ZOLTAN ISTVAN UNGVARI

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N E 10th Street BRC 1303, Oklahoma City, OK 73104
    J Gerontol A Biol Sci Med Sci 68:877-91. 2013
  2. pmc Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation
    Lora C Bailey-Downs
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 68:780-92. 2013
  3. pmc Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype?
    Zoltan Ungvari
    These authors contributed equally to this study
    J Gerontol A Biol Sci Med Sci 68:521-9. 2013
  4. pmc Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients
    Zsuzsanna Tucsek
    Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 68:652-60. 2013
  5. pmc Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N E 10th Street BRC 1303, Oklahoma City, Oklahoma 73104, USA
    J Gerontol A Biol Sci Med Sci 68:359-67. 2013
  6. pmc Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 North East 10th Street, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:811-20. 2012
  7. pmc Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, 975 NE 10th Street, BRC 1315A, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:841-52. 2012
  8. pmc Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging
    Lora C Bailey-Downs
    Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:553-64. 2012
  9. pmc The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:599-610. 2012
  10. doi request reprint Mitochondria and cardiovascular aging
    Dao Fu Dai
    Department of Pathology, University of Washington, Seattle, USA
    Circ Res 110:1109-24. 2012

Research Grants

  1. Hemodynamic Forces Up-regulate BMPs in Coronary Arteries
    Zoltan Ungvari; Fiscal Year: 2007
  2. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
  3. Role of SIRT1 in vasoprotection
    ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. pmc Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N E 10th Street BRC 1303, Oklahoma City, OK 73104
    J Gerontol A Biol Sci Med Sci 68:877-91. 2013
    ....
  2. pmc Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation
    Lora C Bailey-Downs
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 68:780-92. 2013
    ....
  3. pmc Resistance to Genotoxic Stresses in Arctica islandica, the Longest Living Noncolonial Animal: Is Extreme Longevity Associated With a Multistress Resistance Phenotype?
    Zoltan Ungvari
    These authors contributed equally to this study
    J Gerontol A Biol Sci Med Sci 68:521-9. 2013
    ....
  4. pmc Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients
    Zsuzsanna Tucsek
    Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 68:652-60. 2013
    ..We hypothesize that these responses may contribute to the increased vulnerability of elderly patients to multiorgan failure associated with sepsis...
  5. pmc Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa)
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N E 10th Street BRC 1303, Oklahoma City, Oklahoma 73104, USA
    J Gerontol A Biol Sci Med Sci 68:359-67. 2013
    ....
  6. pmc Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 North East 10th Street, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:811-20. 2012
    ..Resveratrol treatment prevents the proinflammatory properties of the aged VSMC secretome, an effect that likely contributes to the demonstrated vasoprotective action of resveratrol in animal models of aging...
  7. pmc Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, 975 NE 10th Street, BRC 1315A, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:841-52. 2012
    ....
  8. pmc Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging
    Lora C Bailey-Downs
    Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:553-64. 2012
    ..Overall, our results are consistent with the available clinical and experimental evidence suggesting that GH/IGF-1 deficiency renders the cardiovascular system more vulnerable to the deleterious effects of obesity...
  9. pmc The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 67:599-610. 2012
    ....
  10. doi request reprint Mitochondria and cardiovascular aging
    Dao Fu Dai
    Department of Pathology, University of Washington, Seattle, USA
    Circ Res 110:1109-24. 2012
    ....
  11. pmc Mitochondria and aging in the vascular system
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N E 10th Street BRC 1303, Oklahoma City, OK 73104, USA
    J Mol Med (Berl) 88:1021-7. 2010
    ....
  12. pmc Mechanisms of vascular aging: new perspectives
    Zoltan Ungvari
    Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 65:1028-41. 2010
    ....
  13. pmc Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    Zoltan Ungvari
    Dept of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th St, Oklahoma City, OK 73104, USA
    Am J Physiol Heart Circ Physiol 299:H18-24. 2010
    ..Taken together, our results indicate that resveratrol both in vitro and in vivo confers endothelial protective effects which are mediated by the activation of Nrf2...
  14. pmc Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1876-81. 2009
    ....
  15. pmc Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Am J Physiol Heart Circ Physiol 300:H1133-40. 2011
    ..Our results suggest that adaptive activation of the Nrf2/ARE pathway confers endothelial protection under diabetic conditions...
  16. pmc Mitochondrial protection by resveratrol
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Departments of Geriatric Medicine and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    Exerc Sport Sci Rev 39:128-32. 2011
    ..This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly...
  17. pmc Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
    J Gerontol A Biol Sci Med Sci 66:741-50. 2011
    ....
  18. pmc Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
    ..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging...
  19. pmc Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Mech Ageing Dev 130:518-27. 2009
    ..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway...
  20. pmc Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H1882-94. 2008
    ..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress...
  21. doi request reprint Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2121-8. 2008
    ..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...
  22. pmc Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H946-56. 2009
    ..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging...
  23. ncbi request reprint Vascular aging in the longest-living rodent, the naked mole rat
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H919-27. 2007
    ..Thus long-living NMRs can maintain a youthful vascular function and cellular oxidant-antioxidant phenotype relatively longer and are better protected against aging-induced oxidative stress than shorter-living rats...
  24. ncbi request reprint Oxidative stress in vascular senescence: lessons from successfully aging species
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:5056-70. 2008
    ....
  25. pmc Resveratrol induces mitochondrial biogenesis in endothelial cells
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 297:H13-20. 2009
    ..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
  26. ncbi request reprint Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY, USA
    Circ Res 90:1159-66. 2002
    ..Thus, aging induces changes in the phenotype of coronary arterioles that could contribute to the development of oxidative stress, which impairs NO-mediated dilations...
  27. ncbi request reprint Resveratrol increases vascular oxidative stress resistance
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H2417-24. 2007
    ..We propose that the antioxidant and antiapoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects...
  28. ncbi request reprint Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H1694-9. 2006
    ..We propose that these anti-inflammatory actions of resveratrol are responsible, at least in part, for its cardioprotective effects...
  29. pmc Free radical production, antioxidant capacity, and oxidative stress response signatures in fibroblasts from Lewis dwarf rats: effects of life span-extending peripubertal GH treatment
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 66:501-10. 2011
    ....
  30. pmc Inflammation and endothelial dysfunction during aging: role of NF-kappaB
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    J Appl Physiol 105:1333-41. 2008
    ..We also discuss the possibility that nucleophosmin (NPM or nuclear phosphoprotein B23), a known modulator of the cellular oxidative stress response, may also regulate NF-kappaB activity in endothelial cells...
  31. pmc Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 295:H569-77. 2008
    ..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation...
  32. pmc Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity
    Attila Feher
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Cardiovasc Res 87:732-9. 2010
    ..We investigated the role of Cav-1 in modulating BK(Ca) channel-mediated, endothelium-derived hyperpolarizing factor (EDHF)-dependent arteriolar dilation in normal condition and in an experimental model of obesity...
  33. pmc The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach
    Francesco Addabbo
    Department of Medicine, Renal Research Institute, Division of Nephrology, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 174:34-43. 2009
    ..These findings may contribute to an early preclinical diagnosis of endothelial dysfunction...
  34. ncbi request reprint Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 293:H37-47. 2007
    ..g., calorie restriction mimetics) will exert significant anti-inflammatory and vasoprotective effects...
  35. pmc Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats
    Anna Csiszar
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Hypertension 54:668-75. 2009
    ..Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension...
  36. pmc Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Donald W Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Gerontol A Biol Sci Med Sci 65:1145-56. 2010
    ....
  37. ncbi request reprint Altered mitochondrial energy metabolism may play a role in vascular aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Med Hypotheses 67:904-8. 2006
    ....
  38. ncbi request reprint Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 111:2364-72. 2005
    ..We tested the hypothesis that BMP-2 expression in endothelial cells is governed by an H2O2 and nuclear factor (NF)-kappaBeta-dependent pathway that can be activated by both proinflammatory and mechanical stimuli...
  39. ncbi request reprint Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice
    Nazar Labinskyy
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 291:H2698-704. 2006
    ....
  40. ncbi request reprint Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Physiol Genomics 17:21-30. 2004
    ....
  41. ncbi request reprint Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries
    Sachin A Gupte
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 285:H2316-26. 2003
    ..Thus PPP inhibition oxidizes NADPH and GSH and appears to activate a novel coordination of redox-controlled relaxing mechanisms in BCAs mediated primarily through decreasing intracellular Ca2+...
  42. ncbi request reprint High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circulation 108:1253-8. 2003
    ..Thus, we tested the hypothesis that high intraluminal pressure (Pi) itself, by activating vascular oxidases, elicits increased superoxide (O2*-) production interfering with flow-induced dilation...
  43. pmc Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, USA
    Circ Res 102:519-28. 2008
    ....
  44. ncbi request reprint Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Aging Cell 6:783-97. 2007
    ..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging...
  45. pmc Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Pathol 168:629-38. 2006
    ..Thus, the proinflammatory effects of BMP-2 may play a role in vascular pathophysiology...
  46. pmc Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Curr Med Chem 13:989-96. 2006
    ..This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds...
  47. pmc Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 170:388-98. 2007
    ..Thus, we propose that anti-TNF-alpha treatment exerts anti-aging vasculoprotective effects...
  48. pmc Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Curr Vasc Pharmacol 3:285-91. 2005
    ....
  49. ncbi request reprint Mechanosensitive production of reactive oxygen species in endothelial and smooth muscle cells: role in microvascular remodeling?
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, 10595, USA
    Antioxid Redox Signal 8:1121-9. 2006
    ....
  50. ncbi request reprint Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    FASEB J 17:1183-5. 2003
    ..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly...
  51. pmc Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase
    Muhammad T Zia
    Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 40:2191-8. 2009
    ....
  52. ncbi request reprint Vascular inflammation in aging
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla 10595, USA
    Herz 29:733-40. 2004
    ....
  53. pmc Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system
    Zoltan Ungvari
    Department of Physiology, Basic Sciences Building, New York Medical College, Valhalla, NY 10595, USA
    Am J Pathol 165:219-26. 2004
    ....
  54. doi request reprint Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy
    Martino Pepe
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 106:1893-903. 2010
    ..Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging as a major cytoprotective factor...
  55. ncbi request reprint Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Arterioscler Thromb Vasc Biol 23:418-24. 2003
    ....
  56. ncbi request reprint Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 282:H1760-7. 2002
    ....
  57. pmc Oxidative stress and accelerated vascular aging: implications for cigarette smoking
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Front Biosci 14:3128-44. 2009
    ..The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly(ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed...
  58. pmc Consequences of intraventricular hemorrhage in a rabbit pup model
    Caroline O Chua
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 40:3369-77. 2009
    ..We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis...
  59. ncbi request reprint Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation
    Zsuzsanna Orosz
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H130-9. 2007
    ..NAD(P)H oxidase-derived H(2)O(2) activates NF-kappaB, leading to proinflammatory alterations in vascular phenotype, which likely promotes development of atherosclerosis, especially if other risk factors are also present...
  60. ncbi request reprint Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Arterioscler Thromb Vasc Biol 27:776-82. 2007
    ..Recent studies suggested that atheroprotective levels of shear stress control endothelial BMP-4 expression; however, the underlying mechanisms remained unknown...
  61. pmc Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response
    Zoltan Ungvari
    Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Physiol Heart Circ Physiol 301:H363-72. 2011
    ..Taken together, aging is associated with Nrf2 dysfunction in the vasculature, which likely exacerbates age-related cellular oxidative stress and increases sensitivity of aged vessels to oxidative stress-induced cellular damage...
  62. ncbi request reprint Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  63. ncbi request reprint Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts
    Zhirong Wang
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 346:367-76. 2006
    ..These results indicate that distinct mechanisms are involved in the regulation of HASMC growth and gene expression by SGE and resveratrol...
  64. pmc Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition
    Govindaiah Vinukonda
    Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
    Brain 133:2264-80. 2010
    ....
  65. pmc Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain
    Govindaiah Vinukonda
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 41:1766-73. 2010
    ..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature...
  66. pmc Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Antioxid Redox Signal 11:1683-97. 2009
    ..This review considers how hemodynamic forces regulate BMP-2/4 expression and explores the role of mechanosensitive generation of reactive oxygen species by NAD(P)H oxidases in the control of BMP signaling...

Research Grants6

  1. Hemodynamic Forces Up-regulate BMPs in Coronary Arteries
    Zoltan Ungvari; Fiscal Year: 2007
    ..The identification of these novel cellular and molecular mechanisms involved in early pro-atherogenic alterations in coronary arteries may ultimately lead to specific therapeutic interventions preventing the development of CAD. ..
  2. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..abstract_text> ..
  3. Role of SIRT1 in vasoprotection
    ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2010
    ..We posit that treatment with SIRT1-activating molecules, or inducing SIRT-1 by dietary restriction or overexpression of SIRT1 by genetic engineering can exert significant vasoprotective effect in aged mice. ..