V G Valcour

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. ncbi request reprint The phrase: "no ifs, ands, or buts" and cognitive testing. Lessons from an Asian-American community
    Victor G Valcour
    Geriatric Medicine Program, John A Burns School of Medicine, University of Hawaii, Kuakini Medical Center, Honolulu, Hawaii, USA
    Hawaii Med J 61:72-4. 2002
  2. ncbi request reprint Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort
    Victor Valcour
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
    J Neurovirol 12:387-91. 2006
  3. ncbi request reprint Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Neurology 68:525-7. 2007
  4. ncbi request reprint Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort
    Victor G Valcour
    Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 43:405-10. 2006
  5. pmc Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapy
    Victor Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Neurovirol 14:362-7. 2008
  6. pmc Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection
    V Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    HIV Med 10:103-10. 2009
  7. ncbi request reprint HIV infection and dementia in older adults
    Victor Valcour
    Hawaii AIDS Clinical Research Program and Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 42:1449-54. 2006
  8. pmc HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
    Neurology 72:992-8. 2009
  9. pmc Diabetes, insulin resistance, and dementia among HIV-1-infected patients
    Victor G Valcour
    University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
    J Acquir Immune Defic Syndr 38:31-6. 2005
  10. ncbi request reprint Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort
    V Valcour
    University of Hawaii NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI 96816, USA
    J Neuroimmunol 157:197-202. 2004

Research Grants

  1. Macrophages, HAART, and HIV dementia in Thailand
    Victor Valcour; Fiscal Year: 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The phrase: "no ifs, ands, or buts" and cognitive testing. Lessons from an Asian-American community
    Victor G Valcour
    Geriatric Medicine Program, John A Burns School of Medicine, University of Hawaii, Kuakini Medical Center, Honolulu, Hawaii, USA
    Hawaii Med J 61:72-4. 2002
    ..68% of all subjects were unable to say the phrase "No ifs, ands, or buts" (83% of cognitively impaired and 67% of cognitively intact, p = 0.122). Specificity for cognitive impairment was poor...
  2. ncbi request reprint Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort
    Victor Valcour
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
    J Neurovirol 12:387-91. 2006
    ..395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001)...
  3. ncbi request reprint Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Neurology 68:525-7. 2007
    ..Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE...
  4. ncbi request reprint Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohort
    Victor G Valcour
    Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    J Acquir Immune Defic Syndr 43:405-10. 2006
    ..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk...
  5. pmc Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapy
    Victor Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    J Neurovirol 14:362-7. 2008
    ..These results highlight the importance of a careful neurological examination in the evaluation of HIV patients...
  6. pmc Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection
    V Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    HIV Med 10:103-10. 2009
    ..We present an open-label single-arm pilot study to evaluate changes in intra-epidermal nerve fibre (IENF) density and mitochondrial DNA (mtDNA) copies/cell among subjects treated with 3000 mg ALC daily...
  7. ncbi request reprint HIV infection and dementia in older adults
    Victor Valcour
    Hawaii AIDS Clinical Research Program and Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 42:1449-54. 2006
    ..A brief discussion of potential adjunctive therapies to reduce cognitive symptoms associated with HIV infection in older individuals is provided...
  8. pmc HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort Study
    V G Valcour
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
    Neurology 72:992-8. 2009
    ..This study aimed to determine if immunologic and virologic factors influence cognition after first-time HAART in Thai individuals with HIV-associated dementia (HAD) and Thai individuals without HAD (non-HAD)...
  9. pmc Diabetes, insulin resistance, and dementia among HIV-1-infected patients
    Victor G Valcour
    University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
    J Acquir Immune Defic Syndr 38:31-6. 2005
    ..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection...
  10. ncbi request reprint Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort
    V Valcour
    University of Hawaii NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI 96816, USA
    J Neuroimmunol 157:197-202. 2004
    ..373 (0.054-1.581)]. Several proposed mechanisms may underlie this association. Consideration of non-traditional risk factors for HAD in older HIV patients may yield new markers of disease in the era of HAART...
  11. pmc Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort
    V Valcour
    University of Hawaii NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
    Neurology 63:822-7. 2004
    ..Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD)...
  12. pmc Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanisms
    Victor G Valcour
    University of Hawaii, NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, Hawaii 96816, USA
    AIDS 18:S79-86. 2004
    ....
  13. ncbi request reprint Self-reported driving, cognitive status, and physician awareness of cognitive impairment
    Victor G Valcour
    John A Hartford Foundation Center of Excellence in Geriatrics, University of Hawaii, Honolulu, Hawaii, USA
    J Am Geriatr Soc 50:1265-7. 2002
    ..To assess self-reported driving rates in older people and correlate these data with cognitive status and physician recognition of cognitive impairment...
  14. ncbi request reprint Symptomatic distal sensory polyneuropathy in HIV after age 50
    M R Watters
    Office of Neurology and Aging Research, Hawaii AIDS Clinical Trials Unit, University of Hawaii, Honolulu 96816, USA
    Neurology 62:1378-83. 2004
    ..To determine if aging changes the frequency, severity, or manifestations of symptomatic distal sensory polyneuropathy (SxDSPN) in patients with HIV-1...
  15. ncbi request reprint Small-vessel vascular disease in human immunodeficiency virus infection: the Hawaii aging with HIV cohort study
    Aaron McMurtray
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
    Cerebrovasc Dis 24:236-41. 2007
    ..This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals...
  16. pmc HIV proviral DNA associated with decreased neuropsychological function
    Bruce Shiramizu
    University of Hawaii, John A Burns School of Medicine, Hawaii AIDS Clinical Research Program, 3675 Kilauea Avenue, Young Building, 5th Floor, Honolulu, HI 96816, USA
    J Neuropsychiatry Clin Neurosci 19:157-63. 2007
    ..However, HIV DNA did not predict future changes in neuropsychological deficits. The data suggest that HIV DNA and neuropsychological deficits may co-vary over time...
  17. pmc HIV DNA and dementia in treatment-naïve HIV-1-infected individuals in Bangkok, Thailand
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    Int J Med Sci 4:13-8. 2007
    ..These results are consistent with a previous report among HAART-experienced subjects, thus further implicating HIV DNA in the pathogenesis of HAD...
  18. pmc Amount of HIV DNA in peripheral blood mononuclear cells is proportional to the severity of HIV-1-associated neurocognitive disorders
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USA
    J Neuropsychiatry Clin Neurosci 21:68-74. 2009
    ..These findings demonstrate for the first time that the severity of HIV-1-associated neurocognitive disorders is proportional to the amount of circulating HIV DNA...
  19. ncbi request reprint Assessment of HIV-1 DNA copies per cell by real-time polymerase chain reaction
    Bruce Shiramizu
    University of Hawaii John A Burns School of Medicine, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
    Front Biosci 9:255-61. 2004
    ..From selected cases with relatively high HIV-1 DNA copies/cell, inverse PCR successfully identified viral integration. This type of assay could facilitate further studies when relatively high viral copies/cell are needed for screening...
  20. pmc Circulating proviral HIV DNA and HIV-associated dementia
    Bruce Shiramizu
    Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA
    AIDS 19:45-52. 2005
    ..To determine if HAD is associated with the level of HIV-1 infection within circulating leukocytes, we quantified HIV-1 DNA copy number in peripheral blood mononuclear cells (PBMC), and in PBMC subsets...
  21. pmc Cortical atrophy and white matter hyperintensities in HIV: the Hawaii Aging with HIV Cohort Study
    Aaron McMurtray
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI
    J Stroke Cerebrovasc Dis 17:212-7. 2008
    ....
  22. pmc Incident neuropathy in HIV-infected patients on HAART
    Beau K Nakamoto
    Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    AIDS Res Hum Retroviruses 26:759-65. 2010
    ..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP...
  23. ncbi request reprint Tetanus immunity in long-term care facilities
    Ritabelle Fernandes
    Department of Geriatric Medicine, John A Burns School ofMedicine, University of Hawaii, Honolulu, USA
    J Am Geriatr Soc 51:1116-9. 2003
    ..To investigate the correlates of tetanus immunity in the elderly residing in a long-term care facility in Hawaii...
  24. pmc Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok Thailand
    Silvia Ratto-Kim
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
    J Neuroimmunol 195:100-7. 2008
    ..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts...
  25. ncbi request reprint Utility of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for dementia in a Japanese-American population
    Keith G Tokuhara
    John A Burns School of Medicine, University of Hawai i, Honolulu 96813, USA
    Hawaii Med J 65:72-5. 2006
    ..Results confirm that the IQCODE is a valuable tool for primary care physicians to detect impairment in this population...
  26. ncbi request reprint HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?
    Cecilia M Shikuma
    Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
    Clin Infect Dis 40:1846-8. 2005
    ..9 vs. 0.9 copies/10(6) PBMCs; P = .006)...

Research Grants3

  1. Macrophages, HAART, and HIV dementia in Thailand
    Victor Valcour; Fiscal Year: 2006
    ..Given this unique cohort, we further intend to use proteomics to generate important molecular markers that predict M/M/phi response to HAART and that distinguish HAD in HAART-treated compared to HAART-naive individuals. ..