Guillermo E Umpierrez

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
    Guillermo E Umpierrez
    Division of Endocrinology and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 87:978-82. 2002
  2. ncbi Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med 117:291-6. 2004
  3. ncbi Diabetic ketoacidosis: risk factors and management strategies
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Treat Endocrinol 2:95-108. 2003
  4. ncbi Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study
    Guillermo E Umpierrez
    Division of Endocrinology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Diabetes Care 26:1181-5. 2003
  5. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery)
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 34:256-61. 2011
  6. ncbi Vascular effects of intravenous intralipid and dextrose infusions in obese subjects
    Aidar R Gosmanov
    Department of Medicine, Division of Endocrinology University of Tennessee Health Science Center, Memphis, TN, USA
    Metabolism 61:1370-6. 2012
  7. ncbi Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:626-31. 2010
  8. ncbi Effects of intravenous glucose load on insulin secretion in patients with ketosis-prone diabetes during near-normoglycemia remission
    Aidar R Gosmanov
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:854-60. 2010
  9. ncbi Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 32:1164-9. 2009
  10. ncbi A comparison study of continuous insulin infusion protocols in the medical intensive care unit: computer-guided vs. standard column-based algorithms
    Christopher A Newton
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 5:432-7. 2010

Collaborators

Detail Information

Publications55

  1. ncbi Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes
    Guillermo E Umpierrez
    Division of Endocrinology and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 87:978-82. 2002
    ..Patients with newly diagnosed hyperglycemia had a significantly higher mortality rate and a lower functional outcome than patients with a known history of diabetes or normoglycemia...
  2. ncbi Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Am J Med 117:291-6. 2004
    ..To compare the efficacy and safety of subcutaneous insulin lispro with that of a standard low-dose intravenous infusion protocol of regular insulin in patients with uncomplicated diabetic ketoacidosis...
  3. ncbi Diabetic ketoacidosis: risk factors and management strategies
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Treat Endocrinol 2:95-108. 2003
    ..Novel approaches to patient education incorporating a variety of healthcare beliefs and socioeconomic issues are critical to an effective prevention program...
  4. ncbi Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study
    Guillermo E Umpierrez
    Division of Endocrinology, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Diabetes Care 26:1181-5. 2003
    ..However, longitudinal studies to determine the natural history of thyroid dysfunction in patients with type 1 diabetes are lacking...
  5. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery)
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 34:256-61. 2011
    ..The optimal treatment of hyperglycemia in general surgical patients with type 2 diabetes mellitus is not known...
  6. ncbi Vascular effects of intravenous intralipid and dextrose infusions in obese subjects
    Aidar R Gosmanov
    Department of Medicine, Division of Endocrinology University of Tennessee Health Science Center, Memphis, TN, USA
    Metabolism 61:1370-6. 2012
    ..Combined Intralipid and dextrose infusion resulted in endothelial dysfunction similar to Intralipid alone...
  7. ncbi Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:626-31. 2010
    ..A high FFA level by intralipid infusion for 48 h was not associated with beta-cell decompensation (lipotoxicity) in KPDM patients...
  8. ncbi Effects of intravenous glucose load on insulin secretion in patients with ketosis-prone diabetes during near-normoglycemia remission
    Aidar R Gosmanov
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:854-60. 2010
    ..The aim of this study was to determine the effect of glucotoxicity on beta-cell function during remission in obese patients with KPD...
  9. ncbi Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Diabetes Care 32:1164-9. 2009
    ..To compare the safety and efficacy of insulin analogs and human insulins both during acute intravenous treatment and during the transition to subcutaneous insulin in patients with diabetic ketoacidosis (DKA)...
  10. ncbi A comparison study of continuous insulin infusion protocols in the medical intensive care unit: computer-guided vs. standard column-based algorithms
    Christopher A Newton
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 5:432-7. 2010
    ..To compare the safety and efficacy of continuous insulin infusion (CII) via a computer-guided and a standard paper form protocol in a medical intensive care unit (ICU)...
  11. ncbi Hyperglycemia is associated with increased hospital complications and mortality during parenteral nutrition
    Francisco J Pasquel
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Hosp Pract (Minneap) 39:81-8. 2011
    ..Hyperglycemia is a recognized complication of parenteral nutrition (PN). We aimed to determine the impact of hyperglycemia during PN unaccompanied by tight blood glucose (BG) control on hospital complications and mortality...
  12. ncbi Thirty years of personal experience in hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, 920 Madison Avenue 909, Memphis, TN 38163, USA
    J Clin Endocrinol Metab 93:1541-52. 2008
    ..This paper summarizes the results of these prospective studies on the management and pathophysiology of DKA...
  13. ncbi Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects
    Joselita Siqueira
    Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 96:3207-16. 2011
    ..Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids...
  14. ncbi [Management of hyperglycemia in the hospitalized patient]
    Francisco J Pasquel
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Medicina (B Aires) 70:275-83. 2010
    ..We also describe options for glucose control, and recommendations for the transition of glucose management to the ambulatory setting...
  15. ncbi Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population
    Amado X Freire
    Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, Memphis, 38163, USA
    Chest 128:3109-16. 2005
    ..Tight glycemic control is recommended for patients in the ICU, as hyperglycemia is associated with increased morbidity and mortality...
  16. ncbi A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, GA, USA
    Crit Care Med 40:1792-8. 2012
    ....
  17. ncbi Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, 956 Court Ave, Suite D334, Memphis, Tennessee 38163, USA
    Diabetes Care 29:2739-48. 2006
  18. ncbi Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, General Clinical Research Center, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:609-14. 2009
    ..We evaluated the effect of sustained elevations of FFA on blood pressure, endothelial function, insulin secretion, inflammatory markers, and renin-angiotensin system...
  19. ncbi Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises
    Frankie B Stentz
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Diabetes 53:2079-86. 2004
    ..Return of these values to normal levels with insulin therapy demonstrates a robust anti-inflammatory effect of insulin...
  20. ncbi Do obese children with diabetic ketoacidosis have type 1 or type 2 diabetes?
    Joey C Low
    Department of Pediatrics, Division of Endocrinology, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303, USA
    Prim Care Diabetes 6:61-5. 2012
    ..We describe the clinical presentation, autoimmune markers and the long-term course of obese and lean children with DKA...
  21. ncbi Glycemic control in non-diabetic critically ill patients
    Farnoosh Farrokhi
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Best Pract Res Clin Endocrinol Metab 25:813-24. 2011
    ..This review aims to present updated recommendations for the inpatient management of hyperglycemia in critically ill patients with and without a history of diabetes...
  22. ncbi Safety and efficacy of continuous insulin infusion in noncritical care settings
    Dawn Smiley
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 5:212-7. 2010
    ..Continuous insulin infusion (CII) to manage hyperglycemia is the accepted standard of care in the intensive care unit (ICU); however, the safety and efficacy of CII in the non-ICU setting has not been determined...
  23. ncbi Comparison of inpatient insulin regimens with detemir plus aspart versus neutral protamine hagedorn plus regular in medical patients with type 2 diabetes
    Guillermo E Umpierrez
    Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
    J Clin Endocrinol Metab 94:564-9. 2009
    ..Studies comparing the use of basal bolus with insulin analogs vs. split-mixed regimens with human insulins in hospitalized patients with type 2 diabetes are lacking...
  24. ncbi Treatment of diabetic ketoacidosis with subcutaneous insulin aspart
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Diabetes Care 27:1873-8. 2004
    ....
  25. ncbi Insulin therapy for the management of hyperglycemia in hospitalized patients
    Marie E McDonnell
    Department of Medicine, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
    Endocrinol Metab Clin North Am 41:175-201. 2012
    ....
  26. ncbi Inpatient management of diabetes: an increasing challenge to the hospitalist physician
    Guillermo E Umpierrez
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    J Hosp Med 2:33-5. 2007
  27. ncbi Perioperative glucose control in the diabetic or nondiabetic patient
    Dawn D Smiley
    Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30303, USA
    South Med J 99:580-9; quiz 590-1. 2006
    ..This paper reviews the pathophysiology of hyperglycemia during trauma and surgical stress and will provide practical recommendations for the preoperative, intraoperative, and postoperative care of diabetic patients...
  28. ncbi Update on diabetes in the elderly and in nursing home residents
    Alexandra Migdal
    Department of Medicine, Division of Endocrinology at Emory University, Atlanta, GA, USA
    J Am Med Dir Assoc 12:627-632.e2. 2011
    ..Evidence from clinical trials indicates that improving glycemic control, as well as cardiovascular risk factors, reduces morbidity and mortality in older individuals with diabetes...
  29. ncbi Management of hyperglycemia in hospitalized patients
    Dawn Smiley
    Department of Medicine, Emory University School of Medicine, 49 Jesse Hill Jr Dr SE, Atlanta, GA 30303, USA
    Ann N Y Acad Sci 1212:1-11. 2010
    ....
  30. ncbi Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery
    Anna Frisch
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Diabetes Care 33:1783-8. 2010
    ..However, the impact of perioperative hyperglycemia on clinical outcome in general and noncardiac surgery patients is not known...
  31. ncbi Prevalence and clinical outcome of inpatient hyperglycemia in a community pediatric hospital
    Andres Palacio
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Hosp Med 3:212-7. 2008
    ..No previous studies, however, have examined the association of hyperglycemia and clinical outcome in children admitted to a community pediatric hospital...
  32. ncbi Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients
    Abbas E Kitabchi
    University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 57:116-20. 2008
    ..We propose a more conservative approach of glycemic control than current American Association of Clinical Endocrinology recommendations until results of prospective, multicenter, randomized studies become available...
  33. ncbi Medical nutrition therapy in hospitalized patients with diabetes
    Aidar R Gosmanov
    Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    Curr Diab Rep 12:93-100. 2012
    ..In this article, we discuss general guidelines for the implementation of appropriate MNT in hospitalized patients with diabetes...
  34. ncbi Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes
    Ebenezer A Nyenwe
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Metabolism 60:1-23. 2011
    ..A review of the evidence supporting the efficacy of the different preventive measures is also provided...
  35. ncbi Diabetes prevention: can insulin secretagogues do the job?
    Barbara Westerhaus
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Prim Care Diabetes 5:73-80. 2011
    ..Three studies were identified with none of them reporting success in preventing diabetes, indicating that insulin secretagogues should not be recommended for diabetes prevention...
  36. ncbi Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises
    Abbas E Kitabchi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Clin Endocrinol Metab 88:2593-6. 2003
    ..The low serum leptin level on admission in subjects with hyperglycemic crises may be the result of impaired adipocyte glucose utilization due to insulin deficiency and/or to increased catecholamine levels...
  37. ncbi Predictors of intensive care unit and hospital length of stay in diabetic ketoacidosis
    Amado X Freire
    Department of Medicine, The University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    J Crit Care 17:207-11. 2002
    ....
  38. ncbi Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes
    Aidar R Gosmanov
    Dept of Physiology, College of Medicine, Univ of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Endocrinol Metab 287:E8-E15. 2004
    ....
  39. ncbi Diabetes mellitus in the Hispanic/Latino population: an increasing health care challenge in the United States
    Guillermo E Umpierrez
    Department of Medicine, Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Med Sci 334:274-82. 2007
    ..In this manuscript, we review recent epidemiologic information on the prevalence, pathophysiology, and complications of diabetes, as well as the recommendations for the management of Hispanics with type 2 diabetes...
  40. ncbi Diabetic ketoacidosis induces in vivo activation of human T-lymphocytes
    Abbas E Kitabchi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem Biophys Res Commun 315:404-7. 2004
    ..We propose DKA changes the T-lymphocytes to insulin sensitive tissues as a compensatory mechanism...
  41. ncbi Diabetes and fractures: an overshadowed association
    Natasha B Khazai
    Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Curr Opin Endocrinol Diabetes Obes 16:435-45. 2009
    ..To review recent literature on fracture risk in patients with type 1 and type 2 diabetes...
  42. ncbi Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma
    Prakash Chandra
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Am J Med Sci 340:414-7. 2010
    ..However, the effect of Y-90 administration seems to be transient and without evidence of tumor shrinkage in imaging studies...
  43. ncbi Euthyroid sick syndrome
    Guillermo E Umpierrez
    Department of Medicine, University of Tennessee Health Science Center, Memphis 38163, USA
    South Med J 95:506-13. 2002
  44. ncbi Ketosis-prone type 2 diabetes: effect of hyperglycemia on beta-cell function and skeletal muscle insulin signaling
    Guillermo E Umpierrez
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    Endocr Pract 13:283-90. 2007
    ..To determine the underlying mechanism for the severe and transient beta-cell dysfunction and impaired insulin action in obese African American patients with ketosis-prone diabetes...
  45. ncbi The use of alkali therapy in severe diabetic ketoacidosis
    Kashif A Latif
    Diabetes Care 25:2113-4. 2002
  46. ncbi Narrative review: ketosis-prone type 2 diabetes mellitus
    Guillermo E Umpierrez
    Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Ann Intern Med 144:350-7. 2006
    ..The underlying mechanisms for beta-cell dysfunction in ketosis-prone type 2 diabetes are not known; however, preliminary evidence suggests an increased susceptibility to glucose desensitization...
  47. ncbi Sliding scale insulin use: myth or insanity?
    Guillermo E Umpierrez
    Department of Medicine Division of Endocrinology, Emory University School of Medicine, Atlanta, GA 30303, USA
    Am J Med 120:563-7. 2007
    ..To understand its wide use and acceptance, we reviewed the origin, advantages, and disadvantages of sliding scale insulin in the inpatient setting...
  48. ncbi Diabetes management in urban African Americans: review of a public hospital experience
    David C Ziemer
    Department of Endocrinology, Emory University School of Medicine, Atlanta, Georgia, USA
    Ethn Dis 18:336-41. 2008
    ..To review characteristics of an urban (primarily African American) diabetes patient population and discuss experience with treatment strategies, we summarize key retrospective and prospective analyses conducted during 15 years...
  49. ncbi Hyperglycemic crises in patients with diabetes mellitus
    Abbas E Kitabchi
    Diabetes Care 26:S109-17. 2003
  50. ncbi Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial)
    Guillermo E Umpierrez
    General Clinical Research Center, Emory University School of Medicine, Grady Health System, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Diabetes Care 30:2181-6. 2007
    ..We sought to study the optimal management of hyperglycemia in non-intensive care unit patients with type 2 diabetes, as few studies thus far have focused on the subject...
  51. ncbi Hyperglycemic crises in diabetes
    Abbas E Kitabchi
    Diabetes Care 27:S94-102. 2004
  52. ncbi Ketosis-prone type 2 diabetes: time to revise the classification of diabetes
    Guillermo E Umpierrez
    Diabetes Care 29:2755-7. 2006
  53. ncbi Pregnancy complicated by diabetic ketoacidosis: maternal and fetal outcomes
    Michael B Schneider
    Diabetes Care 26:958-9. 2003
  54. ncbi Insulin resistance and pubertal changes
    Peter W F Wilson
    J Clin Endocrinol Metab 93:2472-3. 2008
  55. ncbi Diabetic ketoacidosis in type 2 diabetes mellitus--pathophysiology and clinical presentation
    Stephen N Davis
    Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University School of Medicine, Nashville, TN 37232-6303, USA
    Nat Clin Pract Endocrinol Metab 3:730-1. 2007