Fumihiko Urano

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  2. ncbi request reprint Transmission of proteotoxicity across cellular compartments
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Genes Dev 16:1307-13. 2002
  3. pmc Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94
    Chihiro Kakiuchi
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 4:e4134. 2009
  4. pmc Transcriptional regulation of VEGF-A by the unfolded protein response pathway
    Rajarshi Ghosh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e9575. 2010
  5. ncbi request reprint [Stress signaling from the endoplasmic reticulum]
    Fumihiko Urano
    Tanpakushitsu Kakusan Koso 49:1002-5. 2004
  6. pmc Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    J Clin Invest 120:744-55. 2010
  7. ncbi request reprint Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Metab 4:245-54. 2006
  8. ncbi request reprint WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Biol Chem 280:39609-15. 2005
  9. pmc The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e1648. 2008
  10. ncbi request reprint [ER stress signaling in pancreatic beta-cells]
    Fumihiko Urano
    University of Massachusetts Medical School, Program in Molecular Medicine, 364 Plantation Street, Room 522, Worcester, MA 01605, USA
    Seikagaku 79:1055-9. 2007

Research Grants

  1. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
  2. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2005
  3. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2006
  4. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2007
  5. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
  6. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2010

Collaborators

  • Sonya G Fonseca
  • Jason K Kim
  • Lihua J Zhu
  • Daryl A Bosco
  • Mukesh K Jain
  • Tadafumi Kato
  • Dale Greiner
  • Ning Pan
  • Arthur M Mercurio
  • Randal J Kaufman
  • D Ron
  • Heather P Harding
  • Marcus P Cooper
  • I Tanii
  • Takashi Ito
  • RONALD WEK
  • Kazuya Yoshinaga
  • Christine M Oslowski
  • Kathryn L Lipson
  • Shinsuke Ishigaki
  • Bryan O'Sullivan-Murphy
  • Rita Bortell
  • Dae Young Jung
  • Agata Jurczyk
  • Rajarshi Ghosh
  • Steven C Pino
  • Aldo A Rossini
  • Takunari Yoneda
  • Maiko Ogata
  • Soshi Kanemoto
  • Reddy Ranjith K Sama
  • Ilya M Alexandrov
  • Erich A Lidstone
  • John P Mordes
  • Chihiro Kakiuchi
  • Kari T Chambers
  • Dianhong Luo
  • Shinichi Kondo
  • Kazunori Imaizumi
  • Tomohiko Murakami
  • Kaori Kubota
  • Linh X Nguyen
  • Jenny R Allen
  • Scott G Clark
  • Marcella Calfon
  • Juliano L Sartoretto
  • Susan Gray
  • Kristine Yu
  • Yoshihiro Azuma
  • Rajanikanth Maganti
  • Catherine L Ward
  • Domenick A Prosdocimo
  • Randall H Friedline
  • Umadevi Chalasani
  • Nathan Lemay
  • Minwoo Nam
  • Laura J Kaushansky
  • Ashish Velagapudi
  • Mariko Hara
  • Simin Lu
  • Yen Tsung Huang
  • Mei Xu
  • Emiko Hayashi
  • Randall Friedline
  • Takashi Hara
  • Maria Ivshina
  • Simon T Hui
  • Joel D Richter
  • Kohsuke Kanekura
  • Hwi Jin Ko
  • Martha Addorio
  • Karen E Sargent
  • Kevin Fogarty
  • Clive Standley
  • Lawrence Lifshitz
  • Joan S Hunt
  • Philip Diiorio
  • Julie A Unverferth
  • Yun He
  • John A Corbett
  • Hong Chen
  • Shibo Tang
  • Thomas B Thornley
  • Wang Min
  • Luyang Yu
  • Haifeng Zhang
  • Sarah M Weber
  • Zhe Xu
  • Jun ichi Niwa
  • Gen Sobue

Detail Information

Publications32

  1. ncbi request reprint IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  2. ncbi request reprint Transmission of proteotoxicity across cellular compartments
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York 10016, USA
    Genes Dev 16:1307-13. 2002
  3. pmc Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94
    Chihiro Kakiuchi
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 4:e4134. 2009
    ..It has been suggested that the action of valproate is linked to changes in gene expression and induction of endoplasmic reticulum (ER) stress-response proteins...
  4. pmc Transcriptional regulation of VEGF-A by the unfolded protein response pathway
    Rajarshi Ghosh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e9575. 2010
    ..IRE1alpha, PERK, and ATF6alpha, master regulators of the unfolded protein response (UPR), are activated under these conditions and are proposed to have a role in mediating angiogenesis...
  5. ncbi request reprint [Stress signaling from the endoplasmic reticulum]
    Fumihiko Urano
    Tanpakushitsu Kakusan Koso 49:1002-5. 2004
  6. pmc Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    J Clin Invest 120:744-55. 2010
    ..These results reveal a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes...
  7. ncbi request reprint Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Metab 4:245-54. 2006
    ..IRE1 signaling is therefore a potential target for therapeutic regulation of insulin biosynthesis...
  8. ncbi request reprint WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Biol Chem 280:39609-15. 2005
    ..These results indicate that the pathogenesis of Wolfram syndrome involves chronic ER stress in pancreatic beta-cells caused by the loss of function of WFS1...
  9. pmc The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e1648. 2008
    ..IRE1alpha is a central component of the UPR. In pancreatic beta-cells, IRE1alpha also functions in the regulation of insulin biosynthesis...
  10. ncbi request reprint [ER stress signaling in pancreatic beta-cells]
    Fumihiko Urano
    University of Massachusetts Medical School, Program in Molecular Medicine, 364 Plantation Street, Room 522, Worcester, MA 01605, USA
    Seikagaku 79:1055-9. 2007
  11. pmc Measuring ER stress and the unfolded protein response using mammalian tissue culture system
    Christine M Oslowski
    Program in Gene Function and Expression, University of Massachusetts, Medical School, Worcester, Massachusetts, USA
    Methods Enzymol 490:71-92. 2011
    ..These methods will assist us in understanding the UPR and its contribution to ER stress-related disorders such as diabetes and neurodegeneration...
  12. pmc A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells
    Agata Jurczyk
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e11812. 2010
    ....
  13. pmc Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance
    Ilya M Alexandrov
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS Genet 8:e1002457. 2012
    ..Our results show that CPEB regulated translation is a key process involved in insulin signaling...
  14. pmc Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response
    Steven C Pino
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Stress Chaperones 13:421-34. 2008
    ..Collectively, these data suggest that induction of the ER stress response through PKC signaling is an important component for the preparation of a T cell response to antigen...
  15. pmc Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome
    Christine M Oslowski
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Metab 16:265-73. 2012
    ..Collectively, our results suggest that TXNIP is a potential therapeutic target for diabetes and ER stress-related human diseases such as Wolfram syndrome...
  16. pmc The binary switch between life and death of endoplasmic reticulum-stressed beta cells
    Christine M Oslowski
    Program in Gene Function, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Endocrinol Diabetes Obes 17:107-12. 2010
    ..In the present article, we discuss a potential paradigm of ER stress-mediated beta-cell death...
  17. pmc KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance
    Dae Young Jung
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 8:e77851. 2013
    ..This study establishes KLF15 as an important molecular link between ER stress and insulin action. ..
  18. ncbi request reprint Endoplasmic reticulum stress signaling in pancreatic beta-cells
    Sonya G Fonseca
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Antioxid Redox Signal 9:2335-44. 2007
    ..This review focuses on the function of the ER stress-signaling network in pancreatic beta-cells...
  19. ncbi request reprint Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes
    Kathryn L Lipson
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, 01605 2324, USA
    Curr Mol Med 6:71-7. 2006
    ..It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance...
  20. pmc FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress
    Reddy Ranjith K Sama
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 228:2222-31. 2013
    ..Intriguingly, cells with reduced expression of FUS exhibit a loss of cell viability in response to sorbitol, indicating a prosurvival role for endogenous FUS in the cellular response to hyperosmolar stress...
  21. pmc The binary switch that controls the life and death decisions of ER stressed β cells
    Christine M Oslowski
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Cell Biol 23:207-15. 2011
    ..Complete understanding of these mechanisms will lead to novel therapeutic modalities for diabetes...
  22. ncbi request reprint High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin
    Jenny R Allen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Biochem Biophys Res Commun 324:166-70. 2004
    ..If HRD1 serves the same function in humans, it may serve as a target for therapeutic intervention in diabetes...
  23. pmc A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response
    Fumihiko Urano
    Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Cell Biol 158:639-46. 2002
    ....
  24. ncbi request reprint Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation
    Kaori Kubota
    Department of Cytokine Biology, Forsyth Institute, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    J Biol Chem 280:23194-202. 2005
    ..Ire1 levels appeared induced by fluoride treatment, indicating that ER stress may play a role in dental fluorosis. Low dose fluoride, such as that present in fluoridated drinking water, did not induce ER stress...
  25. pmc AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
    Dianhong Luo
    Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:11905-12. 2008
    ..More importantly, AIP1-KO mice show impaired ER stress-induced IRE1-dependent signaling in vivo. We conclude that AIP1 is essential for transducing the IRE1-mediated ER stress response...
  26. ncbi request reprint XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress
    Soshi Kanemoto
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 331:1146-53. 2005
    ..We identified a cis-acting element in the MDG1/ERdj4 promoter region, to which XBP1 specifically binds in response to ER stress. Our results reveal a target sequence for the IRE1-XBP1 pathway under ER stress conditions...
  27. pmc Autophagy is activated for cell survival after endoplasmic reticulum stress
    Maiko Ogata
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 26:9220-31. 2006
    ..Disturbance of autophagy rendered cells vulnerable to ER stress, suggesting that autophagy plays important roles in cell survival after ER stress...
  28. ncbi request reprint Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
    Takunari Yoneda
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Cell Sci 117:4055-66. 2004
    ..These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle...
  29. ncbi request reprint Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity
    Shinsuke Ishigaki
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8500, Japan
    Neurobiol Dis 25:331-41. 2007
    ..Furthermore, Dorfin-CHIP(L) rescued neuronal cells from mutant SOD1-associated toxicity and reduced the aggresome formation induced by mutant SOD1 more effectively than did Dorfin(WT)...
  30. ncbi request reprint Transcriptional and translational control in the Mammalian unfolded protein response
    Heather P Harding
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Annu Rev Cell Dev Biol 18:575-99. 2002
    ..Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding...
  31. ncbi request reprint The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
    Kari T Chambers
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA
    Diabetes 57:124-32. 2008
    ..The UPR, activated by cytokine-induced nitric oxide (NO) production, has been proposed to mediate beta-cell death in response to cytokines. In this study, the role of UPR activation in cytokine-induced beta-cell death was examined...

Research Grants7

  1. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  2. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2005
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  3. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2006
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  4. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2007
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  5. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2009
    ..Understanding this relationship will move us closer to our ultimate goal of developing drugs that block ER stress-mediated beta-cell death. ..
  6. Endoplasmic reticulum stress and diabetes
    Fumihiko Urano; Fiscal Year: 2010
    ..To study the regulation and function of these molecules in the context of ER stress and cells may reveal new information on how chronic ER stress induces cell death and perhaps novel targets for diabetes prevention or treatment. ..