William Valdar

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis
    James J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264
    Genetics 196:321-47. 2014
  2. pmc Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability
    Lars Rönnegård
    Statistics Unit, Dalarna University, SE 781 70 Borlänge, Sweden
    BMC Genet 13:63. 2012
  3. pmc Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging
    William Valdar
    Department of Genetics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7265, USA
    Genet Epidemiol 36:451-62. 2012
  4. pmc Genetic architecture of skewed X inactivation in the laboratory mouse
    John D Calaway
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Genet 9:e1003853. 2013
  5. pmc A general Bayesian approach to analyzing diallel crosses of inbred strains
    Alan B Lenarcic
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7265, USA
    Genetics 190:413-35. 2012
  6. pmc Fine-mapping additive and dominant SNP effects using group-LASSO and fractional resample model averaging
    Jeremy Sabourin
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, United States of America Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, United States of America
    Genet Epidemiol 39:77-88. 2015
  7. pmc Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Genet 47:353-60. 2015

Collaborators

Detail Information

Publications7

  1. pmc Genetics of adverse reactions to haloperidol in a mouse diallel: a drug-placebo experiment and Bayesian causal analysis
    James J Crowley
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264
    Genetics 196:321-47. 2014
    ....
  2. pmc Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability
    Lars Rönnegård
    Statistics Unit, Dalarna University, SE 781 70 Borlänge, Sweden
    BMC Genet 13:63. 2012
    ....
  3. pmc Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging
    William Valdar
    Department of Genetics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7265, USA
    Genet Epidemiol 36:451-62. 2012
    ....
  4. pmc Genetic architecture of skewed X inactivation in the laboratory mouse
    John D Calaway
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Genet 9:e1003853. 2013
    ..Lastly, we conclude that each mouse taxa examined has a different functional Xce allele...
  5. pmc A general Bayesian approach to analyzing diallel crosses of inbred strains
    Alan B Lenarcic
    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7265, USA
    Genetics 190:413-35. 2012
    ..We evaluate our method through simulation and apply it to incomplete diallel data on the founders and F(1)'s of the Collaborative Cross, robustly characterizing the genetic architecture of 48 phenotypes...
  6. pmc Fine-mapping additive and dominant SNP effects using group-LASSO and fractional resample model averaging
    Jeremy Sabourin
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, United States of America Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, United States of America
    Genet Epidemiol 39:77-88. 2015
    ..We also describe how performance can be improved through calibrated randomized penalization, and discuss how dominance in ungenotyped SNPs can be incorporated through either heterozygote dosage or multiple imputation. ..
  7. pmc Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Genet 47:353-60. 2015
    ..We conclude that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals. ..