Research Topics
Species | Pamela M VacekSummaryAffiliation: University of Vermont Country: USA Publications
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Publications
A prospective study of breast cancer risk using routine mammographic breast density measurementsPamela M Vacek
Department of Medical Biostatistics, University of Vermont College of Medicine, Vermont Cancer Center, Burlington, VT 05405, USA
Cancer Epidemiol Biomarkers Prev 13:715-22. 2004....
Breast cancer risk assessment in women aged 70 and olderPamela M Vacek
Departments of Medical Biostatistics and Pathology, University of Vermont College of Medicine, Hills Building, Burlington, VT, 05405, USA
Breast Cancer Res Treat 130:291-9. 2011..Age-related attenuation of the effects of some risk factors makes the prediction of breast cancer in older women particularly difficult...
ERK2 is essential for the growth of human epithelioid malignant mesotheliomasArti Shukla
Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
Int J Cancer 129:1075-86. 2011..After injection of sarcomatoid human MM (PPMMill) cells into SCID mice, both shERK1 and shERK2 lines showed significant decreased tumor growth, suggesting heterogeneous effects of ERKs in individual MMs...- Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisonsPamela M Vacek
University of Vermont, Burlington, VT, USA
Chem Biol Interact 188:668-76. 2010.... - Application of a clinic-based algorithm as a tool to identify female athletes at risk for anterior cruciate ligament injury: a prospective cohort study with a nested, matched case-control analysisJohn Goetschius
University of Vermont College of Medicine, Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, 95 Carrigan Drive, Burlington, VT 05405, USA
Am J Sports Med 40:1978-84. 2012..The ability of this algorithm to identify athletes at increased risk of suffering ACL injury has not been assessed... - Increasing mammography screening among low-income African American women with limited access to health informationNicholas L Danigelis
Department of Sociology, University of Vermont, Burlington, VT 50401, USA
Prev Med 40:880-7. 2005..For these women, using direct contact to deliver educational messages and facilitation of access to services may be the best method available to promote regular mammography... - The use of additional imaging increased specificity and decreased sensitivity in screening mammographyBerta M Geller
University of Vermont, Office of Health Promotion Research, Departments of Family Practice and Radiology, Vermont Cancer Center, 1 South Prospect Street, Burlington, VT 05401 3444, USA
J Clin Epidemiol 58:942-50. 2005..To examine the use of additional imaging after standard mammographic screening views to better understand the value of these additional testing in improving accuracy... - VDJ recombinase-mediated TCR β locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric developmentJanet M Murray
Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
J Immunol 189:2356-64. 2012.... - Predicting biopsy outcome after mammography: what is the likelihood the patient has invasive or in situ breast cancer?Donald L Weaver
Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Health Science Complex, 89 Beaumont Avenue, Burlington, Vermont 05405 0068, USA
Ann Surg Oncol 12:660-73. 2005..Although substantial effort has been devoted to estimating breast cancer risk, there have been no studies to predict outcome in women undergoing breast biopsy... - Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sitesPamela M Vacek
Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
Environ Mol Mutagen 45:339-45. 2005..The results suggest that HPRT Mf may not be a sensitive biomarker for the genotoxic effects of environmental exposures in children, particularly when substantial time has elapsed since exposure... - Analysis of genetic alterations and clonal proliferation in children treated for acute lymphocytic leukemiaHeather E Kendall
Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
Cancer Res 66:8455-61. 2006.... - Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomasArti Shukla
Authors Affiliations Departments of Pathology and Medical Biostatistics, University of Vermont College of Medicine, Burlington, Vermont Lampire Biological Laboratories Inc, Pipersville, Pennsylvania and Department of Cardiothoracic Surgery, New York University School of Medicine, New York, New York
Clin Cancer Res 19:2071-83. 2013..Malignant mesothelioma is a devastating disease with a need for new treatment strategies. In the present study, we showed the importance of extracellular signal-regulated kinase 5 (ERK5) in malignant mesothelioma tumor growth and treatment... - Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel diseaseTruc Nguyen
Department of Pediatrics, University of Vermont, Burlington, Vermont 05445 0068, USA
Cancer Res 69:7004-12. 2009..001). These findings provide in vivo evidence for mutation induction as a potential carcinogenic mechanism associated with chronic thiopurine intervention... - Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975-1999Pamela M Vacek
Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
Cancer 94:2160-8. 2002..This study examined the effects of mammography on tumor size and axillary lymph node metastasis in Vermont over 25 years... - The relationship between menstrual cycle phase and anterior cruciate ligament injury: a case-control study of recreational alpine skiersBruce D Beynnon
Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, Stafford Hall, Room 438A, University of Vermont, Burlington, VT 05405 0084, USA
Am J Sports Med 34:757-64. 2006..Female athletes suffer a greater incidence of anterior cruciate ligament tears compared with male athletes when participating in common sports; however, very little is known about the factors that explain this disparity... - Evaluation of a community breast screening promotion programJohn K Worden
Office of Health Promotion Research, University of Vermont, Burlington 05401, USA
Prev Med 35:349-61. 2002..This program promoted increased use of mammography, clinical breast examination, and breast self-examination through community organization, physician training, and public education... - Mutational spectral analysis at the HPRT locus in healthy childrenBarry A Finette
Department of Pediatrics, University of Vermont, Burlington 05405, USA
Mutat Res 505:27-41. 2002..These patterns of mutations provide insight into important spontaneous, genotoxic, and site-specific recombinational somatic mutational events associated with the age-specific development of human disease in children as well as adults... - Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicityArti Shukla
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Am J Respir Cell Mol Biol 41:114-23. 2009..Results reveal that ATF3 modulates production of inflammatory cytokines (IL-1 beta, IL-13, G-CSF) and growth factors (VEGF and PDGF-BB) in human mesothelial cells... - A prospective evaluation of the Landing Error Scoring System (LESS) as a screening tool for anterior cruciate ligament injury riskHelen C Smith
Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, University of Vermont College of Medicinet, Burlington, VT 05405 0084, USA
Am J Sports Med 40:521-6. 2012..The Landing Error Scoring System (LESS) has been developed as a tool that can be applied to identify individuals who display at-risk movement patterns during the DVJ... - Relationships between cigarette smoking during pregnancy, gestational age, maternal weight gain, and infant birthweightRoger H Secker-Walker
Office of Health Promotion Research RHS W, University of Vermont, Burlington, VT, USA
Addict Behav 28:55-66. 2003..To estimate the effect of smoking on infant birthweight independent of gestational age and maternal weight gain during pregnancy... - Factors influencing quality of life in breast cancer survivorsPamela M Vacek
Department of Medical Biostatistics, University of Vermont, Burlington 05405, USA
Qual Life Res 12:527-37. 2003..Breast cancer survivors experience a reduction in quality of life that persists for years after treatment and is similar in magnitude to that associated with other health problems... - Reproducibility of BI-RADS breast density measures among community radiologists: a prospective cohort studyMary C Spayne
Canadian Partnership Against Cancer, Toronto, Ontario, Canada
Breast J 18:326-33. 2012..1% to 87.4% and simple kappa ranging from 0.19 to 0.69 across individual radiologists. Our findings underscore the need for additional evaluation of the BI-RADS breast density categorization system in clinical practice... - Analysis of microsatellite instability in children treated for acute lymphocytic leukemia with elevated HPRT mutant frequenciesHeather E Kendall
Department of Pediatrics, Department of Medical Biostatistics, Vermont Cancer Center, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Mutagenesis 19:409-12. 2004..However, in a small number of patients chemotherapy may play a role in the selection of cells with defects in MMR that may have long-term clinical implications... - Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicinArti Shukla
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Mol Cancer 9:314. 2010..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox... - Mortality in Vermont granite workers and its association with silica exposurePamela M Vacek
Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
Occup Environ Med 68:312-8. 2011..Mortality from malignant and non-malignant kidney disease was not significantly increased or associated with exposure... - Comparative analysis of HPRT mutant frequency in children with cancerSederick C Rice
Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
Environ Mol Mutagen 42:44-9. 2003.... - Infant birth weight as a measure of harm reduction during smoking cessation trials in pregnancyRoger H Secker-Walker
Health Promotion Research, Burlington, Vermont 05401 3444, USA
Health Educ Behav 29:557-69. 2002..These results indicate that this birth weight comparison does not provide a valid estimate of the harm reduction associated with a reduction of 50% or more in cigarette consumption during pregnancy... - First-time inversion ankle ligament trauma: the effects of sex, level of competition, and sport on the incidence of injuryBruce D Beynnon
University of Vermont, College of Medicine, Department of Orthopaedics and Rehabilitation, Stafford Hall, Room 438A, Burlington, VT 05405 0084, USA
Am J Sports Med 33:1485-91. 2005..Inversion ankle trauma is disabling, yet little is known regarding the incidence rate of first-time ankle sprains and how it is influenced by factors including sex, level of competition, and sport... - Winter depression recurrence one year after cognitive-behavioral therapy, light therapy, or combination treatmentKelly J Rohan
Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405 0134, USA
Behav Ther 40:225-38. 2009..If these findings are replicated, CBT could represent a more effective, practical, and palatable approach to long-term SAD management than light therapy... - Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisonsRichard J Albertini
BioMosaics, Inc, 665 Spear Street, Burlington, VT 05401, USA
Chem Biol Interact 166:63-77. 2007..However, as in the first, differences in the metabolic detoxification of BD as reflected in relative amounts of the M1 and M2 urinary metabolites were associated with genotypes, this time both GST and EH... - Induction of V(D)J-mediated recombination of an extrachromosomal substrate following exposure to DNA-damaging agentsRobert L Pinsonneault
Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
Environ Mol Mutagen 48:440-50. 2007.... - Efficacy of plantar loading parameters during gait in terms of reliability, variability, effect of gender and relationship between contact area and plantar pressureDarlene F Murphy
McClure Musculoskeletal Research Center, Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, VT 05405, USA
Foot Ankle Int 26:171-9. 2005..This measurement technique can now be used in risk factor studies designed to identify individuals at risk for injury to the foot, ankle, and other lower extremity structures... - Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cellsJedd M Hillegass
Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Part Fibre Toxicol 7:26. 2010.... - Biennial versus annual mammography and the risk of late-stage breast cancerEmily White
School of Public Health, University of Washington, Seattle, WA, USA
J Natl Cancer Inst 96:1832-9. 2004..Mammography screening may reduce breast cancer mortality by detecting cancers at an earlier stage. However, certain questions remain, including the ideal interval between mammograms... - Prospective breast cancer risk prediction model for women undergoing screening mammographyWilliam E Barlow
Cancer Research and Biostatistics, 1730 Minor Avenue, Suite 1900, Seattle, WA 98101, USA
J Natl Cancer Inst 98:1204-14. 2006..We used prospective risk information to predict a diagnosis of breast cancer in a cohort of 1 million women undergoing screening mammography... - Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer riskKarla Kerlikowske
Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco, CA, USA
J Natl Cancer Inst 99:386-95. 2007..Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown... - Using the European guidelines to evaluate the Norwegian Breast Cancer Screening ProgramSolveig Hofvind
Department of Screening based Research, The Cancer Registry of Norway, Montebello, Oslo, 0310, Norway
Eur J Epidemiol 22:447-55. 2007..Based on the results, we anticipate a future mortality reduction from breast cancer in women invited to the NBCSP... - Breast density in relation to risk of ductal carcinoma in situ of the breast in women undergoing screening mammographyTodd A MacKenzie
Department of Community and Family Medicine, Dartmouth Medical School, Norris Cotton Cancer Center, Hanover, NH, USA
Cancer Causes Control 18:939-45. 2007..To examine the association between breast density and risk of breast ductal carcinoma in situ (DCIS)... - Comparing screening mammography for early breast cancer detection in Vermont and NorwaySolveig Hofvind
Department of Screening based Research, The Cancer Registry of Norway, Oslo, Norway
J Natl Cancer Inst 100:1082-91. 2008..We examined how these differences affect early detection of breast cancer by comparing performance measures and histopathologic outcomes in women undergoing opportunistic screening in Vermont and organized screening in Norway... - Risk factors for breast carcinoma in situ versus invasive breast cancer in a prospective study of pre- and post-menopausal womenKyndaron S Reinier
Division of Cardiovascular Medicine, Cardiology UHN 62, Oregon Health and Science University, Portland, OR 97239, USA
Breast Cancer Res Treat 103:343-8. 2007..Results indicating that BMI is related to post-menopausal invasive cancers but unrelated to in situ cancers are consistent with the hypothesis that concomitants of obesity activate proliferation...