Fatih M Uckun

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells
    Dorothea E Myers
    Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles CHLA, Los Angeles, CA 90027, USA
    Integr Biol (Camb) 6:766-80. 2014
  2. pmc Novel Bruton's tyrosine kinase inhibitors currently in development
    OSMOND J D'CRUZ
    Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Onco Targets Ther 6:161-76. 2013
  3. pmc Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients
    Fatih M Uckun
    Systems Immunobiology Laboratory and Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, United States of America Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America Developmental Therapeutics Program, USC Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
    PLoS ONE 8:e80732. 2013
  4. pmc Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase
    Hong Ma
    Systems Immunobiology Laboratory, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e71302. 2013
  5. ncbi request reprint Vaginal microbicides and their delivery platforms
    OSMOND J D'CRUZ
    Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Smith Research Tower Suite 316, 4650 Sunset Boulevard, CHLA Mailstop 160, Los Angeles, CA, USA
    Expert Opin Drug Deliv 11:723-40. 2014
  6. ncbi request reprint Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase
    Fatih M Uckun
    Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Childrens Hospital Los Angeles, CA, USA
    Arzneimittelforschung 60:218-25. 2010
  7. ncbi request reprint Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas
    Fatih M Uckun
    Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Children s Hospital Los Angeles, MS 57, Los Angeles, CA 90027, USA
    Expert Rev Anticancer Ther 10:1407-18. 2010
  8. doi request reprint Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity
    Fatih M Uckun
    University of Southern California Keck School of Medicine, Children s Center for Cancer and Blood Diseases, Division of Hematology Oncology, Department of Pediatrics, Los Angeles, CA 90027 0367, USA
    Expert Opin Ther Pat 20:1457-70. 2010
  9. doi request reprint In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors
    Fatih Uckun
    Division of Hematology Oncology, Department of Pediatrics, Childrens Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA 90027 0367, USA
    Arzneimittelforschung 61:252-9. 2011
  10. doi request reprint Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network
    Fatih M Uckun
    Department of Pediatrics, Division of Hematology Oncology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Br J Haematol 153:741-52. 2011

Collaborators

Detail Information

Publications95

  1. ncbi request reprint CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells
    Dorothea E Myers
    Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles CHLA, Los Angeles, CA 90027, USA
    Integr Biol (Camb) 6:766-80. 2014
    ..This unique nanostructural therapeutic modality targeting the SYK-dependent anti-apoptotic blast cell survival machinery shows promise for overcoming the clinical radiochemotherapy resistance of B-precursor ALL cells. ..
  2. pmc Novel Bruton's tyrosine kinase inhibitors currently in development
    OSMOND J D'CRUZ
    Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Onco Targets Ther 6:161-76. 2013
    ..Btk has emerged as a new antiapoptotic molecular target for treatment of B-lineage leukemias and lymphomas. Preclinical and early clinical results indicate that Btk inhibitors may be useful in the treatment of leukemias and lymphomas...
  3. pmc Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients
    Fatih M Uckun
    Systems Immunobiology Laboratory and Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, United States of America Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America Developmental Therapeutics Program, USC Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
    PLoS ONE 8:e80732. 2013
    ..These results demonstrate that a lost or diminished IK function is not a characteristic feature of leukemic cells in Ph(+) or Ph(-) high-risk BPL. ..
  4. pmc Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase
    Hong Ma
    Systems Immunobiology Laboratory, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e71302. 2013
    ..Our results further demonstrate that BTK-induced activating phosphorylation is critical for the optimal transcription factor function of Ikaros. ..
  5. ncbi request reprint Vaginal microbicides and their delivery platforms
    OSMOND J D'CRUZ
    Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Smith Research Tower Suite 316, 4650 Sunset Boulevard, CHLA Mailstop 160, Los Angeles, CA, USA
    Expert Opin Drug Deliv 11:723-40. 2014
    ....
  6. ncbi request reprint Prevention of UVB-induced skin inflammation, genotoxicity, and photocarcinogenesis in mice by WHI-P131, a dual-function inhibitor of Janus kinase 3 and EGF receptor kinase
    Fatih M Uckun
    Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Childrens Hospital Los Angeles, CA, USA
    Arzneimittelforschung 60:218-25. 2010
    ..6 +/- 4.3 mm3 vs. 3.2 +/- 0.9 mm3 at 20 weeks, P < 0.05). These experimental findings provide unprecedented evidence that WHI-P131 may be useful as a chemopreventive agent against NMSC...
  7. ncbi request reprint Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas
    Fatih M Uckun
    Developmental Therapeutics Program, Institute for Pediatric Clinical Research, Children s Hospital Los Angeles, MS 57, Los Angeles, CA 90027, USA
    Expert Rev Anticancer Ther 10:1407-18. 2010
    ..The further development of rationally designed SYK inhibitors may provide the foundation for therapeutic innovation against B-lineage leukemias and lymphomas...
  8. doi request reprint Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity
    Fatih M Uckun
    University of Southern California Keck School of Medicine, Children s Center for Cancer and Blood Diseases, Division of Hematology Oncology, Department of Pediatrics, Los Angeles, CA 90027 0367, USA
    Expert Opin Ther Pat 20:1457-70. 2010
    ..BTK inhibitors may also be helpful in prevention and treatment of thromboembolic complications as well as inflammatory disorders...
  9. doi request reprint In vitro and in vivo chemosensitizing activity of LFM-A13, a dual-function inhibitor of Bruton's tyrosine kinase and polo-like kinases, against human leukemic B-cell precursors
    Fatih Uckun
    Division of Hematology Oncology, Department of Pediatrics, Childrens Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA 90027 0367, USA
    Arzneimittelforschung 61:252-9. 2011
    ..Also presented are the results of a comprehensive meta-analysis of the overexpression of genes for LFM-A13 targeted kinases and their downstream effector molecules in B-lineage lymphoid malignancies utilizing the Oncomine database...
  10. doi request reprint Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network
    Fatih M Uckun
    Department of Pediatrics, Division of Hematology Oncology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Br J Haematol 153:741-52. 2011
    ..The identification of the HSPA5 as a chemoresistance biomarker and molecular target for B-lineage ALL may lead to new anti-leukaemic treatment strategies that are much needed...
  11. doi request reprint JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia
    Fatih M Uckun
    Division of Hematology Oncology, Department of Pediatrics, Children s Center for Cancer and Blood Diseases, University of Southern California, Keck School of Medicine, Los Angeles, CA 90027 0367, USA
    Expert Rev Anticancer Ther 11:37-48. 2011
    ....
  12. pmc CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia
    Fatih M Uckun
    Division of Hematology Oncology, Department of Pediatrics, Children s Center for Cancer and Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA 90027 0367, USA
    Proc Natl Acad Sci U S A 107:16852-7. 2010
    ..These striking findings implicate CD22ΔE12 as a previously undescribed pathogenic mechanism in human B-precursor leukemia...
  13. doi request reprint Augmentation of the antileukemia potency of total-body irradiation (TBI) by a novel P-site inhibitor of spleen tyrosine kinase (SYK)
    F M Uckun
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine and Developmental Therapeutics Program, Children s Hospital Los Angeles, Los Angeles, California 90027 0367, USA
    Radiat Res 174:526-31. 2010
    ....
  14. doi request reprint Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic
    Fatih M Uckun
    Developmental Therapeutics Program, Institute for Peadiatric Clinical Research, Childrens Hospital Los Angeles, and Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90027 0367, USA
    Br J Haematol 149:508-17. 2010
    ..Further development of C-61 may provide the foundation for therapeutic innovation against chemotherapy-resistant BPL...
  15. doi request reprint Recombinant human CD19-ligand protein as a potent anti-leukaemic agent
    Fatih M Uckun
    Institute for Pediatric Clinical Research, Children s Hospital, LA, CA, USA
    Br J Haematol 153:15-23. 2011
    ..The identification of human CD19-L may lead to therapeutic innovation for B-lineage ALL and other B-lineage lymphoid malignancies as well as B-cell lymphoproliferative states and systemic autoimmunity...
  16. doi request reprint Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress
    Fatih M Uckun
    Department of Pediatrics, University of Southern California Keck School of Medicine, USA
    Br J Haematol 148:714-25. 2010
    ..This study is the first to identify PLK1 as a regulator of SYK tyrosine kinase and a molecular target to overcome SYK-mediated resistance of B-lineage ALL cells to OS...
  17. ncbi request reprint Therapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells
    Fatih M Uckun
    Molecular Oncology and Drug Discovery Program, Parker Hughes Institute, St Paul, MN, USA
    Arzneimittelforschung 60:210-7. 2010
    ..0001). These experimental results demonstrate that the nanotechnology-enabled delivery of WHI-P131 shows therapeutic potential against leukemias with constitutive activation of the JAK3-STAT3/STAT5 molecular target...
  18. ncbi request reprint PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide
    OSMOND J D'CRUZ
    Drug Discovery Program, Department of Reproductive Biology, Parker Hughes Institute, St Paul, MN 55113, USA
    Biol Reprod 71:2037-47. 2004
    ..5%- 2% PHI-443 gel was found to be safe in rabbits and lacked systemic absorption. PHI-443 has clinical potential as a prophylactic broad-spectrum anti-HIV microbicide without contraceptive activity...
  19. ncbi request reprint Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract
    OSMOND J D'CRUZ
    Paradigm Pharmaceuticals, LLC, St Paul, Minnesota 55113, USA
    J Appl Toxicol 28:303-14. 2008
    ....
  20. ncbi request reprint Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide
    OSMOND J D'CRUZ
    Drug Discovery Program, Department of Reproductive Biology, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Biol Reprod 69:1843-51. 2003
    ....
  21. ncbi request reprint Anti-cancer activity profile of 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003), a novel nucleoside analog
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Arzneimittelforschung 54:715-31. 2004
    ..Notably, Compound 003 prolonged cancer-free survival in the MMTVneu transgenic mouse model of HER2 positive breast cancer. These results indicate that Compound 003 may be useful in the treatment of cancer patients...
  22. ncbi request reprint In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:176-92. 2006
    ..No STAMP-related toxic lesions were found in any of the organs from STAMP-treated cats or dogs. These findings encourage the further development of stampidine for possible clinical use in HIV-infected persons...
  23. ncbi request reprint In vivo pharmacokinetics, metabolism, toxicity, and anti-HIV activity of N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)]thiourea (HI-443), a potent non-nucleoside inhibitor of HIV reverse transcriptase
    Fatih M Uckun
    Paradigm Pharmaceuticals, White Bear Lake, MN, USA
    Arzneimittelforschung 57:483-96. 2007
    ..These preclinical research studies provide the basis for future preclinical studies and clinical development of HI-443 as a new NNRTI candidate...
  24. ncbi request reprint Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study
    Fatih M Uckun
    Parker Hughes Institute, Roseville, MN, USA
    Arzneimittelforschung 57:112-21. 2007
    ....
  25. ncbi request reprint Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat
    OSMOND J D'CRUZ
    Drug Discovery Program, Paradigm Pharmaceuticals, LLC, St Paul, MN 55113, USA
    Toxicol Pathol 35:910-27. 2007
    ..Therefore, the combined use of WHI-07 and VDDTC via gel-microemulsion appears safe for topical use as a prophylactic anti-HIV microbicide...
  26. ncbi request reprint Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07)
    Fatih M Uckun
    Drug Discovery Program, Departments of Virology, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Arzneimittelforschung 55:50-65. 2005
    ....
  27. pmc Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Antimicrob Agents Chemother 48:1082-8. 2004
    ....
  28. ncbi request reprint Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor
    Marina Cetkovic-Cvrlje
    Experimental BMT Program, Parker Hugher Cancer Center, St Paul, MN 55113, USA
    Leuk Lymphoma 43:1447-53. 2002
    ..Taken together, these observations establish JAK3 as a key mediator of severe GVHD after allogeneic BMT in the context of a major-HLA disparity...
  29. ncbi request reprint Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide
    OSMOND J D'CRUZ
    Drug Discovery Program, Department of Virology, Parker Hughes Institute, 2657 Patton Road, St Paul, MN 55113, USA
    Fertil Steril 81:831-41. 2004
    ..This study investigated the potential utility of stampidine as a nonspermicidal microbicide...
  30. ncbi request reprint A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Toxicol Pathol 30:687-95. 2002
    ..PHI-346 may be useful as an active ingredient of a safe vaginal microbicide for prevention of the sexual transmission of multidrug-resistant HIV-1...
  31. ncbi request reprint High resolution X-ray structure and potent anti-HIV activity of recombinant dianthin antiviral protein
    Igor V Kurinov
    Biotherapy and Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Arzneimittelforschung 54:692-702. 2004
    ..In accordance with the predictions of the modeling studies, rDAP was more potent than rPAP in depurinating HIV-1 RNA. To the knowledge of the authors, this is the first structural and functional characterization of recombinant DAP...
  32. ncbi request reprint Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model
    Marina Cetkovic-Cvrlje
    Experimental BMT Program, Parker Hughes Cancer Center, St Paul, MN 55113, USA
    Br J Haematol 126:821-7. 2004
    ..Taken together, these results indicate that targeting BTK with the chemical inhibitor LFM-A13 may attenuate the severity of GVHD, especially when it is combined with other anti-GVHD drugs, such as MTX and JANEX-1...
  33. ncbi request reprint In vivo toxicity and antithrombotic profile of the oral formulation of the antileukemic agent, LFM-A13-F
    Heather E Tibbles
    Paradigm Pharmaceuticals, LLC, Roseville, MN, USA
    Arzneimittelforschung 54:330-9. 2004
    ..LFM-A13 could be combined with dipyridamole (CAS 58-32-2) without side effects. These results indicate that LFM-A13 may be particularly useful in the treatment of leukemia patients who are at risk for thromboembolic complications...
  34. ncbi request reprint Synthesis, separation and anti-HIV activity of distereoisomers of N-[p-(4-bromophenyl) -2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester (stampidine)
    Taracad K Venkatachalam
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:152-8. 2006
    ..Both isomers were active against the HIV-1 strain HTLV(IIIB) and neither isomer was more or less active than distereoisomeric mixture of stampidine...
  35. ncbi request reprint Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1
    OSMOND J D'CRUZ
    Drug Discovery Program, Paradigm Pharmaceuticals, LLC, Patton Road, St Paul, MN 55113, USA
    Fertil Steril 88:1197-206. 2007
    ..To investigate the in vitro and in vivo mucosal safety of a nonnucleoside reverse transcriptase (RT) inhibitor (PHI-443) and a nucleoside analogue RT inhibitor (stampidine)-based anti-HIV microbicide either alone or in combination...
  36. ncbi request reprint Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus
    Fatih M Uckun
    Department of Virology, Parker Hughes Institute, 2720 Patton Road, St Paul, MN 55113, USA
    Eur J Med Chem 39:225-34. 2004
    ..The remarkable anti-ADV potency of the lead compounds stampidine and compound 609 warrants the further development of these promising new antiviral agents for possible clinical use in ADV infected patients...
  37. ncbi request reprint In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates
    Fatih M Uckun
    Drug Discovery Program, Department of Virology, and Chemistry, Parker Hughes Cancer Center, St Paul, MN 55113, USA
    Arzneimittelforschung 54:69-77. 2004
    ..2 +/- 6.5 nmol/L. The remarkable potency of STAMP against clinical HIV-1 isolates with NRTI- or NNRTI-resistance warrants the further development of this promising new antiviral agent...
  38. ncbi request reprint In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs
    Fatih M Uckun
    Drug Discovery Program, Department of Virology, Parker Hughes Institute, St Paul, MN 55113, USA
    Arzneimittelforschung 55:223-31. 2005
    ....
  39. ncbi request reprint Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Biol Reprod 67:1959-74. 2002
    ....
  40. ncbi request reprint Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide
    OSMOND J D'CRUZ
    Department of Reproductive Biology, Drug Discovery Program, Parker Hughes Institute, St Paul, MN 55113, USA
    Mol Hum Reprod 11:767-77. 2005
    ..PHI-236 has particular clinical utility as a non-spermicidal microbicide as well as a prophylactic antiviral agent to inactivate cell-free and cell-associated HIV-1 in semen before assisted reproductive technology procedures...
  41. ncbi request reprint The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism
    Fatih M Uckun
    Parker Hughes Cancer Center, Parker Hughes Institute, St Paul, MN 55113, USA
    Leuk Lymphoma 44:1569-77. 2003
    ..To our knowledge, LFM-A13 is the first anti-thrombotic agent which prevents platelet aggregation by inhibiting BTK...
  42. ncbi request reprint Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits
    OSMOND J D'CRUZ
    Drug Discovery Program, Department of Reproductive Biology, Parker Hughes Institute, Paradigm Pharmaceuticals, LLC, St Paul, MN, USA
    Arzneimittelforschung 53:515-21. 2003
    ..Intravaginal application of 2% WHI-05 containing gel also inhibited the pregnancy rate by 90%. WHI-05 had no side effects for the offspring of rabbits who became pregnant despite WHI-05...
  43. pmc In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice
    Fatih M Uckun
    Drug Discovery Program, Departments of Virology, Immunology, Pathology, Pharmaceutical Sciences, and Chemistry, Parker Hughes Institute, St Paul, and Parker Hughes Center for Clinical Immunology, Roseville, Minnesota 55113, USA
    Antimicrob Agents Chemother 46:3428-36. 2002
    ..The remarkable in vivo safety and potency of STAMP warrants the further development of this promising new antiretroviral agent for possible clinical use in patients harboring NRTI-resistant HIV-1...
  44. ncbi request reprint Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent
    OSMOND J D'CRUZ
    Department of Reproductive Biology, Parker Hughes Institute, St Paul, MN 55113, USA
    Toxicology 179:61-77. 2002
    ..We conclude that long-term intravaginal administration of WHI-07 is not associated with systemic toxicity or increased carcinogenicity in mice. WHI-07 has clinical potential as an active ingredient of a safe vaginal/rectal microbicide...
  45. ncbi request reprint In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase
    Fatih M Uckun
    Parker Hughes Cancer Center, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Clin Cancer Res 8:1224-33. 2002
    ..274: 9587-9599, 1999). BTK inhibitors such as LFM-A13 may be useful as a new class of chemosensitizing and apoptosis-promoting antileukemic agents for treatment of patients with chemotherapy-resistant B-lineage leukemias or lymphomas...
  46. ncbi request reprint Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, MN 55113, USA
    Biochem Biophys Res Commun 302:253-64. 2003
    ....
  47. ncbi request reprint Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent
    Darin DuMez
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:136-51. 2006
    ..STAMP was prepared under current Good Manufacturing Practice (cGMP) conditions on the scale of kilograms. Solid STAMP was subsequently formulated as a capsule under GMP conditions for oral administration...
  48. ncbi request reprint Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein
    OSMOND J D'CRUZ
    Drug Discovery Program, Department of Reproductive Biology, Parker Hughes Institute, 2657 Patton Road, St Paul, Minnesota 55113, USA
    Toxicol Pathol 32:212-21. 2004
    ..These findings indicate careful monitoring of vaginal irritation will be required in the clinical development of PAP as a nonspermicidal microbicide...
  49. pmc Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity
    Fatih M Uckun
    Biotherapy Program, Parker Hughes Cancer Center, St Paul, Minnesota 55113, USA
    Antimicrob Agents Chemother 47:1052-61. 2003
    ....
  50. ncbi request reprint Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, 2657 Patton Road, St Paul, MN 55113, USA
    J Enzyme Inhib Med Chem 21:329-50. 2006
    ..The high rate of treatment failure due to the emergence of drug resistance mutations makes the discovery of broad-spectrum PETT, HEPT and DABO-based NNRTIs useful as a component of effective combination regimens...
  51. ncbi request reprint Anti-proliferative and anti-leukemic activity of DDE46 (compound WHI-07), a novel bromomethoxylated arylphosphate derivative of zidovudine, and related compounds. Studies using human acute lymphoblastic leukemia cells and the zebrafish model
    Alexey O Benyumov
    Departments of Embryology, Parker Hughes Institute, Roseville, MN 55113, USA
    Arzneimittelforschung 55:114-22. 2005
    ..These results justify the further development of this agent as a new anti-leukemic drug candidate...
  52. pmc Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations
    Fatih M Uckun
    Drug Discovery Program, Departments of Virology, Bioinformatics, Immunology, and Chemistry, Parker Hughes Institute, St Paul Parker Hughes Center for Clinical Immunology, Roseville, Minnesota 55113, USA
    Antimicrob Agents Chemother 46:3613-6. 2002
    ....
  53. ncbi request reprint Site-specific enzymatic activation of the anti-HIV agent stampidine
    Taracad K Venkatachalam
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:167-75. 2006
    ..Enzymes such as lipase, esterase and protease did not hydrolyze the butyl substituted STAMP analog. These experimental results show that the site of attack for the enzymatic hydrolysis of STAMP is the ester side chain of the molecule...
  54. pmc Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia
    Fatih M Uckun
    Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Blood 121:4348-54. 2013
    ..Our findings establish SYK as an attractive molecular target for therapy of B-precursor ALL. Further development of the C61 NLF may provide the foundation for therapeutic innovation against therapy-refractory B-precursor ALL...
  55. pmc Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros
    Fatih M Uckun
    Division of Hematology Oncology, Systems Immunobiology Laboratory, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Proc Natl Acad Sci U S A 109:18072-7. 2012
    ..Mechanistically, we establish that SYK-induced Ikaros activation is essential for its nuclear localization and optimal transcription factor function...
  56. ncbi request reprint Toxicity and pharmacokinetics of stampidine in mice and rats
    Fatih M Uckun
    Drug Discovery Program, Departments of Virology, Immunology, Parker Hughes Institute, St Paul, MN, USA
    Arzneimittelforschung 53:357-67. 2003
    ..administration of the nontoxic 25-50 mg/kg bolus doses of stampidine. The remarkable in vivo safety of stampidine warrants the further development of this promising new antiviral agent for possible clinical use in HIV-infected patients...
  57. pmc STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress
    Fatih M Uckun
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine and Developmental Therapeutics Program, Childrens Hospital, P O Box 27367, Los Angeles, CA 90027 0367, USA
    Proc Natl Acad Sci U S A 107:2902-7. 2010
    ..Notably, inhibition of SYK with a small molecule drug candidate prevents OS-induced activation of STAT3 and overcomes the resistance of human B-lineage leukemia/lymphoma cells to OS-induced apoptosis...
  58. ncbi request reprint In vitro and in vivo pharmacokinetic features and metabolism of the novel cytotoxic nucleoside analog 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate] (Compound 003)
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Arzneimittelforschung 54:732-45. 2004
    ..This study provides the basis for future preclinical as well as clinical pharmacodynamic studies of Compound 003...
  59. pmc In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Cancer Center, St Paul, Minnesota, USA
    Antimicrob Agents Chemother 47:1233-40. 2003
    ....
  60. doi request reprint A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea])
    OSMOND J D'CRUZ
    Microbicide Development Laboratory, Developmental Therapeutics Program, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, CA, USA
    Expert Opin Investig Drugs 21:265-79. 2012
    ..A focal point in contemporary research aimed at preventing the heterosexual spread of AIDS has been the development of intravaginal anti-HIV microbicides to curb the mucosal human immunodeficiency virus type 1 (HIV-1) transmission...
  61. ncbi request reprint Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice
    Marina Cetkovic-Cvrlje
    Department of Immunology, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    Clin Immunol 106:213-25. 2003
    ..To our knowledge, this is the first report of the immunosuppressive activity of a JAK3 inhibitor in the context of an autoimmune disease...
  62. ncbi request reprint Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds
    T K Venkatachalam
    Department of Chemistry, Parker Hughes Institute, 2699 Patton Road, Roseville, MN 55113, USA
    Bioorg Med Chem 12:4275-84. 2004
    ..Our data provides experimental evidence that the stereochemistry as well as regiochemistry of NNRTI can profoundly affect their anti-HIV activity...
  63. ncbi request reprint Vaginal contraceptive activity of a chelated vanadocene
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, MN 55113, USA
    Contraception 72:146-56. 2005
    ..These results suggest that VDDTC is a potent contraceptive agent in vivo. Intravaginal use of VDDTC via a gel microemulsion has clinical potential as a safe alternative to currently used detergent-type contraceptives...
  64. ncbi request reprint A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate
    OSMOND J D'CRUZ
    Drug Discovery Program, Experimental Pathology, Parker Hughes Institute LLC, 2657 Patton Road, St Paul, MN 55113, USA
    Toxicol Pathol 33:465-76. 2005
    ..These results demonstrate that key cervicovaginal inflammatory cytokines are useful in vivo biomarkers for predicting the mucosal toxicity potential of vaginal products in the physiologically relevant and sensitive porcine model...
  65. ncbi request reprint Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Toxicol Pathol 31:698-708. 2003
    ..These findings indicated that WHI-07 shows unique clinical potential to become the active ingredient of a new female-controlled topical microbicidal vaginal contraceptive for women who are at high risk of acquiring HIV/AIDS...
  66. ncbi request reprint Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors
    Alexei O Vassilev
    Parker Hughes Cancer Center Parker Hughes Institute, Drug Discovery Program, Paradigm Pharmaceuticals, St Paul, MN 55113, USA
    Curr Drug Targets 7:327-43. 2006
    ..Here we review advances in JAK3 and BTK inhibitors and describe the therapeutic potential of these potent agents in the clinical setting...
  67. ncbi request reprint Developmental safety profile of the anti-HIV agent stampidine in rabbits
    OSMOND J D'CRUZ
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:159-66. 2006
    ..STAMP did not adversely affect the reproductive health of female rabbits and it lacked teratogenicity or other developmental toxicity in their progeny...
  68. doi request reprint CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia
    Hong Ma
    Division of Hematology Oncology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Br J Haematol 156:89-98. 2012
    ..Our study implicates the CD22ΔE12 genetic defect in the aggressive biology of relapsed or therapy-refractory paediatric B-lineage ALL...
  69. ncbi request reprint Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats
    Chun Lin Chen
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Drug Metab Dispos 30:1523-31. 2002
    ..These findings encourage the further development of this new antiviral agent for possible clinical use in human immunodeficiency virus-infected patients...
  70. ncbi request reprint Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells
    Fatih M Uckun
    Department of Oncology, Drug Discovery Program, Parker Hughes Cancer Center and Parker Hughes Institute, St Paul, MN, USA
    Arzneimittelforschung 53:428-39. 2003
    ....
  71. ncbi request reprint Anti-inflammatory activity profile of JANEX-1 in preclinical animal models
    Fatih M Uckun
    Parker Hughes Cancer Center, 2848 Patton Road, St Paul, MN 55113, USA
    Bioorg Med Chem 16:1287-98. 2008
    ..Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders...
  72. ncbi request reprint Effect of targeting janus kinase 3 on the development of intestinal tumors in the adenomatous polyposis coli(min) mouse model of familial adenomatous polyposis
    Fatih M Uckun
    Parker Hughes Cancer Center, 2665 Long Lake Road, St Paul, Minnesota 55113, USA
    Arzneimittelforschung 57:320-9. 2007
    ..JAK3 inhibitors may therefore be useful in the prevention of colorectal cancer in individuals with FAP...
  73. ncbi request reprint Potency of stampidine against multi-nucleoside reverse transcriptase inhibitor resistant human immunodeficiency viruses
    Fatih M Uckun
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:193-203. 2006
    ..Stampidine exhibited potent anti-HIV activity against each one of these 33 HIV-1 isolates with subnanomolar to nanomolar IC50 values...
  74. ncbi request reprint Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives
    Taracad K Venkatachalam
    Department of Chemistry, Structural Biology and Virology, Parker Hughes Institute, 2657 Patton Road, St Paul, MN 55113, USA
    Biochem Pharmacol 67:1933-46. 2004
    ..Our data provides experimental evidence that the stereochemistry and the regiochemistry of non-nucleoside inhibitors can profoundly affect their anti-HIV activity...
  75. ncbi request reprint Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity
    Fatih M Uckun
    Parker Hughes Institute, Roseville, Minnesota, USA
    Arzneimittelforschung 56:121-35. 2006
    ....
  76. ncbi request reprint CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation
    Fatih M Uckun
    Department of Pharmaceutical Sciences, Parker Hughes Cancer Center, 2665 Long Lake Road, Suite 330, St Paul, MN 55113, USA
    Drug Metab Dispos 30:74-85. 2002
    ..1 +/- 1926.2 ml/h/kg versus 1458.0 +/- 258.6 ml/h/kg). Consequently, the area under the curve value for JANEX-1-M was much smaller than that for JANEX-1 (27.5 +/- 8.0 versus 94.8 +/- 18.4 microM. h; P < 0.001)...
  77. ncbi request reprint Prevention of islet allograft rejection in diabetic mice by targeting Janus Kinase 3 with 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (JANEX-1)
    Marina Cetkovic-Cvrlje
    Department of Immunology, Parker Hughes Institute and Parker Hughes Cancer Center, St Paul, MN, USA
    Arzneimittelforschung 53:648-54. 2003
    ..The combination of JANEX-1 and cyclosporin A (CAS 59865-13-3) was more effective than either agent alone...
  78. ncbi request reprint Organic phenyl arsonic acid compounds with potent antileukemic activity
    Xing Ping Liu
    Parker Hughes Cancer Center, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    Bioorg Med Chem Lett 13:581-3. 2003
    ..5+/-0.3 microM against NALM-6 and 2.3+/-0.5 microM against MOLT-3) exhibited potent antileukemic activity at low micromolar concentrations...
  79. ncbi request reprint Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model
    Fatih M Uckun
    Experimental BMT Program, Parker Hughes Cancer Center and Department of Immunology, Parker Hughes Institute, St Paul, MN 55113, USA
    Blood 99:4192-9. 2002
    ....
  80. ncbi request reprint Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07)
    OSMOND J D'CRUZ
    Department of Reproductive Biology, Parker Hughes Institute, 2657 Patton Road, St Paul, MN 55113, USA
    J Antimicrob Chemother 50:793-803. 2002
    ....
  81. ncbi request reprint Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Cancer Center, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    Expert Opin Investig Drugs 11:1829-36. 2002
    ..Metvan could represent the first vanadium complex as an alternative to platinum-based chemotherapy...
  82. ncbi request reprint CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants
    Carla M Wood
    Department of Molecular Genetics, Parker Hughes Institute, St Paul, MN, USA
    Eur J Haematol 70:156-71. 2003
    ..The low level of expression of functional full length FAS transcripts with corresponding low level of FAS protein expression in the ALL cells contribute to their resistance to CD95-mediated apoptosis...
  83. ncbi request reprint A dual function anti-leukemic agent with anti-thrombotic activity
    Heather Tibbles
    Parker Hughes Cancer Center, Parker Hughes Institute, St Paul, MN 55113, USA
    Leuk Lymphoma 43:1121-7. 2002
    ..We propose that LFM-A13 induces a conformational change in the PH domain of BTK and causes BTK to associate with PIP2 which effects actin bundling and shape change...
  84. ncbi request reprint Non-receptor tyrosine kinases as molecular targets for patient tailored cancer therapy
    Fatih M Uckun
    Parker Hughes Cancer Center and Parker Hughes Institute, St Paul, MN, USA
    Anticancer Agents Med Chem 7:593. 2007
  85. ncbi request reprint Defective expression of Bruton's tyrosine kinase in acute lymphoblastic leukemia
    Patricia A Goodman
    Department of Molecular Genetics, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    Leuk Lymphoma 44:1011-8. 2003
    ..Since BTK is required for radiation induced apoptosis, reduced to absent expression of functional BTK in infant ALL cells could contribute to their radiation resistance...
  86. ncbi request reprint Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study
    Adam S Levy
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Pediatr Hematol Oncol 25:688-95. 2003
    ..The purpose of this study was to assess whether reduced folate carrier (RFC) and DHFR expression in untreated leukemic blasts correlated with outcome...
  87. ncbi request reprint Vinorelbine-based salvage chemotherapy for therapy-refractory aggressive leukaemias
    Fatih M Uckun
    Department of Hematology Oncology, Parker Hughes Cancer Center, Roseville, MN, USA
    Br J Haematol 135:500-8. 2006
    ..Vinorelbine-sensitivity testing of primary leukaemia cells might help tailor Vinorelbine-based salvage regimens to those patients who are most likely to respond...
  88. ncbi request reprint Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Institute, St Paul, MN 55113, USA
    Reprod Toxicol 16:57-64. 2002
    ..Sodium arsanilate and its N-substituted pyrimidine derivative, PHI-370, are useful probes to further evaluate the mechanism of pentavalent arsanilate-induced human sperm dysfunction...
  89. ncbi request reprint Targeting JAK3 tyrosine kinase-linked signal transduction pathways with rationally-designed inhibitors
    Fatih M Uckun
    Parker Hughes Cancer Center and Parker Hughes Institute, St Paul, MN 55113, USA
    Anticancer Agents Med Chem 7:612-23. 2007
    ..Here we discuss the clinical potential of targeting JAK3-linked signal transduction pathways with small molecule inhibitors such as JANEX-1...
  90. ncbi request reprint Bruton's tyrosine kinase as a new therapeutic target
    Fatih M Uckun
    Parker Hughes Cancer Center, 2848 Patton Road, St Paul, MN 55113, USA
    Anticancer Agents Med Chem 7:624-32. 2007
    ..The therapeutic potential of targeting BTK is illustrated by discussion of the biologic activity profile of the rationally designed BTK inhibitor LFM-A13...
  91. ncbi request reprint Expression of a unique helios isoform in human leukemia cells
    Lei Sun
    Department of Molecular Biology, Parker Hughes Cancer Center, Parker Hughes Institute, St Paul, MN 55113, USA
    Leuk Lymphoma 43:841-9. 2002
    ..Helios 3 exhibited a unique protein interaction profile via its N-terminal portion, which may have biological significance in pathogenesis of human leukemias...
  92. ncbi request reprint Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1
    OSMOND J D'CRUZ
    Drug Discovery Program, Paradigm Pharmaceuticals, St Paul, MN 55113, USA
    Am J Reprod Immunol 58:75-97. 2007
    ..We hypothesize that JAK3 inhibitors, especially JANEX-1, may prove useful to prevent or alleviate the symptoms of EMS...
  93. ncbi request reprint Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1
    OSMOND J D'CRUZ
    Parker Hughes Institute, St Paul, MN 55113, USA
    Am J Reprod Immunol 57:353-60. 2007
    ..SCID mice reconstituted with human peripheral blood lymphocytes (PBL) are amenable to vaginal transmission of HIV-1. We investigated the effectiveness of this model to establish systemic HIV-1 infection...
  94. ncbi request reprint Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    Curr Pharm Des 10:1083-91. 2004
    ..We present a structural comparison of kinase inhibitors with a special emphasis on inhibitors of JAK3 and BTK...
  95. ncbi request reprint Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells
    Ravi Malaviya
    Department of Allergy, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    J Immunol 168:421-6. 2002
    ..These findings provide unprecedented evidence that STAT6 plays a pivotal role in mast cell responses to IgE/Ag stimulation...