Research Topics
| Fuminori UmenishiSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Identification and characterization of a novel hypertonicity-responsive element in the human aquaporin-1 geneFuminori Umenishi
Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Biochem Biophys Res Commun 292:771-5. 2002..These data suggest that the transcription of the AQP1 by hypertonicity in renal cells is upregulated by the interaction with putative DNA binding proteins to a novel HRE located at -54 to -46 in the AQP1 gene...- cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathwayFuminori Umenishi
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Biochim Biophys Acta 1758:1100-5. 2006..These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway... - Effect on stability, degradation, expression, and targeting of aquaporin-2 water channel by hyperosmolality in renal epithelial cellsFuminori Umenishi
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Biochem Biophys Res Commun 338:1593-9. 2005..These results indicate that hyperosmolality plays an important role in the stability, degradation, expression, and targeting of ng-AQP2... - Modulation of hypertonicity-induced aquaporin-1 by sodium chloride, urea, betaine, and heat shock in murine renal medullary cellsFuminori Umenishi
Address correspondence to Dr Fuminori Umenishi, Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
J Am Soc Nephrol 16:600-7. 2005..Taken together, NaCl, urea, betaine, and heat shock that regulate hypertonicity-induced AQP1 expression are potentially important factors in urinary concentration and contribute to the steady-state level of AQP1 expression... - Hypertonic induction of aquaporin-1 water channel independent of transcellular osmotic gradientFuminori Umenishi
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Biochem Biophys Res Commun 325:595-9. 2004..These results indicate that AQP1 expression is predominantly mediated by basolateral hypertonicity but a transcellular osmotic gradient is not necessary for its induction... - Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 geneFuminori Umenishi
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C281, Denver, CO 80262, USA
J Biol Chem 278:15765-70. 2003..These data demonstrate that the activation of ERK, p38 kinase, and JNK pathways and the hypertonicity response element in the AQP1 promoter are involved in hypertonicity-induced AQP1 expression in mIMCD-3 cells... - Comparison of three methods to quantify urinary aquaporin-2 proteinFuminori Umenishi
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Kidney Int 62:2288-93. 2002..Recently, we have established an enzyme-linked immunosorbent assay (ELISA) for quantitation of urinary AQP2. The purpose of our current study was to compare three different immunoassay methods for measurement of urinary AQP2... - Induction of human aquaporin-1 gene by retinoic acid in human erythroleukemia HEL cellsFuminori Umenishi
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Biochem Biophys Res Commun 293:913-7. 2002..These results indicate that RAs strongly stimulate the human AQP1 gene expression through the RARE and define a novel role in the regulation of erythropoiesis... - Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro ratsChunling Li
Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Box B173, Denver, CO 80262, USA
J Am Soc Nephrol 17:1657-64. 2006..05), and cortex plus outer stripe of outer medulla NKCC2 (142+/-16 versus 100+/-9%; P<0.05). In conclusion, hyperosmolality, secondary to either glucose or NaCl, upregulated renal AQP2 and NKCC2 in vivo in BB rats... - Hyperosmolar mannitol simulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytesHajime Arima
Department of Anesthesia and Critical Care, Okazaki City Hospital, 3 1 Goshoai, Koryuji cho, Okazaki 444 8553, Japan
J Biol Chem 278:44525-34. 2003.... - Interleukin-1beta induces the expression of aquaporin-4 through a nuclear factor-kappaB pathway in rat astrocytesHiroaki Ito
Department of Anesthesiology and Medical Crisis Management, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
J Neurochem 99:107-18. 2006..These findings show that IL-1beta induces expression of AQP4 through a NF-kappaB pathway without involvement of de novo protein synthesis in rat astrocytes...