T Uz

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain
    Tolga Uz
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, USA
    Neurosci Res 42:309-16. 2002
  2. pmc The pattern of melatonin receptor expression in the brain may influence antidepressant treatment
    Eric Hirsch-Rodriguez
    Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 69:120-4. 2007
  3. pmc Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 436:269-72. 2008
  4. pmc Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
  5. ncbi request reprint The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
    Tolga Uz
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 136:45-53. 2005
  6. ncbi request reprint Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum
    T Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Neuroscience 134:1309-16. 2005
  7. ncbi request reprint Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Life Sci 70:3069-75. 2002
  8. ncbi request reprint The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 28:2117-23. 2003
  9. ncbi request reprint Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice
    T Uz
    The Psychiatric Institute, University of Illinois at Chicago, 60612, USA
    J Pineal Res 30:166-70. 2001
  10. doi request reprint Effects of cocaine in 5-lipoxygenase-deficient mice
    M Kurtuncu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA
    J Neural Transm 115:389-95. 2008

Research Grants

Collaborators

  • H Manev
  • Ghanshyam N Pandey
  • M Maccarrone
  • K Sugaya
  • JOHN R LARSON
  • Y Dwivedi
  • Rajiv Sharma
  • Patricia Tueting
  • Marta Imbesi
  • Mustafa Akhisaroglu
  • Radmila Manev
  • Murat Kurtuncu
  • M Imbesi
  • Svetlana Dzitoyeva
  • Nikola Dimitrijevic
  • R Manev
  • M Kurtuncu
  • Eric Hirsch-Rodriguez
  • Emre Yildirim
  • Giorgia Miolo
  • A M Mayer
  • A Dirim Arslan
  • S Yildiz
  • N Battista
  • N Dimitrijevic
  • N Pasquariello
  • A D'Agostino
  • Iris Zavoreo
  • Lance J Luka
  • Rehan Ahmed
  • Ahmet D Arslan
  • Zhijing Zhang
  • Ezgi Akhisaroglu
  • Chang Qing Chen
  • Pietro Giusti
  • Laura Levorato
  • Sergio Caffieri
  • A M Romanic
  • C Pearson
  • W C Prozialeck
  • M Hall
  • P Lamar
  • M J Fay
  • P B Jacobson
  • V K Lehmann

Detail Information

Publications37

  1. ncbi request reprint Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain
    Tolga Uz
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, USA
    Neurosci Res 42:309-16. 2002
    ..Further studies are warranted into the possible functional significance of neuronal expression of AANAT mRNA...
  2. pmc The pattern of melatonin receptor expression in the brain may influence antidepressant treatment
    Eric Hirsch-Rodriguez
    Department of Psychiatry and the Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C912, Chicago, IL 60612, USA
    Med Hypotheses 69:120-4. 2007
    ....
  3. pmc Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 436:269-72. 2008
    ..Future research is needed to evaluate the clinical relevance of our findings...
  4. pmc Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
    A M Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 1:7. 2001
    ....
  5. ncbi request reprint The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
    Tolga Uz
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Brain Res Mol Brain Res 136:45-53. 2005
    ..Further research is needed to understand the regional/cellular functional role of melatonin receptors in the regulation of dopaminergic behaviors, using models such as melatonin receptor knockout mice...
  6. ncbi request reprint Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum
    T Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Neuroscience 134:1309-16. 2005
    ..We propose that the effects of psychoactive drugs on clock transcription factors may mediate long-term drug-induced changes, possibly by regulating the expression of a second set of genes (i.e. clock-controlled genes)...
  7. ncbi request reprint Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA
    Life Sci 70:3069-75. 2002
    ..AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine...
  8. ncbi request reprint The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuropsychopharmacology 28:2117-23. 2003
    ....
  9. ncbi request reprint Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice
    T Uz
    The Psychiatric Institute, University of Illinois at Chicago, 60612, USA
    J Pineal Res 30:166-70. 2001
    ..e., both during the day and in the dark at night. Further studies are needed to fully characterize the behavioral significance of AANAT mutation and its possible link to depression...
  10. doi request reprint Effects of cocaine in 5-lipoxygenase-deficient mice
    M Kurtuncu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois, Chicago, IL, USA
    J Neural Transm 115:389-95. 2008
    ..Our results demonstrated that a 5-LOX deficiency alters sensitivity to repeated cocaine. It should be investigated whether a human 5-LOX gene polymorphism affects cocaine's actions...
  11. pmc Dopamine receptor-mediated regulation of neuronal "clock" gene expression
    M Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Neuroscience 158:537-44. 2009
    ..e. intracellular signaling pathways) and thereby influences neuronal gene expression, neuronal transmission, and brain functioning...
  12. ncbi request reprint Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression
    H Manev
    Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Ann N Y Acad Sci 890:183-90. 1999
    ..The results of our ongoing research are expected to elucidate the role of 5-LO in aging and neurodegeneration and to indicate neuroprotective therapies that would target the 5-LO pathway...
  13. doi request reprint Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells
    M Imbesi
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Neuroscience 155:1160-4. 2008
    ..In conclusion, we showed for the first time that a clinically used MT1/MT2 agonist, ramelteon, is capable of activating neuronal ERK1/2...
  14. ncbi request reprint Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro
    H Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street MC912, 60612, Chicago, IL, USA
    Eur J Pharmacol 411:67-70. 2001
    ..Clomipramine and imipramine produced similar action in vitro; desipramine was ineffective...
  15. ncbi request reprint Putative role of neuronal 5-lipoxygenase in an aging brain
    H Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    FASEB J 14:1464-9. 2000
    ..Thus, the 5-LOX pathway could become a promising target of neuroprotective therapies for the aging brain...
  16. ncbi request reprint Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampus
    R Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL60612, USA
    Eur J Pharmacol 420:R1-2. 2001
    ....
  17. ncbi request reprint 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate
    H Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Exp Gerontol 35:1201-9. 2000
    ..The mechanism of how NS-398 inhibits this action of kainate should be further investigated...
  18. ncbi request reprint 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro
    T Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Eur J Pharmacol 418:15-22. 2001
    ..Their anti-proliferative effect was reversible. We propose that neuronal expression of 5-lipoxygenase is crucial for neurogenesis in vitro, and possibly also in vivo...
  19. doi request reprint Dosing time-dependent actions of psychostimulants
    H Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Int Rev Neurobiol 88:25-41. 2009
    ....
  20. ncbi request reprint Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?
    H Manev
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Ann N Y Acad Sci 939:45-51. 2001
    ..Additional studies should explore whether 5-LOX may participate in neurogenesis related pathologies and whether it should be considered a target for procedures aimed at altering neurogenesis for therapeutic purposes...
  21. ncbi request reprint Valproate administration to mice increases histone acetylation and 5-lipoxygenase content in the hippocampus
    Emre Yildirim
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurosci Lett 345:141-3. 2003
    ..Since the extent of 5-LOX expression may alter mouse behavior, we suggest that VPA-altered chromatin remodeling and 5-LOX expression in the brain may be functionally important...
  22. ncbi request reprint Clock genes: influencing and being influenced by psychoactive drugs
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Trends Pharmacol Sci 27:186-9. 2006
    ..Focusing on clock genes expressed in the brain might lead to the discovery of novel drug-target pathways...
  23. ncbi request reprint 5-Lipoxygenase inhibitor MK-886 increases GluR1 phosphorylation in neuronal cultures in vitro and in the mouse cortex in vivo
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Brain Res 1147:148-53. 2007
    ....
  24. doi request reprint Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice
    Svetlana Dzitoyeva
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neural Transm 115:823-7. 2008
    ..The BDNF transcript IV decrease was attenuated by caffeic acid in wild-type but not in 5-LOX-deficient mice, suggesting a role for 5-LOX in BDNF regulation...
  25. ncbi request reprint DNA hypomethylating agents 5-aza-2'-deoxycytidine and valproate increase neuronal 5-lipoxygenase mRNA
    Hari Manev
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Pharmacol 445:149-50. 2002
    ..We propose that neuronal 5-lipoxygenase expression can be affected by aging-altered DNA methylation and by hypomethylating drugs, such as the anticonvulsant valproate...
  26. doi request reprint Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells
    Marta Imbesi
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912 Chicago, IL 60612, USA
    Neurosci Lett 439:34-6. 2008
    ..Further research is needed to explore the putative influence of ramelteon on BDNF-associated neuroplasticity...
  27. ncbi request reprint Clock genes as a link between addiction and obesity
    Hari Manev
    Eur J Hum Genet 14:5. 2006
  28. ncbi request reprint Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice
    John Larson
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, 60612, USA
    Neurosci Lett 393:23-6. 2006
    ..These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes...
  29. ncbi request reprint Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus
    Mustafa Akhisaroglu
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neuroreport 14:1471-3. 2003
    ..Fluoxetine treatment of old mice further increased hippocampal S100B, suggesting that aging does not interfere with fluoxetine's action on hippocampal S100B...
  30. ncbi request reprint Glia as a putative target for antidepressant treatments
    Hari Manev
    The Psychiatric Institute, Department of Psychiatry, University of Illinois, Chicago 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Affect Disord 75:59-64. 2003
    ..e., astrocytes. We have recently shown that protracted administration of the antidepressant fluoxetine to adult rats upregulated the astrocytic protein S100beta content and increased neurogenesis in the hippocampus...
  31. ncbi request reprint The pineal gland and anxiogenic-like action of fluoxetine in mice
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    Neuroreport 15:691-4. 2004
    ..Fluoxetine was ineffective in pinealectomized C3H or C57BL6 mice. It is possible that the pineal system contributes to the previously observed anxiogenic action of fluoxetine in humans...
  32. ncbi request reprint Diurnal rhythms in cocaine sensitization and in Period1 levels are common across rodent species
    Mustafa Akhisaroglu
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Pharmacol Biochem Behav 79:37-42. 2004
    ..g., time of day and subject strain) to study the role of these genes in psychiatric disorders such as addiction and depression...
  33. ncbi request reprint Diurnal rhythms in quinpirole-induced locomotor behaviors and striatal D2/D3 receptor levels in mice
    Mustafa Akhisaroglu
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, Illinois 60612, USA
    Pharmacol Biochem Behav 80:371-7. 2005
    ..Therefore, we propose that diurnal mechanisms, which participate in drug-induced long-term changes in the dopamine system, are important for the development of dopaminergic behaviors...
  34. ncbi request reprint 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior
    Tolga Uz
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Restor Neurol Neurosci 20:15-20. 2002
    ..Moreover, the 5LOX pathway has been associated with the neurotoxicity of the prion peptide. 5LOX-deficient mice [5LOX(-); B6129S(Alox5tm1Fun)] and their controls (B6129SF2/J) have not been behaviorally characterized...
  35. ncbi request reprint Reliability assessment of an automated forced swim test device using two mouse strains
    Murat Kurtuncu
    The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA
    J Neurosci Methods 149:26-30. 2005
    ..Our results suggest that the tested automated FST system generates reliable data comparable to results obtained by trained observers...
  36. ncbi request reprint Involvement of the pineal gland in diurnal cocaine reward in mice
    Murat Kurtuncu
    Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, M C 912, Chicago, IL 60612, USA
    Eur J Pharmacol 489:203-5. 2004
    ..Circadian mechanisms regulated by the pineal gland thus appear critically involved in cocaine-induced reward...
  37. ncbi request reprint Photoisomerization of fluvoxamine generates an isomer that has reduced activity on the 5-hydroxytryptamine transporter and does not affect cell proliferation
    Giorgia Miolo
    Department of Pharmaceutical Sciences, Padova University, 35131 Padua, Italy
    Eur J Pharmacol 450:223-9. 2002
    ..e., 20 microM) but not the photoproduct was toxic to both immature and mature cultures. We suggest that a mechanism sensitive to fluvoxamine photoisomerization might be involved in the action of antidepressants on cell proliferation...

Research Grants3

  1. 5-HT N-acetyltransferase and Cocaine-Induced Behaviors
    Tolga Uz; Fiscal Year: 2004
    ..e., sensitization and reward. ..