Research Topics
Species | Kenneth TylerSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
The shorthand publications of Sir William Richard GowersK L Tyler
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80206, USA
Neurology 55:289-93. 2000..To examine the shorthand publications of Sir William Richard Gowers...- CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitisK L Tyler
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Neurology 66:361-5. 2006..To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome... - Origins and early descriptions of "Duchenne muscular dystrophy"Kenneth L Tyler
Department of Neurology B 182, University of Colorado Health Sciences Center and Neurology Service, Denver Veterans Affairs Medical Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA
Muscle Nerve 28:402-22. 2003..Many of the original papers describing this disease are now unavailable outside of major medical libraries, and several important contributions, excepting those of Duchenne, which are recognized eponymously, are now virtually forgotten... - COMMENTARY: Gibbs CJ Jr, Amyx HL, Bacote A, Masters CL, Gajdusek DC. Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis 1980; 142:205-208Kenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center, and Neurology Service, Denver Veterans Affairs Medical Center, Denver 80262, USA
J Infect Dis 190:653-60. 2004 - William Richard Gowers (1845-1915)K L Tyler
Neurology B-182, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Neurol 250:1012-3. 2003 - West Nile virus infection in the United StatesKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center and the Denver VA Medical Center, Denver 80262, USA
Arch Neurol 61:1190-5. 2004 - Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret'sKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
Herpes 11:57A-64A. 2004..Many cases are indistinguishable from cases previously classified as "Mollaret's meningitis", a term that should now be reserved for idiopathic cases of recurrent aseptic meningitis... - Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitisKenneth L Tyler
Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
J Infect Dis 189:1664-75. 2004..T3C/96 is capable of systemic spread in newborn mice after peroral inoculation and produces lethal encephalitis. These results suggest that serotype 3 reoviruses can cause meningitis in humans... - The Goltz-Ferrier debates and the triumph of cerebral localizationalist theoryK L Tyler
University of Colorado Health Sciences Center, Denver 80262, USA
Neurology 55:1015-24. 2000..To analyze the significance of the Goltz-Ferrier debates held at the International Medical Congress of 1881 for the development of ideas on cerebral localization... - Reoviruses and the host cellK L Tyler
Dept of Neurology, University of Colorado Health Sciences Center, Campus Box B 182, 4200 E, 9th Avenue, Denver, CO 80262, USA
Trends Microbiol 9:560-4. 2001..Reovirus binding to JAM appears to be required for induction of apoptosis and activation of NF-kappaB, although the precise cellular pathways involved have not yet been identified... 
Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neuronsShoshona S Le
Research Service, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
J Neurochem 94:1025-39. 2005..These results indicate that Rac acts downstream of integrins and growth factors to promote neuronal survival by repressing c-Jun/Bim-mediated mitochondrial apoptosis...- Experimental reovirus-induced acute flaccid paralysis and spinal motor neuron cell deathRobin J Goody
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Neuropathol Exp Neurol 67:231-9. 2008..This study represents the first detailed characterization of a novel and highly efficient experimental model of virus-induced AFP that will facilitate evaluation of therapeutic strategies targeting virus-induced paralysis... - Herpesvirus infections of the nervous systemDonald H Gilden
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Nat Clin Pract Neurol 3:82-94. 2007.... - Fas-mediated apoptotic signaling in the mouse brain following reovirus infectionPenny Clarke
Departments of Neurology, University of Colorado Denver Health Sciences Programs, Anschutz Medical Campus, Aurora, Colorado 80045, USA
J Virol 83:6161-70. 2009.... - Apoptosis in animal models of virus-induced diseasePenny Clarke
Department of Neurology, University of Colorado, Denver Health Sciences Programs, Anschutz Medical Campus, Aurora, Colorado 80045, USA
Nat Rev Microbiol 7:144-55. 2009.... - JAK-STAT signaling pathways are activated in the brain following reovirus infectionRobin J Goody
Departments of Neurology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
J Neurovirol 13:373-83. 2007..The results demonstrate activation of a type I IFN-mediated, JAK-dependent STAT signaling pathway following reovirus infection and suggest that STAT1 is a key component of host defense mechanisms against reovirus infection in the brain... - Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivoRoberta L Debiasi
Pediatrics Infectious Diseases, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B055, Denver, CO 80262, USA
J Virol 78:11040-50. 2004.... - Molecular methods for diagnosis of viral encephalitisRoberta L Debiasi
Department of Pediatrics, Division of Infectious Diseases, University of Colorado Health Sciences Center, Box A036 B055, Denver, CO 80262, USA
Clin Microbiol Rev 17:903-25, table of contents. 2004.... - JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cellsPenny Clarke
Dept of Neurology B 182, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
J Virol 78:13132-8. 2004..This is the first report demonstrating that JNK is associated with regulation of mitochondrial pathways of apoptosis following viral infection... - Dual infections of the central nervous system with Epstein-Barr virusAdriana Weinberg
Department of Pediatrics, University of Colorado Medical School, Denver, CO 80262, USA
J Infect Dis 191:234-7. 2005..EBV lytic-cycle mRNA was detected in the cerebrospinal fluid of 5 of 6 tested samples, indicating EBV replication in the CNS during coinfection... - Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative casesC Alan Anderson
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Neurol 64:439-41. 2007..To describe 2 patients with rapidly progressive dementia and risk factors for exposure to chronic wasting disease (CWD) in whom extensive testing negated the possible transmission of CWD. Design/.. - Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosisPenny Clarke
Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B182, Denver, Colorado 80262, USA
Apoptosis 12:211-23. 2007..The combination of reovirus and TRAIL thus represents a promising new therapeutic approach for the treatment of ovarian cancer... - Minocycline delays disease onset and mortality in reovirus encephalitisSarah M Richardson-Burns
Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Exp Neurol 192:331-9. 2005.... - Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptorsSarah M Richardson-Burns
Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurovirol 8:365-80. 2002..These studies provide a comprehensive profile of the pattern of virus-induced apoptotic pathway activation in neuronal culture... - Use of PCR for the diagnosis of herpesvirus infections of the central nervous systemRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
J Clin Virol 25:S5-11. 2002..This review summarizes the role of CSF PCR in the diagnosis and therapeutic management of herpesvirus infections of the nervous system, particularly those caused by HSV and VZV... - Reovirus-induced apoptosis requires mitochondrial release of Smac/DIABLO and involves reduction of cellular inhibitor of apoptosis protein levelsDouglas J Kominsky
Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
J Virol 76:11414-24. 2002..These studies provide the first evidence for the association of Smac/DIABLO with virus-induced apoptosis... - Quantitative CSF PCR in Epstein-Barr virus infections of the central nervous systemAdriana Weinberg
Department of Pediatrics, University of Colorado Health Sciences Center, Campus Box C227, Denver, CO 80263, USA
Ann Neurol 52:543-8. 2002..These studies demonstrate the utility of quantitative CSF PCR and establish the presence of lytic cycle EBV mRNA in CSF of patients with EBV-associated neurological disease... - MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblastsBruce D Cuevas
Department of Pharmacology, Craniofacial Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
EMBO J 22:3346-55. 2003..Inhibition of ERK1/2 or calpain, but not of JNK, mimics MEKK1 deficiency. Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts... - Gene expression in the brain during reovirus encephalitisKenneth L Tyler
Department of Neurology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
J Neurovirol 16:56-71. 2010.... - Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cellsPenny Clarke
Department of Neurology, Medicine, Microbiology, and Immunology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
J Biol Chem 278:18092-100. 2003..Our findings demonstrate that two distinct phases of virus-induced NF-kappaB regulation are required to efficiently activate host cell apoptotic responses to reovirus infection... - Naturally acquired West Nile virus encephalomyelitis in transplant recipients: clinical, laboratory, diagnostic, and neuropathological featuresB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Arch Neurol 61:1210-20. 2004.... - Recurrent dermatomal vesicular skin lesions: a clue to diagnosis of herpes simplex virus 2 meningitisNicole Gonzales
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA
Arch Neurol 60:868-9. 2003 - Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotypeShelley D Miyamoto
Department of Pediatrics, University of Colorado Denver Health Sciences Center, Denver, Colorado, USA
J Card Fail 15:529-39. 2009..The pathophysiologic mechanisms underlying viral myocarditis are not well defined. As a result, effective treatments do not exist and viral myocarditis remains a potentially lethal infection of the heart... - Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinaseJ David Beckham
Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Virol 81:6984-92. 2007..Given the efficacy of the inhibitor in protecting mice from viral encephalitis, JNK inhibition represents a promising and novel treatment strategy for viral encephalitis... - Update on herpes simplex encephalitisKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center, and the Neurology Service of the Denver Veterans Affairs Medical Center, Denver, CO, USA
Rev Neurol Dis 1:169-78. 2004..Neuroimaging patterns in infants and children differ significantly from those seen in adults and include a higher frequency of extratemporal lesions... - Novel nuclear herniations induced by nuclear localization of a viral proteinCristen C Hoyt
Department of Neurology (B-182, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Denver, CO 80262, USA
J Virol 78:6360-9. 2004..These herniations represent a previously undescribed mechanism by which cytoplasmic viral infection can perturb nuclear architecture and induce cytopathic effects, which ultimately lead to disease pathogenesis in the infected host... - Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injuryRobin J Goody
Department of Neurology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Exp Neurol 195:379-90. 2005..Our findings provide the first evidence of reovirus-induced iNOS expression and the first demonstration that NO inhibits mammalian reovirus replication, suggesting that NO may play an antiviral role during reovirus infection... - Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitisRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
J Infect Dis 186:1547-57. 2002..These results suggest that neuronal apoptosis is an important contributing factor to acute CNS injury and may serve as a novel therapeutic target in these patients... - Regional differences in viral growth and central nervous system injury correlate with apoptosisSarah M Richardson-Burns
Neuroscience Program, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Virol 78:5466-75. 2004..These results suggest that the decreased neurovirulence of VarK may be due to its failure to efficiently induce apoptosis in cortical neurons... - Emerging viral infections of the central nervous system: part 2Kenneth L Tyler
Department of Neurology, University of Colorado Denver Health Sciences Center, Aurora, CO 80045, USA
Arch Neurol 66:1065-74. 2009.... - Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipientsMarilyn E Levi
Division of Infectious Diseases, Department of Internal Medicine, University of Colorado Denver, Anschutz Medical Campus, Denver, CO 80045, USA
Clin Transplant 24:223-8. 2010..She experienced a rapidly progressive and devastating neurological course despite treatment and died three wk after onset of her symptoms. Autopsy revealed extensive meningoencephalomyelitis... - Creutzfeldt-Jakob diseaseKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center, Denver, USA
N Engl J Med 348:681-2. 2003 - TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cellsAaron C Spalding
Department of Pharmacology, University of Colorado Cancer Center, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, Colorado, CO 80262, USA
Oncogene 21:260-71. 2002..These findings demonstrate that TRAIL signaling via its death receptors is a significant contributor to genotoxin-induced apoptosis in human epithelial carcinomas... - Infectious disease - developments in the field of Creutzfeldt-Jakob diseaseJ David Beckham
University of Colorado Health Sciences Center, Denver, CO, USA
Rev Neurol Dis 4:168-72. 2007 - Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous systemCristen C Hoyt
Department of Neurology (B-182, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Denver, CO 80262, USA
J Virol 79:2743-53. 2005..These results demonstrate that sigma1s is a determinant of the magnitude and extent of reovirus-induced apoptosis in both the heart and CNS and thereby contributes to reovirus pathogenesis and virulence... - Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosisB K Kleinschmidt-Demasters
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
N Engl J Med 353:369-74. 2005..There was extensive tissue destruction and cavitation in the left frontoparietal area, large numbers of bizarre astrocytes, and inclusion-bearing oligodendrocytes, which were positive for JC virus DNA on in situ hybridization... - West Nile virus meningoencephalitisRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Nat Clin Pract Neurol 2:264-75. 2006..In this review, we discuss epidemiology, risk factors, clinical features, diagnosis and prognosis of WNV meningoencephalitis, along with potential treatments... - Management of acute shingles (herpes zoster)Kenneth L Tyler
University of Colorado Health Sciences Center, Denver, CO, USA
Rev Neurol Dis 4:203-8. 2007..This article summarizes the key findings and recommendations that were generated from this meeting and reviews some of the research on which these guidelines are based... - Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesisRoberta L Debiasi
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:8934-47. 2003..This provides the first comparative analysis of altered gene expression after infection with viruses of differing apoptotic phenotypes and provides insight into pathogenic mechanisms of virus-induced disease... - Natalizumab and progressive multifocal leukoencephalopathy: highlights of the International Workshop on JC Virus/PML and Multiple Sclerosis, June 3-4, 2005, Philadelphia PAKenneth L Tyler
Department of Neurology, University of Colorado Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, CO, USA
Rev Neurol Dis 2:144-9. 2005 - Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondriaAngela K Zimmermann
Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, Denver, Colorado 80208, USA
J Biol Chem 282:29296-304. 2007..We conclude that this novel GSH binding property of Bcl-2 likely plays a central role in its antioxidant function at mitochondria... 
Chapter 28: a history of bacterial meningitisKenneth L Tyler
Department of Neurology, University of Colorado Denver Health Sciences Center and Denver Veterans Affairs Medical Center, Denver, CO, USA
Handb Clin Neurol 95:417-33. 2010..Vaccination against meningitis debuted in the early 20th century, and progressed to the development of vaccines against Neisseria meningitidis and Haemophilus influenzae, which remain mainstays of modern medicine...- Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infectionPennelope K Blakely
Department of Neurology, University of Michigan Medical Center, Ann Arbor, MI 48109 2200, USA
J Neuropathol Exp Neurol 68:1061-72. 2009..The pathogenesis of this increasingly common disorder likely involves immune response and excitotoxicity mechanisms that are potential therapeutic targets... - Reovirus-induced alterations in gene expression related to cell cycle regulationGeorge J Poggioli
Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
J Virol 76:2585-94. 2002..A hypothetical model describing serotype 3 reovirus-induced inhibition of cdc2 kinase is presented, and reovirus-induced perturbations of the G(1)-to-S, G(2)-to-M, and mitotic spindle checkpoints are discussed... - West Nile virus neuroinvasive diseaseLarry E Davis
Neurology Services, New Mexico Veterans Affairs Health Care System, University of New Mexico, Albuquerque, NM, USA
Ann Neurol 60:286-300. 2006..Recovery from neurological sequelae of WNV infection including cognitive deficits and weakness may be prolonged and incomplete... - North American encephalitic arbovirusesLarry E Davis
New Mexico Veterans Affairs Health Care System, 1500 San Pedro Drive SE, Albuquerque, NM 87108, USA
Neurol Clin 26:727-57, ix. 2008..Unfortunately, no antiviral drugs are approved for the treatment of arbovirus infection and current therapy is supportive... - Viral infections of the nervous system, 2002: update on diagnosis and treatmentJohn J Redington
Arch Neurol 59:712-8. 2002 - Persistent neurobehavioral signs and symptoms following West Nile feverDeborah A Hall
J Neuropsychiatry Clin Neurosci 20:122-3. 2008 - Bell's palsy--is glucocorticoid treatment enough?Donald H Gilden
N Engl J Med 357:1653-5. 2007 - Through a glass, darkly: cerebrospinal fluid viral load measurements and the pathogenesis of human immunodeficiency virus infection of the central nervous systemKenneth L Tyler
Arch Neurol 59:909-12. 2002 - Type 3 reovirus neuroinvasion after intramuscular inoculation: viral genetic determinants of lethality and spinal cord infectionMary Anne Mann
Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
Virology 303:213-21. 2002..These studies indicate that the S1, L2, and L3 genes all play a potential role in neuroinvasiveness and provide the first identification of a role in pathogenesis for the L3 gene... - Does Toll-like receptor 3 play a biological role in virus infections?Kurt H Edelmann
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Virology 322:231-8. 2004.... - The uninvited guest: JC virus infection of neurons in PMLKenneth L Tyler
Neurology 61:734-5. 2003
Research Grants
- Mechanisms of virus-induced apoptosis in neurons and CNSKenneth L Tyler; Fiscal Year: 2010..pathways involved, as well as an easily accessible in mouse model of CNS apoptosis that allows rapid testing of results obtained in cell culture for their significance on the pathogenesis of CNS viral disease in vivo ..
- Mechanisms of apoptosis in the central nervous systemKenneth Tyler; Fiscal Year: 2009..They are expected to have direct therapeutic implications for the development of novel therapies for CNS disease. ..
- Mechanisms of virus-induced apoptosis in neurons and CNSKenneth Tyler; Fiscal Year: 2007..and the cellular pathways involved, as well as an easily accessible in mouse model of CNS apoptosis that allows rapid testing of results obtained in cell culture for their significance on the pathogenesis of CNS viral disease in vivo ..
- Mechanisms of apoptosis in the central nervous systemKenneth Tyler; Fiscal Year: 2009..In addition, the proposed studies will evaluate the role of these genes and pathways as novel therapeutic targets for these diseases. ..