Mark L Unruh

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival
    Nizar Younas
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Nephrol 11:5. 2010
  2. pmc Correlates and outcomes of fatigue among incident dialysis patients
    Manisha Jhamb
    Department of Medicine, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 4:1779-86. 2009
  3. doi request reprint The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis
    Mark L Unruh
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1608-17. 2008
  4. pmc Subjective and objective sleep quality in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 52:305-13. 2008
  5. pmc Impact of sleep quality on cardiovascular outcomes in hemodialysis patients: results from the frequent hemodialysis network study
    Mark Unruh
    University of Pittsburgh, Presbyterian Hospital C1111, Pittsburgh, PA 15213, USA
    Am J Nephrol 33:398-406. 2011
  6. doi request reprint Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
  7. ncbi request reprint Sleep apnea and dialysis therapies: things that go bump in the night?
    Mark L Unruh
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Hemodial Int 11:369-78. 2007
  8. ncbi request reprint Sleep quality and its correlates in the first year of dialysis
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261
    Clin J Am Soc Nephrol 1:802-10. 2006
  9. ncbi request reprint Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health Study
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:3503-9. 2006
  10. ncbi request reprint Skipped treatments, markers of nutritional nonadherence, and survival among incident hemodialysis patients
    Mark L Unruh
    Renal Electrolyte Division, Epidemiology Data Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 46:1107-16. 2005

Detail Information

Publications48

  1. pmc HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival
    Nizar Younas
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Nephrol 11:5. 2010
    ..We evaluated the predictors of statin use following kidney transplantation and examined its association with patient and allograft survival...
  2. pmc Correlates and outcomes of fatigue among incident dialysis patients
    Manisha Jhamb
    Department of Medicine, Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 4:1779-86. 2009
    ..This study examines the correlates of self-reported fatigue at initiation of dialysis and after 1 yr and assesses the extent to which fatigue was associated with health-related quality of life and survival...
  3. doi request reprint The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis
    Mark L Unruh
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:1608-17. 2008
    ..To assess the extent to which persons aged 70 and older undergoing hemodialysis (HD) had greater changes in health-related quality of life (HRQOL) over 3 years than younger patients undergoing HD...
  4. pmc Subjective and objective sleep quality in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 52:305-13. 2008
    ..It therefore is uncertain whether poor sleep quality in the HD population reflects age, chronic health conditions, or effects of conventional HD therapy...
  5. pmc Impact of sleep quality on cardiovascular outcomes in hemodialysis patients: results from the frequent hemodialysis network study
    Mark Unruh
    University of Pittsburgh, Presbyterian Hospital C1111, Pittsburgh, PA 15213, USA
    Am J Nephrol 33:398-406. 2011
    ..This report examines whether sleep quality is associated with dialysis treatment factors and other modifiable clinical factors in a large group of hemodialysis (HD) patients...
  6. doi request reprint Subjective and objective sleep quality and aging in the sleep heart health study
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Am Geriatr Soc 56:1218-27. 2008
    ..To examine the extent to which subjective and objective sleep quality are related to age independent of chronic health conditions...
  7. ncbi request reprint Sleep apnea and dialysis therapies: things that go bump in the night?
    Mark L Unruh
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Hemodial Int 11:369-78. 2007
    ..The impact of sleep apnea treatment in this high-risk population may include reduced sleepiness, better mood and blood pressure, and lowered risk of cardiovascular disease...
  8. ncbi request reprint Sleep quality and its correlates in the first year of dialysis
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261
    Clin J Am Soc Nephrol 1:802-10. 2006
    ..13 to 1.83; P = 0.003). Future work should examine the link between sleep quality and daytime functioning in the kidney failure population and the extent to which improving sleep quality will improve dialysis patient outcomes...
  9. ncbi request reprint Sleep apnea in patients on conventional thrice-weekly hemodialysis: comparison with matched controls from the Sleep Heart Health Study
    Mark L Unruh
    University of Pittsburgh Medical Center, Renal Electrolyte Division, 3550 Terrace Street, A909 Scaife Hall, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:3503-9. 2006
    ..The potential mechanisms for the higher likelihood of SDB in the HD population must be identified to provide specific prevention and therapy...
  10. ncbi request reprint Skipped treatments, markers of nutritional nonadherence, and survival among incident hemodialysis patients
    Mark L Unruh
    Renal Electrolyte Division, Epidemiology Data Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 46:1107-16. 2005
    ..Skipping hemodialysis treatments and failing to adhere to prescribed diets are thought to injure hemodialysis patients...
  11. ncbi request reprint Racial differences in health-related quality of life among hemodialysis patients
    Mark Unruh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Kidney Int 65:1482-91. 2004
    ..While African Americans with end-stage renal disease (ESRD) survive longer than members of other races, few studies have compared the HRQOL of African Americans with that of non-African Americans...
  12. ncbi request reprint Restless legs symptoms among incident dialysis patients: association with lower quality of life and shorter survival
    Mark L Unruh
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 43:900-9. 2004
    ..We investigated the relation between symptoms of restless legs, quality of life, and survival among incident hemodialysis and peritoneal dialysis patients...
  13. ncbi request reprint Effects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO Study
    Mark Unruh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Kidney Int 66:355-66. 2004
    ....
  14. ncbi request reprint Health-related quality of life in nephrology research and clinical practice
    Mark L Unruh
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Semin Dial 18:82-90. 2005
    ..Moreover, the effective assessment and interpretation of HRQOL will be aided by continued publication of norms, outcomes of randomized controlled trials, and continued experience of investigators and clinicians...
  15. pmc Cancer-related symptom clusters, eosinophils, and survival in hepatobiliary cancer: an exploratory study
    Jennifer L Steel
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Pain Symptom Manage 39:859-71. 2010
    ..The study of symptom clusters is gaining increased attention in the field of oncology in an attempt to improve the quality of life of patients diagnosed with cancer...
  16. pmc Numeracy skills in CKD: correlates and outcomes
    Khaled Abdel-Kader
    University of Pittsburgh, Renal Electrolyte Division, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 5:1566-73. 2010
    ..Healthcare providers communicate the risks and benefits of treatments using frequencies, percentages, or proportions. However, many patients lack the numerical skills needed to interpret this information accurately to make informed choices...
  17. pmc Sleep-disordered breathing and excessive daytime sleepiness in chronic kidney disease and hemodialysis
    Maria Eleni Roumelioti
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, 200 Lothrop Street, PUH C 1111, Pittsburgh, PA 15213, USA
    Clin J Am Soc Nephrol 6:986-94. 2011
    ..This paper describes and compares the prevalence, severity, and patterns of SDB and EDS among patients with advanced CKD, HD-dependent patients, and community individuals without known renal disease...
  18. doi request reprint Peripheral vascular disease severity impacts health outcomes and health-related quality of life in maintenance hemodialysis patients in the HEMO Study
    Tao Liu
    University of Pittsburgh School of Medicine, Department of Biostatistics, Pittsburgh, PA, USA
    Nephrol Dial Transplant 27:2929-36. 2012
    ..We assessed the extent to which severity of PVD predicts mortality, hospitalizations and health-related quality of life (HRQOL) in hemodialysis (HD) patients enrolled in the Hemodialysis (HEMO) Study...
  19. ncbi request reprint Hemodialysis timing, survival, and cardiovascular outcomes in the Hemodialysis (HEMO) Study
    Yue Harn Ng
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Kidney Dis 47:614-24. 2006
    ..This report examines the extent to which hemodialysis treatment time of day was associated with cardiovascular mortality and morbidity and all-cause mortality in a secondary analysis of the Hemodialysis Study...
  20. pmc Resistant hypertension and obstructive sleep apnea in the setting of kidney disease
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Hypertens 30:960-6. 2012
    ..To explore the relationship between obstructive sleep apnea (OSA) and resistant hypertension in chronic kidney disease (CKD) and end-stage renal disease (ESRD)...
  21. pmc Symptom burden, depression, and quality of life in chronic and end-stage kidney disease
    Khaled Abdel-Kader
    Renal Section and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA
    Clin J Am Soc Nephrol 4:1057-64. 2009
    ..The authors sought to compare symptoms, depression, and quality of life in patients with ESRD and those with CKD...
  22. doi request reprint Changes in anthropometry and mortality in maintenance hemodialysis patients in the HEMO Study
    Chi Ting Su
    Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Division of Nephrology, National Taiwan University Hospital, Yun Lin branch, Taiwan
    Am J Kidney Dis 62:1141-50. 2013
    ..Accordingly, we explored this association in the Hemodialysis (HEMO) Study...
  23. ncbi request reprint Associations of race with depression and symptoms in patients on maintenance haemodialysis
    Steven D Weisbord
    VA Pittsburgh Healthcare System, Mailstop 111F U, Pittsburgh, PA 15240, USA
    Nephrol Dial Transplant 22:203-8. 2007
    ..The aim of this study was to compare these domains between African American and White patients on chronic haemodialysis...
  24. ncbi request reprint Renal provider recognition of symptoms in patients on maintenance hemodialysis
    Steven D Weisbord
    Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
    Clin J Am Soc Nephrol 2:960-7. 2007
    ..The aim of this study was to assess renal provider recognition of symptoms and their severity in hemodialysis patients...
  25. pmc Health-related quality of life in hypertension, chronic kidney disease, and coexistent chronic health conditions
    Ritu K Soni
    Department of Medicine, University of Pittsburgh Medical Center, PA, USA
    Adv Chronic Kidney Dis 17:e17-26. 2010
    ..Although there is evidence in favor of angiotensin-converting enzyme-inhibition for improving renal and cardiovascular outcomes in hypertensive patients, its role in ameliorating HRQOL outcomes remains to be established...
  26. pmc Abnormal nocturnal heart rate variability response among chronic kidney disease and dialysis patients during wakefulness and sleep
    Maria Eleni Roumelioti
    Renal Electrolyte Division, University of Pittsburgh Medical Center, A909 Scaife Hall, Pittsburgh, PA 15261, USA
    Nephrol Dial Transplant 25:3733-41. 2010
    ..We hypothesized that high-frequency (HF) HRV (vagal tone) will be attenuated from wakefulness to non-rapid eye movement (NREM) and then to rapid eye movement (REM) sleep in dialysis patients as compared to patients with CKD...
  27. pmc Sleep-disordered breathing and frailty in the Cardiovascular Health Study Cohort
    Yohannes W Endeshaw
    Division of Geriatrics and Gerontology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Am J Epidemiol 170:193-202. 2009
    ..The finding of an independent association between SDB and frailty indicator variables among older women could have important implications in interventions aimed at preventing or delaying the progression of frailty...
  28. pmc Sleep and fatigue symptoms in children and adolescents with CKD: a cross-sectional analysis from the chronic kidney disease in children (CKiD) study
    Maria Eleni Roumelioti
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Kidney Dis 55:269-80. 2010
    ..Although symptoms of sleepiness and fatigue are common in adults with chronic kidney disease (CKD), little is known about the prevalence of these symptoms in children with CKD...
  29. pmc Sleep quality, mood, alertness and their variability in CKD and ESRD
    Maria Eleni Roumelioti
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Nephron Clin Pract 114:c277-87. 2010
    ..In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease...
  30. doi request reprint Heart failure severity scoring system and medical- and health-related quality-of-life outcomes: the HEMO study
    Kelly V Liang
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 58:84-92. 2011
    ..We aimed to determine the prognostic importance of the Index of Disease Severity (IDS) of the Index of Coexistent Disease (ICED) scoring system as an HF severity measure...
  31. doi request reprint Sexual function in women receiving maintenance dialysis
    Srikanth Seethala
    Department of Medicine, University of Pittsburgh Medical Center, Mercy Hospital, Pittsburgh, Pennsylvania 15240, USA
    Hemodial Int 14:55-60. 2010
    ..However, few women discuss this issue with their providers or receive treatment...
  32. pmc Automated clinical reminders for primary care providers in the care of CKD: a small cluster-randomized controlled trial
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 58:894-902. 2011
    ..Studies suggest that PCPs may deliver suboptimal CKD care. One means to improve PCP treatment of CKD is clinical decision support systems (CDSSs)...
  33. pmc Nephrogenic systemic fibrosis: a survey of nephrologists' perceptions and practices
    Khaled Abdel-Kader
    University of Pittsburgh, Renal Electrolyte Division, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 5:964-71. 2010
    ..Given the unique role nephrologists play in caring for patients at risk to develop NSF, this study surveyed their perceptions and practices regarding NSF...
  34. pmc Health-related quality of life outcomes in chronic kidney disease
    Ritu K Soni
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Nephrol Hypertens 19:153-9. 2010
    ..This article reviews the recent evidence on HRQOL, its correlates and proposed intervention strategies to improve HRQOL in CKD...
  35. pmc Characterizing pre-dialysis care in the era of eGFR reporting: a cohort study
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, USA
    BMC Nephrol 12:12. 2011
    ..One strategy to improve disease awareness and treatment is estimated glomerular filtration rate (eGFR) reporting. We examined PCP and nephrologist CKD practices before and after routine eGFR reporting...
  36. pmc Primary care of the renal transplant patient
    Gaurav Gupta
    Nephrology Division, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Gen Intern Med 25:731-40. 2010
    ..In this narrative review, we examine the common medical problems seen in KTR from the PCP's perspective. Medical management issues related to immunosuppressive medications are also briefly discussed...
  37. doi request reprint Nocturia and aging: diagnosis and treatment
    Sarinya Boongird
    Department of Medicine, University of Pittsburgh Medical Center Shadyside, PA, USA
    Adv Chronic Kidney Dis 17:e27-40. 2010
    ..This review will provide an overview of the effect of aging on the kidneys and urinary system, the pathophysiology, clinical assessment, and treatment strategies of nocturia, and its effect on health-related quality of life...
  38. ncbi request reprint Bias in assessment of health-related quality of life in a hemodialysis population: a comparison of self-administered and interviewer-administered surveys in the HEMO study
    Mark Unruh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Am Soc Nephrol 14:2132-41. 2003
    ..Future investigation should include research of survey modalities with a low response burden such as telephone interview, computer-assisted interview, and proxy administration...
  39. pmc Individual quality of life in chronic kidney disease: influence of age and dialysis modality
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin J Am Soc Nephrol 4:711-8. 2009
    ..We also examined the strength of association between (1) multidimensional health-related quality-of-life measures and IQOL and (2) psychosocial factors and IQOL...
  40. ncbi request reprint Assessment of health-related quality of life among patients with chronic kidney disease
    Mark L Unruh
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Adv Chronic Kidney Dis 14:345-52. 2007
    ..The routine use of HRQOL assessments in the care of patients with CKD represents an important opportunity for the nephrologist to better incorporate the values and concerns of the patient into their care...
  41. pmc Considerations in the statistical analysis of hemodialysis patient survival
    Christos Argyropoulos
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 20:2034-43. 2009
    ..Accelerated failure time models may be useful adjuncts to the Cox model when studying outcomes of dialysis patients...
  42. doi request reprint Comparison of sleep/wake behavior in CKD stages 4 to 5 and hemodialysis populations using wrist actigraphy
    Babak Barmar
    Renal Electrolyte Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    Am J Kidney Dis 53:665-72. 2009
    ..We assessed the influence of hemodialysis on sleep/wake behavior by using wrist actigraphy and self-reported sleep quality compared with patients with chronic kidney disease (CKD) stages 4 to 5...
  43. pmc Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience
    Tripti Singh
    Renal Electrolyte Division, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin J Am Soc Nephrol 8:1533-9. 2013
    ..This work presents five cases, in which extracorporeal therapy was performed for dabigatran removal in acutely bleeding patients...
  44. pmc Fatigue in patients receiving maintenance dialysis: a review of definitions, measures, and contributing factors
    Manisha Jhamb
    Western Pennsylvania Medical Center, Pittsburgh, PA, USA
    Am J Kidney Dis 52:353-65. 2008
    ....
  45. ncbi request reprint Sleep disordered breathing in patients with chronic kidney disease
    Manju Mavanur
    Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Indian J Med Res 131:277-84. 2010
    ..Early diagnosis and treatment of SDB may provide better quality of life and attenuate the cardiovascular risk of morbidity and mortality in these patients...
  46. ncbi request reprint Comorbid conditions in kidney transplantation: association with graft and patient survival
    Christine Wu
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Am Soc Nephrol 16:3437-44. 2005
    ....
  47. ncbi request reprint Benefits of short daily home hemodialysis in the FREEDOM Study: is it about person, place, time, or treatment?
    Khaled Abdel-Kader
    Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Kidney Int 82:511-3. 2012
    ..Further research exploring the mechanisms by which these benefits are realized is also important, as many patients are likely to opt out of short daily HD...
  48. ncbi request reprint Kidney transplantation in elderly people: the influence of recipient comorbidity and living kidney donors
    Christine Wu
    Department of Medicine, Renal Electrolyte Division, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 56:231-8. 2008
    ..To examine the extent to which donor and recipient characteristics were associated with transplant outcomes in elderly kidney transplant recipients...