M Reed
  • Kristy Huysman
  • Alison J Logar
  • Anthony St Leger
  • Qi Yang
  • Kenneth A Foon
  • John A Kellum
  • Amy Perkins
  • Lan Kong
  • Sachin Yende
  • Rachel Gerstein
  • John J Paat
  • Per Basse
  • Laurent Brossay
  • Nikola Vujanovic
  • David T Montag
  • Eric L Matteson
  • Cristina Iclozan
  • Carl Turesson
  • Sarah R Atkins
  • Cornelia M Weyand
  • Seisuke Takemura

Detail Information

Publications17

  1. pmc Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A
    Abbe N Vallejo
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15201, USA
    Proc Natl Acad Sci U S A 106:11252-7. 2009
    ..These data suggest an IGF-immune axis of healthy longevity. Controlling the availability of IGF in the thymus by targeted manipulation of PAPPA could be a way to maintain immune homeostasis during postnatal development and aging...
  2. pmc NK-like T cells and plasma cytokines, but not anti-viral serology, define immune fingerprints of resilience and mild disability in exceptional aging
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e26558. 2011
    ..Correlation of particular NKR(+) T cell subsets and IL-5 with unimpaired performance, and NKR-driven TCR-independent activation of T cells suggest novel immunopathway(s) that could be exploited to improve immunity in old age...
  3. pmc Immunological hurdles of ageing: indispensable research of the human model
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Ageing Res Rev 10:315-8. 2011
    ....
  4. pmc Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells
    Abbe N Vallejo
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Ageing Res Rev 10:354-61. 2011
    ..Understanding the biology of NKR(+) αβT cells could lead to new avenues for age-specific intervention to improve protective immunity...
  5. pmc Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis
    Jeffrey A Dvergsten
    Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Arthritis Rheum 65:2201-10. 2013
    ..Because of recent evidence that loss of CD28 cells is typical of terminally differentiated lymphocytes, the aim of this study was to examine functional subsets of CD8+ T cells in patients with JIA...
  6. ncbi request reprint Induction of CD56 and TCR-independent activation of T cells with aging
    Bonnie H Lemster
    Department of Pediatrics, University of Pittsburgh, PA 15213, USA
    J Immunol 180:1979-90. 2008
    ..CD56(+) T cells are unique effectors capable of mediating TCR-independent immune cascades that could be harnessed to enhance protective immunity in the elderly...
  7. ncbi request reprint CD56-expressing T cells that have features of senescence are expanded in rheumatoid arthritis
    Joshua J Michel
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Arthritis Rheum 56:43-57. 2007
    ..T cells deficient in CD28 expression have been implicated in the pathogenesis of rheumatoid arthritis (RA). Given that CD28-null T cells are functionally heterogeneous, we undertook this study to screen for novel receptors on these cells...
  8. ncbi request reprint Diversity of NKR expression in aging T cells and in T cells of the aged: the new frontier into the exploration of protective immunity in the elderly
    Sameem Abedin
    Division of Rheumatology, Children s Hospital of Pittsburgh, PA 15213, USA
    Exp Gerontol 40:537-48. 2005
    ..We suggest that appreciation of the functional diversity of these unusual NK-like T cells is central to the creative development of new strategies to enhance protective immunity in the aged...
  9. ncbi request reprint The ontogeny and fate of NK cells marked by permanent DNA rearrangements
    Kristy Pilbeam
    Department of Immunology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Immunol 180:1432-41. 2008
    ....
  10. pmc Integration of immunity with physical and cognitive function in definitions of successful aging
    Patricia Griffin
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    Aging Dis 3:34-50. 2012
    ....
  11. ncbi request reprint Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunol Res 36:221-8. 2006
    ..Understanding the biology of NKR+ T cells will be pivotal to the development of strategies to enhance immunity in the elderly...
  12. ncbi request reprint Immune remodeling: lessons from repertoire alterations during chronological aging and in immune-mediated disease
    Abbe N Vallejo
    Departments of Pediatrics and Immunology, University of Pittsburgh School of Medicine, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Trends Mol Med 13:94-102. 2007
    ....
  13. pmc Successful aging as a continuum of functional independence: lessons from physical disability models of aging
    Kristin A Lowry
    Division of Geriatric Medicine, University of Pittsburgh, 3471 Fifth Avenue, Kaufmann Medical Building, Suite 500, Pittsburgh PA 15213, USA
    Aging Dis 3:5-15. 2012
    ..A better understanding of immunological functioning in late life may help unlock novel ways to promote successful aging...
  14. pmc The effects of age on inflammatory and coagulation-fibrinolysis response in patients hospitalized for pneumonia
    Sachin Kale
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13852. 2010
    ..To determine whether inflammatory and hemostasis response in patients hospitalized for pneumonia varies by age and whether these differences explain higher mortality in the elderly...
  15. pmc The B lineage transcription factor E2A regulates apoptosis in chronic lymphocytic leukemia (CLL) cells
    Lela Kardava
    Department of Immunology, University of Pittsburgh School of Medicine, PA 15261, USA
    Int Immunol 23:375-84. 2011
    ..Thus, E2A, a key transcription factor associated with the B-cell activation profile, regulates apoptosis in CLL and may contribute to disease pathology...
  16. ncbi request reprint CD28 extinction in human T cells: altered functions and the program of T-cell senescence
    Abbe N Vallejo
    Department of Pediatrics, University of Pittsburgh School of Medicine, Division of Rheumatology, Children s Hospital of Pittsburgh, PA 15213, USA
    Immunol Rev 205:158-69. 2005
    ..Dissection of the machinery regulating CD28 expression is paving the way in elucidating the molecular events leading to immune senescence as well as providing clues into the functional rejuvenation of senescent T cells...
  17. ncbi request reprint Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis
    Andrea Braun
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Arthritis Rheum 50:2140-50. 2004
    ..Because resident fibroblast-like synoviocytes (FLS) express receptors for LTbeta, we examined the consequences of FLS activation by LTbeta...