B Tyrberg

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes
    Bj rn Tyrberg
    UCSD Cancer Center, La Jolla, CA 92037 0912, USA
    BMC Endocr Disord 2:2. 2002
  2. ncbi request reprint Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 50:301-7. 2001
  3. ncbi request reprint Current and future treatment strategies for type 2 diabetes: the beta-cell as a therapeutic target
    B Tyrberg
    UCSD Cancer Center, La Jolla, CA 92037 0912, USA
    Curr Opin Investig Drugs 2:1568-74. 2001
  4. ncbi request reprint Species differences in susceptibility of transplanted and cultured pancreatic islets to the beta-cell toxin alloxan
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, SE 751 23, Sweden
    Gen Comp Endocrinol 122:238-51. 2001
  5. ncbi request reprint Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Endocrinology 137:5694-9. 1996
  6. ncbi request reprint Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Pharmacol Toxicol 85:269-75. 1999
  7. ncbi request reprint Microcirculation of human pancreatic islets transplanted under the renal capsule of nude mice
    L Jansson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Transplantation 72:730-2. 2001
  8. ncbi request reprint Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
    C A Delaney
    Department of Medical Cell Biology, Uppsala University, Sweden Carol
    FEBS Lett 394:300-6. 1996
  9. ncbi request reprint Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
    M Flodstrom
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 48:706-13. 1999
  10. ncbi request reprint NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor
    P Itkin-Ansari
    Cancer Center, University of California, San Diego, School of Medicine, Stem Cell Program, The Burnham Institute, La Jolla, California 92093 0816, USA
    Dev Dyn 233:946-53. 2005

Collaborators

Detail Information

Publications11

  1. pmc Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes
    Bj rn Tyrberg
    UCSD Cancer Center, La Jolla, CA 92037 0912, USA
    BMC Endocr Disord 2:2. 2002
    ..An increase of Ogg1 in islet cell mitochondria is consistent with a model in which hyperglycemia and consequent increased beta-cell oxidative metabolism lead to DNA damage and the induction of Ogg1 expression...
  2. ncbi request reprint Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 50:301-7. 2001
    ..Altogether, these data and previous results from our laboratory suggest that human beta-cell neogenesis becomes more dependent on differentiation and less dependent on proliferation with increasing age...
  3. ncbi request reprint Current and future treatment strategies for type 2 diabetes: the beta-cell as a therapeutic target
    B Tyrberg
    UCSD Cancer Center, La Jolla, CA 92037 0912, USA
    Curr Opin Investig Drugs 2:1568-74. 2001
    ..The treatment strategies presented include promotion of beta-cell proliferation and differentiation by glucagon-like peptide 1 receptor agonists...
  4. ncbi request reprint Species differences in susceptibility of transplanted and cultured pancreatic islets to the beta-cell toxin alloxan
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Uppsala, SE 751 23, Sweden
    Gen Comp Endocrinol 122:238-51. 2001
    ..Finally, no correlation between high alloxan sensitivity and high lysosomal enzyme activity was found. Thus, the beta-cell lysosomes are hardly specific targets for alloxan...
  5. ncbi request reprint Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Endocrinology 137:5694-9. 1996
    ..Moreover, beta-cells from adult human donors respond with increased proliferation to glucose in vitro and show a decreased proliferation in vivo with increasing donor age...
  6. ncbi request reprint Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity
    B Tyrberg
    Department of Medical Cell Biology, Uppsala University, Sweden
    Pharmacol Toxicol 85:269-75. 1999
    ..Alloxan-insensitive human islets protect mouse beta-cells against alloxan-induced lesions, suggesting that yet to be identified extracellular factors are involved in human islet resistance to alloxan toxicity...
  7. ncbi request reprint Microcirculation of human pancreatic islets transplanted under the renal capsule of nude mice
    L Jansson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Transplantation 72:730-2. 2001
    ..The aim was to measure the capillary blood pressure in transplanted human islets...
  8. ncbi request reprint Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
    C A Delaney
    Department of Medical Cell Biology, Uppsala University, Sweden Carol
    FEBS Lett 394:300-6. 1996
    ..This study demonstrates for the first time that cultured human pancreatic islets are susceptible to the noxious effects of peroxynitrite...
  9. ncbi request reprint Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
    M Flodstrom
    Department of Medical Cell Biology, Uppsala University, Sweden
    Diabetes 48:706-13. 1999
    ..In conclusion, the present study provides evidence that iNOS may contribute to beta-cell damage after exposure to IL-1beta in vitro and treatment with MLDS in vivo...
  10. ncbi request reprint NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor
    P Itkin-Ansari
    Cancer Center, University of California, San Diego, School of Medicine, Stem Cell Program, The Burnham Institute, La Jolla, California 92093 0816, USA
    Dev Dyn 233:946-53. 2005
    ....
  11. ncbi request reprint Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo
    D de la Tour
    University of California San Diego Cancer Center La Jolla, California 92093-0912, USA
    Mol Endocrinol 15:476-83. 2001
    ..The ability to grow unlimited quantities of human beta-cells is a major step toward developing a cell transplantation therapy for diabetes...