Urs Utzinger

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Fiber optic probes for biomedical optical spectroscopy
    Urs Utzinger
    University of Arizona, Biomedical Engineering and Obstetrics and Gynecology, Tucson, Arizona 85724, USA
    J Biomed Opt 8:121-47. 2003
  2. doi request reprint Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer
    Jennifer M Watson
    University of Arizona, Tucson, Arizona 85721, USA
    Lasers Surg Med 45:155-66. 2013
  3. pmc Comparisons of planar and tubular biaxial tensile testing protocols of the same porcine coronary arteries
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, P O Box 210119, Tucson, AZ 85721 0119, USA
    Ann Biomed Eng 41:1579-91. 2013
  4. doi request reprint The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721 0119, USA
    J Biomech 45:772-9. 2012
  5. doi request reprint Enhanced visibility of colonic neoplasms using formulaic ratio imaging of native fluorescence
    Bhaskar Banerjee
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, 85724 Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, Arizona, 85721 College of Optical Sciences, University of Arizona, Tucson, Arizona, 85721
    Lasers Surg Med 45:573-81. 2013
  6. pmc Wide-field spectral imaging of human ovary autofluorescence and oncologic diagnosis via previously collected probe data
    Timothy E Renkoski
    University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85721, USA
    J Biomed Opt 17:036003. 2012
  7. pmc A gimbal-mounted pressurization chamber for macroscopic and microscopic assessment of ocular tissues
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    J Biomech Eng 133:095001. 2011
  8. ncbi request reprint Endogenous optical biomarkers of ovarian cancer evaluated with multiphoton microscopy
    Nathaniel D Kirkpatrick
    Biomedical Engineering Program, University of Arizona, Arizona, USA
    Cancer Epidemiol Biomarkers Prev 16:2048-57. 2007
  9. ncbi request reprint Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA
    Comp Med 57:175-85. 2007
  10. ncbi request reprint Imaging of the ovary
    Molly A Brewer
    Biomedical Engineering Program, University of Arizona, 1515 N Campbell Ave, Room 1968, Tucson, AZ 85724 5024, USA
    Technol Cancer Res Treat 3:617-27. 2004

Research Grants

  1. Optical Spectroscopy of Ovarian Cancer
    Urs Utzinger; Fiscal Year: 2005
  2. Advanced Intravital Microscope
    Urs Utzinger; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Fiber optic probes for biomedical optical spectroscopy
    Urs Utzinger
    University of Arizona, Biomedical Engineering and Obstetrics and Gynecology, Tucson, Arizona 85724, USA
    J Biomed Opt 8:121-47. 2003
    ..The design of probes for reflectance, polarized reflectance, fluorescence, and Raman spectroscopy is illustrated. We cover universal design principles as well as technologies for beam deflecting and reshaping...
  2. doi request reprint Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer
    Jennifer M Watson
    University of Arizona, Tucson, Arizona 85721, USA
    Lasers Surg Med 45:155-66. 2013
    ..In order to aid understanding of disease etiology and progression, we identify the endogenous fluorophores present in a mouse model of ovarian cancer and describe changes in fluorophore abundance and distribution with age and disease...
  3. pmc Comparisons of planar and tubular biaxial tensile testing protocols of the same porcine coronary arteries
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, P O Box 210119, Tucson, AZ 85721 0119, USA
    Ann Biomed Eng 41:1579-91. 2013
    ..There was a shift towards the circumferential direction upon flattening of 8.0°. There was also noticeable collagen uncrimping in the flattened tissue...
  4. doi request reprint The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721 0119, USA
    J Biomech 45:772-9. 2012
    ..We chose here to investigate the effect of angiotensin II (AngII) in C57BL/6 mice as a first step towards understanding how such changes occur in the established ApoE(-/-) AngII infused mouse model of AAA...
  5. doi request reprint Enhanced visibility of colonic neoplasms using formulaic ratio imaging of native fluorescence
    Bhaskar Banerjee
    Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, 85724 Department of Biomedical Engineering, College of Engineering, University of Arizona, Tucson, Arizona, 85721 College of Optical Sciences, University of Arizona, Tucson, Arizona, 85721
    Lasers Surg Med 45:573-81. 2013
    ..Colonoscopy is the preferred method for colon cancer screening, but can miss polyps and flat neoplasms with low color contrast. The objective was to develop a new autofluorescence method that improves image contrast of colonic neoplasms...
  6. pmc Wide-field spectral imaging of human ovary autofluorescence and oncologic diagnosis via previously collected probe data
    Timothy E Renkoski
    University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85721, USA
    J Biomed Opt 17:036003. 2012
    ..Benign neoplasm ovaries were also found to classify as nonmalignant using the same algorithm. Although applied ex vivo, the method described here appears useful for quick assessment of cancer presence in the human ovary...
  7. pmc A gimbal-mounted pressurization chamber for macroscopic and microscopic assessment of ocular tissues
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    J Biomech Eng 133:095001. 2011
    ..This ability to move the sclera in space about the center of the globe, coupled with an upright multiphoton microscope, allows for collecting collagen, and elastin signal in a rapid automated fashion so the entire globe can be imaged...
  8. ncbi request reprint Endogenous optical biomarkers of ovarian cancer evaluated with multiphoton microscopy
    Nathaniel D Kirkpatrick
    Biomedical Engineering Program, University of Arizona, Arizona, USA
    Cancer Epidemiol Biomarkers Prev 16:2048-57. 2007
    ..Additionally, multiwavelength 2PEF provided an estimation of the cellular redox ratio of epithelial cells...
  9. ncbi request reprint Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, AZ, USA
    Comp Med 57:175-85. 2007
    ..OCT and LIF appear to be useful and complementary modalities for ex vivo imaging of mouse GI tissues...
  10. ncbi request reprint Imaging of the ovary
    Molly A Brewer
    Biomedical Engineering Program, University of Arizona, 1515 N Campbell Ave, Room 1968, Tucson, AZ 85724 5024, USA
    Technol Cancer Res Treat 3:617-27. 2004
    ..The combination of optical technologies supported by modern molecular biology may lead to an instrument that can accurately detect early carcinogenesis...
  11. ncbi request reprint Fluorescence spectroscopy as a biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents
    Molly Brewer
    University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biomed Opt 7:20-6. 2002
    ..The objective of this study was to compare the effects of chemopreventive agents on natural fluorescence emission of ovarian cells in a cell culture and in a primate model as a feasibility trial to monitor drug activity...
  12. pmc Analysis of second-harmonic-generation microscopy in a mouse model of ovarian carcinoma
    Jennifer M Watson
    University of Arizona, Biomedical Engineering, 1657 E Helen Street, Building 240, P O Box 210240, Tucson, Arizona 85721, USA
    J Biomed Opt 17:076002. 2012
    ..5% and 81.1%. These results suggest that using SHG to visualize collagen structure in ovaries could help with early cancer detection...
  13. doi request reprint Parallel factor analysis of ovarian autofluorescence as a cancer diagnostic
    Ronie George
    College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Lasers Surg Med 44:282-95. 2012
    ..We evaluate the potential of these changes in fluorescence to predict a diagnosis of malignancy and to estimate the risk of developing ovarian cancer...
  14. ncbi request reprint Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model
    Lida P Hariri
    Division of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    Lasers Surg Med 38:305-13. 2006
    ..The diagnostic feasibility of optical coherence tomography (OCT) and laser-induced fluorescence (LIF) have been evaluated for human colorectal cancer. This study applies these technologies to a murine model of colorectal adenoma...
  15. ncbi request reprint Task-based imaging of colon cancer in the Apc(Min/+) mouse model
    James B McNally
    University of Arizona, Tuscon 85721 0104, USA
    Appl Opt 45:3049-62. 2006
    ..The magnitude of the 680 nm signal correlates with chlorophyll content in the mouse diet, suggesting that the autofluorescent compound is a dietary metabolite...
  16. ncbi request reprint Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoring
    Nathaniel D Kirkpatrick
    Division of Biomedical Engineering, University of Arizona, Tucson, AZ, USA
    Photochem Photobiol 81:125-34. 2005
    ..Given that each cell line has been shown to have a different apoptotic response to 4HPR, fluorescence redox values along with changes in tryptophan fluorescence may be a response as well as an endpoint marker for chemopreventive drugs...
  17. ncbi request reprint 4-HPR modulates gene expression in ovarian cells
    Molly Brewer
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Arizona Cancer Center, Tucson, 85724, USA
    Int J Cancer 119:1005-13. 2006
    ..These findings suggest that 4-HPR acts through different mechanisms in premalignant ovarian surface cells and cancer cells, with a preventive effect in premalignant cells and a treatment effect in cancer cells...
  18. ncbi request reprint Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement
    Alexandre R Tumlinson
    University of Arizona, 1230 East Speedway Boulevard, Tucson, Arizona 85721 0104, USA
    Appl Opt 43:113-21. 2004
    ..We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo...
  19. pmc Scanning two-photon microscopy with upconverting lanthanide nanoparticles via Richardson-Lucy deconvolution
    Christian F Gainer
    The University of Arizona, Department of Biomedical Engineering, Tucson, Arizona, 85721 0240, USA
    J Biomed Opt 17:076003. 2012
    ..This deconvolution technique combined with the functionalized nanoparticles will enable three-dimensional functional tissue imaging at exceptionally low excitation power densities...
  20. pmc Ratio images and ultraviolet C excitation in autofluorescence imaging of neoplasms of the human colon
    Timothy E Renkoski
    University of Arizona, College of Optical Sciences, 1630 E University Boulevard, Tucson, Arizona 85721, USA
    J Biomed Opt 18:16005. 2013
    ..The newly discovered ratio images can potentially improve detection rate in screening with a novel AF colonoscope...
  21. doi request reprint Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, University of Arizona, Tucson, Ariz, USA
    Cell Tissue Res 347:267-77. 2012
    ..The ability to reveal the presence of altered biomechanics and microstructure coupled with subtle changes in TGFβ signaling provides a novel surrogate measure of tissue susceptibility to aneurysm before disease onset...
  22. pmc Adaptation of a planar microbiaxial optomechanical device for the tubular biaxial microstructural and macroscopic characterization of small vascular tissues
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    J Biomech Eng 133:075001. 2011
    ..Several other hard-to-test tubular specimens such as cerebral aneurysm arteries and atherosclerotic coronary arteries can also be tested using the described modular device...
  23. pmc Clinical research device for ovarian cancer detection by optical spectroscopy in the ultraviolet C-visible
    Ronie George
    University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85724, USA
    J Biomed Opt 15:057009. 2010
    ..If proven effective, this technique can be useful in screening women at high risk of developing ovarian cancer to determine whether oophorectomy is necessary...
  24. ncbi request reprint Spectral background and transmission characteristics of fiber optic imaging bundles
    Joshua Anthony Udovich
    Optical Sciences Center, University of Arizona, Tucson, Arizona 85724, USA
    Appl Opt 47:4560-8. 2008
    ..Knowledge of these properties allows users of high-resolution imaging bundles to optimally design systems that utilize such bundles...
  25. ncbi request reprint In vitro model for endogenous optical signatures of collagen
    Nathaniel D Kirkpatrick
    Biomedical Engineering Program, University of Arizona, Life Sciences North, Rm 362, 1501 N Campbell Ave, Tucson, Arizona 85724, USA
    J Biomed Opt 11:054021. 2006
    ..The developed measurement system will allow further studies on the effect of enzymatic cleavages and structural alterations on collagen fluorescence and SHG...
  26. ncbi request reprint Fiber optic probe for polarized reflectance spectroscopy in vivo: design and performance
    Alexey Myakov
    University of Texas, Biomedical Engineering Program, Austin, Texas 78712, USA
    J Biomed Opt 7:388-97. 2002
    ..Finally, the feasibility of in vivo measurements with the fiber optic based polarization sensitive light scattering spectroscopy is demonstrated...
  27. ncbi request reprint Depth-sensitive reflectance measurements using obliquely oriented fiber probes
    Adrien Ming Jer Wang
    Rice University, Department of Bioengineering, Houston, Texas 77251 1892, USA
    J Biomed Opt 10:44017. 2005
    ....
  28. ncbi request reprint Influence of fiber optic probe geometry on the applicability of inverse models of tissue reflectance spectroscopy: computational models and experimental measurements
    Jiantang Sun
    Rice University, Houston, TX 77005, USA
    Appl Opt 45:8152-62. 2006
    ..5-3 mm that is compatible with endoscopic specifications. The presented inversion method is computationally efficient for eventual real-time in vivo tissue diagnostics application...
  29. ncbi request reprint Optimal visual perception and detection of oral cavity neoplasia
    Urs Utzinger
    Department of Biomedical Engineering and Obstetrics and Gynecology, The University of Arizona, Tucson, AZ 85724 USA
    IEEE Trans Biomed Eng 50:396-9. 2003
    ..To optimally visualize fluorescence at 340-nm excitation, the emission should be observed through a blue bandpass filter transmitting light at 430 nm...
  30. ncbi request reprint Effects of biographical variables on cervical fluorescence emission spectra
    Carrie Brookner
    University of Texas at Austin, Biomedical Engineering Program, Austin, Texas 78712, USA
    J Biomed Opt 8:479-83. 2003
    ..The addition of these biographical variables in the preprocessing of data could dramatically improve algorithm performance and applicability...
  31. ncbi request reprint Fluorescence spectroscopy for cervical precancer detection: Is there variance across the menstrual cycle?
    Sung K Chang
    University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712, USA
    J Biomed Opt 7:595-602. 2002
    ..The menstrual cycle affects intra-patient variation but does not appear to cause a significant level of inter-patient variation. It does not need to be controlled for in optical detection strategies based on fluorescence spectroscopy...
  32. ncbi request reprint Detecting the signal of the menstrual cycle in fluorescence spectroscopy of the cervix
    Dennis D Cox
    Department of Statistics, Rice University, Houston, Texas 77005, USA
    Appl Spectrosc 57:67-72. 2003
    ..This suggests that any problems from the menstrual cycle can be avoided with a simple requirement that the device not be used during the period of menstrual bleeding...

Research Grants4

  1. Optical Spectroscopy of Ovarian Cancer
    Urs Utzinger; Fiscal Year: 2005
    ..The proposed project will take an important step toward improving the overall survival in ovarian cancer, a statistic that has not changed in the last 50 years. ..
  2. Advanced Intravital Microscope
    Urs Utzinger; Fiscal Year: 2007
    ....