Yoshikazu Uchida

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
  2. doi request reprint Omega-O-acylceramide, a lipid essential for mammalian survival
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States
    J Dermatol Sci 51:77-87. 2008
  3. doi request reprint Ceramide signaling in mammalian epidermis
    Yoshikazu Uchida
    Department of Dermatology, University of California, San Francisco, CA, USA School of Medicine, University of California, San Francisco, CA, USA Dermatology Service and Research Unit, Veterans Affairs Medical Center, San Francisco, CA, USA Northern California Institute for Research and Education, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:453-62. 2014
  4. pmc On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Dermatol Sci 51:37-43. 2008
  5. ncbi request reprint Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
    J Biol Chem 282:13211-9. 2007
  6. doi request reprint Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 130:2472-80. 2010
  7. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
  8. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
  9. ncbi request reprint Serine protease signaling of epidermal permeability barrier homeostasis
    Jean Pierre Hachem
    Department of Dermatology and Medical Services Metabolism, VA Medical Center, San Francisco, California, USA
    J Invest Dermatol 126:2074-86. 2006
  10. doi request reprint Ceramides stimulate caspase-14 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    Exp Dermatol 22:113-8. 2013

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Basis for the permeability barrier abnormality in lamellar ichthyosis
    Peter M Elias
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Exp Dermatol 11:248-56. 2002
    ....
  2. doi request reprint Omega-O-acylceramide, a lipid essential for mammalian survival
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States
    J Dermatol Sci 51:77-87. 2008
    ..These results indicate not only that acylCer are critical lipid components for mammalian survival, but also that keratinocytes deploy a complex metabolic pathway leading to the formation of these unique Cer...
  3. doi request reprint Ceramide signaling in mammalian epidermis
    Yoshikazu Uchida
    Department of Dermatology, University of California, San Francisco, CA, USA School of Medicine, University of California, San Francisco, CA, USA Dermatology Service and Research Unit, Veterans Affairs Medical Center, San Francisco, CA, USA Northern California Institute for Research and Education, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:453-62. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. ..
  4. pmc On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
    J Dermatol Sci 51:37-43. 2008
    ..However, since the metabolic fates of each pseudo-Cer remain unknown, their widespread deployment in topical agents has raised concern about potential toxicities...
  5. ncbi request reprint Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
    J Biol Chem 282:13211-9. 2007
    ..Thus, late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis...
  6. doi request reprint Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB
    Yoshikazu Uchida
    Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 130:2472-80. 2010
    ..Thus, Cer → sphingosine → S1Pmetabolic conversion protects against UVB-induced, Cer-mediated apoptosis in keratinocytes, but excessive UVB overwhelms this mechanism, thereby leading to keratinocyte apoptosis...
  7. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
    ..Additionally, some of these activators exhibit potent antihyperplastic and anti-inflammatory activity in irritant contact dermatitis and acute allergic contact dermatitis murine models...
  8. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
    ..These results provide direct evidence for the "outside-inside" pathogenesis of AD and further suggest that maintenance of an acidic SC pH could prevent the emergence of AD in humans...
  9. ncbi request reprint Serine protease signaling of epidermal permeability barrier homeostasis
    Jean Pierre Hachem
    Department of Dermatology and Medical Services Metabolism, VA Medical Center, San Francisco, California, USA
    J Invest Dermatol 126:2074-86. 2006
    ....
  10. doi request reprint Ceramides stimulate caspase-14 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    Exp Dermatol 22:113-8. 2013
    ..These studies show that ceramides, an important structural lipid, stimulate caspase-14 expression providing a mechanism for coordinately regulating the formation of lipid lamellar membranes with the formation of corneocytes...
  11. pmc Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production
    Kyungho Park
    Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 133:1942-9. 2013
    ..These results demonstrate that the dietary stilbenoid RESV stimulates S1P signaling of CAMP production through an NF-κB-->C/EBPα-dependent mechanism, leading to enhanced antimicrobial defense against exogenous microbial pathogens...
  12. pmc Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis
    Peter M Elias
    Dermatology Service 190, VA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Pathol 173:689-99. 2008
    ....
  13. pmc Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
    J Biol Chem 284:18942-52. 2009
    ....
  14. pmc Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges
    Mao Qiang Man
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Invest Dermatol 128:79-86. 2008
    ..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD...
  15. pmc A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity
    Kyungho Park
    Department of Dermatology, School of Medicine, University of California, San Francisco, Veterans Affairs Medical Center, San Francisco, California, USA
    Mol Cell Biol 33:752-62. 2013
    ....
  16. pmc Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway
    Kyungho Park
    Department of Dermatology, School of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 286:34121-30. 2011
    ..Hence, ER stress increases CAMP expression via NF-κB-C/EBPα activation, independent of VDR, illuminating a novel VDR-independent role for ER stress in stimulating innate immunity...
  17. ncbi request reprint Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    Matthias Schmuth
    Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
    J Invest Dermatol 122:909-22. 2004
    ..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma...
  18. ncbi request reprint Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing
    Mao Qiang Man
    Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 126:386-92. 2006
    ..Since the liposensors are activated by endogenous lipid metabolites, they may serve as unique regulators of barrier homeostasis...
  19. pmc Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation
    Yuko Oda
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 129:1367-78. 2009
    ..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized...
  20. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ....
  21. doi request reprint Formation and functions of the corneocyte lipid envelope (CLE)
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA Department of Dermatology, University of California, San Francisco, CA, USA Electronic address
    Biochim Biophys Acta 1841:314-8. 2014
    ..This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias. ..
  22. pmc Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles
    Andrew W Borkowski
    Division of Dermatology, University of California, San Diego, San Diego, California 92093 0869, USA
    J Invest Dermatol 133:2031-40. 2013
    ..These observations show that dsRNA can stimulate some events in keratinocytes that are important for skin barrier repair and maintenance. ..
  23. pmc Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation
    Alexandra Charruyer
    Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 283:16682-92. 2008
    ....
  24. ncbi request reprint De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes
    Yoshikazu Uchida
    Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA
    J Invest Dermatol 120:662-9. 2003
    ..Thus, increased de novo ceramide synthesis signals ultraviolet B-induced apoptosis, by a pathway independent of, but in concert with, caspase-3 activation...
  25. ncbi request reprint Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity
    Jean Pierre Hachem
    Dermatology, VA Medical Center, University of California, San Francisco, 94121, USA
    J Invest Dermatol 125:510-20. 2005
    ..In conclusion, prolonged SC neutralization provokes profound abnormalities in SC function, due to pH-induced high SP activity that, in turn, degrades lipid processing enzymes and CD proteins...
  26. ncbi request reprint Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  27. doi request reprint Increased glucocorticoid activation during mouse skin wound healing
    Ana Tiganescu
    Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA
    J Endocrinol 221:51-61. 2014
    ....
  28. doi request reprint Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing
    Jong Kyung Youm
    Department of Dermatology, Veterans Affairs Medical Center, San Francisco, California Northern California Institute for Research and Education, University of California, San Francisco, California
    Wound Repair Regen 21:715-22. 2013
    ..Local blockade or down-regulation of cutaneous GC activation could help enhance WH in various clinical settings. ..
  29. pmc Cellular changes that accompany shedding of human corneocytes
    Tzu Kai Lin
    Department of Veterans Affairs Medical Center and Department of Dermatology, Dermatology Service, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 132:2430-9. 2012
    ..Hydration also provoked degradation of membranes by activating contiguous acidic ceramidase activity. Together, these studies identify several parallel mechanisms that orchestrate exfoliation from the surface of normal human skin...
  30. ncbi request reprint Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress
    Yoshikazu Uchida
    Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    J Lipid Res 43:1293-302. 2002
    ..Thus, SMase-induced stress initiates a response in keratinocytes that includes upregulation of GlcCer synthesis which may protect against the deleterious effects of excess Cer...
  31. ncbi request reprint Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity
    Robert H Rice
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616 8588, USA
    Arch Dermatol Res 297:127-33. 2005
    ....
  32. pmc A murine model of isolated cardiac steatosis leads to cardiomyopathy
    DENIS J GLENN
    Department of Medicine and Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, USA
    Hypertension 57:216-22. 2011
    ..These findings suggest that triglyceride accumulation, in the absence of systemic metabolic derangement, results in cardiac dysfunction and decreased mitochondrial biogenesis...
  33. pmc Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis
    Nicolas Loiseau
    Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA Veteran Affairs Medical Center, San Francisco, CA, USA Northern California Institute for Research and Education, San Francisco, CA, USA Integrative Toxicology and Metabolism, Pôle de Toxicologie Alimentaire, Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse, France
    J Dermatol Sci 72:296-303. 2013
    ..Pertinently, alterations of lipid profile, including ceramide and ceramidase activities occur in atopic dermatitis (AD)...
  34. ncbi request reprint Epidermal sphingolipids: metabolism, function, and roles in skin disorders
    Walter M Holleran
    Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA
    FEBS Lett 580:5456-66. 2006
    ..Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review...
  35. ncbi request reprint Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
    Evi Houben
    Department of Toxicology, Dermato Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium
    J Lipid Res 47:1063-70. 2006
    ....
  36. ncbi request reprint Human epidermal glucosylceramides are major precursors of stratum corneum ceramides
    Sumiko Hamanaka
    Sphingolipid Expression Laboratory, Supra Biomolecular System Research, RIKEN Frontier Research System, Wako, Japan
    J Invest Dermatol 119:416-23. 2002
    ....
  37. pmc Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death
    Vidyullatha Vasireddy
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    Hum Mol Genet 16:471-82. 2007
    ..These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment...
  38. ncbi request reprint Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features
    Mariko Hara-Chikuma
    Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
    J Invest Dermatol 123:464-9. 2004
    ....
  39. pmc Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis
    Khemissa Bejaoui
    Day Neuromuscular Research Laboratory, Charlestown, Massachusetts, USA
    J Clin Invest 110:1301-8. 2002
    ..These results indicate that the HSN1-associated mutations in LCB1 confer dominant negative effects on the SPT enzyme...
  40. ncbi request reprint A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    Stephen B Ting
    Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
    Science 308:411-3. 2005
    ..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
  41. ncbi request reprint Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells
    Yoshikazu Uchida
    Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Cancer Res 64:6271-9. 2004
    ..Together, the results suggest that transcriptional up-regulation of GCS through DOX-induced activation of Sp1 is one potential mechanism to regulate ceramide increase and apoptosis in HL-60/ADR cells...

Research Grants5

  1. Epidermal Mechanisms Opposing Ceramide-Induced Apoptosis
    Yoshikazu Uchida; Fiscal Year: 2009
    ....