Aliye Uc

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Pancreatic and biliary secretion are both altered in cystic fibrosis pigs
    Aliye Uc
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 303:G961-8. 2012
  2. doi request reprint Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers
    Aliye Uc
    Department of Pediatrics, University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Pediatr Gastroenterol Nutr 54:471-6. 2012
  3. doi request reprint Metabolism of haem in Caco-2 cells
    Aliye Uc
    Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Physiol 95:296-303. 2010
  4. ncbi request reprint Treatment of Helicobacter pylori gastritis improves dyspeptic symptoms in children
    Aliye Uc
    Betton Clinic, Little Rock, Arkansas, USA
    J Pediatr Gastroenterol Nutr 34:281-5. 2002
  5. ncbi request reprint Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes
    Aliye Uc
    The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 292:C1906-14. 2007
  6. pmc Functional gastrointestinal disorders in African American children in primary care
    Aliye Uc
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Pediatr Gastroenterol Nutr 42:270-4. 2006
  7. ncbi request reprint Hemin induces active chloride secretion in Caco-2 cells
    Aliye Uc
    2865 JPP Pediatrics, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 289:G202-8. 2005
  8. ncbi request reprint Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process
    Aliye Uc
    Department of Pediatrics, Veterans Administration Medical Center, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1150-7. 2004
  9. ncbi request reprint Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells
    Aliye Uc
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Dig Dis Sci 48:2353-9. 2003
  10. ncbi request reprint Does heme oxygenase-1 have a role in Caco-2 cell cycle progression?
    Aliye Uc
    Department of Pediatrics and Internal Medicine, Veterans Administration Medical Center and University of Iowa, Iowa City, 52242, USA
    Exp Biol Med (Maywood) 228:590-5. 2003

Collaborators

Detail Information

Publications18

  1. pmc Pancreatic and biliary secretion are both altered in cystic fibrosis pigs
    Aliye Uc
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Gastrointest Liver Physiol 303:G961-8. 2012
    ..These results indicate that pancreatic and biliary secretions are altered in CF pigs. Abnormal pancreatic and biliary secretion in CF may have important implications in disease pathogenesis...
  2. doi request reprint Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers
    Aliye Uc
    Department of Pediatrics, University of Iowa Carver College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Pediatr Gastroenterol Nutr 54:471-6. 2012
    ..The objective of our study is to examine the protective effects of an antioxidant and anti-inflammatory enzyme, heme oxygenase-1 (HO-1), in NSAID-induced gastric injury...
  3. doi request reprint Metabolism of haem in Caco-2 cells
    Aliye Uc
    Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Physiol 95:296-303. 2010
    ..We conclude that Caco-2 cells metabolize haem and export its metabolic product, bilirubin, principally to the lumen, where it may exert antioxidant and anti-inflammatory functions...
  4. ncbi request reprint Treatment of Helicobacter pylori gastritis improves dyspeptic symptoms in children
    Aliye Uc
    Betton Clinic, Little Rock, Arkansas, USA
    J Pediatr Gastroenterol Nutr 34:281-5. 2002
    ..The purpose of this study was to determine whether treatment of H. pylori gastritis would improve symptoms of dyspepsia in children...
  5. ncbi request reprint Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes
    Aliye Uc
    The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 292:C1906-14. 2007
    ..These novel effects of SnPP-photosensitized oxidation may also lead to a new understanding of how intestinal Cl(-) secretion can be regulated by the redox environment of the cell...
  6. pmc Functional gastrointestinal disorders in African American children in primary care
    Aliye Uc
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Pediatr Gastroenterol Nutr 42:270-4. 2006
    ..To determine the prevalence of functional gastrointestinal disorders (FGIDs) in a primary care setting and to assess the usefulness of pediatric Rome criteria...
  7. ncbi request reprint Hemin induces active chloride secretion in Caco-2 cells
    Aliye Uc
    2865 JPP Pediatrics, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 289:G202-8. 2005
    ..These effects are probably the consequence of CO formation. Heme and CO may be important regulators of intestinal fluid-electrolyte homeostasis...
  8. ncbi request reprint Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process
    Aliye Uc
    Department of Pediatrics, Veterans Administration Medical Center, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1150-7. 2004
    ..Trypsin applied to the apical surface increased hemin absorption, suggesting that protease activity can uncover a process for heme uptake that is otherwise quiescent. These processes may be involved in preventing iron overload in humans...
  9. ncbi request reprint Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells
    Aliye Uc
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Dig Dis Sci 48:2353-9. 2003
    ..Peroxynitrite abolished EGF-stimulated receptor autophosphorylation and nitrated EGF receptor tyrosine residues. Peroxynitrite generated during inflammation may disrupt the EGF-induced signaling in intestinal epithelial cells...
  10. ncbi request reprint Does heme oxygenase-1 have a role in Caco-2 cell cycle progression?
    Aliye Uc
    Department of Pediatrics and Internal Medicine, Veterans Administration Medical Center and University of Iowa, Iowa City, 52242, USA
    Exp Biol Med (Maywood) 228:590-5. 2003
    ..SnPP decreased the cell number and viability of preconfluent cells and delayed the ALP enzyme activity of confluent cells. HO-1 may be involved in intestinal cell cycle progression...
  11. pmc Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways
    Maisam Abu-El-Haija
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Am J Pathol 181:499-507. 2012
    ..Proinflammatory, complement cascade, proapoptotic, and profibrotic pathways are activated in CF pig pancreas, and likely contribute to the destructive process...
  12. pmc The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs
    Lynda S Ostedgaard
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 3:74ra24. 2011
    ..These findings help elucidate the molecular pathogenesis of the common CF mutation and will guide strategies for developing new therapeutics...
  13. pmc Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
    David A Stoltz
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Sci Transl Med 2:29ra31. 2010
    ....
  14. pmc Simplified and versatile method for isolation of high-quality RNA from pancreas
    Michelle Griffin
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Biotechniques 52:332-4. 2012
    ..In addition, when compared to the previously reported in situ ductal perfusion technique, our method does not cause histological artifacts...
  15. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
    ..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment...
  16. pmc An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis
    Maisam Abu-El-Haija
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pancreatology 11:506-15. 2011
    ..Although inflammatory cells have been detected in the pancreas of humans and pigs with CF, their subtypes have not been characterized...
  17. ncbi request reprint Polyethylene glycol 3350 without electrolytes: a new safe, effective, and palatable bowel preparation for colonoscopy in children
    Dinesh S Pashankar
    Division of Gastroenterology, Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    J Pediatr 144:358-62. 2004
    ..Stool frequency and adverse effects were monitored during PEG therapy. Compliance, tolerance, and quality of colonic preparation were assessed. Serum electrolytes were measured before and after PEG therapy in 29 children...
  18. ncbi request reprint Is recurrent abdominal pain of childhood a psychosomatic disorder?
    Aliye Uc
    University of Iowa, College of Medicine, Iowa City, USA
    J Pediatr Gastroenterol Nutr 39:571-2. 2004

Research Grants4

  1. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    Project Summary: In this proposal, Dr. Aliye Uc is seeking a RO3 award to expand on her studies of intestinal heme uptake and transport mechanisms initiated under her KO8 grant, DK-63135. With the support of her KO8 funding, Dr...
  2. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  3. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2009
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  4. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..