JOAN VALENTINE

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1569, USA
    Annu Rev Biochem 74:563-93. 2005
  2. pmc Tetramerization reinforces the dimer interface of MnSOD
    Yuewei Sheng
    Department of Chemistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e62446. 2013
  3. ncbi SOD1 aggregation and ALS: role of metallation states and disulfide status
    Yuewei Sheng
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095, USA
    Curr Top Med Chem 12:2560-72. 2012
  4. pmc Reactive oxygen species special feature
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 1569, USA
    Proc Natl Acad Sci U S A 105:8178. 2008
  5. pmc Cloning, expression, and spectroscopic characterization of Cucumis sativus stellacyanin in its nonglycosylated form
    A M Nersissian
    Department of Chemistry and Biochemistry, UCLA 90095, USA
    Protein Sci 5:2184-92. 1996
  6. pmc Misfolded CuZnSOD and amyotrophic lateral sclerosis
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90025 1569, USA
    Proc Natl Acad Sci U S A 100:3617-22. 2003
  7. ncbi Do oxidatively modified proteins cause ALS?
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 1569, USA
    Free Radic Biol Med 33:1314-20. 2002
  8. ncbi The dark side of dioxygen biochemistry
    J S Valentine
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 1569, USA
    Curr Opin Chem Biol 2:253-62. 1998
  9. pmc Initiation and elongation in fibrillation of ALS-linked superoxide dismutase
    Madhuri Chattopadhyay
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:18663-8. 2008
  10. pmc Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature
    Armando Durazo
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:34382-9. 2009

Research Grants

  1. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2003
  2. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2007
  3. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    Joan Selverstone Valentine; Fiscal Year: 2010
  4. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2003
  5. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2001
  6. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2002
  7. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2002
  8. HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2001
  9. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2000
  10. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2000

Collaborators

  • K F Faull
  • PETER JOHN HART
  • Valter Longo
  • Jon Fukuto
  • Martina Wiedau-Pazos
  • James A Roe
  • Lawrence Hayward
  • James Imlay
  • Ashutosh Tiwari
  • S Samar Hasnain
  • L Banci
  • Laran T Jensen
  • Valeria Culotta
  • Robert H Brown
  • G Rotilio
  • TODD YEATES
  • I Bertini
  • Paola Turano
  • Peter A Doucette
  • Edith Butler Gralla
  • Armando Durazo
  • Madhuri Chattopadhyay
  • Jorge A Rodriguez
  • Yuewei Sheng
  • Richard W Strange
  • Matthew Alan Wallace
  • Aram M Nersissian
  • Jennifer Stine Elam
  • Bryan Francis Shaw
  • Soshanna Zittin Potter
  • Michael A Hough
  • Diane E Cabelli
  • Bryan F Shaw
  • Julian P Whitelegge
  • Xiaohang Cao
  • Se Hui Sohn
  • Alberto Ferri
  • Svetlana V Antonyuk
  • Lisa J Whitson
  • Alexander B Taylor
  • Svetlana Antonyuk
  • Edith B Gralla
  • Kevin Barnese
  • William Munroe
  • Ruth Danzeisen
  • Claudia Crosio
  • Chandra Srinivasan
  • Mauro Cozzolino
  • Monica Nencini
  • Maria Teresa Carri
  • Raylene J Sanchez
  • Sasaneh Bailey
  • Jacob Martins
  • Mark C Carroll
  • Lee Loung Liou
  • Paola Fabrizio
  • Eric L Shipp
  • Duilio Cascio
  • Mikhail Schumacher
  • Julian Whitelegge
  • Shelby Padua
  • Jeffrey A Cohlberg
  • Sai V Seetharaman
  • Cynthia D Strong
  • Stephen P Holloway
  • Carolyn Kingsley
  • Haining Zhu
  • Tilmann Achsel
  • Ulrich Bederke
  • Arianna Casciati
  • Malte Frenzel
  • Lea Huber
  • Albert Ludolph
  • Tina Y Kao
  • Kate Le
  • Daryl K Eggers
  • William H Munroe
  • Phillip C Wong
  • Jeffrey C Hansen
  • Jamuna R Subramaniam
  • Jody B Girouard
  • Janella L Ulloa
  • J Gunter Grossmann
  • Virgil Schirf
  • Matthew H S Clement
  • Borries Demeler
  • Kevin Malek
  • Francesca Cantini
  • Vanessa N Moy
  • Richard Strange

Detail Information

Publications40

  1. ncbi Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1569, USA
    Annu Rev Biochem 74:563-93. 2005
    ....
  2. pmc Tetramerization reinforces the dimer interface of MnSOD
    Yuewei Sheng
    Department of Chemistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e62446. 2013
    ..We conclude that the tetrameric assembly strongly reinforces the dimer interface, which is critical for MnSOD activity...
  3. ncbi SOD1 aggregation and ALS: role of metallation states and disulfide status
    Yuewei Sheng
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095, USA
    Curr Top Med Chem 12:2560-72. 2012
    ..Investigations of the mechanism of SOD1 aggregation enhance our understanding of onset and progression of ALS and have implications for therapeutic approaches for treating ALS...
  4. pmc Reactive oxygen species special feature
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 1569, USA
    Proc Natl Acad Sci U S A 105:8178. 2008
  5. pmc Cloning, expression, and spectroscopic characterization of Cucumis sativus stellacyanin in its nonglycosylated form
    A M Nersissian
    Department of Chemistry and Biochemistry, UCLA 90095, USA
    Protein Sci 5:2184-92. 1996
    ....
  6. pmc Misfolded CuZnSOD and amyotrophic lateral sclerosis
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90025 1569, USA
    Proc Natl Acad Sci U S A 100:3617-22. 2003
    ....
  7. ncbi Do oxidatively modified proteins cause ALS?
    Joan Selverstone Valentine
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 1569, USA
    Free Radic Biol Med 33:1314-20. 2002
    ....
  8. ncbi The dark side of dioxygen biochemistry
    J S Valentine
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 1569, USA
    Curr Opin Chem Biol 2:253-62. 1998
    ..These reactive oxygen species have historically been perceived almost exclusively as agents of the dark side, but it has recently become clear that they play beneficial roles as well...
  9. pmc Initiation and elongation in fibrillation of ALS-linked superoxide dismutase
    Madhuri Chattopadhyay
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:18663-8. 2008
    ..Our findings provide a rare glimpse into the specific changes in a protein that can lead to nucleation and into the ability of amyloid nuclei to recruit diverse forms of the same protein into fibrils...
  10. pmc Metal-free superoxide dismutase-1 and three different amyotrophic lateral sclerosis variants share a similar partially unfolded beta-barrel at physiological temperature
    Armando Durazo
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:34382-9. 2009
    ..e. beta3 and beta4, residues 21-53). Together, these results show that human wild-type apo-SOD1 and variants have a partially unfolded beta-barrel at physiological temperature and unfold non-cooperatively...
  11. ncbi Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein
    Soshanna Zittin Potter
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Am Chem Soc 129:4575-83. 2007
    ..The relevance of these findings to amyotrophic lateral sclerosis is discussed...
  12. pmc Aggregation of copper-zinc superoxide dismutase in familial and sporadic ALS
    Madhuri Chattopadhyay
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA
    Antioxid Redox Signal 11:1603-14. 2009
    ..We here review the recent research on the significance, causes, and mechanisms of SOD1 fibril formation from a biophysical perspective...
  13. ncbi Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry
    Bryan Francis Shaw
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Biol Chem 281:18167-76. 2006
    ..These local and global unfolding events could facilitate intermolecular protein-protein interactions that cause the aggregation or neurotoxicity of A4V SOD1...
  14. ncbi In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeast
    James A Roe
    Department of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA 90045 8225, USA
    Free Radic Biol Med 32:169-74. 2002
    ..This study also presents an in vivo model system to study free radical production in FALS-associated CuZnSOD mutations...
  15. ncbi How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?
    Bryan F Shaw
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Biochem Sci 32:78-85. 2007
    ..Thus, it seems likely that different ALS-associated mutations promote SOD1 aggregation by fundamentally distinct mechanisms. Understanding this complexity has implications for drug development and treatment of the disease...
  16. ncbi Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD
    Raylene J Sanchez
    Department of Chemistry and Biochemistry, UCLA, 607 Charles E Young Drive, East, Los Angeles, CA 90095 1569, USA
    J Biol Inorg Chem 10:913-23. 2005
    ..Mechanisms by which ionic manganese can effect this rescue, while the mimetic compounds do not, are discussed...
  17. ncbi Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability
    Peter A Doucette
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    J Biol Chem 279:54558-66. 2004
    ..By combining the sedimentation data with previous crystallographic results, a molecular explanation is provided for the existence of different SOD1 macromolecular shapes and multiple SOD1 dimeric species with different stabilities...
  18. ncbi The perplexing role of copper-zinc superoxide dismutase in amyotrophic lateral sclerosis (Lou Gehrig's disease)
    Soshanna Zittin Potter
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 1569, USA
    J Biol Inorg Chem 8:373-80. 2003
    ..Results and implications of the role of CuZnSOD in FALS are discussed...
  19. pmc Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis
    Jorge A Rodriguez
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:10516-21. 2005
    ..Thus, the ALS mutant Cu,Zn-superoxide dismutase apoproteins do not all share reduced global stability, and additional properties must be identified and understood to explain the toxicity of all of the mutant proteins...
  20. ncbi Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds
    Matthew Alan Wallace
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E Young Drive East, Los Angeles, California 90095 1569, USA
    Chem Res Toxicol 18:1279-86. 2005
    ..Using this method, we analyzed the Parkinsonism-inducing compound 1-methyl-4-phenylpyridinium and found that redox cycling and superoxide toxicity are not the predominant factor in its toxic mechanism...
  21. pmc Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes
    William Munroe
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095 1569, USA
    J Inorg Biochem 101:1875-82. 2007
    ..Our results suggest the possibility that the beneficial effects of some of the so-called "SOD mimic drugs" may be due to some property other than in vivo superoxide dismutase activity...
  22. doi Manganous phosphate acts as a superoxide dismutase
    Kevin Barnese
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 130:4604-6. 2008
    ....
  23. ncbi Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase
    Matthew Alan Wallace
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095 1569, USA
    J Biol Chem 279:32055-62. 2004
    ..Thus, we conclude that when Sod1p is absent a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originates in the intermembrane space and diffuses across the inner membrane...
  24. pmc SOD2 functions downstream of Sch9 to extend longevity in yeast
    Paola Fabrizio
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    Genetics 163:35-46. 2003
    ..cerevisiae to superoxide dismutases and suggest that the induction of other stress-resistance genes regulated by Msn2/4 and Rim15 is required for maximum longevity extension...
  25. pmc SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization
    Lucia Banci
    Magnetic Resonance Center CERM, Department of Chemistry, University of Florence, Florence, Italy
    PLoS ONE 3:e1677. 2008
    ..The mechanism here proposed for SOD1 mutant oligomerization is absolutely general and it provides a common unique picture for the behaviors of the many SOD1 mutants, of different nature and distributed all over the protein...
  26. pmc Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis
    Xiaohang Cao
    Department of Biochemistry and the X ray Crystallography Core Laboratory, The University of Texas Health Ssience Center, San Antonio, Texas 78229, USA
    J Biol Chem 283:16169-77. 2008
    ..These findings support the notion that metal-deficient and/or disulfide-reduced mutant SOD1 species contribute to toxicity in SOD1-linked amyotrophic lateral sclerosis...
  27. ncbi Metalation of the amyotrophic lateral sclerosis mutant glycine 37 to arginine superoxide dismutase (SOD1) apoprotein restores its structural and dynamical properties in solution to those of metalated wild-type SOD1
    Lucia Banci
    Magnetic Resonance Center, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    Biochemistry 46:9953-62. 2007
    ..These results suggest further that it is the metal-free apo forms of the mutant SOD1 protein that are the agents of its toxicity...
  28. pmc Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS
    Lucia Banci
    Magnetic Resonance Center CERM and Department of Chemistry, University of Florence, Italy
    Proc Natl Acad Sci U S A 104:11263-7. 2007
    ..Although we cannot exclude other mechanisms in SOD1-linked familial ALS, the one proposed here has the strength of explaining how a large and diverse set of SOD1 mutant proteins all could lead to disease through the same mechanism...
  29. ncbi Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution
    Lucia Banci
    Magnetic Resonance Center, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Biol Chem 280:35815-21. 2005
    ..We have here also established that the two free cysteines (6 and 111) do not play a role in this behavior...
  30. ncbi An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate
    Jennifer Stine Elam
    Department of Biochemistry and the X ray Crystallography Core Laboratory, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:21032-9. 2003
    ..The orientation of the enzyme-associated oxyanion suggests that both the self-oxidative and external oxidative pathways can proceed through an enzyme-associated peroxycarbonate intermediate...
  31. ncbi Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS
    Jennifer Stine Elam
    Department of Biochemistry and the Center for Biomolecular Structure Analysis, The University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
    Nat Struct Biol 10:461-7. 2003
    ..Loss of this protection through conformational rearrangement in the metal-deficient enzyme could be a toxic property common to mutants of SOD1 linked to FALS...
  32. pmc Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone
    Mark C Carroll
    Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 101:5964-9. 2004
    ..The possible implications of multiple pathways for SOD1 activation are discussed in the context of SOD1 evolutionary biology and familial amyotrophic lateral sclerosis...
  33. ncbi Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase
    Laran T Jensen
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 279:29938-43. 2004
    ..By comparison, the sod1Delta lysine auxotrophy appears to be reversed in the seo mutants by increased expression of genes in the lysine biosynthetic pathway, perhaps through sensing of mitochondrial damage by the retrograde response...
  34. pmc Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg
    Svetlana Antonyuk
    Molecular Biophysics Group, CCLRC Daresbury Laboratory, Warrington, Cheshire, WA4 4AD, UK
    Protein Sci 14:1201-13. 2005
    ....
  35. ncbi Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis
    Lawrence J Hayward
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 277:15923-31. 2002
    ..Further characterization of these as-isolated SOD1 proteins may provide new insights regarding mutant SOD1 enzyme toxicity in ALS...
  36. ncbi Variable metallation of human superoxide dismutase: atomic resolution crystal structures of Cu-Zn, Zn-Zn and as-isolated wild-type enzymes
    Richard W Strange
    Molecular Biophysics Group, CCLRC Daresbury Laboratory, Warrington, Cheshire WA4 4AD, UK
    J Mol Biol 356:1152-62. 2006
    ..These data raise the possibility that in a cellular environment with low availability of free copper, Zn-Zn may be the preferred metallation state of SOD1 prior to its interaction with the copper chaperone...
  37. ncbi Dynamic properties of the G93A mutant of copper-zinc superoxide dismutase as detected by NMR spectroscopy: implications for the pathology of familial amyotrophic lateral sclerosis
    Eric L Shipp
    Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy
    Biochemistry 42:1890-9. 2003
    ..Alternatively, a motor neuron-specific substrate may bind this region of the protein, leading to deleterious modifications and/or reactions...
  38. pmc Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants
    Michael A Hough
    Molecular Biophysics Group, Council for the Central Laboratory of the Research Councils, Daresbury Laboratory, Warrington, Cheshire WA4 4AD, United Kingdom
    Proc Natl Acad Sci U S A 101:5976-81. 2004
    ....
  39. ncbi Superoxide dismutase 1 modulates expression of transferrin receptor
    Ruth Danzeisen
    Department of Neurology, University of Ulm, Ulm, Germany
    J Biol Inorg Chem 11:489-98. 2006
    ..We propose that changes in superoxide levels due to alteration of SOD1 activity affect iron metabolism in glial and neuronal cells from higher eukaryotes and that this may be relevant to diseases of the nervous system...
  40. pmc Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
    Alberto Ferri
    Institute of Neuroscience, Department of Psychobiology and Psychopharmacology, Consiglio Nazionale delle Ricerche, 00100 Rome, Italy
    Proc Natl Acad Sci U S A 103:13860-5. 2006
    ....

Research Grants49

  1. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2003
    ....
  2. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2007
    ..Together, these studies will shed light on the complex interactions of small molecules and proteins that all eukaryotes use to protect their mitochondria from superoxide-mediated damage. ..
  3. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    Joan Selverstone Valentine; Fiscal Year: 2010
    ..Together, these studies will shed light on the complex interactions of small molecules and proteins that all eukaryotes use to protect their mitochondria from superoxide-mediated damage. ..
  4. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2003
    ....
  5. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2001
    ..The roles played by the different metal ions will also be examined in yeast model systems designed to investigate processes related to aging, cell death and disease. ..
  6. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2002
    ....
  7. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2002
    ....
  8. HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2001
    ..Finally, new metalloproteins will be designed, based on CuZn SOD and stellacyanin. They will be prepared using site-directed mutagenesis, expressed, and purified and their new properties will be characterized. ..
  9. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2000
    ..The roles played by the different metal ions will also be examined in yeast model systems designed to investigate processes related to aging, cell death and disease. ..
  10. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2000
    ..The roles played by the different metal ions will also be examined in yeast model systems designed to investigate processes related to aging, cell death and disease. ..
  11. HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2000
    ..Finally, new metalloproteins will be designed, based on CuZn SOD and stellacyanin. They will be prepared using site-directed mutagenesis, expressed, and purified and their new properties will be characterized. ..
  12. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2003
    ....
  13. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2004
    ....
  14. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2009
    ..Together, these studies will shed light on the complex interactions of small molecules and proteins that all eukaryotes use to protect their mitochondria from superoxide-mediated damage. ..
  15. Molecular Mechanisms of SOD1-linked ALS (P01)
    JOAN VALENTINE; Fiscal Year: 2007
    ..Through our combined efforts we will be able to define structure and disease-function relationships at an unprecedented level. ..
  16. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2006
    ..Together, these studies will shed light on the complex interactions of small molecules and proteins that all eukaryotes use to protect their mitochondria from superoxide-mediated damage. ..
  17. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 2005
    ....
  18. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2005
    ....
  19. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2004
    ....
  20. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 2004
    ....
  21. HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1999
    ..Finally, new metalloproteins will be designed, based on CuZn SOD and stellacyanin. They will be prepared using site-directed mutagenesis, expressed, and purified and their new properties will be characterized. ..
  22. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 1999
    ..The roles played by the different metal ions will also be examined in yeast model systems designed to investigate processes related to aging, cell death and disease. ..
  23. FUNCTIONAL STUDIES OF CYTOSOLIC ANTIOXIDANT PROTEINS
    JOAN VALENTINE; Fiscal Year: 1993
    ..We believe that our results will be highly relevant to some of the fundamental processes that lead to cancer...
  24. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1980
    ..Such information about superoxide dismutase may facilitate development of new treatments for disorders which are believed to involve superoxide anion such as rheumatoid arthritis...
  25. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1993
    ..Information gained from this project will add to our understanding of the mechanism of reactions of CuZnSOD and of its physical properties as well as of metalloproteins in general...
  26. HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1992
    ..Information gained from this project will add to our understanding of the mechanism of reactions of CuZnSOD and of its physical properties as well as of metalloproteins in general...
  27. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1991
    ..Information gained from this project will add to our understanding of the mechanism of reactions of CuZnSOD and of its physical properties as well as of metalloproteins in general...
  28. THE HISTIDYL IMIDAZOLE LIGAND IN METALLOPROTEINS
    JOAN VALENTINE; Fiscal Year: 1990
    ..Information gained from this project will add to our understanding of the mechanism of reactions of CuZnSOD and of its physical properties as well as of metalloproteins in general...