Research Topics
Species | V G ValcourSummaryAffiliation: University of Hawaii Country: USA Publications
Research Grants
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Detail Information
Publications
The phrase: "no ifs, ands, or buts" and cognitive testing. Lessons from an Asian-American communityVictor G Valcour
Geriatric Medicine Program, John A Burns School of Medicine, University of Hawaii, Kuakini Medical Center, Honolulu, Hawaii, USA
Hawaii Med J 61:72-4. 2002..68% of all subjects were unable to say the phrase "No ifs, ands, or buts" (83% of cognitively impaired and 67% of cognitively intact, p = 0.122). Specificity for cognitive impairment was poor...- Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV CohortVictor Valcour
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
J Neurovirol 12:387-91. 2006..395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001)... - Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infectionV G Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
Neurology 68:525-7. 2007..Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE... - Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohortVictor G Valcour
Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 43:405-10. 2006..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk... 
Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapyVictor Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
J Neurovirol 14:362-7. 2008..These results highlight the importance of a careful neurological examination in the evaluation of HIV patients...- Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infectionV Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
HIV Med 10:103-10. 2009..We present an open-label single-arm pilot study to evaluate changes in intra-epidermal nerve fibre (IENF) density and mitochondrial DNA (mtDNA) copies/cell among subjects treated with 3000 mg ALC daily... - HIV infection and dementia in older adultsVictor Valcour
Hawaii AIDS Clinical Research Program and Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
Clin Infect Dis 42:1449-54. 2006..A brief discussion of potential adjunctive therapies to reduce cognitive symptoms associated with HIV infection in older individuals is provided... - HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort StudyV G Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
Neurology 72:992-8. 2009..This study aimed to determine if immunologic and virologic factors influence cognition after first-time HAART in Thai individuals with HIV-associated dementia (HAD) and Thai individuals without HAD (non-HAD)... - Diabetes, insulin resistance, and dementia among HIV-1-infected patientsVictor G Valcour
University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
J Acquir Immune Defic Syndr 38:31-6. 2005..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection... - Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV CohortV Valcour
University of Hawaii NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI 96816, USA
J Neuroimmunol 157:197-202. 2004..373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART... - Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 CohortV Valcour
University of Hawaii NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
Neurology 63:822-7. 2004..Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD)... - Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanismsVictor G Valcour
University of Hawaii, NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, Hawaii 96816, USA
AIDS 18:S79-86. 2004.... - Self-reported driving, cognitive status, and physician awareness of cognitive impairmentVictor G Valcour
John A Hartford Foundation Center of Excellence in Geriatrics, University of Hawaii, Honolulu, Hawaii, USA
J Am Geriatr Soc 50:1265-7. 2002..To assess self-reported driving rates in older people and correlate these data with cognitive status and physician recognition of cognitive impairment... - Symptomatic distal sensory polyneuropathy in HIV after age 50M R Watters
Office of Neurology and Aging Research, Hawaii AIDS Clinical Trials Unit, University of Hawaii, Honolulu 96816, USA
Neurology 62:1378-83. 2004..SxDSPN is associated with both dementia and low nadir CD4 in HIV-positive patients aged 50 and greater... - Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort studyAaron McMurtray
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
Cerebrovasc Dis 24:236-41. 2007..This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals... - HIV proviral DNA associated with decreased neuropsychological functionBruce Shiramizu
University of Hawaii, John A Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA
J Neuropsychiatry Clin Neurosci 19:157-63. 2007..However, HIV DNA did not predict future changes in neuropsychological deficits. The data suggest that HIV DNA and neuropsychological deficits may co-vary over time... 
HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, ThailandBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
Int J Med Sci 4:13-8. 2007..These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD...- Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disordersBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
J Neuropsychiatry Clin Neurosci 21:68-74. 2009..These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA... - Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reactionBruce Shiramizu
University of Hawaii John A Burns School of Medicine, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
Front Biosci 9:255-61. 2004..From selected cases with relatively high HIV-1 DNA copies/cell, inverse PCR successfully identified viral integration. This type of assay could facilitate further studies when relatively high viral copies/cell are needed for screening... - Circulating proviral HIV DNA and HIV-associated dementiaBruce Shiramizu
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
AIDS 19:45-52. 2005..To determine if HAD is associated with the level of HIV-1 infection within circulating leukocytes, we quantified HIV-1 DNA copy number in peripheral blood mononuclear cells (PBMC), and in PBMC subsets... - Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort StudyAaron McMurtray
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI
J Stroke Cerebrovasc Dis 17:212-7. 2008.... - Incident neuropathy in HIV-infected patients on HAARTBeau K Nakamoto
Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
AIDS Res Hum Retroviruses 26:759-65. 2010..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP... - Tetanus immunity in long-term care facilitiesRitabelle Fernandes
Department of Geriatric Medicine, John A Burns School ofMedicine, University of Hawaii, Honolulu, USA
J Am Geriatr Soc 51:1116-9. 2003..To investigate the correlates of tetanus immunity in the elderly residing in a long-term care facility in Hawaii... 
Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok ThailandSilvia Ratto-Kim
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
J Neuroimmunol 195:100-7. 2008..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...- Utility of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for dementia in a Japanese-American populationKeith G Tokuhara
John A. Burns School of Medicine, University of Hawai'i, Honolulu 96813, USA
Hawaii Med J 65:72-5. 2006..Results confirm that the IQCODE is a valuable tool for primary care physicians to detect impairment in this population... - HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?Cecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
Clin Infect Dis 40:1846-8. 2005..9 vs. 0.9 copies/10(6) PBMCs; P = .006)...
Research Grants
- Macrophages, HAART, and HIV dementia in ThailandVictor Valcour; Fiscal Year: 2006..Given this unique cohort, we further intend to use proteomics to generate important molecular markers that predict M/M/phi response to HAART and that distinguish HAD in HAART-treated compared to HAART-naive individuals. ..