Christian Vaisse

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations
    Cecile Lubrano-Berthelier
    Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Hum Mol Genet 12:145-53. 2003
  2. pmc Narrowing down the role of common variants in the genetic predisposition to obesity
    Melissa A Calton
    Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Genome Med 1:31. 2009
  3. pmc A statistical approach for array CGH data analysis
    Franck Picard
    Institut National Agronomique Paris Grignon, UMR INAPG ENGREF INRA MIA 518, Paris, France
    BMC Bioinformatics 6:27. 2005
  4. pmc Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    C Vaisse
    Centre National de la Recherche Scientifique, UPRES A 8090, Institute of Biology of Lille, Lille, France
    J Clin Invest 106:253-62. 2000
  5. pmc Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 114:1158-64. 2004
  6. ncbi request reprint Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
    Cecile Lubrano-Berthelier
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
    J Clin Endocrinol Metab 91:1811-8. 2006
  7. doi request reprint Replication and extension of association between common genetic variants in SIM1 and human adiposity
    Michael M Swarbrick
    Diabetes Center and Department of Medicine, University of California, San Francisco, California, USA
    Obesity (Silver Spring) 19:2394-403. 2011
  8. ncbi request reprint Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function
    Cedric Govaerts
    Cellular and Molecular Pharmacology Department, University of California, San Francisco, CA 94143, USA
    Peptides 26:1909-19. 2005
  9. ncbi request reprint The human MC4R promoter: characterization and role in obesity
    Cecile Lubrano-Berthelier
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
    Diabetes 52:2996-3000. 2003
  10. ncbi request reprint Molecular genetics of human obesity-associated MC4R mutations
    Cecile Lubrano-Berthelier
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 994:49-57. 2003

Research Grants

  1. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2009
  2. Role of Pro-opiomelanocortin mutations in human obesity
    Christian Vaisse; Fiscal Year: 2007
  3. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2007
  4. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2005
  5. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations
    Cecile Lubrano-Berthelier
    Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Hum Mol Genet 12:145-53. 2003
    ..This result has implications for the potential pharmacologic rescue of childhood obesity-associated MC4R mutations and for the treatment of patients presenting with this condition...
  2. pmc Narrowing down the role of common variants in the genetic predisposition to obesity
    Melissa A Calton
    Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Genome Med 1:31. 2009
    ....
  3. pmc A statistical approach for array CGH data analysis
    Franck Picard
    Institut National Agronomique Paris Grignon, UMR INAPG ENGREF INRA MIA 518, Paris, France
    BMC Bioinformatics 6:27. 2005
    ..Two major problems arise: to determine which parameters are affected by the abrupt changes (the mean and the variance, or the mean only), and the selection of the number of segments in the profile...
  4. pmc Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    C Vaisse
    Centre National de la Recherche Scientifique, UPRES A 8090, Institute of Biology of Lille, Lille, France
    J Clin Invest 106:253-62. 2000
    ..Taken together, these results demonstrate that MC4-R mutations are a frequent but heterogeneous genetic cause of morbid obesity...
  5. pmc Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 114:1158-64. 2004
    ..Our results also suggest that the tonic satiety signal provided by the constitutive activity of MC4R may be required for maintaining long-term energy homeostasis in humans...
  6. ncbi request reprint Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
    Cecile Lubrano-Berthelier
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
    J Clin Endocrinol Metab 91:1811-8. 2006
    ..There are conflicting reports regarding the prevalence, nature, and pathogenic effects of MC4R mutations in adults with severe late-onset obesity...
  7. doi request reprint Replication and extension of association between common genetic variants in SIM1 and human adiposity
    Michael M Swarbrick
    Diabetes Center and Department of Medicine, University of California, San Francisco, California, USA
    Obesity (Silver Spring) 19:2394-403. 2011
    ..In white males, rs4072568 in ARNT2 was also associated with BMI (P = 9 × 10(-4)) and % body fat (P = 0.001). Our findings implicate heritable defects of the SIM1-ARNT2 axis in the predisposition to human obesity...
  8. ncbi request reprint Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function
    Cedric Govaerts
    Cellular and Molecular Pharmacology Department, University of California, San Francisco, CA 94143, USA
    Peptides 26:1909-19. 2005
    ....
  9. ncbi request reprint The human MC4R promoter: characterization and role in obesity
    Cecile Lubrano-Berthelier
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
    Diabetes 52:2996-3000. 2003
    ....
  10. ncbi request reprint Molecular genetics of human obesity-associated MC4R mutations
    Cecile Lubrano-Berthelier
    Department of Medicine, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 994:49-57. 2003
    ....
  11. pmc Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study
    Melissa A Calton
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 18:1140-7. 2009
    ..However, our data suggest that MC3R mutations are not associated with severe obesity in this population...
  12. ncbi request reprint A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans
    Cecile Lubrano-Berthelier
    Department of Medicine, University of California, San Francisco, California 94143 0573, USA
    J Clin Endocrinol Metab 89:2028-32. 2004
    ..In addition, complete MC4R deficiency is not a cause of relative hyperinsulinemia as recently observed in children with heterozygous MC4R mutations...
  13. pmc Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
    Baran A Ersoy
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Nat Chem Biol 8:725-30. 2012
    ....
  14. pmc Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations
    Ivy R Aslan
    Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, CA 94143, USA
    Obes Surg 21:930-4. 2011
    ..Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood...
  15. pmc Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e668. 2007
    ..Our study also demonstrates the use of human genetic variation for protein engineering...
  16. ncbi request reprint Engineering the melanocortin-4 receptor to control G(s) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    Ann N Y Acad Sci 994:225-32. 2003
    ..The MC4R G(s) RASSL could be used to control many physiological responses associated with G(s) signaling such as heart rate, energy homeostasis, and cell proliferation...
  17. doi request reprint Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus
    Sayali A Ranadive
    Department of Pediatrics, Division of Endocrinology, University of California San Francisco, San Francisco, CA 94143, USA
    Clin Endocrinol (Oxf) 71:388-93. 2009
    ..We report two infants with XNDI, and present the characterization and functional rescue of a novel V2R mutation...
  18. pmc Lack of support for the association between GAD2 polymorphisms and severe human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California, USA
    PLoS Biol 3:e315. 2005
    ....
  19. ncbi request reprint Emerging trends in the search for genetic variants predisposing to human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California 94143 0540, USA
    Curr Opin Clin Nutr Metab Care 6:369-75. 2003
    ..The models currently proposed for the genetic architecture of obesity are critically reviewed in the light of recent developments in the search for genetic causes of this condition...
  20. doi request reprint Lessons from extreme human obesity: monogenic disorders
    Sayali A Ranadive
    Department of Pediatrics, Division of Endocrinology, University of California San Francisco, 513 Parnassus Avenue, Room S672D, San Francisco, CA 94143 0434, USA
    Endocrinol Metab Clin North Am 37:733-51, x. 2008
    ..This finding suggests that the genetic basis for human obesity is likely to be extremely heterogeneous, with contributions from numerous genes acting by various, yet undiscovered, molecular mechanisms...
  21. ncbi request reprint Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain
    Beatrice Dubern
    Center of Research on Human Nutrition Ile de France, 75004 Paris, France
    Pediatr Res 63:211-6. 2008
    ..The novel heterozygous mutation Phe144Leu leading to the absence of melanocortin signaling was associated with early-onset obesity suggesting its pathogenic role...
  22. ncbi request reprint Elevated plasma ghrelin levels in Prader Willi syndrome
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
    Nat Med 8:643-4. 2002

Research Grants15

  1. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2009
    ..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..
  2. Role of Pro-opiomelanocortin mutations in human obesity
    Christian Vaisse; Fiscal Year: 2007
    ....
  3. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2007
    ..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..
  4. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2005
    ....
  5. The Melanocortin-4 Receptor in Human Obesity
    Christian Vaisse; Fiscal Year: 2010
    ..These experiments could lead to new strategies to pharmacologically target MC4R for the treatment of obesity. ..