Research Topics
| D UrsicSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
The yeast SEN1 gene is required for the processing of diverse RNA classesD Ursic
Laboratories of Molecular Biology and Genetics, 1525 Linden Drive, University of Wisconsin, Madison, WI 53706, USA
Nucleic Acids Res 25:4778-85. 1997..We propose that Sen1 is an RNA helicase acting on a wide range of RNA classes. Its effects on the targeted RNAs in turn enable ribonuclease activity...
Inactivation of the yeast Sen1 protein affects the localization of nucleolar proteinsD Ursic
Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
Mol Gen Genet 249:571-84. 1995..Possible mechanisms are discussed for several related nuclear functions of Sen1p, including tRNA splicing and the maintenance of a normal crescent-shaped nucleolus...
The essential yeast Tcp1 protein affects actin and microtubulesD Ursic
Laboratories of Molecular Biology and Genetics, University of Wisconsin, Madison 53706
Mol Biol Cell 5:1065-80. 1994..Based on our results, we propose that Tcp1p is required for normal development and function of actin and microtubules either through direct or indirect interaction with the major cytoskeletal components...
The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivoD J Demarini
Laboratory of Genetics and Molecular Biology, University of Wisconsin, Madison 53706, USA
Mol Cell Biol 15:6311-21. 1995....
Yeast frameshift suppressor mutations in the genes coding for transcription factor Mbf1p and ribosomal protein S3: evidence for autoregulation of S3 synthesisJ L Hendrick
Laboratories of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 157:1141-58. 2001..A change in mRNA decay rate may be the primary mechanism for regulation...
SEN1, a positive effector of tRNA-splicing endonuclease in Saccharomyces cerevisiaeD J Demarini
Laboratory of Genetics, University of Wisconsin, Madison 53706
Mol Cell Biol 12:2154-64. 1992..The mutation that creates the temperature-sensitive sen1-1 allele is located within this 500-amino-acid region, and it causes a substitution for an amino acid that is conserved in all three proteins...
The yeast homolog to mouse Tcp-1 affects microtubule-mediated processesD Ursic
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
Mol Cell Biol 11:2629-40. 1991..We also observed that strains carrying tcp1-1 were hypersensitive to antimitotic compounds. Taken together, these observations imply that the TCP1 protein affects microtubule-mediated processes...
A Drosophila melanogaster gene encodes a protein homologous to the mouse t complex polypeptide 1D Ursic
Laboratory of Genetics, University of Wisconsin, Madison 53706
Gene 68:267-74. 1988..The presence of TCP-1-related polypeptides in organisms such as Drosophila and yeast should facilitate biochemical and genetic analysis of its function...
