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Genomes and Genes | Rita J ValentinoSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Sex-biased stress signaling: the corticotropin-releasing factor receptor as a modelRita J Valentino
The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Mol Pharmacol 83:737-45. 2013..The possibility that analogous sex differences may occur with other G-protein-coupled receptors underscores the impact of this effect and is discussed...
Molecular and cellular sex differences at the intersection of stress and arousalRita J Valentino
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Neuropharmacology 62:13-20. 2012..The clinical and therapeutic considerations arising from this perspective are discussed. This article is part of a Special Issue entitled 'Anxiety and Depression'...- Corticotropin-releasing factor in the dorsal raphe nucleus: Linking stress coping and addictionRita J Valentino
The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Brain Res 1314:29-37. 2010..Finally, work on CRF regulation of the DRN-5-HT system is integrated with literature on the role of 5-HT-dopamine interactions in addiction... - Individual differences in reactivity to social stress predict susceptibility and resilience to a depressive phenotype: role of corticotropin-releasing factorSusan K Wood
The Children s Hospital of Philadelphia, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
Endocrinology 151:1795-805. 2010..Together, these data suggest that inherent differences in stress reactivity, perhaps as a result of differences in CRF regulation, may predict long-term consequences of social stress and vulnerability to depressive-like symptoms... - Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleusMaria Waselus
Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, Philadelphia, Pennsylvania 19107, USA
Biol Psychiatry 66:76-83. 2009..CRF(1) and CRF(2) receptor subtypes have opposing effects on this system that are associated with active versus passive coping strategies, respectively... - Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neuronsBeverly A S Reyes
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, Pennsylvania 19107, USA
Endocrinology 149:122-30. 2008.... 
The role of noradrenergic tone in the dorsal raphe nucleus of the mouse in the acute behavioral effects of antidepressant drugsAnita J Bechtholt
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Eur Neuropsychopharmacol 17:215-26. 2007....- Hypothalamic projections to locus coeruleus neurons in rat brainBeverly A S Reyes
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
Eur J Neurosci 22:93-106. 2005..Moreover, PVN neurons that use CRF as a neurohormone are distinct from those that use CRF as a neuromodulator to impact on the LC... - Differential blockade of CRF-evoked behaviors by depletion of norepinephrine and serotonin in ratsOwen Howard
Department of Psychiatry, University of Pennsylvania, 125 South 31st Street, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 199:569-82. 2008..Central administration of corticotropin-releasing factor (CRF) elicits a specific pattern of behavioral responses resembling a stress-like state and is anxiogenic in rodent models of anxiety... - Sexually dimorphic responses of the brain norepinephrine system to stress and corticotropin-releasing factorAndre L Curtis
Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Neuropsychopharmacology 31:544-54. 2006..These sex differences in the CRF regulation of the LC-NE system translate to a differential response to stress and may play a role in the increased vulnerability of females to stress-related psychiatric disorders... - Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actionsLuise Pernar
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:1305-11. 2004..Importantly, the tone of the DR-5-HT system can be regulated in a dynamic manner through CRF-R2 activation, being either decreased or increased depending on the level of endogenous or exogenous ligand... - Convergent responses of Barrington's nucleus neurons to pelvic visceral stimuli in the rat: a juxtacellular labelling studyMarie-Laure Rouzade-Dominguez
The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, 402 Abramson Pediatric Research Center, Philadelphia, PA 19104, USA
Eur J Neurosci 18:3325-34. 2003..Dysfunctions in this circuit may underlie the coexistence of colon and bladder symptoms observed in functional bowel disorders... - Agonist-induced internalization of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleusBeverly A S Reyes
Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut Street, Suite 400, Philadelphia, PA 19107, USA
Eur J Neurosci 23:2991-8. 2006..This process may be a pivotal target by which stressors or pharmacological agents regulate the sensitivity of the LC-NE system to CRF and subsequent stressors... - Presynaptic inhibition of diverse afferents to the locus ceruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine systemArati Kreibich
The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:6516-25. 2008..The results implicate kappa-ORs as a novel target for alleviating symptoms of opiate withdrawal, stress-related disorders, or disorders characterized by abnormal sensory responses, such as autism... - Overexpression of corticotropin-releasing factor in Barrington's nucleus neurons by adeno-associated viral transduction: effects on bladder function and behaviorKile McFadden
The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Eur J Neurosci 36:3356-64. 2012..The findings support an inhibitory influence of CRF in Barrington's nucleus regulation of the bladder and an excitatory influence on the brain norepinephrine system that translates to behavioral activation... - Impact of overactive bladder on the brain: central sequelae of a visceral pathologyElizabeth Rickenbacher
Departments of Anesthesiology and Critical Care Medicine and Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:10589-94. 2008..The results further imply that pharmacological manipulation of central NE function may alleviate central sequelae of these visceral disorders... - Circuitry underlying regulation of the serotonergic system by swim stressMichelle Roche
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Neurosci 23:970-7. 2003..This circuitry may underlie some of the acute behavioral responses to swim stress as well as the neuronal plasticity involved in long-term behavioral changes produced by this stress... - Differential projections of dorsal raphe nucleus neurons to the lateral septum and striatumMaria Waselus
Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, 900 Walnut Street, Philadelphia, PA 19107, USA
J Chem Neuroanat 31:233-42. 2006..Taken together with previous microdialysis studies, these results support the existence of distinct DRN-5-HT-forebrain projections that are differentially regulated by stress... - Depressive and cardiovascular disease comorbidity in a rat model of social stress: a putative role for corticotropin-releasing factorSusan K Wood
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 222:325-36. 2012..Depression is associated with medical comorbidities, particularly cardiovascular disease. However, mechanisms linking depression and cardiovascular disease remain unclear... - Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neuronsAndre L Curtis
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, United States
Neuropharmacology 62:1737-45. 2012..Changes in the balance of CRF:opioid regulation of the LC could have consequences for stress vulnerability... - Antidepressant-like effects of kappa-opioid receptor antagonists in Wistar Kyoto ratsGregory V Carr
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropsychopharmacology 35:752-63. 2010..These results support the use of the WKY rat as a model of affective disorders potentially involving KOR overactivity and provide more evidence that KOR antagonists could potentially be used as novel antidepressants... - Overlapping and distinct brain regions associated with the anxiolytic effects of chlordiazepoxide and chronic fluoxetineAnita J Bechtholt
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Neuropsychopharmacology 33:2117-30. 2008..These findings identified brain regions where the effects of chronic antidepressants and benzodiazepines may converge to produce anxiolytic activity, as well as distinct sites of action for the two classes of drugs... - Ultrastructural evidence for a role of gamma-aminobutyric acid in mediating the effects of corticotropin-releasing factor on the rat dorsal raphe serotonin systemMaria Waselus
Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, Philadelphia, Pennsylvania 19107, USA
J Comp Neurol 482:155-65. 2005.... - Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stressGuang-Ping Xu
Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:8193-7. 2004..g., hyperarousal, attentional dysfunction), and this may contribute to the maintenance of opiate-seeking behavior... - Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving ratsDarcie A Kiddoo
Department of Surgery, The Children's Hospital of Philadelphia, 402C Abramson Bldg, Osler Cr, Philadelphia, PA 19104, USA
Am J Physiol Regul Integr Comp Physiol 290:R1697-706. 2006..In addition, the results provide evidence for an inhibitory influence of CRF in the spinal pathway on micturition. Targeting the CRF system in the spinal cord may provide a novel approach for treating urinary disorders... - Substance P Acts through local circuits within the rat dorsal raphe nucleus to alter serotonergic neuronal activityRita J Valentino
The Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, Pennsylvania 19104, USA
J Neurosci 23:7155-9. 2003..Interactions between NK1 and 5-HT1A receptors within DR neural networks may contribute to the mechanism of action of novel antidepressants acting at NK1 receptors... - A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disordersKathryn G Commons
The Children s Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, PA 19104, USA
Neuropsychopharmacology 28:206-15. 2003..This circuit may be relevant for understanding the mechanism of action of novel psychotherapeutic agents that act through NK1 or CRF receptors... - Sexual dimorphism in locus coeruleus dendritic morphology: a structural basis for sex differences in emotional arousalDebra A Bangasser
Department of Anesthesiology and Critical Care Medicine, Division Stress Neurobiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, United States
Physiol Behav 103:342-51. 2011..This may be a structural basis for heightened arousal in females, an effect which may, in part, account for the sex bias in incidence of stress-related psychiatric disorders... - Identifying genes in monoamine nuclei that may determine stress vulnerability and depressive behavior in Wistar-Kyoto ratsKimberly A Pearson
Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
Neuropsychopharmacology 31:2449-61. 2006..The specific genes revealed by the present analysis as being differentially expressed in WKY rats may contribute to their unique behavioral profile and suggest targets that confer susceptibility to stress-related psychiatric disorders... - Corticotropin-releasing factor promotes growth of brain norepinephrine neuronal processes through Rho GTPase regulators of the actin cytoskeleton in ratJerome D Swinny
Department of Pediatrics, 402C Abramson Bldg, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Eur J Neurosci 24:2481-90. 2006..By regulating the extension of processes into pericoerulear regions where limbic afferents terminate, these peptides may determine the degree to which the LC-NE system is influenced by limbic structures that mediate emotional expression... - Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatmentAlana C Conti
Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:1967-75. 2004.... - Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factorSusan K Wood
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Physiol Regul Integr Comp Physiol 296:R1671-8. 2009..This mechanism may underlie dysfunctional voiding in children and/or contribute to the development of stress-induced bladder disorders in adulthood... - Convergent regulation of locus coeruleus activity as an adaptive response to stressRita J Valentino
The Children s Hospital of Philadelphia, 402C Abramson Building, Osler Cr, Philadelphia, PA 19104, United States
Eur J Pharmacol 583:194-203. 2008..This review focuses specifically on the locus coeruleus because it is the major source of norepinephrine to the forebrain and has been implicated in behavioral and cognitive aspects of stress responses... - Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimmingMichelle L Price
David Mahoney Institute Neurological Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 162:406-14. 2002..Modulation of the 5-HT system by CRF during acute stress may underlie certain coping behaviors, while stress-induced adaptation of this effect may be involved in psychiatric manifestations of repeated stress... - Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming testJohn F Cryan
Department of Psychiatry and Pharmacology, University of Pennsylvania, 538A Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Neurosci Biobehav Rev 29:547-69. 2005..Finally, a physiological model of performance in the rat FST has been proposed involving the regulation of 5-HT transmission by corticotropin releasing factor (CRF)... - Sex differences in molecular and cellular substrates of stressDebra A Bangasser
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Cell Mol Neurobiol 32:709-23. 2012..The implications of these sex differences for the treatment of stress-related psychiatric disorders also will be discussed... - Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibilityKevin Snyder
The University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 37:520-30. 2012.... - Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleusKathryn G Commons
Children s Hospital of Philadelphia, Joseph Stokes Research Institute, 402 Abramson Research Center, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 447:82-97. 2002..This circuitry could contribute to, as well as coordinate, effects of SP on pain perception and mood... - The bladder-brain connection: putative role of corticotropin-releasing factorRita J Valentino
Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Civic Center Boulevard, Philadelphia, PA 19104, USA
Nat Rev Urol 8:19-28. 2011..The stress-related neuropeptide, corticotropin-releasing factor, which is prominent in Barrington's nucleus neurons, is a potential mediator of these effects... - Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding proteinLisa A Briand
Department of Pharmacology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:16149-59. 2010.... - Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathyJenna C Carroll
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, School of Medicine and Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 31:14436-49. 2011..These studies also implicate CRF in AD pathophysiology and suggest that pharmacological manipulation of this neuropeptide may be a potential therapeutic strategy for AD... - Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responsesFu-chun Hsu
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 100:12213-8. 2003.... - Central representation of bladder and colon revealed by dual transsynaptic tracing in the rat: substrates for pelvic visceral coordinationMarie-Laure Rouzade-Dominguez
The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, 402 Abramson Pediatric Research Center, Philadelphia, PA 19104, USA
Eur J Neurosci 18:3311-24. 2003..These anatomical substrates may underlie the central coordination of bladder and colon function and play a role in disorders characterized by a coexistence of bladder and colonic symptoms...