Francisco A Uzal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Experimental Clostridium perfringens type D enterotoxemia in goats
    F A Uzal
    Department of Veterinary Pathology, The University of Queensland, Brisbane, Australia
    Vet Pathol 35:132-40. 1998
  2. ncbi request reprint Clostridial enteric infections in pigs
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson 85721, USA
    J Vet Diagn Invest 17:528-36. 2005
  3. doi request reprint Extranodal follicular lymphoma in the lung of a free-ranging red deer (Cervus elaphus)
    Elizabeth Chang Reissig
    Institute of Pathology, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Argentina
    J Vet Diagn Invest 25:158-61. 2013
  4. doi request reprint Acute respiratory distress in an alpaca
    F A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, Davis, San Bernardino, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Pathol 49:1070-3. 2012
  5. pmc Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA
    Microbes Infect 14:1009-16. 2012
  6. doi request reprint Clostridium perfringens type C and Clostridium difficile co-infection in foals
    F A Uzal
    California Animal Health and Food Safety Laboratory, San Bernardino Branch, UC Davis, CA, USA
    Vet Microbiol 156:395-402. 2012
  7. doi request reprint Evidence-based medicine concerning efficacy of vaccination against Clostridium chauvoei infection in cattle
    Francisco A Uzal
    California Animal Health and Food Safety, San Bernardino Branch, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Clin North Am Food Anim Pract 28:71-7, viii. 2012
  8. doi request reprint Pathology of Clostridium perfringens type C enterotoxemia in horses
    S S Diab
    California Animal Health and Food Safety Laboratory System, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Pathol 49:255-63. 2012
  9. pmc Cervical leiomyoma in an aged goat leading to massive hemorrhage and death
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, Faculty of Veterinary Medicine, University of California, San Bernardino, San Bernardino, California 92408, USA
    Can Vet J 49:177-9. 2008
  10. ncbi request reprint Diagnosis of Clostridium perfringens intestinal infections in sheep and goats
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 20:253-65. 2008

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Experimental Clostridium perfringens type D enterotoxemia in goats
    F A Uzal
    Department of Veterinary Pathology, The University of Queensland, Brisbane, Australia
    Vet Pathol 35:132-40. 1998
    ..The protocol thus provided a reasonable model of naturally occurring enterotoxemia in goats, producing a range of clinical signs and postmortem changes similar to those observed in the natural disease...
  2. ncbi request reprint Clostridial enteric infections in pigs
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson 85721, USA
    J Vet Diagn Invest 17:528-36. 2005
    ..Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents...
  3. doi request reprint Extranodal follicular lymphoma in the lung of a free-ranging red deer (Cervus elaphus)
    Elizabeth Chang Reissig
    Institute of Pathology, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Argentina
    J Vet Diagn Invest 25:158-61. 2013
    ..The histologic and immunohistochemical characteristics are consistent with follicular lymphoma, which is frequently seen in human beings and less frequently in domestic animals...
  4. doi request reprint Acute respiratory distress in an alpaca
    F A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, Davis, San Bernardino, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Pathol 49:1070-3. 2012
    ..The need to examine phrenic nerves and diaphragm in camelids with respiratory distress is emphasized, as failure to examine these samples will preclude a diagnosis of diaphragmatic paralysis...
  5. pmc Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA
    Microbes Infect 14:1009-16. 2012
    ..CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood...
  6. doi request reprint Clostridium perfringens type C and Clostridium difficile co-infection in foals
    F A Uzal
    California Animal Health and Food Safety Laboratory, San Bernardino Branch, UC Davis, CA, USA
    Vet Microbiol 156:395-402. 2012
    ..perfringens infection acted as a predisposing factor for C. difficile and/or vice versa. This report also stresses the need to perform a complete diagnostic workup in all cases of foal digestive disease...
  7. doi request reprint Evidence-based medicine concerning efficacy of vaccination against Clostridium chauvoei infection in cattle
    Francisco A Uzal
    California Animal Health and Food Safety, San Bernardino Branch, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Clin North Am Food Anim Pract 28:71-7, viii. 2012
    ..A greater participation of practitioners in clinical research and greater access to informational tools such as systematic reviews must be part of the objectives of veterinary medicine...
  8. doi request reprint Pathology of Clostridium perfringens type C enterotoxemia in horses
    S S Diab
    California Animal Health and Food Safety Laboratory System, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Vet Pathol 49:255-63. 2012
    ..A definitive diagnosis of C. perfringens type C enterotoxemia in all 8 cases was based on the clinical history, gross and histologic lesions, and detection of the beta toxin in intestinal contents...
  9. pmc Cervical leiomyoma in an aged goat leading to massive hemorrhage and death
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, Faculty of Veterinary Medicine, University of California, San Bernardino, San Bernardino, California 92408, USA
    Can Vet J 49:177-9. 2008
    ..Necropsy, histologic examination, and immunohistochemical staining revealed the presence of a leiomyoma that originated from the uterine cervix, occupied most of the vaginal lumen, and had a bleeding, frayed artery in the caudal end...
  10. ncbi request reprint Diagnosis of Clostridium perfringens intestinal infections in sheep and goats
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 20:253-65. 2008
    ..However, although such tests have a presumptive diagnostic value when positive, they cannot be used to rule out a diagnosis of enterotoxemia when negative...
  11. ncbi request reprint Ulcerative enterocolitis in two goats associated with enterotoxin- and beta2 toxin-positive Clostridium perfringens type D
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, University of California, Davis, CA 92408, USA
    J Vet Diagn Invest 20:668-72. 2008
    ..These findings indicate that CPB2 may have contributed to the necrotic changes observed in the intestine, possibly assisting ETX transit across the intestinal mucosa...
  12. pmc Development and application of new mouse models to study the pathogenesis of Clostridium perfringens type C Enterotoxemias
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, California 92408, USA
    Infect Immun 77:5291-9. 2009
    ..This study proves that CPB is a major contributor to the systemic effects of type C infections and provides new mouse models for investigating the pathogenesis of type C-induced lethality...
  13. ncbi request reprint Notoedric mange in two free-ranging mountain lions (Puma concolor)
    Francisco A Uzal
    California Animal Health and Food Safety, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, CA 92408, USA
    J Wildl Dis 43:274-8. 2007
    ..This is the first report of the pathological changes associated with notoedric mange in free-ranging mountain lions...
  14. pmc Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections
    F A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 W Central Ave, San Bernardino, CA 92408, USA
    Vet Microbiol 153:37-43. 2011
    ....
  15. ncbi request reprint PCR detection of Clostridium chauvoei in pure cultures and in formalin-fixed, paraffin-embedded tissues
    F A Uzal
    Instituto Nacional de Tecnologi a Agropecuaria INTA, CC 277 8400, Bariloche, Argentina
    Vet Microbiol 91:239-48. 2003
    ..Therefore, the PCR primer sets appear to be very specific for identifying C. chauvoei in both cultures and tissues...
  16. ncbi request reprint Malassezia slooffiae-associated dermatitis in a goat
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California Davis, CA 92408, USA
    Vet Dermatol 18:348-52. 2007
    ..This is the first report of M. slooffiae-associated dermatitis in goats...
  17. ncbi request reprint A study of "white spotted kidneys" in cattle
    F A Uzal
    School of Veterinary Sciences and Animal Production, The University of Queensland, QLD 4072, St Lucia, Australia
    Vet Microbiol 86:369-75. 2002
    ..The histological lesions were consistent in most cases with FCIN. The results suggest that neither Leptospira spp. nor active infection by other bacteria are associated with the so-called "white spotted kidneys"...
  18. pmc Development and application of an oral challenge mouse model for studying Clostridium perfringens type D infection
    Mariano E Fernandez-Miyakawa
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, University of California Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Infect Immun 75:4282-8. 2007
    ..This study provides an economical new model for studying the pathogenesis of C. perfringens type D infections...
  19. pmc Clostridium perfringens type A enterotoxin damages the rabbit colon
    Jorge P Garcia
    California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California Davis, San Bernardino, California, USA
    Infect Immun 82:2211-8. 2014
    ..Collectively, these results offer support for the possible involvement of the colon in CPE-mediated GI disease. ..
  20. pmc Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model
    Mariano E Fernandez-Miyakawa
    California Animal Health and Food Safety Laboratory San Bernardino Branch, University of California Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    Infect Immun 75:1443-52. 2007
    ..However, our results suggest that both CPB and ETX are likely the most important contributors to the pathogenesis of C. perfringens type B infections in domestic animals...
  21. pmc Necrotizing enterocolitis and death in a goat kid associated with enterotoxin (CPE)-producing Clostridium perfringens type A
    Mariano E Fernandez Miyakawa
    California Animal Health and Food Safety Laboratory System, University of California Davis, San Bernardino Branch, Calfornia 92408, USA
    Can Vet J 48:1266-9. 2007
    ..Isolation of Clostridium perfringens type A secreting enterotoxin (CPE) and presence of CPE in the small intestine suggest that CPE contributed to the death of this kid...
  22. ncbi request reprint Fatal musculoskeletal injuries of Quarter Horse racehorses: 314 cases (1990-2007)
    Tiffany L Sarrafian
    JD Wheat Veterinary Orthopedic Research Laboratory, School of Veterinary Medicine, University of California Davis, 95616, USA
    J Am Vet Med Assoc 241:935-42. 2012
    ..To determine major causes of death and the anatomic location of musculoskeletal injuries in Quarter Horse racehorses in California...
  23. ncbi request reprint Toxinotypes of Clostridium perfringens isolated from sick and healthy avian species
    Rocio Crespo
    California Animal Health and Food Safety Laboratory System, University of California Davis, Fresno Branch, 2789 South Orange Avenue, Fresno, CA 93725, USA
    J Vet Diagn Invest 19:329-33. 2007
    ..These data from this investigation do not suggest a causal relationship between beta2 toxin and necrotic enteritis in birds...
  24. ncbi request reprint Morphologic and physiologic changes induced by Clostridium perfringens type A alpha toxin in the intestine of sheep
    Mariano E Fernandez Miyakawa
    Unidad de Salud Animal, Instituto Nacional de Tecnologia Agropecuaria, Bariloche, Argentina
    Am J Vet Res 66:251-5. 2005
    ..To evaluate the morphologic and physiologic changes induced by Clostridium perfringens type A (alpha toxin in the ileum and colon of sheep...
  25. pmc Lethal effects of Clostridium perfringens epsilon toxin are potentiated by alpha and perfringolysin-O toxins in a mouse model
    Mariano E Fernandez-Miyakawa
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 W Central Avenue, San Bernardino, CA 92408, USA
    Vet Microbiol 127:379-85. 2008
    ..The results of the present study suggest that both CPA and PFO have the potential to enhance the ETX lethal effects during enterotoxemia in natural hosts such as sheep and goats...
  26. ncbi request reprint Clostridium perfringens type A toxin production in 3 commonly used culture media
    Mariano E Fernandez-Miyakawa
    California Animal Health and Food Safety Laboratory, San Bernardino Branch, Faculty of Veterinary Medicine, University of California Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 19:184-6. 2007
    ..No supernatants from any isolates grown in TGY produced lethality in mice. Phospholipase C activity was highest when the isolates were grown in BHI and CMM and significantly lower when grown in TGY...
  27. doi request reprint Freezing or adding trypsin inhibitor to equine intestinal contents extends the lifespan of Clostridium perfringens beta toxin for diagnostic purposes
    Melissa Macias Rioseco
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, UC Davis, San Bernardino, CA 92408, USA
    Anaerobe 18:357-60. 2012
    ..Freezing the samples at -20 °C or adding trypsin inhibitor before storage at 4 °C preserves the lifespan of CPB for at least 5 weeks...
  28. pmc Development and application of a mouse intestinal loop model to study the in vivo action of Clostridium perfringens enterotoxin
    Justin A Caserta
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Infect Immun 79:3020-7. 2011
    ....
  29. doi request reprint The pathology of enterotoxemia by Clostridium perfringens type C in calves
    Jorge P Garcia
    California Animal Health and Food Safety Laboratory, San Bernardino Branch, 105 West Central Avenue, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 25:438-42. 2013
    ..A diagnosis of C. perfringens type C infection was confirmed based on pathological findings and detection of beta toxin in the intestinal content of the 3 animals...
  30. ncbi request reprint Seasonal meningoencephalitis in Holstein cattle caused by Naegleria fowleri
    Barbara M Daft
    University of California, Davis, School of Veterinary Medicine, California Animal Health and Food Safety Laboratory System, San Bernardino Branch, CA 92408, USA
    J Vet Diagn Invest 17:605-9. 2005
    ..Naegleria meningoencephalitis should be included among differential diagnoses of central nervous system disease in cattle during the summer season in areas with high ambient temperatures...
  31. ncbi request reprint Abortion and ulcerative posthitis associated with caprine herpesvirus-1 infection in goats in California
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 16:478-84. 2004
    ..The results presented here support the hypothesis that the male goat is involved in the transmission of CHV-1. However, other forms of transmission cannot be ruled out...
  32. pmc Clostridium perfringens enterotoxin damages the human intestine in vitro
    M E Fernandez Miyakawa
    California Animal Health and Food Safety Laboratory San Bernardino Branch, University of California Davis, 105 W Central Avenue, San Bernardino, CA 92408
    Infect Immun 73:8407-10. 2005
    ..CPE also binds to the human colon in vitro but causes only slight morphological and transport changes that are not statistically significant...
  33. ncbi request reprint Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California Davis, CA, USA
    Future Microbiol 9:361-77. 2014
    ..Producing many toxins with diverse characteristics likely imparts virulence flexibility to C. perfringens so it can cause an array of diseases. ..
  34. ncbi request reprint Yersinia pseudotuberculosis infections in goats and other animals diagnosed at the California Animal Health and Food Safety Laboratory System: 1990-2012
    Federico Giannitti
    1Federico Giannitti, California Animal Health and Food Safety Laboratory, 620 West Health Sciences Drive, Davis, CA 95616
    J Vet Diagn Invest 26:88-95. 2014
    ..3%), followed by abscessation (14.3%), abortion (11.9%), conjunctivitis (4.75%), and hepatitis (4.75%). Among other animal species, 59 cases were diagnosed in non-poultry avian species and 33 in mammals other than goats. ..
  35. doi request reprint Diagnosing clostridial enteric disease in poultry
    Kerry K Cooper
    California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California Davis, 105 West Central Avenue, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 25:314-27. 2013
    ..colinum from the intestine of affected birds. Other clostridial enteric diseases include infections produced by Clostridium difficile, Clostridium fallax, and Clostridium baratii...
  36. doi request reprint Cerebrospinal nematodiasis outbreak in an urban outdoor aviary of cockatiels (Nymphicus hollandicus) in southern California
    Santiago S Diab
    California Animal Health and Food Safety Laboratory, University of California Davis, 105 W Central Avenue, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 24:994-9. 2012
    ..Nematode larvae morphologically compatible with Baylisascaris sp. were observed in the brain of 5 birds, away from the lesion site...
  37. doi request reprint An outbreak of equine botulism type A associated with feeding grass clippings
    Stephanie R Ostrowski
    California Animal Health and Food Safety Laboratory, PO Box 1770, Davis, CA 95616 1770, USA
    J Vet Diagn Invest 24:601-3. 2012
    ..Emphasis should be placed on early case recognition, rapid initiation of treatment with the trivalent antitoxin product, and preventing exposure to BoNT in spoiled forages...
  38. pmc Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685
    Jorge E Vidal
    Hubert Department of Global Health, Division of Infectious Diseases, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Mol Microbiol 83:179-94. 2012
    ..The Agr-like system, but not the LuxS-mediated AI-2 system, was also important for CN3685 to cause fatal enterotoxemia. These results provide the first direct evidence supporting a role for any QS system in clostridial infections...
  39. ncbi request reprint Simple multichannel system for the measurement of the net water flux across biological tissues
    Mariano E Fernandez-Miyakawa
    California Animal Health and Food Safety Laboratory, San Bernardino Branch, University of California Davis, 105 W Central Avenue, San Bernardino, CA 92408, USA
    Comput Methods Programs Biomed 85:95-100. 2007
    ..It is a flexible and affordable device, which allows comparatively more information per unit to be obtained than previously described methods...
  40. ncbi request reprint The early effects of Clostridium perfringens type D epsilon toxin in ligated intestinal loops of goats and sheep
    M E Fernandez Miyakawa
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Vet Res Commun 27:231-41. 2003
    ..These results suggest that epsilon toxin modifies ion and water transport in the small and the large intestine of goats and sheep through different mechanisms...
  41. ncbi request reprint Malignant oedema associated with blood-sampling in sheep
    W E Morris
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Aust Vet J 80:280-1. 2002
    ....
  42. ncbi request reprint Resistance of ovine, caprine and bovine endothelial cells to Clostridium perfringens type D epsilon toxin in vitro
    F A Uzal
    School of Veterinary Sciences and Animal Production, The University of Queensland, Brisbane, Australia
    Vet Res Commun 23:275-84. 1999
    ..All the MDCK cells were dead after 3 h of exposure to all concentrations of epsilon toxin. The results indicate that ovine, caprine and bovine endothelial cells are not morphologically responsive to the action of epsilon toxin in vitro...
  43. ncbi request reprint Association between findings on palmarodorsal radiographic images and detection of a fracture in the proximal sesamoid bones of forelimbs obtained from cadavers of racing Thoroughbreds
    Lucy A Anthenill
    JD Wheat Veterinary Orthopedic Research Laboratory, Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Vet Res 67:858-68. 2006
    ..To determine the distribution for limbs and bones in horses with fractures of the proximal sesamoid bones and relationships with findings on palmarodorsal radiographic images...
  44. ncbi request reprint Malignant edema in postpartum dairy cattle
    Jenee S Odani
    California Animal Health and Food Safety Laboratory System, University of California Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 21:920-4. 2009
    ..These cases of malignant edema were considered to be produced by C. septicum and predisposed by the trauma occurring during parturition...
  45. ncbi request reprint Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, San Bernadino, USA
    J Vet Diagn Invest 17:626-9. 2005
    ..This first documented case of gossypol poisoning in a dog, caused by the ingestion of cottonseed bedding, demonstrates how specific toxicological analysis is crucial in reaching an accurate diagnosis...
  46. ncbi request reprint Effects of intravenous injection of Clostridium perfringens type D epsilon toxin in calves
    F A Uzal
    Animal Health Unit, The National Institute of Agricultural Technology, CC 277 8400 Bariloche, QLD 4072, Argentina
    J Comp Pathol 126:71-5. 2002
    ..These results show that calves are susceptible to the intravenous injection of epsilon toxin, and that they can show at least some of the histological lesions produced in sheep and goats by this toxin...
  47. doi request reprint Zygomycotic lymphadenitis in slaughtered feedlot cattle
    J Ortega
    California Animal Health and Food Safety Laboratory, University of California Davis, West Health Sciences Drive, Davis, CA 95616, USA
    Vet Pathol 47:108-15. 2010
    ..Zygomycosis should be considered in the differential diagnosis for granulomatous lymphadenitis in feedlot steers...
  48. pmc Targeted delivery of bleomycin to the brain using photo-chemical internalization of Clostridium perfringens epsilon prototoxin
    Henry Hirschberg
    Beckman Laser Institute, University of California, Irvine, CA, USA
    J Neurooncol 95:317-29. 2009
    ..PCI delivered ETXp was effective in opening the BBB in a limited region of the brain. ETXp-PCI mediated BBB opening clearly increased the efficacy of BLM therapy...
  49. ncbi request reprint Pulmonary aspergillosis in a great rhea (Rhea americana)
    Elizabeth Chang Reissig
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Avian Dis 46:754-6. 2002
    ..Aspergillus fumigatus grew readily on Sabouraud dextrose agar. This report appears to be the first of mycotic pneumonia in great rheas...
  50. ncbi request reprint An indirect ELISA using a monoclonal anti IgG1 enzyme conjugate for the diagnosis of bovine brucellosis
    F A Uzal
    Animal Health Unit, National Institute of Agricultural Technology INTA, Bariloche, Argentina
    Vet Microbiol 52:175-80. 1996
    ....
  51. ncbi request reprint Ovine pulmonary adenomatosis in Patagonia, Argentina
    F A Uzal
    Animal Health Unit, The National Institute of Agricultural Technology, Bariloche, Argentina
    Vet Res Commun 28:159-70. 2004
    ..The presence of the Jaagsiekte retrovirus was demonstrated in the lungs by immunocytochemistry and PCR. To the best of our knowledge, this is the first report of OPA in Patagonia...
  52. ncbi request reprint Comparison of four techniques for the detection of Clostridium perfringens type D epsilon toxin in intestinal contents and other body fluids of sheep and goats
    F A Uzal
    School of Veterinary Sciences and Animal Production, The University of Queensland, Brisbane, Queensland, Australia
    J Vet Diagn Invest 15:94-9. 2003
    ..Until more consistent results are achieved, the diagnosis of enterotoxemia should not only be based solely on epsilon toxin detection, but also on clinical and pathological data...
  53. pmc Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model
    Derek J Fisher
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 74:5200-10. 2006
    ..Collectively, our results highlight the importance of beta toxin for type C-induced toxemia...
  54. ncbi request reprint Evaluation of different fluids for detection of Clostridium perfringens type D epsilon toxin in sheep with experimental enterotoxemia
    Jorge E Layana
    The National Institute of Agricultural Technology CC 277, 8400 Bariloche, Argentina
    Anaerobe 12:204-6. 2006
    ..The results of this study indicate that with the diagnostic capture ELISA used, intestinal content (preferably ileum) should be used for C. perfringens type D epsilon toxin detection in suspected cases of sheep enterotoxemia...
  55. ncbi request reprint Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model
    Sameera Sayeed
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Microbiol 67:15-30. 2008
    ..These results indicate that CPB is both required and sufficient for CN3685-induced enteric pathology, supporting a key role for this toxin in type C intestinal pathogenesis...
  56. pmc Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon
    Jorge E Vidal
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Infect Immun 76:4396-404. 2008
    ..perfringens isolates...
  57. pmc Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model
    Sameera Sayeed
    E1240 BSTWR, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA
    Infect Immun 73:7413-21. 2005
    ..Collectively, these results indicate that, under the experimental conditions used in the present study, ETX is necessary for the lethal properties of most genotype D vegetative supernatants in the mouse i.v. injection model...
  58. pmc Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity
    James G Smedley
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Infect Immun 76:3793-800. 2008
    ..Finally, rCPE(168-319) was able to partially inhibit CPE-induced histologic damage, suggesting that noncytotoxic rCPE variants might be useful for protecting against some intestinal effects of CPE...
  59. pmc Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin
    James G Smedley
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Infect Immun 75:2381-90. 2007
    ..Collectively these findings reveal a new step in CPE action, whereby receptor binding is followed by formation of a prepore large complex, which then inserts into membranes to form a pore...
  60. pmc Epsilon-toxin plasmids of Clostridium perfringens type D are conjugative
    Meredith L Hughes
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Victoria 3800, Australia
    J Bacteriol 189:7531-8. 2007
    ..Our study demonstrated the fluid nature of the toxinotypes and their dependence upon the presence or absence of toxin plasmids, some of which have for the first time been shown to be conjugative...