Fumihiko Urano

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  2. ncbi request reprint Transmission of proteotoxicity across cellular compartments
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Genes Dev 16:1307-13. 2002
  3. ncbi request reprint [Stress signaling from the endoplasmic reticulum]
    Fumihiko Urano
    Tanpakushitsu Kakusan Koso 49:1002-5. 2004
  4. pmc AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
    Dianhong Luo
    Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:11905-12. 2008
  5. ncbi request reprint [ER stress signaling in pancreatic beta-cells]
    Fumihiko Urano
    University of Massachusetts Medical School, Program in Molecular Medicine, 364 Plantation Street, Room 522, Worcester, MA 01605, USA
    Seikagaku 79:1055-9. 2007
  6. ncbi request reprint Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Metab 4:245-54. 2006
  7. ncbi request reprint WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Biol Chem 280:39609-15. 2005
  8. ncbi request reprint Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    Kaori Kubota
    Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23194-202. 2005
  9. pmc A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response
    Fumihiko Urano
    Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Cell Biol 158:639-46. 2002
  10. ncbi request reprint High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin
    Jenny R Allen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochem Biophys Res Commun 324:166-70. 2004

Research Grants

  1. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2007
  2. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
  3. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2010

Collaborators

  • D Ron
  • Heather P Harding
  • Kazuya Yoshinaga
  • I Tanii
  • Takashi Ito
  • RONALD WEK
  • Kathryn L Lipson
  • Sonya G Fonseca
  • Takunari Yoneda
  • Shinsuke Ishigaki
  • Maiko Ogata
  • Soshi Kanemoto
  • Linh X Nguyen
  • Jenny R Allen
  • Kari T Chambers
  • Dianhong Luo
  • Shinichi Kondo
  • Kazunori Imaizumi
  • Tomohiko Murakami
  • Kaori Kubota
  • Scott G Clark
  • Marcella Calfon
  • Julie A Unverferth
  • Yun He
  • John A Corbett
  • Hong Chen
  • Shibo Tang
  • Rajarshi Ghosh
  • Luyang Yu
  • Sarah M Weber
  • Zhe Xu
  • Wang Min
  • Haifeng Zhang
  • Gen Sobue
  • Jun Sone
  • Shin ichi Yamada
  • Jun ichi Niwa
  • Miho Takahashi
  • Manabu Doyu
  • Manabu Taniguchi
  • Elizabeth Foss
  • Rita Bortell
  • Sadao Shiosaka
  • Keisuke Morikawa
  • Aldo A Rossini
  • James A Hammarback
  • Atsushi Saito
  • Shin Ichiro Hino
  • John D Bartlett
  • Eric T Everett
  • Mariko Fukuma
  • Daniel H Lee
  • Esperanza A Martinez-Mier
  • Masahiro Tsuchiya
  • Yoshitomo Oka
  • Malcolm L Snead
  • Linh Nguyen
  • Conan S Young
  • Cristina Benedetti
  • Karen E G Sargent
  • Anthony Hackett
  • Stevan R Hubbard
  • Jeffery H Till
  • Huiqing Zeng

Detail Information

Publications19

  1. ncbi request reprint IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  2. ncbi request reprint Transmission of proteotoxicity across cellular compartments
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Genes Dev 16:1307-13. 2002
  3. ncbi request reprint [Stress signaling from the endoplasmic reticulum]
    Fumihiko Urano
    Tanpakushitsu Kakusan Koso 49:1002-5. 2004
  4. pmc AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
    Dianhong Luo
    Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:11905-12. 2008
    ..More importantly, AIP1-KO mice show impaired ER stress-induced IRE1-dependent signaling in vivo. We conclude that AIP1 is essential for transducing the IRE1-mediated ER stress response...
  5. ncbi request reprint [ER stress signaling in pancreatic beta-cells]
    Fumihiko Urano
    University of Massachusetts Medical School, Program in Molecular Medicine, 364 Plantation Street, Room 522, Worcester, MA 01605, USA
    Seikagaku 79:1055-9. 2007
  6. ncbi request reprint Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Metab 4:245-54. 2006
    ..IRE1 signaling is therefore a potential target for therapeutic regulation of insulin biosynthesis...
  7. ncbi request reprint WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Biol Chem 280:39609-15. 2005
    ..These results indicate that the pathogenesis of Wolfram syndrome involves chronic ER stress in pancreatic beta-cells caused by the loss of function of WFS1...
  8. ncbi request reprint Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    Kaori Kubota
    Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23194-202. 2005
    ..Ire1 levels appeared induced by fluoride treatment, indicating that ER stress may play a role in dental fluorosis. Low dose fluoride, such as that present in fluoridated drinking water, did not induce ER stress...
  9. pmc A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response
    Fumihiko Urano
    Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Cell Biol 158:639-46. 2002
    ....
  10. ncbi request reprint High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin
    Jenny R Allen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochem Biophys Res Commun 324:166-70. 2004
    ..If HRD1 serves the same function in humans, it may serve as a target for therapeutic intervention in diabetes...
  11. ncbi request reprint Transcriptional and translational control in the Mammalian unfolded protein response
    Heather P Harding
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Annu Rev Cell Dev Biol 18:575-99. 2002
    ..Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding...
  12. ncbi request reprint The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
    Kari T Chambers
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Diabetes 57:124-32. 2008
    ..The UPR, activated by cytokine-induced nitric oxide (NO) production, has been proposed to mediate beta-cell death in response to cytokines. In this study, the role of UPR activation in cytokine-induced beta-cell death was examined...
  13. ncbi request reprint Endoplasmic reticulum stress signaling in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Antioxid Redox Signal 9:2335-44. 2007
    ..This review focuses on the function of the ER stress-signaling network in pancreatic beta-cells...
  14. ncbi request reprint Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity
    Shinsuke Ishigaki
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8500, Japan
    Neurobiol Dis 25:331-41. 2007
    ..Furthermore, Dorfin-CHIP(L) rescued neuronal cells from mutant SOD1-associated toxicity and reduced the aggresome formation induced by mutant SOD1 more effectively than did Dorfin(WT)...
  15. pmc Autophagy is activated for cell survival after endoplasmic reticulum stress
    Maiko Ogata
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 26:9220-31. 2006
    ..Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress...
  16. ncbi request reprint Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Curr Mol Med 6:71-7. 2006
    ..It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance...
  17. ncbi request reprint Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Cell Sci 117:4055-66. 2004
    ..These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle...
  18. ncbi request reprint XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress
    Soshi Kanemoto
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 331:1146-53. 2005
    ..We identified a cis-acting element in the MDG1/ERdj4 promoter region, to which XBP1 specifically binds in response to ER stress. Our results reveal a target sequence for the IRE1-XBP1 pathway under ER stress conditions...
  19. pmc The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e1648. 2008
    ..IRE1alpha is a central component of the UPR. In pancreatic beta-cells, IRE1alpha also functions in the regulation of insulin biosynthesis...

Research Grants7

  1. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2007
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  2. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  3. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2010
    ..To study the regulation and function of these molecules in the context of ER stress and cells may reveal new information on how chronic ER stress induces cell death and perhaps novel targets for diabetes prevention or treatment. ..