R H Unger

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Lipotoxic diseases of nonadipose tissues in obesity
    R H Unger
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8854, USA
    Int J Obes Relat Metab Disord 24:S28-32. 2000
  2. ncbi request reprint Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
    R H Unger
    Department of Internal Medicine, Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas 75390 8854, USA
    Diabetes 50:S118-21. 2001
  3. pmc Regulation of fatty acid homeostasis in cells: novel role of leptin
    R H Unger
    Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 96:2327-32. 1999
  4. ncbi request reprint Leptin physiology: a second look
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75235 8854, Dallas, TX, USA
    Regul Pept 92:87-95. 2000
  5. ncbi request reprint Diseases of liporegulation: new perspective on obesity and related disorders
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    FASEB J 15:312-21. 2001
  6. ncbi request reprint The role of leptin resistance in the lipid abnormalities of aging
    Z w Wang
    Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    FASEB J 15:108-114. 2001
  7. ncbi request reprint Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
    Z Wang
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochem Biophys Res Commun 277:20-6. 2000
  8. ncbi request reprint Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia
    Y Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    J Biol Chem 276:5629-35. 2001
  9. pmc PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
    Y Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:11848-53. 2002
  10. ncbi request reprint Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression
    T Kakuma
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Endocrinology 141:4576-82. 2000

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Lipotoxic diseases of nonadipose tissues in obesity
    R H Unger
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8854, USA
    Int J Obes Relat Metab Disord 24:S28-32. 2000
    ....
  2. ncbi request reprint Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
    R H Unger
    Department of Internal Medicine, Gifford Laboratories, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas 75390 8854, USA
    Diabetes 50:S118-21. 2001
    ..All abnormalities in these tissues can be blocked by troglitazone, an inhibitor of FA accumulation...
  3. pmc Regulation of fatty acid homeostasis in cells: novel role of leptin
    R H Unger
    Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 96:2327-32. 1999
    ....
  4. ncbi request reprint Leptin physiology: a second look
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75235 8854, Dallas, TX, USA
    Regul Pept 92:87-95. 2000
    ....
  5. ncbi request reprint Diseases of liporegulation: new perspective on obesity and related disorders
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    FASEB J 15:312-21. 2001
    ..Given the evidence for a similar etiology for the complications of human obesity, it would be appropriate to develop strategies to avert the predicted epidemic of lipotoxic disorders...
  6. ncbi request reprint The role of leptin resistance in the lipid abnormalities of aging
    Z w Wang
    Gifford Laboratories, Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    FASEB J 15:108-114. 2001
    ..We conclude that the anorexic and antilipopenic actions of leptin decline with age, possibly through increased SOCS-3 expression, and that this could account for the associated abnormalities in lipid metabolism of the elderly...
  7. ncbi request reprint Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling
    Z Wang
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochem Biophys Res Commun 277:20-6. 2000
    ....
  8. ncbi request reprint Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia
    Y Lee
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    J Biol Chem 276:5629-35. 2001
    ..We conclude that a physiologic role of the hyperleptinemia of caloric excess is to protect nonadipocytes from steatosis and lipotoxicity by preventing the up-regulation of lipogenesis and increasing fatty-acid oxidation...
  9. pmc PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
    Y Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:11848-53. 2002
    ....
  10. ncbi request reprint Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression
    T Kakuma
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Endocrinology 141:4576-82. 2000
    ..We conclude that leptin action is required for normal basal and cold-stimulated PGC-1 expression in BAT in rodents and that hyperleptinemia rapidly up-regulates its expression, at least in part, by direct action...
  11. ncbi request reprint Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM
    Y Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8854, USA
    Diabetes 46:408-13. 1997
    ..We conclude that, in the presence of comparable elevations in FFA concentrations, the islets of obese prediabetic rats have a higher lipogenic capacity than controls. This could be a factor in their high risk of diabetes...
  12. ncbi request reprint Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition
    X Yu
    Gifford Laboratories of the Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetologia 47:2012-21. 2004
    ....
  13. doi request reprint Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents
    Y Lee
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int J Obes (Lond) 34:396-400. 2010
    ..As the fat content of whole pancreas, but not islets, can now be measured in humans by magnetic resonance spectroscopy (MRS), such measurements could be used as a predictor of impending T2DM and an indication for preventive intervention...
  14. ncbi request reprint Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity
    W S Cook
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 2:385-7. 2002
    ..In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2...
  15. ncbi request reprint A novel leptin receptor isoform in rat
    M Y Wang
    Gifford Laboratories for Diabetes Research, Dallas, TX 75235, USA
    FEBS Lett 392:87-90. 1996
    ....