K M Utzschneider

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women
    Kristina M Utzschneider
    VA Puget Sound Health Care System, Department of Medicine, Division of Endocrinology and Metabolism, Seattle, WA University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA Electronic address
    J Diabetes Complications 28:177-84. 2014
  2. doi request reprint Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Br J Nutr 109:1096-104. 2013
  3. ncbi request reprint The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 31:108-13. 2008
  4. ncbi request reprint Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies
    K M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 50:2516-25. 2007
  5. ncbi request reprint Review: The role of insulin resistance in nonalcoholic fatty liver disease
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 South Columbian Way, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 91:4753-61. 2006
  6. ncbi request reprint Effectiveness of gastric bypass surgery in a patient with familial partial lipodystrophy
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Diabetes Care 29:1380-2. 2006
  7. ncbi request reprint Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes Care 29:356-62. 2006
  8. ncbi request reprint Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans
    K M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Veterans Affairs Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Diabetologia 48:2330-3. 2005
  9. pmc Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Diabetes Care 32:335-41. 2009
  10. ncbi request reprint Diet-induced weight loss is associated with an improvement in beta-cell function in older men
    Kristina M Utzschneider
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:2704-10. 2004

Detail Information

Publications38

  1. doi request reprint Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women
    Kristina M Utzschneider
    VA Puget Sound Health Care System, Department of Medicine, Division of Endocrinology and Metabolism, Seattle, WA University of Washington, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, Seattle, WA Electronic address
    J Diabetes Complications 28:177-84. 2014
    ..We sought to determine whether NAFLD is associated with poorer β-cell function and if any β-cell dysfunction is associated with abnormal markers of iron or inflammation...
  2. doi request reprint Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Br J Nutr 109:1096-104. 2013
    ..HSAT diet was a predictor of changes in lipid parameters but not liver fat. We conclude that diet composition may be an important factor in the accumulation of liver fat, with a low-fat/low-saturated fat/LGI diet being beneficial...
  3. ncbi request reprint The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 31:108-13. 2008
    ..To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects with impaired fasting glucose (IFG)...
  4. ncbi request reprint Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies
    K M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 50:2516-25. 2007
    ..We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT...
  5. ncbi request reprint Review: The role of insulin resistance in nonalcoholic fatty liver disease
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 South Columbian Way, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 91:4753-61. 2006
    ..This review outlines the evidence linking insulin resistance and NAFLD, explores whether liver fat is a cause or consequence of insulin resistance, and reviews the current evidence for treatment of NAFLD...
  6. ncbi request reprint Effectiveness of gastric bypass surgery in a patient with familial partial lipodystrophy
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Diabetes Care 29:1380-2. 2006
  7. ncbi request reprint Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes Care 29:356-62. 2006
    ..To determine whether the hyperbolic relationship between insulin sensitivity and the acute insulin response to glucose (AIRg) exists in subjects with impaired fasting glucose (IFG) or decreased glucose tolerance...
  8. ncbi request reprint Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans
    K M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Veterans Affairs Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Diabetologia 48:2330-3. 2005
    ..The aim of this study was to further elucidate the relationship between resistin and insulin sensitivity, body fat distribution and the metabolic syndrome in humans...
  9. pmc Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Diabetes Care 32:335-41. 2009
    ..First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function...
  10. ncbi request reprint Diet-induced weight loss is associated with an improvement in beta-cell function in older men
    Kristina M Utzschneider
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:2704-10. 2004
    ..05). Thus, the weight loss-associated improvements in both insulin sensitivity and beta-cell function may explain the beneficial effects of a lifestyle intervention on delaying the development of diabetes in older subjects...
  11. doi request reprint Hereditary hemochromatosis and diabetes mellitus: implications for clinical practice
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Nat Rev Endocrinol 6:26-33. 2010
    ..Further research into the long-term effects of treatment on prevention of diabetes mellitus in HH is needed...
  12. doi request reprint Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes
    Kristina M Utzschneider
    VA Puget Sound Health Care System, Seattle, Washington, USA
    Obesity (Silver Spring) 18:1781-7. 2010
    ..Further, as many lean individuals with a first-degree relative with type 2 diabetes are IR and metabolically unhealthy, they may all benefit from metabolic testing...
  13. ncbi request reprint Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 53:2867-72. 2004
    ....
  14. ncbi request reprint Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects
    J Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Diabetologia 50:439-42. 2007
    ..We have examined whether in humans increased PP levels are associated with increased intra-abdominal fat (IAF), and thereby insulin resistance...
  15. ncbi request reprint Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans
    J Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151 and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USA
    Diabetologia 50:1156-60. 2007
    ..Our aim was to determine whether IAF accumulation predicts the future development of MetS in non-diabetic Japanese-Americans...
  16. pmc Interactions between genetic background, insulin resistance and β-cell function
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Obes Metab 14:46-56. 2012
    ....
  17. doi request reprint Preeclampsia and risk of developing subsequent diabetes
    D B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Hypertens Pregnancy 28:435-47. 2009
    ..Determine whether preeclampsia is associated with developing diabetes...
  18. doi request reprint An examination of beta-cell function measures and their potential use for estimating beta-cell mass
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Diabetes Obes Metab 10:63-76. 2008
    ..However, until beta-cell volume can be quantified reliably and non-invasively, we will need to rely on the ability of glucose to potentiate insulin release as the best surrogate estimate of the number of beta-cells...
  19. ncbi request reprint Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151 and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
    ..We investigated the relationships between adiponectin and leptin, body fat distribution, insulin sensitivity and lipoproteins...
  20. ncbi request reprint Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 48:1350-8. 2005
    ..We therefore sought to determine whether the impaired beta cell adaptation is due to inadequate expansion of the beta cell population or to a lack of an adaptive increase in insulin release...
  21. pmc Arm length is associated with type 2 diabetes mellitus in Japanese-Americans
    M M Smits
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Diabetologia 55:1679-84. 2012
    ..The aim of the study was to examine the association of type 2 diabetes mellitus with arm length as a marker for early life environment and development...
  22. pmc The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
    S E Kahn
    Department of Medicine, Division of Metabolism, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1003-12. 2009
    ..Based on human and animal studies, it appears that neither alone is sufficient. Rather, for glucose to rise to the level at which diabetes would be diagnosed, defects in beta cell mass and in beta cell function are required...
  23. ncbi request reprint Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes
    Miriam Cnop
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 30:677-82. 2007
    ..First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia...
  24. ncbi request reprint Effects of sex and hormone replacement therapy use on the prevalence of isolated impaired fasting glucose and isolated impaired glucose tolerance in subjects with a family history of type 2 diabetes
    Renate E van Genugten
    VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:3529-35. 2006
    ..Based on the influence of sex and HRT on the prevalence of isolated IFG and isolated IGT, we conclude that female sex hormones may play an important role in the pathogenesis of IFG and IGT...
  25. ncbi request reprint A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function
    Darcy B Carr
    Department of ObstetricsGynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes 54:340-7. 2005
    ..However, such changes did not improve beta-cell function, suggesting that this degree of lifestyle modifications may be limited in preventing type 2 diabetes over the long term...
  26. ncbi request reprint Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E703-9. 2005
    ..These findings underscore the importance of genetic and environmental factors in studying metabolic disease...
  27. ncbi request reprint Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l...
  28. pmc Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution
    Fernando Gerchman
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 94:3781-8. 2009
    ..Although obesity has been, in general, associated with glomerular hyperfiltration, visceral adiposity has been suggested to be associated with reduced glomerular filtration...
  29. pmc Glucose- and time-dependence of islet amyloid formation in vitro
    Sakeneh Zraika
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Biochem Biophys Res Commun 354:234-9. 2007
    ..It thus enables studies investigating the mechanism(s) underlying the amyloid-associated loss of beta-cell mass in type 2 diabetes...
  30. ncbi request reprint Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 54:2235-44. 2005
    ....
  31. ncbi request reprint Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes Care 29:2078-83. 2006
    ..We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes...
  32. doi request reprint Modestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes Care 31:1037-9. 2008
    ..To determine whether 1-h oral glucose challenge test (OGCT) or 3-h oral glucose tolerance test (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes...
  33. pmc Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans
    Fernando Gerchman
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Diabetes Res Clin Pract 77:320-6. 2007
    ....
  34. ncbi request reprint Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat
    Tara M Wallace
    Department of Medicine, VA Puget Sound Health Care System, and University of Washington, Seattle, WA 98108, USA
    Diabetes Care 30:2673-8. 2007
    ..The purpose of this study was to determine the relationship between plasma liver enzyme concentrations, insulin sensitivity, and intra-abdominal fat (IAF) distribution...
  35. ncbi request reprint Mechanisms linking obesity to insulin resistance and type 2 diabetes
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Nature 444:840-6. 2006
    ..This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention...
  36. ncbi request reprint Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis
    Sakeneh Zraika
    Division of Metabolism, Endocrinology anmd Nutrition, Department of Medicine, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 56:304-10. 2007
    ..Together, these findings demonstrate that neprilysin is a factor associated with islet amyloid accumulation and subsequent deterioration of beta-cell function in hIAPP transgenic male mice...
  37. pmc Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  38. ncbi request reprint Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:12152-62. 2004
    ..These observations suggest that the HMW adiponectin complex is the active form of this protein, which we directly demonstrate in vivo by its ability to depress serum glucose levels in a dose-dependent manner...