Research Topics
| ZOLTAN ISTVAN UNGVARISummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)Zoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N E 10th Street BRC 1303, Oklahoma City, Oklahoma 73104, USA
J Gerontol A Biol Sci Med Sci 68:359-67. 2013....
Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?Anna Csiszar
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, 975 NE 10th Street, BRC 1315A, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 67:841-52. 2012....- Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatmentAnna Csiszar
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 North East 10th Street, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 67:811-20. 2012..Resveratrol treatment prevents the proinflammatory properties of the aged VSMC secretome, an effect that likely contributes to the demonstrated vasoprotective action of resveratrol in animal models of aging... - The emerging role of IGF-1 deficiency in cardiovascular aging: recent advancesZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 67:599-610. 2012.... - Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular agingLora C Bailey-Downs
Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 67:553-64. 2012..Overall, our results are consistent with the available clinical and experimental evidence suggesting that GH/IGF-1 deficiency renders the cardiovascular system more vulnerable to the deleterious effects of obesity... - Mitochondria and cardiovascular agingDao Fu Dai
Department of Pathology, University of Washington, Seattle, USA
Circ Res 110:1109-24. 2012.... - Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cellsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 297:H1876-81. 2009.... - Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2Zoltan Ungvari
Dept of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th St, Oklahoma City, OK 73104, USA
Am J Physiol Heart Circ Physiol 299:H18-24. 2010..Taken together, our results indicate that resveratrol both in vitro and in vivo confers endothelial protective effects which are mediated by the activation of Nrf2... - Mechanisms of vascular aging: new perspectivesZoltan Ungvari
Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 65:1028-41. 2010.... - Mitochondria and aging in the vascular systemZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N E 10th Street BRC 1303, Oklahoma City, OK 73104, USA
J Mol Med (Berl) 88:1021-7. 2010.... - Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemiaZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Am J Physiol Heart Circ Physiol 300:H1133-40. 2011..Our results suggest that adaptive activation of the Nrf2/ARE pathway confers endothelial protection under diabetic conditions... - Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animalZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
J Gerontol A Biol Sci Med Sci 66:741-50. 2011.... - Mitochondrial protection by resveratrolZoltan Ungvari
Reynolds Oklahoma Center on Aging, Departments of Geriatric Medicine and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
Exerc Sport Sci Rev 39:128-32. 2011..This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly... - Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterationsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2721-35. 2008..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging... - Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1Anna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Mech Ageing Dev 130:518-27. 2009..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway... - Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf miceAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 295:H1882-94. 2008..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress... - Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopusNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 296:H946-56. 2009..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging... - Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged ratsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2121-8. 2008..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells... 
Vascular aging in the longest-living rodent, the naked mole ratAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H919-27. 2007..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats...- Resveratrol induces mitochondrial biogenesis in endothelial cellsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 297:H13-20. 2009..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases... - Oxidative stress in vascular senescence: lessons from successfully aging speciesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Front Biosci 13:5056-70. 2008.... - Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibitionAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H1694-9. 2006..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects... - Resveratrol increases vascular oxidative stress resistanceZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H2417-24. 2007..We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects... - Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar functionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY, USA
Circ Res 90:1159-66. 2002..Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations... - The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approachFrancesco Addabbo
Department of Medicine, Renal Research Institute, Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 174:34-43. 2009..These findings may contribute to an early preclinical diagnosis of endothelial dysfunction... - Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cellsAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 295:H569-77. 2008..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation... - Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesityAttila Feher
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Cardiovasc Res 87:732-9. 2010..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity... - Inflammation and endothelial dysfunction during aging: role of NF-kappaBAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
J Appl Physiol 105:1333-41. 2008..We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells... - Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatmentZoltan Ungvari
Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 66:501-10. 2011.... - Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteriesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 293:H37-47. 2007..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects... - Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteriesSachin A Gupte
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 285:H2316-26. 2003..Thus PPP inhibition oxidizes NADPH and GSH and appears to activate a novel coordination of redox-controlled relaxing mechanisms in BCAs mediated primarily through decreasing intracellular Ca2+... - Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Physiol Genomics 17:21-30. 2004.... - Resveratrol prevents monocrotaline-induced pulmonary hypertension in ratsAnna Csiszar
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Hypertension 54:668-75. 2009..Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension... - Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressureAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 111:2364-72. 2005..We tested the hypothesis that BMP-2 expression in endothelial cells is governed by an H2O2 and nuclear factor (NF)-kappaBeta-dependent pathway that can be activated by both proinflammatory and mechanical stimuli... - Altered mitochondrial energy metabolism may play a role in vascular agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Med Hypotheses 67:904-8. 2006.... - Bone morphogenetic protein-2 induces proinflammatory endothelial phenotypeAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Pathol 168:629-38. 2006..Thus, the proinflammatory effects of BMP-2 may play a role in vascular pathophysiology... - Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf ratsZoltan Ungvari
Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Gerontol A Biol Sci Med Sci 65:1145-56. 2010.... - Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevityAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Aging Cell 6:783-97. 2007..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging... - Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, USA
Circ Res 102:519-28. 2008.... - Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and miceNazar Labinskyy
Dept. of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 291:H2698-704. 2006.... - High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circulation 108:1253-8. 2003.... - Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Curr Vasc Pharmacol 3:285-91. 2005.... - Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidaseMuhammad T Zia
Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:2191-8. 2009.... - Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?Zoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, 10595, USA
Antioxid Redox Signal 8:1121-9. 2006.... - Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in agingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 170:388-98. 2007..Thus, we propose that anti-TNF-alpha treatment exerts anti-aging vasculoprotective effects... - Aging-induced proinflammatory shift in cytokine expression profile in coronary arteriesAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
FASEB J 17:1183-5. 2003..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly... - Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogenNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Curr Med Chem 13:989-96. 2006..This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds... - Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthaseZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Arterioscler Thromb Vasc Biol 23:418-24. 2003..Thus, TNF-alpha induces a proinflammatory vascular phenotype in HHcy that potentially contributes to the development of coronary atherosclerosis... - Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctionsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 282:H1760-7. 2002.... - Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin systemZoltan Ungvari
Department of Physiology, Basic Sciences Building, New York Medical College, Valhalla, NY 10595, USA
Am J Pathol 165:219-26. 2004.... - Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activationZsuzsanna Orosz
Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 292:H130-9. 2007..NAD(P)H oxidase-derived H(2)O(2) activates NF-kappaB, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present... - Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathyMartino Pepe
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Circ Res 106:1893-903. 2010..Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor... - Vascular inflammation in agingZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla 10595, USA
Herz 29:733-40. 2004.... - Consequences of intraventricular hemorrhage in a rabbit pup modelCaroline O Chua
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:3369-77. 2009..We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis... - Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathwayAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Arterioscler Thromb Vasc Biol 27:776-82. 2007..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown... - Oxidative stress and accelerated vascular aging: implications for cigarette smokingAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Front Biosci 14:3128-44. 2009..The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly(ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed... - Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant responseZoltan Ungvari
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Am J Physiol Heart Circ Physiol 301:H363-72. 2011..Taken together, aging is associated with Nrf2 dysfunction in the vasculature, which likely exacerbates age-related cellular oxidative stress and increases sensitivity of aged vessels to oxidative stress-induced cellular damage... - Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainGovindaiah Vinukonda
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 41:1766-73. 2010..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature... - Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extractsZhirong Wang
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
Biochem Biophys Res Commun 346:367-76. 2006..These results indicate that distinct mechanisms are involved in the regulation of HASMC growth and gene expression by SGE and resveratrol... - Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expressionAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, New York, USA
Antioxid Redox Signal 11:1683-97. 2009..This review considers how hemodynamic forces regulate BMP-2/4 expression and explores the role of mechanosensitive generation of reactive oxygen species by NAD(P)H oxidases in the control of BMP signaling... - Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibitionGovindaiah Vinukonda
Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
Brain 133:2264-80. 2010.... - Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
Research Grants
- Hemodynamic Forces Up-regulate BMPs in Coronary ArteriesZoltan Ungvari; Fiscal Year: 2007..The identification of these novel cellular and molecular mechanisms involved in early pro-atherogenic alterations in coronary arteries may ultimately lead to specific therapeutic interventions preventing the development of CAD. ..
- Hemodynamic forces regulate BMPs in coronary arteriesZoltan Ungvari; Fiscal Year: 2009..abstract_text> ..
- Role of SIRT1 in vasoprotectionZOLTAN ISTVAN UNGVARI; Fiscal Year: 2010..We posit that treatment with SIRT1-activating molecules, or inducing SIRT-1 by dietary restriction or overexpression of SIRT1 by genetic engineering can exert significant vasoprotective effect in aged mice. ..