Pamela M Vacek

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint A prospective study of breast cancer risk using routine mammographic breast density measurements
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont College of Medicine, Vermont Cancer Center, Burlington, VT 05405, USA
    Cancer Epidemiol Biomarkers Prev 13:715-22. 2004
  2. doi request reprint Breast cancer risk assessment in women aged 70 and older
    Pamela M Vacek
    Departments of Medical Biostatistics and Pathology, University of Vermont College of Medicine, Hills Building, Burlington, VT, 05405, USA
    Breast Cancer Res Treat 130:291-9. 2011
  3. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
  4. doi request reprint Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisons
    Pamela M Vacek
    University of Vermont, Burlington, VT, USA
    Chem Biol Interact 188:668-76. 2010
  5. doi request reprint Application of a clinic-based algorithm as a tool to identify female athletes at risk for anterior cruciate ligament injury: a prospective cohort study with a nested, matched case-control analysis
    John Goetschius
    University of Vermont College of Medicine, Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, 95 Carrigan Drive, Burlington, VT 05405, USA
    Am J Sports Med 40:1978-84. 2012
  6. ncbi request reprint Increasing mammography screening among low-income African American women with limited access to health information
    Nicholas L Danigelis
    Department of Sociology, University of Vermont, Burlington, VT 50401, USA
    Prev Med 40:880-7. 2005
  7. ncbi request reprint The use of additional imaging increased specificity and decreased sensitivity in screening mammography
    Berta M Geller
    University of Vermont, Office of Health Promotion Research, Departments of Family Practice and Radiology, Vermont Cancer Center, 1 South Prospect Street, Burlington, VT 05401 3444, USA
    J Clin Epidemiol 58:942-50. 2005
  8. doi request reprint VDJ recombinase-mediated TCR β locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development
    Janet M Murray
    Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
    J Immunol 189:2356-64. 2012
  9. ncbi request reprint Predicting biopsy outcome after mammography: what is the likelihood the patient has invasive or in situ breast cancer?
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Health Science Complex, 89 Beaumont Avenue, Burlington, Vermont 05405 0068, USA
    Ann Surg Oncol 12:660-73. 2005
  10. ncbi request reprint Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
    Environ Mol Mutagen 45:339-45. 2005

Detail Information

Publications41

  1. ncbi request reprint A prospective study of breast cancer risk using routine mammographic breast density measurements
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont College of Medicine, Vermont Cancer Center, Burlington, VT 05405, USA
    Cancer Epidemiol Biomarkers Prev 13:715-22. 2004
    ....
  2. doi request reprint Breast cancer risk assessment in women aged 70 and older
    Pamela M Vacek
    Departments of Medical Biostatistics and Pathology, University of Vermont College of Medicine, Hills Building, Burlington, VT, 05405, USA
    Breast Cancer Res Treat 130:291-9. 2011
    ..Age-related attenuation of the effects of some risk factors makes the prediction of breast cancer in older women particularly difficult...
  3. pmc ERK2 is essential for the growth of human epithelioid malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405 0068, USA
    Int J Cancer 129:1075-86. 2011
    ..After injection of sarcomatoid human MM (PPMMill) cells into SCID mice, both shERK1 and shERK2 lines showed significant decreased tumor growth, suggesting heterogeneous effects of ERKs in individual MMs...
  4. doi request reprint Hemoglobin adducts in 1,3-butadiene exposed Czech workers: female-male comparisons
    Pamela M Vacek
    University of Vermont, Burlington, VT, USA
    Chem Biol Interact 188:668-76. 2010
    ....
  5. doi request reprint Application of a clinic-based algorithm as a tool to identify female athletes at risk for anterior cruciate ligament injury: a prospective cohort study with a nested, matched case-control analysis
    John Goetschius
    University of Vermont College of Medicine, Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, 95 Carrigan Drive, Burlington, VT 05405, USA
    Am J Sports Med 40:1978-84. 2012
    ..The ability of this algorithm to identify athletes at increased risk of suffering ACL injury has not been assessed...
  6. ncbi request reprint Increasing mammography screening among low-income African American women with limited access to health information
    Nicholas L Danigelis
    Department of Sociology, University of Vermont, Burlington, VT 50401, USA
    Prev Med 40:880-7. 2005
    ..This report describes a controlled evaluation of a component of a community-based breast screening promotion program focused on increasing screening among low-income African American women...
  7. ncbi request reprint The use of additional imaging increased specificity and decreased sensitivity in screening mammography
    Berta M Geller
    University of Vermont, Office of Health Promotion Research, Departments of Family Practice and Radiology, Vermont Cancer Center, 1 South Prospect Street, Burlington, VT 05401 3444, USA
    J Clin Epidemiol 58:942-50. 2005
    ..To examine the use of additional imaging after standard mammographic screening views to better understand the value of these additional testing in improving accuracy...
  8. doi request reprint VDJ recombinase-mediated TCR β locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development
    Janet M Murray
    Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
    J Immunol 189:2356-64. 2012
    ....
  9. ncbi request reprint Predicting biopsy outcome after mammography: what is the likelihood the patient has invasive or in situ breast cancer?
    Donald L Weaver
    Department of Pathology, University of Vermont College of Medicine and Vermont Cancer Center, Health Science Complex, 89 Beaumont Avenue, Burlington, Vermont 05405 0068, USA
    Ann Surg Oncol 12:660-73. 2005
    ..Although substantial effort has been devoted to estimating breast cancer risk, there have been no studies to predict outcome in women undergoing breast biopsy...
  10. ncbi request reprint Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
    Environ Mol Mutagen 45:339-45. 2005
    ..The results suggest that HPRT Mf may not be a sensitive biomarker for the genotoxic effects of environmental exposures in children, particularly when substantial time has elapsed since exposure...
  11. ncbi request reprint Analysis of genetic alterations and clonal proliferation in children treated for acute lymphocytic leukemia
    Heather E Kendall
    Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
    Cancer Res 66:8455-61. 2006
    ....
  12. pmc Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Clin Cancer Res 19:2071-83. 2013
    ..Malignant mesothelioma is a devastating disease with a need for new treatment strategies. In the present study, we showed the importance of extracellular signal-regulated kinase 5 (ERK5) in malignant mesothelioma tumor growth and treatment...
  13. ncbi request reprint The relationship between menstrual cycle phase and anterior cruciate ligament injury: a case-control study of recreational alpine skiers
    Bruce D Beynnon
    Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, Stafford Hall, Room 438A, University of Vermont, Burlington, VT 05405 0084, USA
    Am J Sports Med 34:757-64. 2006
    ..Female athletes suffer a greater incidence of anterior cruciate ligament tears compared with male athletes when participating in common sports; however, very little is known about the factors that explain this disparity...
  14. pmc Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease
    Truc Nguyen
    Department of Pediatrics, University of Vermont, Burlington, Vermont 05445 0068, USA
    Cancer Res 69:7004-12. 2009
    ..001). These findings provide in vivo evidence for mutation induction as a potential carcinogenic mechanism associated with chronic thiopurine intervention...
  15. ncbi request reprint Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975-1999
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
    Cancer 94:2160-8. 2002
    ..This study examined the effects of mammography on tumor size and axillary lymph node metastasis in Vermont over 25 years...
  16. pmc Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 41:114-23. 2009
    ..Results reveal that ATF3 modulates production of inflammatory cytokines (IL-1 beta, IL-13, G-CSF) and growth factors (VEGF and PDGF-BB) in human mesothelial cells...
  17. ncbi request reprint Evaluation of a community breast screening promotion program
    John K Worden
    Office of Health Promotion Research, University of Vermont, Burlington 05401, USA
    Prev Med 35:349-61. 2002
    ..This program promoted increased use of mammography, clinical breast examination, and breast self-examination through community organization, physician training, and public education...
  18. ncbi request reprint Mutational spectral analysis at the HPRT locus in healthy children
    Barry A Finette
    Department of Pediatrics, University of Vermont, Burlington 05405, USA
    Mutat Res 505:27-41. 2002
    ..These patterns of mutations provide insight into important spontaneous, genotoxic, and site-specific recombinational somatic mutational events associated with the age-specific development of human disease in children as well as adults...
  19. doi request reprint A prospective evaluation of the Landing Error Scoring System (LESS) as a screening tool for anterior cruciate ligament injury risk
    Helen C Smith
    Department of Orthopaedics and Rehabilitation, McClure Musculoskeletal Research Center, University of Vermont College of Medicinet, Burlington, VT 05405 0084, USA
    Am J Sports Med 40:521-6. 2012
    ..The Landing Error Scoring System (LESS) has been developed as a tool that can be applied to identify individuals who display at-risk movement patterns during the DVJ...
  20. ncbi request reprint Factors influencing quality of life in breast cancer survivors
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington 05405, USA
    Qual Life Res 12:527-37. 2003
    ..Breast cancer survivors experience a reduction in quality of life that persists for years after treatment and is similar in magnitude to that associated with other health problems...
  21. ncbi request reprint Relationships between cigarette smoking during pregnancy, gestational age, maternal weight gain, and infant birthweight
    Roger H Secker-Walker
    Office of Health Promotion Research RHS W, University of Vermont, Burlington, VT, USA
    Addict Behav 28:55-66. 2003
    ..To estimate the effect of smoking on infant birthweight independent of gestational age and maternal weight gain during pregnancy...
  22. pmc Reproducibility of BI-RADS breast density measures among community radiologists: a prospective cohort study
    Mary C Spayne
    Canadian Partnership Against Cancer, Toronto, Ontario, Canada
    Breast J 18:326-33. 2012
    ..1% to 87.4% and simple kappa ranging from 0.19 to 0.69 across individual radiologists. Our findings underscore the need for additional evaluation of the BI-RADS breast density categorization system in clinical practice...
  23. ncbi request reprint Analysis of microsatellite instability in children treated for acute lymphocytic leukemia with elevated HPRT mutant frequencies
    Heather E Kendall
    Department of Pediatrics, Department of Medical Biostatistics, Vermont Cancer Center, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mutagenesis 19:409-12. 2004
    ..However, in a small number of patients chemotherapy may play a role in the selection of cells with defects in MMR that may have long-term clinical implications...
  24. pmc Cognitive-behavioral therapy vs. light therapy for preventing winter depression recurrence: study protocol for a randomized controlled trial
    Kelly J Rohan
    Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT, 05405 0134, USA
    Trials 14:82. 2013
    ..Time-limited alternative treatments with effects that endure beyond the cessation of acute treatment are needed to prevent the annual recurrence of SAD...
  25. pmc Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin
    Arti Shukla
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Mol Cancer 9:314. 2010
    ..Using the MEK1/2 inhibitor, U0126 and stably transfected shERK1 and shERK2 MM cell lines, we show that inhibition of both ERK1 and 2 sensitizes MM cells to Dox...
  26. pmc Mortality in Vermont granite workers and its association with silica exposure
    Pamela M Vacek
    Department of Medical Biostatistics, University of Vermont, Burlington, Vermont 05405, USA
    Occup Environ Med 68:312-8. 2011
    ..Mortality from malignant and non-malignant kidney disease was not significantly increased or associated with exposure...
  27. ncbi request reprint First-time inversion ankle ligament trauma: the effects of sex, level of competition, and sport on the incidence of injury
    Bruce D Beynnon
    University of Vermont, College of Medicine, Department of Orthopaedics and Rehabilitation, Stafford Hall, Room 438A, Burlington, VT 05405 0084, USA
    Am J Sports Med 33:1485-91. 2005
    ..Inversion ankle trauma is disabling, yet little is known regarding the incidence rate of first-time ankle sprains and how it is influenced by factors including sex, level of competition, and sport...
  28. ncbi request reprint Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons
    Richard J Albertini
    BioMosaics, Inc, 665 Spear Street, Burlington, VT 05401, USA
    Chem Biol Interact 166:63-77. 2007
    ..However, as in the first, differences in the metabolic detoxification of BD as reflected in relative amounts of the M1 and M2 urinary metabolites were associated with genotypes, this time both GST and EH...
  29. doi request reprint Winter depression recurrence one year after cognitive-behavioral therapy, light therapy, or combination treatment
    Kelly J Rohan
    Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405 0134, USA
    Behav Ther 40:225-38. 2009
    ..If these findings are replicated, CBT could represent a more effective, practical, and palatable approach to long-term SAD management than light therapy...
  30. ncbi request reprint Induction of V(D)J-mediated recombination of an extrachromosomal substrate following exposure to DNA-damaging agents
    Robert L Pinsonneault
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Environ Mol Mutagen 48:440-50. 2007
    ....
  31. ncbi request reprint Comparative analysis of HPRT mutant frequency in children with cancer
    Sederick C Rice
    Department of Pediatrics, University of Vermont, Burlington, Vermont, USA
    Environ Mol Mutagen 42:44-9. 2003
    ....
  32. ncbi request reprint Infant birth weight as a measure of harm reduction during smoking cessation trials in pregnancy
    Roger H Secker-Walker
    Health Promotion Research, Burlington, Vermont 05401 3444, USA
    Health Educ Behav 29:557-69. 2002
    ..These results indicate that this birth weight comparison does not provide a valid estimate of the harm reduction associated with a reduction of 50% or more in cigarette consumption during pregnancy...
  33. ncbi request reprint Efficacy of plantar loading parameters during gait in terms of reliability, variability, effect of gender and relationship between contact area and plantar pressure
    Darlene F Murphy
    McClure Musculoskeletal Research Center, Department of Orthopaedics and Rehabilitation, University of Vermont, Burlington, VT 05405, USA
    Foot Ankle Int 26:171-9. 2005
    ....
  34. pmc Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells
    Jedd M Hillegass
    Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Part Fibre Toxicol 7:26. 2010
    ....
  35. ncbi request reprint Prospective breast cancer risk prediction model for women undergoing screening mammography
    William E Barlow
    Cancer Research and Biostatistics, 1730 Minor Avenue, Suite 1900, Seattle, WA 98101, USA
    J Natl Cancer Inst 98:1204-14. 2006
    ..We used prospective risk information to predict a diagnosis of breast cancer in a cohort of 1 million women undergoing screening mammography...
  36. ncbi request reprint Risk factors for breast carcinoma in situ versus invasive breast cancer in a prospective study of pre- and post-menopausal women
    Kyndaron S Reinier
    Division of Cardiovascular Medicine, Cardiology UHN 62, Oregon Health and Science University, Portland, OR 97239, USA
    Breast Cancer Res Treat 103:343-8. 2007
    ..Results indicating that BMI is related to post-menopausal invasive cancers but unrelated to in situ cancers are consistent with the hypothesis that concomitants of obesity activate proliferation...
  37. ncbi request reprint Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk
    Karla Kerlikowske
    Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 99:386-95. 2007
    ..Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown...
  38. pmc Comparing screening mammography for early breast cancer detection in Vermont and Norway
    Solveig Hofvind
    Department of Screening based Research, The Cancer Registry of Norway, Oslo, Norway
    J Natl Cancer Inst 100:1082-91. 2008
    ..We examined how these differences affect early detection of breast cancer by comparing performance measures and histopathologic outcomes in women undergoing opportunistic screening in Vermont and organized screening in Norway...
  39. ncbi request reprint Biennial versus annual mammography and the risk of late-stage breast cancer
    Emily White
    School of Public Health, University of Washington, Seattle, WA, USA
    J Natl Cancer Inst 96:1832-9. 2004
    ..Mammography screening may reduce breast cancer mortality by detecting cancers at an earlier stage. However, certain questions remain, including the ideal interval between mammograms...
  40. ncbi request reprint Breast density in relation to risk of ductal carcinoma in situ of the breast in women undergoing screening mammography
    Todd A MacKenzie
    Department of Community and Family Medicine, Dartmouth Medical School, Norris Cotton Cancer Center, Hanover, NH, USA
    Cancer Causes Control 18:939-45. 2007
    ..To examine the association between breast density and risk of breast ductal carcinoma in situ (DCIS)...
  41. ncbi request reprint Using the European guidelines to evaluate the Norwegian Breast Cancer Screening Program
    Solveig Hofvind
    Department of Screening based Research, The Cancer Registry of Norway, Montebello, Oslo, 0310, Norway
    Eur J Epidemiol 22:447-55. 2007
    ..Based on the results, we anticipate a future mortality reduction from breast cancer in women invited to the NBCSP...