Research Topics
Genomes and Genes
| Yoshikazu UchidaSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Basis for the permeability barrier abnormality in lamellar ichthyosisPeter M Elias
Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
Exp Dermatol 11:248-56. 2002....- Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiationYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
J Biol Chem 282:13211-9. 2007..Thus, late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis... 
Omega-O-acylceramide, a lipid essential for mammalian survivalYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States
J Dermatol Sci 51:77-87. 2008..These results indicate not only that acylCer are critical lipid components for mammalian survival, but also that keratinocytes deploy a complex metabolic pathway leading to the formation of these unique Cer...
On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramidesYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA
J Dermatol Sci 51:37-43. 2008..However, since the metabolic fates of each pseudo-Cer remain unknown, their widespread deployment in topical agents has raised concern about potential toxicities...- Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVBYoshikazu Uchida
Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA
J Invest Dermatol 130:2472-80. 2010..Thus, Cer → sphingosine → S1Pmetabolic conversion protects against UVB-induced, Cer-mediated apoptosis in keratinocytes, but excessive UVB overwhelms this mechanism, thereby leading to keratinocyte apoptosis... - Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitisYutaka Hatano
Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 129:1824-35. 2009..These results provide direct evidence for the "outside-inside" pathogenesis of AD and further suggest that maintenance of an acidic SC pH could prevent the emergence of AD in humans... - Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activatorsYutaka Hatano
Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
J Allergy Clin Immunol 125:160-9.e1-5. 2010..Additionally, some of these activators exhibit potent antihyperplastic and anti-inflammatory activity in irritant contact dermatitis and acute allergic contact dermatitis murine models... - Serine protease signaling of epidermal permeability barrier homeostasisJean Pierre Hachem
Department of Dermatology and Medical Services Metabolism, VA Medical Center, San Francisco, California, USA
J Invest Dermatol 126:2074-86. 2006.... - Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytesYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
J Biol Chem 284:18942-52. 2009.... - A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunityKyungho Park
Department of Dermatology, School of Medicine, University of California, San Francisco, Veterans Affairs Medical Center, San Francisco, California, USA
Mol Cell Biol 33:752-62. 2013.... - Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathwayKyungho Park
Department of Dermatology, School of Medicine, University of California, San Francisco, California 94143, USA
J Biol Chem 286:34121-30. 2011..Hence, ER stress increases CAMP expression via NF-κB-C/EBPα activation, independent of VDR, illuminating a novel VDR-independent role for ER stress in stimulating innate immunity... - Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasisPeter M Elias
Dermatology Service 190, VA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Am J Pathol 173:689-99. 2008.... - Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formationYuko Oda
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 129:1367-78. 2009..In contrast, DRIP silencing had no apparent effect on these processes indicating that the two classes of coactivators are differentially utilized... - Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challengesMao Qiang Man
Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, California 94121, USA
J Invest Dermatol 128:79-86. 2008..Because of its reproducibility, predictability, and low cost, this model could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD... - Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processingMao-Qiang Man
Department of Dermatology, University of California and VA Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 126:386-92. 2006..Since the liposensors are activated by endogenous lipid metabolites, they may serve as unique regulators of barrier homeostasis... - SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's diseaseAnna Celli
Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
J Invest Dermatol 132:1188-95. 2012.... - Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)Matthias Schmuth
Dermatology and Metabolism Medicine Services, Veterans Affairs Medical Center, San Francisco, USA
J Invest Dermatol 122:909-22. 2004..But in contrast to lamellar ichthyosis, the CE scaffold partially normalizes in the outer SC in loricrin keratoderma... - Ceramides stimulate caspase-14 expression in human keratinocytesYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
Exp Dermatol 22:113-8. 2013..These studies show that ceramides, an important structural lipid, stimulate caspase-14 expression providing a mechanism for coordinately regulating the formation of lipid lamellar membranes with the formation of corneocytes... - De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytesYoshikazu Uchida
Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA
J Invest Dermatol 120:662-9. 2003..Thus, increased de novo ceramide synthesis signals ultraviolet B-induced apoptosis, by a pathway independent of, but in concert with, caspase-3 activation... - Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytesMatthias Schmuth
Department of Medicine, University of California, San Francisco, California, USA
J Invest Dermatol 122:971-83. 2004..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes... - Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrityJean Pierre Hachem
Dermatology, VA Medical Center, University of California, San Francisco, 94121, USA
J Invest Dermatol 125:510-20. 2005..In conclusion, prolonged SC neutralization provokes profound abnormalities in SC function, due to pH-induced high SP activity that, in turn, degrades lipid processing enzymes and CD proteins... - Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiationAlexandra Charruyer
Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, and Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Biol Chem 283:16682-92. 2008.... - Cellular changes that accompany shedding of human corneocytesTzu Kai Lin
Department of Veterans Affairs Medical Center and Department of Dermatology, Dermatology Service, University of California, San Francisco, San Francisco, California, USA
J Invest Dermatol 132:2430-9. 2012..Hydration also provoked degradation of membranes by activating contiguous acidic ceramidase activity. Together, these studies identify several parallel mechanisms that orchestrate exfoliation from the surface of normal human skin... - Structural changes in epidermal scale and appendages as indicators of defective TGM1 activityRobert H Rice
Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616 8588, USA
Arch Dermatol Res 297:127-33. 2005.... - Glucosylceramide synthesis and synthase expression protect against ceramide-induced stressYoshikazu Uchida
Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
J Lipid Res 43:1293-302. 2002..Thus, SMase-induced stress initiates a response in keratinocytes that includes upregulation of GlcCer synthesis which may protect against the deleterious effects of excess Cer... - A murine model of isolated cardiac steatosis leads to cardiomyopathyDENIS J GLENN
Department of Medicine and Diabetes Center, University of California at San Francisco, San Francisco, CA 94143 0540, USA
Hypertension 57:216-22. 2011..These findings suggest that triglyceride accumulation, in the absence of systemic metabolic derangement, results in cardiac dysfunction and decreased mitochondrial biogenesis... - Epidermal sphingolipids: metabolism, function, and roles in skin disordersWalter M Holleran
Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA
FEBS Lett 580:5456-66. 2006..Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review... - Human epidermal glucosylceramides are major precursors of stratum corneum ceramidesSumiko Hamanaka
Sphingolipid Expression Laboratory, Supra-Biomolecular System Research, RIKEN Frontier Research System, Wako, Japan
J Invest Dermatol 119:416-23. 2002.... - Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like featuresMariko Hara-Chikuma
Basic Research Laboratory, Kanebo Ltd, 5 chome Kotobuki cho, Odawara shi, Kanagawa ken 250 0002, Japan
J Invest Dermatol 123:464-9. 2004.... - Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermisEvi Houben
Department of Toxicology, Dermato Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium
J Lipid Res 47:1063-70. 2006.... - Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal deathVidyullatha Vasireddy
Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
Hum Mol Genet 16:471-82. 2007..These findings demonstrate that ELOVL4 is required for generating VLFA critical for epidermal barrier function, and that the lack of epidermal omega-O-acylceramides is incompatible with survival in a desiccating environment... - Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesisKhemissa Bejaoui
Day Neuromuscular Research Laboratory, Charlestown, Massachusetts, USA
J Clin Invest 110:1301-8. 2002..These results indicate that the HSN1-associated mutations in LCB1 confer dominant negative effects on the SPT enzyme... - Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cellsYoshikazu Uchida
Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Cancer Res 64:6271-9. 2004..Together, the results suggest that transcriptional up-regulation of GCS through DOX-induced activation of Sp1 is one potential mechanism to regulate ceramide increase and apoptosis in HL-60/ADR cells... - A homolog of Drosophila grainy head is essential for epidermal integrity in miceStephen B Ting
Rotary Bone Marrow Research Laboratories, c o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050
Science 308:411-3. 2005..These findings suggest that the functional mechanisms involving protein cross-linking that maintain the epidermal barrier and induce tissue repair are conserved across 700 million years of evolution...
Research Grants
- Epidermal Mechanisms Opposing Ceramide-Induced ApoptosisYoshikazu Uchida; Fiscal Year: 2009....