Research Topics
Genomes and GenesSpecies | Christian VaisseSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutationsCecile Lubrano-Berthelier
Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
Hum Mol Genet 12:145-53. 2003..This result has implications for the potential pharmacologic rescue of childhood obesity-associated MC4R mutations and for the treatment of patients presenting with this condition...
Narrowing down the role of common variants in the genetic predisposition to obesityMelissa A Calton
Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Genome Med 1:31. 2009....- A statistical approach for array CGH data analysisFranck Picard
Institut National Agronomique Paris Grignon, UMR INAPG ENGREF INRA MIA 518, Paris, France
BMC Bioinformatics 6:27. 2005..Two major problems arise: to determine which parameters are affected by the abrupt changes (the mean and the variance, or the mean only), and the selection of the number of segments in the profile... - Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesityC Vaisse
Centre National de la Recherche Scientifique, UPRES A 8090, Institute of Biology of Lille, Lille, France
J Clin Invest 106:253-62. 2000..Taken together, these results demonstrate that MC4-R mutations are a frequent but heterogeneous genetic cause of morbid obesity... - Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humansSupriya Srinivasan
Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94143 0540, USA
J Clin Invest 114:1158-64. 2004..Our results also suggest that the tonic satiety signal provided by the constitutive activity of MC4R may be required for maintaining long-term energy homeostasis in humans... - Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eatingCecile Lubrano-Berthelier
Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
J Clin Endocrinol Metab 91:1811-8. 2006..There are conflicting reports regarding the prevalence, nature, and pathogenic effects of MC4R mutations in adults with severe late-onset obesity... 
Replication and extension of association between common genetic variants in SIM1 and human adiposityMichael M Swarbrick
Diabetes Center and Department of Medicine, University of California, San Francisco, California, USA
Obesity (Silver Spring) 19:2394-403. 2011..In white males, rs4072568 in ARNT2 was also associated with BMI (P = 9 × 10(-4)) and % body fat (P = 0.001). Our findings implicate heritable defects of the SIM1-ARNT2 axis in the predisposition to human obesity...- Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its functionCedric Govaerts
Cellular and Molecular Pharmacology Department, University of California, San Francisco, CA 94143, USA
Peptides 26:1909-19. 2005.... - The human MC4R promoter: characterization and role in obesityCecile Lubrano-Berthelier
Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
Diabetes 52:2996-3000. 2003.... - Molecular genetics of human obesity-associated MC4R mutationsCecile Lubrano-Berthelier
Department of Medicine, University of California, San Francisco, California 94143, USA
Ann N Y Acad Sci 994:49-57. 2003.... - Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control studyMelissa A Calton
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
Hum Mol Genet 18:1140-7. 2009..However, our data suggest that MC3R mutations are not associated with severe obesity in this population... - A homozygous null mutation delineates the role of the melanocortin-4 receptor in humansCecile Lubrano-Berthelier
Department of Medicine, University of California, San Francisco, California 94143 0573, USA
J Clin Endocrinol Metab 89:2028-32. 2004..In addition, complete MC4R deficiency is not a cause of relative hyperinsulinemia as recently observed in children with heterozygous MC4R mutations... - Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCRBaran A Ersoy
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Nat Chem Biol 8:725-30. 2012.... - Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutationsIvy R Aslan
Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, CA 94143, USA
Obes Surg 21:930-4. 2011..Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood... - Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivoSupriya Srinivasan
Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
PLoS ONE 2:e668. 2007..Our study also demonstrates the use of human genetic variation for protein engineering... - Engineering the melanocortin-4 receptor to control G(s) signaling in vivoSupriya Srinivasan
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
Ann N Y Acad Sci 994:225-32. 2003..The MC4R G(s) RASSL could be used to control many physiological responses associated with G(s) signaling such as heart rate, energy homeostasis, and cell proliferation... - Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidusSayali A Ranadive
Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, CA 94143, USA
Clin Endocrinol (Oxf) 71:388-93. 2009..We report two infants with XNDI, and present the characterization and functional rescue of a novel V2R mutation... - Lack of support for the association between GAD2 polymorphisms and severe human obesityMichael M Swarbrick
Diabetes Center, University of California, San Francisco, California, USA
PLoS Biol 3:e315. 2005.... - Emerging trends in the search for genetic variants predisposing to human obesityMichael M Swarbrick
Diabetes Center, University of California, San Francisco, California 94143-0540, USA
Curr Opin Clin Nutr Metab Care 6:369-75. 2003.... - Lessons from extreme human obesity: monogenic disordersSayali A Ranadive
Department of Pediatrics, Division of Endocrinology, University of California San Francisco, 513 Parnassus Avenue, Room S672D, San Francisco, CA 94143 0434, USA
Endocrinol Metab Clin North Am 37:733-51, x. 2008..This finding suggests that the genetic basis for human obesity is likely to be extremely heterogeneous, with contributions from numerous genes acting by various, yet undiscovered, molecular mechanisms... - Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domainBeatrice Dubern
Center of Research on Human Nutrition Ile de France, 75004 Paris, France
Pediatr Res 63:211-6. 2008..The novel heterozygous mutation Phe144Leu leading to the absence of melanocortin signaling was associated with early-onset obesity suggesting its pathogenic role... - Elevated plasma ghrelin levels in Prader Willi syndromeDavid E Cummings
Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
Nat Med 8:643-4. 2002
Research Grants
- The Melanocortin-4 Receptor in Human ObesityChristian Vaisse; Fiscal Year: 2009..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..
- Role of Pro-opiomelanocortin mutations in human obesityChristian Vaisse; Fiscal Year: 2007....
- The Melanocortin-4 Receptor in Human ObesityChristian Vaisse; Fiscal Year: 2007..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..
- The Melanocortin-4 Receptor in Human ObesityChristian Vaisse; Fiscal Year: 2005....
- The Melanocortin-4 Receptor in Human ObesityChristian Vaisse; Fiscal Year: 2010..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..