Research Topics
Genomes and GenesSpecies | S TyringSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Publications
Detection of human papillomavirus in cutaneous clear cell squamous cell carcinoma in situ: viral-associated oncogenesis may contribute to the development of this pathologic variant of skin cancerPhilip R Cohen
J Cutan Pathol 35:513-4. 2008- A randomized, double-blind trial of famciclovir versus acyclovir for the treatment of localized dermatomal herpes zoster in immunocompromised patientsS Tyring
University of Texas Medical Branch, Galveston, TX 77555, USA
Cancer Invest 19:13-22. 2001..Treatment with famciclovir was well tolerated, with a safety profile comparable to that of acyclovir. Thus oral famciclovir is a convenient, effective, and well-tolerated regimen for immunocompromised patients with herpes zoster... - Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trialsStephen K Tyring
University of Texas Medical Branch, Galveston, USA
J Cutan Med Surg 7:449-54. 2003..Genital herpes is a very common sexually transmitted disease. Safe and effective therapies are needed for patients with frequent recurrences... - Vulvar squamous cell carcinoma: guidelines for early diagnosis and treatmentStephen K Tyring
UTMB Center for Clinical Studies, University of Texas Medical Branch, 301 University Boulevard, Route 1070, Galveston, TX 77555, USA
Am J Obstet Gynecol 189:S17-23. 2003..This review discusses the etiology, clinical characteristics, and diagnostic staging of vulvar SCC. Treatment options are reviewed, including novel topical immunotherapies such as imiquimod... - Molluscum contagiosum: the importance of early diagnosis and treatmentStephen K Tyring
UTMB Center for Clinical Studies, University of Texas Medical Branch, 301 University Boulevard, Route 1070, Galveston, TX 77555, USA
Am J Obstet Gynecol 189:S12-6. 2003..This review summarizes the clinical diagnosis of molluscum contagiosum and provides a critical assessment of several current and emerging treatment options... - Imiquimod; an international update on therapeutic uses in dermatologyStephen Tyring
Department of Dermatology, University of Texas Medical Branch, Galveston, TX 77555, USA
Int J Dermatol 41:810-6. 2002..These properties highlight the potential of imiquimod not only as an effective treatment for genital warts, but also as a treatment for other cutaneous viral infections and cutaneous neoplasms... - Valacyclovir for herpes simplex virus infection: long-term safety and sustained efficacy after 20 years' experience with acyclovirStephen K Tyring
University of Texas Medical Branch, Galveston, Texas 77555, USA
J Infect Dis 186:S40-6. 2002..Extensive sensitivity monitoring of HSV isolates confirmed a very low rate of acyclovir resistance among immunocompetent subjects (<0.5%). The incidence of resistance among immunocompromised patients remains low at about 5%... 
Famciclovir for ophthalmic zoster: a randomised aciclovir controlled studyS Tyring
University of Texas Medical Branch, Galveston, TX, USA
Br J Ophthalmol 85:576-81. 2001..There was no significant difference between groups for visual acuity loss. CONCLUSION: Famciclovir 500 mg three times daily was well tolerated and demonstrated efficacy similar to aciclovir 800 mg five times daily...- Effect of imiquimod in anogenital warts from HIV-positive menSilvia Herrera
GRID, Dermatology Section, Department of Internal Medicine, University of Antioquia, Medellin, Colombia
J Clin Virol 39:210-4. 2007..HIV-positive patients have unpredictable local immune responses even with severe systemic immunosuppression and data reported to date is insufficient to predict the effect of imiquimod in HIV-positive patients... - Human papillomaviruses and genital diseaseAmmar M Ahmed
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dermatol Clin 24:157-65, vi. 2006..The authors conclude with the latest information on prophylactic vaccine development and prospects for future control of HPV-related disease... - Actinic keratoses: sequelae and treatments. Recommendations from a consensus panelBrian Berman
Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida, USA
J Fam Pract 55:suppl 1-8. 2006 - Regulation of adrenal glucocorticoid synthesis by interleukin-10: a preponderance of IL-10 receptor in the adrenal zona fasciculataNina Koldzic-Zivanovic
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
Brain Behav Immun 20:460-8. 2006..These data demonstrate that IL-10 could play an important role in the regulation of glucocorticoid biosynthesis and in maintenance of homeostasis and immunity during periods of stress... - Human papillomavirus infection and P53 codon 72 genotypes in a Hispanic population at high-risk for cervical cancerAndrea L Fuessel Haws
Department of Microbiology, University of Texas Medical Branch, Galveston, TX 77030, USA
J Med Virol 77:265-72. 2005..These data are further evidence that in this underserved population HPV infections are associated with high rates of malignancy, but that host p53 genotypic variations are unlikely to be primary factors in oncogenesis... - Altered expression of myocilin in the brain of a mouse model for phenylketonuria (PKU)Sankar Surendran
Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555 0632, USA
Neurosci Lett 382:323-6. 2005..These data suggest that PAH defect alters other genes expression likely to contribute neurophysiological abnormalities seen in the mouse, if documented also in patients with PKU... - Aspartoacylase gene knockout in the mouse: impact on reproductionSankar Surendran
Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
Reprod Toxicol 20:281-3. 2005..KO/KO mothers mated with KO/+ males showed fetal death. KO/KO mothers produced fewer offspring compared to KO/+ mothers. These data suggest that ASPA is necessary for normal reproduction and postnatal survival... - Viral and nonviral uses of imiquimod: a reviewAditya K Gupta
Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
J Cutan Med Surg 8:338-52. 2004..This drug has been recently approved for the treatment of actinic keratoses and superficial basal cell carcinoma. There is a growing body of evidence for its effectiveness in treating a variety of other skin conditions... - Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: possible role on cognitive defect seen in PKUSankar Surendran
Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555 0632, USA
Neurochem Int 46:595-9. 2005..These changes in the PKU mouse brain are likely to contribute cognitive impairment seen in the PKU mouse, if documented also in patients with PKU... - Molecular diagnosis of cutaneous diseasesKaran K Sra
Center for Clinical Studies, Houston, TX, USA
Arch Dermatol 141:225-41. 2005.... - Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouseSankar Surendran
Department of Pediatrics, The University of Texas Medical Branch, Childrens Hospital, 301 University Boulevard, Galveston, TX 77555 0359, USA
Neurobiol Dis 18:385-9. 2005.... - HLA-DQB1 and cervical cancer in Venezuelan womenDat D Dao
Houston Advanced Research Center HARC, The Woodlands, TX 77381, USA
Gynecol Oncol 96:349-54. 2005..The role of the HLA system in presenting peptides to antigen-specific T-cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma... - Upregulation of aspartoacylase activity in the duodenum of obesity induced diabetes mouse: implications on diabetic neuropathySankar Surendran
Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX, USA
Biochem Biophys Res Commun 345:973-5. 2006.... - Valacyclovir for the treatment of genital herpesJulie S Brantley
The University of Texas Medical Branch, Department of Dermatology, 301 University Boulevard, Galveston, TX 77555 0783, USA
Expert Rev Anti Infect Ther 4:367-76. 2006..The less frequent dosing regimen makes it an attractive option in the treatment of genital herpes and other viral infections, and may contribute to increased patient adherence to therapy... - Managing herpes zoster in immunocompromised patientsAmmar M Ahmed
Baylor College of Medicine, Houston, TX, USA
Herpes 14:32-6. 2007..Appropriate analgesic therapy should be combined with early antiviral treatment to reduce the incidence and severity of acute zoster pain and post-herpetic neuralgia... - Varicella-zoster virus in the saliva of patients with herpes zosterSatish K Mehta
Enterprise Advisory Services, Inc, USA
J Infect Dis 197:654-7. 2008..Analysis of human saliva has potential usefulness in the diagnosis of neurological disease produced by VZV without rash... - Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trialKaren E Mark
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 195:1324-31. 2007..In animal models, induction of Th1-specific responses modifies experimental herpes simplex virus (HSV) infection... - Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER2 mutation with imiquimodCindy Berthelot
Medical School, University of Texas Southwestern Medical Center at Dallas, USA
J Am Acad Dermatol 56:882-6. 2007..EV may be caused by mutations of the genes EVER1 or EVER2, which are located on the EV1 locus, 17q25. We describe a patient with EV and a novel homozygous gene mutation of EVER2 gene who was treated successfully with topical imiquimod... - Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis originHuolin Tu
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
Cell Mol Neurobiol 27:161-70. 2007..Little is known, however, about IL-10's functions in the HPA axis... - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - Novel homozygous frameshift mutation of EVER1 gene in an epidermodysplasia verruciformis patientMichael D Gober
Department of Dermatology, University of Maryland, Medical Center, Baltimore, Maryland 21201, USA
J Invest Dermatol 127:817-20. 2007..This is the third report on the presence of EVER1 mutations in an EV patient, and this result supports better understanding, diagnosis, and genetic counseling of EV patients... - Hyaluronidase increases the biodistribution of acid alpha-1,4 glucosidase in the muscle of Pompe disease mice: an approach to enhance the efficacy of enzyme replacement therapyReuben Matalon
Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555 0359, USA
Biochem Biophys Res Commun 350:783-7. 2006..These studies suggest that hyase enhances penetration of enzyme into the tissues including muscle during ERT and therefore hyase pretreatment may be important in treating Pompe disease... - Physiological role of N-acetylaspartate: contribution to myelinogenesisRobert W Ledeen
Dept. Neurology and Neurosciences, New Jersey Medical School, UMDNJ, 185 So. Orange Ave, Newark, NJ 07103, USA
Adv Exp Med Biol 576:131-43; discussion 361-3. 2006 - Canavan disease: studies on the knockout mouseReuben Matalon
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA
Adv Exp Med Biol 576:77-93; discussion 361-3. 2006..Adenoassociated virus mediated gene transfer and stem cell therapy in the knockout mouse are the latest attempts to alter pathophysiology in the CD mouse... 
Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reactionS David Hudnall
Department of Pathology and Laboratory Medicine, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
Transfusion 48:1180-7. 2008..Also, blood-borne herpesvirus from healthy persistently infected blood donors can lead to active primary infection of immunocompromised transfusion recipients...- Emerging therapies for herpes viral infections (types 1 - 8)Arun Chakrabarty
Solano Clinical Research, Davis, California, USA
Expert Opin Emerg Drugs 9:237-56. 2004..The new helicase primase inhibitors, which are the first non-nucleoside antiviral compounds, are being investigated for treatment of HSV disease, including infections resistant to existing therapy... - Recent clinical experience with famciclovir--a "third generation" nucleoside prodrugArun Chakrabarty
Solano Research, Davis, Calif, USA
Antivir Chem Chemother 15:251-3. 2004..This short review points to recent experience with famciclovir in the management of HSV and varicella-zoster virus... - Resiquimod: a new immune response modifier with potential as a vaccine adjuvant for Th1 immune responsesJashin J Wu
Department of Dermatology, University of California, Irvine, Irvine, CA, USA
Antiviral Res 64:79-83. 2004..Resiquimod shows promise for other viral infections and as a vaccine adjuvant... - Valacyclovir in the treatment of herpes simplex, herpes zoster, and other viral infectionsJashin J Wu
Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA
J Cutan Med Surg 7:372-81. 2003..CONCLUSION: Valacyclovir is safe and effective in the therapy of patients with herpes simplex and herpes zoster and may be useful in other viral infections... - Rapidly enlarging growth of the proximal nail foldWhitney A High
Department of Dermatology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9192, USA
Dermatol Surg 29:984-6. 2003..CONCLUSION: SCC must be considered in the differential diagnosis of nail fold neoplasm. An immunocompromised condition such as HIV/AIDS may predispose to malignant degeneration of lesions caused by infection with HPV... - Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan diseaseSankar Surendran
Departments of Pediatrics, Children s Hospital, The University of Texas Medical Branch, Galveston, TX 77555 0359, USA
Brain Res Bull 61:427-35. 2003..This first report showing abnormal expression of EAAT4, GABRA6, Spi2 combined with lower levels of glutamate and GABA are likely to be associated with the pathophysiology of CD... - Recurrent genital herpes treatments and their impact on quality of lifeMathijs H Brentjens
Departments of Dermatology, Microbiology/Immunology and Internal Medicine, University of Texas Medical Branch-Galveston, Houston, Texas 77058, USA
Pharmacoeconomics 21:853-63. 2003..Newer therapeutic modalities, including the topical immune response modifier resiquimod and herpes vaccines, may eventually be shown to further decrease the psychological morbidity of recurrent genital herpes... - Vaccines for viral diseases with dermatologic manifestationsMathijs H Brentjens
University of Texas Medical Branch-Galveston, Department of Dermatology, Galveston, TX, USA
Dermatol Clin 21:349-69. 2003..Ongoing research shows promise in prophylactic and therapeutic vaccination for viral infections with cutaneous manifestations. Further studies are necessary before vaccines for HSV, HPV, and HIV become commercially available... - Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan diseaseReuben Matalon
Department of Pediatrics, Galveston, Texas 77555 0359, USA
Mol Ther 7:580-7. 2003..MRS revealed that in vivo NAA levels were also reduced. These data indicate that rAAV-mediated ASPA delivery may be an interesting avenue for the treatment of CD... - Nonspecific cell-mediated immunity in patients with epidermodysplasia verruciformisWalmar Roncalli Pereira de Oliveira
, Brazil
J Dermatol 30:203-9. 2003.... - Polymorphisms for chemical metabolizing genes and risk for cervical neoplasiaCarlos H Sierra-Torres
Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
Environ Mol Mutagen 41:69-76. 2003..Further studies using larger populations will be needed to confirm our observations and to validate data for disease prevention... - Antiviral agents: Non-antiretroviral [correction of Nonantiviral] drugsTricia J Brown
Department of Dermatology, Microbiology/Immunology and Internal Medicine, University of Texas Medical Branch, Galveston 77555, USA
J Am Acad Dermatol 47:581-99. 2002..This review of antiviral agents discusses the treatments available for viral infections such as herpes simplex virus, varicella zoster virus, cytomegalovirus, human papillomavirus, chronic viral hepatitis, and others... - Treatment of anogenital warts with imiquimod 5% cream followed by surgical excision of residual lesionsDaniel Carrasco
Department of Dermatology, University of Texas Medical Branch at Galveston, Texas, USA
J Am Acad Dermatol 47:S212-6. 2002..Therefore, treatment with imiquimod followed by excision of residual lesions may provide long-term clearance of anogenital warts in those patients in whom imiquimod monotherapy is insufficient... - CD4+ T lymphocytopenia with disseminated HPVCloyce L Stetson
Department of Dermatology, Texas Tech University, Lubbock, Texas 79430, USA
J Cutan Pathol 29:502-5. 2002.... - Herpes simplex viruses 1 and 2Kimberly A Yeung-Yue
Departments of Dermatology, Microbiology/Immunology, and Internal Medicine, University of Texas Medical Branch-Galveston, Galveston, TX 77555, USA
Dermatol Clin 20:249-66. 2002..Newer treatments, such as resiquimod, actually may alter the course of HSV infection, reducing the severity and frequency of recurrences. Vaccines are being explored as preventive and therapeutic measures against HSV... - Canavan disease: a monogenic trait with complex genomic interactionSankar Surendran
Department of Pediatrics, Children's Hospital, The University of Texas Medical Branch, Galveston, TX 77555-0359, USA
Mol Genet Metab 80:74-80. 2003..Aspartoacylase gene transfer trial in the mouse brain using adenoassociated virus (AAV) as a vector are encouraging showing improved myelination and decrease in spongy degeneration in the area of the injection and also beyond that site... - Molecular basis of Canavan's disease: from human to mouseSankar Surendran
Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555-0359, USA
J Child Neurol 18:604-10. 2003..These developments have afforded new tools for research in the attempts to understand the pathophysiology of Canavan's disease, design new therapies, and explore methods for gene transfer to the central nervous system... - Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapyUlrich R Hengge
Department of Dermatology, Venereology and Allergology, University of Essen, Germany
Lancet Infect Dis 2:281-92. 2002..Part 2, to be published next month, will summarise recent insights in the pathogenesis of KS and will discuss other HHV8-related diseases such as Castleman's disease and primary effusion lymphoma... - Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosisMohammad Athar
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Cancer Res 64:7545-52. 2004.... - Nested PCR with the PGMY09/11 and GP5(+)/6(+) primer sets improves detection of HPV DNA in cervical samplesAndrea L Fuessel Haws
Department of Microbiology, University of Texas Medical Branch, Galveston, TX 77030, USA
J Virol Methods 122:87-93. 2004..Standardization and use of the PGMY/GP(+) PCR system could aid physicians in providing more efficient HPV screening and better treatment for patients... - Mouse neural progenitor cells differentiate into oligodendrocytes in the brain of a knockout mouse model of Canavan diseaseSankar Surendran
Pediatrics Rm # 3.350, Department of Pediatrics, Childrens Hospital, The University of Texas Medical Branch, Galveston, TX 77555-0359, USA
Brain Res Dev Brain Res 153:19-27. 2004..This is the first report to describe the survival, distribution and differentiation of NPCs within the brain of CD mouse and a first step toward the potential clinical use of cell therapy to treat CD... - Aspartoacylase deficiency does not affect N-acetylaspartylglutamate level or glutamate carboxypeptidase II activity in the knockout mouse brainSankar Surendran
Department of Pediatrics, Childrens Hospital, The University of Texas Medical Branch, Rm 3 350, Galveston, TX 77555 0359, USA
Brain Res 1016:268-71. 2004..These data suggest that ASPA deficiency does not affect the NAAG or GCP II level in the knockout mouse brain, if documented also in patients with CD... - Association of p53 arginine polymorphism with skin cancerWalmar Roncalli P de Oliveira
Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil
Int J Dermatol 43:489-93. 2004..The presence of arginine at codon 72 in p53 protein is proposed to be a genetic risk factor in human papillomavirus (HPV)-related carcinogenesis... - High level of orexin A observed in the phenylketonuria mouse brain is due to the abnormal expression of prepro-orexinSankar Surendran
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA
Biochem Biophys Res Commun 317:522-6. 2004..The metabolic environment in the brain of PKU mouse affects normal expression of other genes possibly to result in pathophysiology seen in the PKU mouse, if documented also in patients with PKU... - Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trialStephen D Shafran
Division of Infectious Diseases, Department of Medicine, 2E4 16 Walter C Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440 112 Street, Edmonton, Alta, Canada T6G 2B7
J Clin Virol 29:248-53. 2004.... - Species identification of all eight human herpesviruses with a single nested PCR assayS David Hudnall
Department of Pathology, WHO Collaborating Center for Tropical Disease, University of Texas Medical Branch, Galveston, TX 77555 0741, USA
J Virol Methods 116:19-26. 2004..This method should prove useful for rapid and accurate species identification of all eight human herpesviruses from clinical material... - Once-daily valacyclovir to reduce the risk of transmission of genital herpesLawrence Corey
Department of Medicine, University of Washington, Seattle, USA
N Engl J Med 350:11-20. 2004..Nucleoside analogues against herpes simplex virus (HSV) have been shown to suppress shedding of HSV type 2 (HSV-2) on genital mucosal surfaces and may prevent sexual transmission of HSV... - Changing paradigms in dermatology: antivirals in dermatologyPeggy Lin
Department of Dermatology, Northwestern University School of Medicine, Chicago, Illinois, USA
Clin Dermatol 21:426-46. 2003..Most of these antiviral drugs are virastatic and not viracidal. Vaccines and public health measures are much more effective and cost effective than antiviral drugs and must be promoted accordingly in the defense against viral infections... - Acquired and genetic susceptibility to cervical cancerWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
Mutat Res 544:361-4. 2003..Our study indicates that different acquired and genetic susceptibility factors can make significant contributions to the development of environmental disease such as cervical cancer... - Metabolic changes in the knockout mouse for Canavan's disease: implications for patients with Canavan's diseaseSankar Surendran
Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555 0359, USA
J Child Neurol 18:611-5. 2003..These changes might be similar to what is seen in patients with Canavan's disease and could have therapeutic implications... - An unusual presentation of two simultaneous primary melanomasJashin J Wu
Department of Dermatology, University of California, Irvine, CA 92697-2400, USA
Int J Dermatol 45:580-2. 2006