Yulia Y Tyurina

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Characterization of cardiolipins and their oxidation products by LC-MS analysis
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Electronic address
    Chem Phys Lipids 179:3-10. 2014
  2. pmc LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Nutr Food Res 57:1410-22. 2013
  3. pmc Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 586:235-41. 2012
  4. pmc Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Dept of Environmental and Occupational Health, Univ of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA
    Am J Physiol Lung Cell Mol Physiol 299:L73-85. 2010
  5. pmc Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    ACS Nano 5:7342-53. 2011
  6. pmc Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA, USA
    Radiat Res 175:610-21. 2011
  7. ncbi request reprint Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation
    Yulia Y Tyurina
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 279:6056-64. 2004
  8. ncbi request reprint NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearance
    Antonio Arroyo
    Department of Environmental and Occupational Health, Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Biol Chem 277:49965-75. 2002
  9. ncbi request reprint The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells
    Alexander A Kapralov
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, PA 15260, USA
    Biochemistry 46:14232-44. 2007
  10. ncbi request reprint Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants
    Mitchell P Fink
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:S461-7. 2007

Collaborators

Detail Information

Publications69

  1. doi request reprint Characterization of cardiolipins and their oxidation products by LC-MS analysis
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA Electronic address
    Chem Phys Lipids 179:3-10. 2014
    ..LC-MS-based oxidative lipidomics with high mass accuracy instrumentation as well as new software packages are promising in achieving the goals of expedited and reliable analysis of cardiolipin oxygenated species in biosamples. ..
  2. pmc LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: implications for mitochondrial dysfunction associated with Parkinson's disease
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Mol Nutr Food Res 57:1410-22. 2013
    ..Rotenone is a toxicant believed to contribute to the development of Parkinson's disease...
  3. pmc Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    FEBS Lett 586:235-41. 2012
    ..This caused suppression of apoptosis induced by actinomycin D. Triacsin C, an inhibitor of acyl-CoA synthase, blocked integration of oleic acid into cardiolipin and restored cell sensitivity to apoptosis...
  4. pmc Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Dept of Environmental and Occupational Health, Univ of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA
    Am J Physiol Lung Cell Mol Physiol 299:L73-85. 2010
    ....
  5. pmc Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    ACS Nano 5:7342-53. 2011
    ....
  6. pmc Oxidative lipidomics of γ-radiation-induced lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA, USA
    Radiat Res 175:610-21. 2011
    ....
  7. ncbi request reprint Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation
    Yulia Y Tyurina
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 279:6056-64. 2004
    ....
  8. ncbi request reprint NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearance
    Antonio Arroyo
    Department of Environmental and Occupational Health, Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Biol Chem 277:49965-75. 2002
    ....
  9. ncbi request reprint The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells
    Alexander A Kapralov
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, PA 15260, USA
    Biochemistry 46:14232-44. 2007
    ....
  10. ncbi request reprint Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants
    Mitchell P Fink
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 35:S461-7. 2007
    ..Compounds like XJB-5-131 warrant further evaluation for the treatment of hemorrhagic shock as well as other acute conditions associated with increased mitochondrial production of ROS...
  11. ncbi request reprint Oxidation of phosphatidylserine: a mechanism for plasma membrane phospholipid scrambling during apoptosis?
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biochem Biophys Res Commun 324:1059-64. 2004
    ..PSox did not inhibit APT. Rate of transmembrane PS diffusion was fourfold higher in cells with integrated PSox than with PS. Thus, PSox acts as a "non-enzymatic scramblase" likely contributing to PS externalization...
  12. ncbi request reprint Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis
    Natalia A Belikova
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Radiat Oncol Biol Phys 69:176-86. 2007
    ..To determine whether cytochrome c (cyt c) content and associated cardiolipin oxidation can be determinants of cell sensitivity to irradiation-induced apoptosis...
  13. pmc Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, PA 15219, USA
    Adv Drug Deliv Rev 61:1375-85. 2009
    ..Particular emphasis is placed on the employment of triphenylphosphonium- and hemi-gramicidin S-moieties as two effective vehicles for mitochondrial delivery of antioxidants...
  14. pmc Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219 9361, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2863-72. 2009
    ....
  15. ncbi request reprint Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants
    Mitchell P Fink
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States
    Biochem Pharmacol 74:801-9. 2007
    ..One of these hemigramicidin-TEMPO conjugates, XJB-5-131, has been shown to ameliorate intestinal mucosal injury and prolong survival in rats subjected to lethal hemorrhage...
  16. ncbi request reprint Vitamin E inhibits anti-Fas-induced phosphatidylserine oxidation but does not affect its externalization during apoptosis in Jurkat T cells and their phagocytosis by J774A.1 macrophages
    Behice F Serinkan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, U S A
    Antioxid Redox Signal 6:227-36. 2004
    ..1 macrophages. We conclude that vitamin E does not significantly interfere with extrinsic (death receptor-triggered) pathways of apoptosis and does not affect phagocytosis of anti-Fas-triggered apoptotic cells...
  17. ncbi request reprint The plasma membrane is the site of selective phosphatidylserine oxidation during apoptosis: role of cytochrome C
    Yulia Y Tyurina
    Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Antioxid Redox Signal 6:209-25. 2004
    ..Selective plasma membrane-based PS oxidation and subsequent externalization during oxidant-induced apoptosis may be mediated through the redox activity of cytochrome c...
  18. ncbi request reprint Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells
    Jianfei Jiang
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurochem 90:1036-49. 2004
    ..Thus, COX-2 generated carbon-centered radicals but not oxygen radicals or thiyl radicals are responsible for oxidative stress in AA-challenged PC12 cells overexpressing COX-2...
  19. pmc Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease
    Hulya Bayir
    Center for Free Radical and Antioxidant Health, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 3130, USA
    J Biol Chem 284:15951-69. 2009
    ..This immediate protective function of Syn is associated with the formation of the peroxidase complex representing a source of oxidative stress and postponed damage...
  20. ncbi request reprint Mechanisms of cardiolipin oxidation by cytochrome c: relevance to pro- and antiapoptotic functions of etoposide
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of EOH, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA
    Mol Pharmacol 70:706-17. 2006
    ..Thus, oxidation of cardiolipin by the cytochrome c/cardiolipin peroxidase complex, which is essential for apoptosis, is not inhibited by proapoptotic concentrations of the drug...
  21. doi request reprint Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 610:353-74. 2010
    ..This has important implications for evaluation of apoptosis in vivo. The anionic phospholipids, cardiolipin (CL) and phosphatidylserine (PS), are the preferred peroxidation substrates...
  22. pmc Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA, USA
    J Neurochem 107:1614-33. 2008
    ..These oxidation products participate in mitochondrial membrane permeability transition and in PtdSer externalization leading to recognition and uptake of apoptotic cells by professional phagocytes...
  23. pmc Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury
    Jing Ji
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 15:1407-13. 2012
    ..We conclude that cardiolipin oxygenation generates neuronal death signals and that prevention of it by mitochondria-targeted small molecule inhibitors represents a new target for neuro-drug discovery...
  24. pmc Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids
    Jing Ji
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 29:776-88. 2012
    ..The delayed emergence of apoptotic neuronal death after the immediate mechanical damage to mitochondria suggests a possible window of opportunity for targeted therapies...
  25. doi request reprint Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Methods Mol Biol 580:153-83. 2009
    ..The protocols described may be utilized in studies of signaling functions of oxidized phospholipids in cell physiology and pathology...
  26. ncbi request reprint Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Brain Res 1093:71-82. 2006
    ..Thus, we conclude that both peroxidase and cyclooxygenase half-cycles of COX-2-catalyzed reactions are essential for COX-2-dependent activation of 6-OHDA oxidation, oxygen radical production, oxidative stress, and cytotoxicity...
  27. pmc Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
    Free Radic Biol Med 46:1439-53. 2009
    ..Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with antiapoptotic effects are presented...
  28. pmc Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes
    Alexandr A Kapralov
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Biochim Biophys Acta 1808:2147-55. 2011
    ..Thus, the highly conserved Tyr67 is a likely electron-donor (radical acceptor) in the oxygenase half-reaction of the cyt c/CL peroxidase complex...
  29. ncbi request reprint Cytochrome c release is required for phosphatidylserine peroxidation during Fas-triggered apoptosis in lung epithelial A549 cells
    Jianfei Jiang
    Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Lipids 39:1133-42. 2004
    ..Overall, we concluded that cyt c acts as a catalyst of PtdSer oxidation during Fas-triggered A549 cell apoptosis...
  30. pmc Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin
    Alejandro K Samhan-Arias
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
    Biochim Biophys Acta 1818:2413-23. 2012
    ..This article is part of a Special Issue entitled: Oxidized phospholipids - their properties and interactions with proteins...
  31. ncbi request reprint Quantification of selective phosphatidylserine oxidation during apoptosis
    James P Fabisiak
    Department of Environmental and Occupational Health, University of Pittsburgh, PA, USA
    Methods Mol Biol 291:449-56. 2005
    ..These experimental approaches can provide insight into the roles and mechanisms of PS oxidation in the identification and clearance of apoptotic cells...
  32. ncbi request reprint Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Int J Radiat Oncol Biol Phys 58:851-61. 2004
    ....
  33. ncbi request reprint Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis
    Hulya Bayir
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Neurol 62:154-69. 2007
    ..Enhanced lipid peroxidation is well established in traumatic brain injury. However, its molecular targets, identity of peroxidized phospholipid species, and their signaling role have not been deciphered...
  34. ncbi request reprint Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Chem Biol 1:223-32. 2005
    ..These results provide insight into the role of reactive oxygen species in triggering the cell-death pathway and describe an early role for cytochrome c before caspase activation...
  35. ncbi request reprint Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria
    Jianfei Jiang
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Free Radic Biol Med 35:814-25. 2003
    ....
  36. pmc Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo
    Nagarjun V Konduru
    Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e4398. 2009
    ..Thus, PS-coating can be utilized for targeted delivery of SWCNT with specified cargoes into professional phagocytes, hence for therapeutic regulation of specific populations of immune-competent cells...
  37. ncbi request reprint Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?
    Martin Modriansky
    Department of Environmental and Occupational Health, University of Pittsburgh, FORBL Room 234, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Toxicology 177:105-17. 2002
    ..However, the latter retain high reactivity towards critical biomolecules in cells such as lipids, thiols, ascorbate, thereby, rendering colchicine metabolites effective radical scavengers but not effective chain-breaking antioxidants...
  38. pmc Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Mol Nutr Food Res 53:104-14. 2009
    ..Therefore, mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes and suppression of CL peroxidation represent new strategies in anti-apoptotic drug discovery...
  39. ncbi request reprint Glutathione propagates oxidative stress triggered by myeloperoxidase in HL-60 cells. Evidence for glutathionyl radical-induced peroxidation of phospholipids and cytotoxicity
    Grigory G Borisenko
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 279:23453-62. 2004
    ..Thus, GSH, commonly viewed as a universal free radical scavenger and major intracellular antioxidant, acts as a pro-oxidant during myeloperoxidase-catalyzed metabolism of phenol in HL-60 cells...
  40. pmc A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death
    Jeffrey Atkinson
    Center for Free Radical and Antioxidant Health and Center for Medical Countermeasures against Radiation, University of Pittsburgh, Bridgeside Point, Pennsylvania 15219, USA
    Nat Commun 2:497. 2011
    ..Significant radioprotective/radiomitigative effects of imidazole-substituted oleic acid are observed after pretreatment of mice from 1 h before through 24 h after the irradiation...
  41. ncbi request reprint Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, Pittsburgh, PA 15260, USA
    Free Radic Biol Med 37:1963-85. 2004
    ..We also show that this new concept is compatible with a leading role for reactive oxygen species in the execution of the apoptotic program, with cyt c as the main executioner...
  42. ncbi request reprint Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, and Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 282:8498-509. 2007
    ..scavenger, DAF-2. Thus, macrophage-induced nitrosylation/oxidation plays an important role in cell clearance, and hence in the resolution of inflammation...
  43. pmc Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
    Charleen T Chu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Cell Biol 15:1197-205. 2013
    ..These data indicate that redistribution of cardiolipin serves as an 'eat-me' signal for the elimination of damaged mitochondria from neuronal cells. ..
  44. doi request reprint Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation
    Valerian E Kagan
    Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Nanotechnol 5:354-9. 2010
    ..Our findings suggest that the extent to which carbon nanotubes are biodegraded may be a major determinant of the scale and severity of the associated inflammatory responses in exposed individuals...
  45. ncbi request reprint Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats
    Rainer Kentner
    Department of Anesthesiology Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pennsylvania 15260, USA
    J Trauma 53:968-77. 2002
    ..We hypothesized that the combination of free Tempol with polynitroxylated albumin (PNA)-bound Tempol (which prolongs half-life and decreases toxicity) improves outcome after HS in rats...
  46. pmc A mitochondria-targeted triphenylphosphonium-conjugated nitroxide functions as a radioprotector/mitigator
    Jianfei Jiang
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Radiat Res 172:706-17. 2009
    ..We conclude that mitochondrial targeting of TPP-conjugated nitroxides represents a promising approach for the development of novel radioprotectors...
  47. ncbi request reprint MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute and School of Environmental Health, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    In Vivo 19:997-1004. 2005
    ..The biochemical combination of superoxide and nitric oxide radicals forms peroxynitrite, a potent oxidant known to induce lipid peroxidation...
  48. pmc Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock
    Carlos A Macias
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg 245:305-14. 2007
    ..We sought to develop a therapeutic agent that would permit prolongation of survival in rats subjected to lethal hemorrhagic shock (HS), even in the absence of resuscitation with asanguinous fluids or blood...
  49. doi request reprint Oxidative lipidomics of gamma-irradiation-induced intestinal injury
    Yulia Y Tyurina
    Center for Medical Countermeasures Against Radiation, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Free Radic Biol Med 44:299-314. 2008
    ....
  50. pmc Cytoprotective effects of albumin, nitrosated or reduced, in cultured rat pulmonary vascular cells
    Hui Hua Li
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Lung Cell Mol Physiol 300:L526-33. 2011
    ....
  51. ncbi request reprint Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols
    Detcho A Stoyanovsky
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Chem Soc 127:15815-23. 2005
    ..We conclude that both thioredoxin and dihydrolipoic acid may be involved in the regulation of cellular S-nitrosothiols...
  52. doi request reprint Oxidative lipidomics of programmed cell death
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Methods Enzymol 442:375-93. 2008
    ..We conclude that oxidative lipidomics is a powerful technique to study lipid oxidation and its role in cell death across a spectrum of tissues and insults...
  53. pmc The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury
    Wenjin Li
    Geriatric Research Educational and Clinical Center, VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, Pennsylvania 15205, USA
    J Neurochem 113:965-77. 2010
    ..Taken together, these results indicate that the cyclooxygenase activity of COX-2 is necessary to exacerbate neuronal hypoxia/ischemia injury rather than the peroxidase activity of the enzyme...
  54. doi request reprint Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria
    Natalia A Belikova
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, 100 Technology Drive, Suite 350, Pittsburgh, Pennsylvania 15219 3130, USA
    J Am Chem Soc 131:11288-9. 2009
    ..Regulation of FFA-OOH metabolism may be an important function of cyt c that is associated with elimination of toxic FFA-OOH and synthesis of physiologically active hydroxy-fatty acids in mitochondria...
  55. ncbi request reprint Depletion of Bcl-2 by an antisense oligonucleotide induces apoptosis accompanied by oxidation and externalization of phosphatidylserine in NCI-H226 lung carcinoma cells
    Patrick P Koty
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, PA, USA
    Mol Cell Biochem 234:125-33. 2002
    ..This observed externalization of PS may facilitate the 'labeling' of apoptotic cells for recognition by macrophage scavenger receptors and subsequent phagocytic clearance...
  56. pmc A high-throughput screening assay of ascorbate in brain samples
    Natalia A Belikova
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Neurosci Methods 201:185-90. 2011
    ..Assay was validated with high performance liquid chromatography method. The concentration of ascorbate in murine tissue samples, including brain samples after traumatic brain injury and hemorrhagic shock, was measured...
  57. ncbi request reprint A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis
    Valerian E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Immunol 169:487-99. 2002
    ..Taken together, our data suggest that the presence of PS-OX in conjunction with nonoxidized PS on the cell surface is an important signal for macrophage clearance of apoptotic cells...
  58. ncbi request reprint The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress
    Yulia Y Tyurina
    Pediatric Center for Neuroscience, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Aging Cell 4:187-96. 2005
    ....
  59. pmc Specificity of lipoprotein-associated phospholipase A(2) toward oxidized phosphatidylserines: liquid chromatography-electrospray ionization mass spectrometry characterization of products and computer modeling of interactions
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Biochemistry 51:9736-50. 2012
    ....
  60. pmc The enzymatic oxidation of graphene oxide
    Gregg P Kotchey
    Department of Chemistry, University of Pittburgh, Pittsburgh, PA 15260, USA
    ACS Nano 5:2098-108. 2011
    ..This p-type behavior rendered hRGO, which can be conceptualized as interconnected graphene nanoribbons, as a potentially attractive material for FET sensors...
  61. ncbi request reprint Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling
    Yulia Y Tyurina
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Methods Enzymol 352:159-74. 2002
  62. ncbi request reprint Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children
    Hulya Bayir
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatr Res 51:571-8. 2002
    ..Progressive compromise of antioxidant defenses and evidence of free radical-mediated lipid peroxidation are noted. These markers could be used to monitor antioxidant strategies in clinical trials...
  63. ncbi request reprint Quantitation of S-nitrosothiols in cells and biological fluids
    Vladimir A Tyurin
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Methods Enzymol 352:347-60. 2002
  64. pmc Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals
    Vladimir A Tyurin
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Biochem Biophys Res Commun 413:149-53. 2011
    ....
  65. doi request reprint N-acetylcysteine does not prevent hepatorenal ischaemia-reperfusion injury in patients undergoing orthotopic liver transplantation
    Ibtesam A Hilmi
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
    Nephrol Dial Transplant 25:2328-33. 2010
    ..N-acetylcysteine (NAC) replenishes GSH stores. The aims of this study were to evaluate the efficacy of NAC in improving liver graft performance and reducing the incidence of post-operative acute kidney injury (AKI)...
  66. doi request reprint Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer
    Michael R Shurin
    Department of Pathology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Cancer Res 69:2487-96. 2009
    ..Thus, labeling of tumors with phosphatidylserine is a promising strategy for cancer immunotherapy...
  67. ncbi request reprint Antioxidants and coronary artery disease among individuals with type 1 diabetes: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study
    Tina Costacou
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Diabetes Complications 20:387-94. 2006
    ..Oxidative stress has been implicated in the development of diabetes and cardiovascular disease. We evaluated the effect of serum antioxidants and total antioxidant reserve (TAR) on coronary artery disease (CAD) incidence in type 1 diabetes...
  68. pmc Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation
    Alejandro K Samhan-Arias
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, PA, USA
    J Clin Biochem Nutr 48:91-5. 2011
    ....
  69. ncbi request reprint Antioxidant Tempol enhances hypothermic cerebral preservation during prolonged cardiac arrest in dogs
    Wilhelm Behringer
    Safar Center for Resuscitation Research, Department of Anesthesiology Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Cereb Blood Flow Metab 22:105-17. 2002
    ..The mechanisms involved in this beneficial effect need further clarification...