Suresh C Tyagi

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Role of nitric oxide in matrix remodeling in diabetes and heart failure
    Suresh C Tyagi
    Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Heart Fail Rev 8:23-8. 2003
  2. pmc Role of copper and homocysteine in pressure overload heart failure
    William M Hughes
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cardiovasc Toxicol 8:137-44. 2008
  3. pmc Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Physiol 220:257-66. 2009
  4. pmc Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery
    Munish Kumar
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Neurochem Int 53:214-9. 2008
  5. pmc Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Endocrinol Metab 295:E1205-12. 2008
  6. ncbi request reprint Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Can J Physiol Pharmacol 83:583-94. 2005
  7. pmc Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery
    Poulami Basu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Arch Physiol Biochem 117:270-82. 2011
  8. pmc Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, Potentia Pharmaceuticals, Louisville, KY, USA
    Am J Physiol Heart Circ Physiol 295:H890-7. 2008
  9. doi request reprint Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Pharmacology 82:201-13. 2008
  10. pmc Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice
    Soumi Kundu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 106:119-26. 2009

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Role of nitric oxide in matrix remodeling in diabetes and heart failure
    Suresh C Tyagi
    Department of Physiology and Biophysics, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Heart Fail Rev 8:23-8. 2003
    ..In addition Hcy competes with PPAR ligands. The understanding of molecular, cellular, and extracellular mechanisms by which Hcy amplifies DM will have therapeutic ramifications for diabetic cardiomyopathy...
  2. pmc Role of copper and homocysteine in pressure overload heart failure
    William M Hughes
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cardiovasc Toxicol 8:137-44. 2008
    ..In conclusion, our data suggest that copper supplement helps improve cardiac function in a pressure overload dilated cardiomyopathic heart...
  3. pmc Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Physiol 220:257-66. 2009
    ..Furthermore muscimol attenuated Hcy-induced MMP-9 via ERK signaling pathway. These results suggest that Hcy competes with GABA-A receptors, inducing the oxidative stress transduction pathway and leading to ERK activation...
  4. pmc Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery
    Munish Kumar
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Neurochem Int 53:214-9. 2008
    ..These results suggested that Hcy caused arterial remodeling in part, by increase in collagen/elastin ratio thereby increasing VR leading to the decrease in CA blood flow...
  5. pmc Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Endocrinol Metab 295:E1205-12. 2008
    ..CZ, however, protected diabetic nephropathy in part by activating PPARgamma and clearing glomerular tissue Hcy...
  6. ncbi request reprint Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Can J Physiol Pharmacol 83:583-94. 2005
    ....
  7. pmc Chronic hyperhomocysteinemia causes vascular remodelling by instigating vein phenotype in artery
    Poulami Basu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Arch Physiol Biochem 117:270-82. 2011
    ..We summarize that chronic HHcy causes vascular remodelling that transduces changes in vascular wall in a way that artery expresses vein phenotype...
  8. pmc Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, Potentia Pharmaceuticals, Louisville, KY, USA
    Am J Physiol Heart Circ Physiol 295:H890-7. 2008
    ..We conclude that HHCY activates mtMMP-9 and induces MPT, leading to myocyte mechanical dysfunction by agonizing NMDA-R1...
  9. doi request reprint Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Pharmacology 82:201-13. 2008
    ..Sodium thiosulfate (STS) has been shown to be an antioxidant and calcium solubilizer, but the possible role of STS in dysfunctional ventricles remains unknown. Here, we assessed the effects of STS in the failing heart...
  10. pmc Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice
    Soumi Kundu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 106:119-26. 2009
    ..The results concluded that homocysteine generated nitrotyrosine in the vicinity of endothelium, caused MMP activation and endothelium-myocyte uncoupling. The generation of nitrotyrosine was independent of iNOS...
  11. pmc 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice
    Alexander V Ovechkin
    Department of Physiology and Biophysics, Health Sciences Center A 1115, School of Medicine, University of Louisville, KY 40202, USA
    Am J Physiol Lung Cell Mol Physiol 291:L905-11. 2006
    ..The results show that arterial hypertension in HHcy mice is, in part, associated with arterial remodeling and E-M uncoupling in response to MMP activation...
  12. pmc Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol
    Paras K Mishra
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Cardiovasc Diabetol 9:49. 2010
    ..Hyperhomocysteinemia (HHcy) and hyperglycemia cause diabetic cardiomyopathy by inducing oxidative stress and attenuating peroxisome proliferator- activated receptor (PPAR) gamma. However, their synergistic contribution is not clear...
  13. pmc Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice
    Natia Qipshidze
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 299:H1484-93. 2010
    ..We showed that FA supplementation resulted in significant improvement of myocardial function after MI. The study eluted the importance of homocysteine (Hcy) metabolism and FA supplementation in cardiovascular disease...
  14. pmc Cardiac specific deletion of N-methyl-d-aspartate receptor 1 ameliorates mtMMP-9 mediated autophagy/mitophagy in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    J Recept Signal Transduct Res 30:78-87. 2010
    ..This led to mitophagy, in part, by activating NMDA-R1. The findings of this study will lead to therapeutic ramifications for mitigating cardiovascular diseases by inhibiting the mitochondrial mitophagy and NMDA-R1 receptor...
  15. pmc Arrhythmia and neuronal/endothelial myocyte uncoupling in hyperhomocysteinemia
    Dorothea Rosenberger
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Arch Physiol Biochem 112:219-27. 2006
    ..This review suggest that Hcy increases iNOS/NO, superoxide, metalloproteinase activity, and disrupts connexin-43, exacerbates endothelial-myocyte uncoupling and cardiac failure secondary to inducing NMDA-R1...
  16. pmc Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice
    Mesia M Steed
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Physiol Lung Cell Mol Physiol 299:L301-11. 2010
    ..Results show that an increase in iNOS activity is a key contributor to HHcy-mediated collagen/elastin switch and resulting decline in aortic compliance...
  17. pmc GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells
    Suresh Shastry
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY, USA
    Cell Biochem Biophys 45:157-65. 2006
    ....
  18. pmc H2S ameliorates oxidative and proteolytic stresses and protects the heart against adverse remodeling in chronic heart failure
    Paras K Mishra
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Am J Physiol Heart Circ Physiol 298:H451-6. 2010
    ..The levels of ADAM-12, apoptosis, and fibrosis were robust and integrin were decreased in AVF hearts. The treatment with H(2)S donor attenuated the fibrosis, apoptosis, and decrease in integrin...
  19. pmc Homocysteine mediated decrease in bone blood flow and remodeling: role of folic acid
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Orthop Res 29:1511-6. 2011
    ..Interestingly, these effects were ameliorated by FA and suggested that FA supplementation may have therapeutic potential against genetically HHcy induced bone loss...
  20. pmc Matrix imbalance by inducing expression of metalloproteinase and oxidative stress in cochlea of hyperhomocysteinemic mice
    Soumi Kundu
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Mol Cell Biochem 332:215-24. 2009
    ..Hcy induced higher protein nitrotyrosination and cytosolic NADPHoxidase subunit p22(phox) in cochlea. It is thus suggested that Hcy induced matrix imbalance, structural changes and oxidative stress in cochlea...
  21. pmc GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice
    Munish Kumar
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Brain Res 1221:147-53. 2008
    ..The results suggested that Hcy caused cerebral interstitial remodeling in brain by distorting the extracellular matrix, thus increasing the blood brain permeability; treatment with muscimol mitigated BBB permeability...
  22. doi request reprint Renal mitochondrial damage and protein modification in type-2 diabetes
    Ganesh K Kartha
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, 500 South Preston Street, HSC Building A, Louisville, KY 40202, USA
    Acta Diabetol 45:75-81. 2008
    ..We conclude that diabetes-induced intra-renal mitochondrial oxidative stress is reflected by an increase in mitochondrial membrane permeability and protein modifications by nitrotyrosine generation...
  23. pmc Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy
    Paras Kumar Mishra
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 401:175-81. 2010
    ..It points to the involvement of beta2-AR in diabetic cardiomyopathy. We conclude that degradation of beta2-AR and impairment of Hcy metabolism is implicated in diabetic cardiomyopathy...
  24. ncbi request reprint Pioglitazone mitigates renal glomerular vascular changes in high-fat, high-calorie-induced type 2 diabetes mellitus
    Walter E Rodriguez
    Department of Physiology and Biophysics, University of Louisville School of Medicine, A 1115, 500 South Preston St, Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 291:F694-701. 2006
    ..Results suggest that a PPARgamma agonist ameliorates preglomerular arteriole remodeling in diabetes by decreasing tissue levels of Hcy and MMP-2 activity and increasing NO...
  25. pmc Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Kentucky, USA
    Am J Physiol Cell Physiol 303:C41-51. 2012
    ..We conclude that conversion of Hcy to H(2)S by CBS, CSE, or 3MST triple gene therapy improves renovascular function in HHcy...
  26. ncbi request reprint Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 293:C1779-87. 2007
    ..However, in vitro DZA and CBS gene therapy successfully treated the HHcy-induced inflammatory reaction in the methionine metabolism pathway...
  27. pmc MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure
    Srikanth Givvimani
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Arch Physiol Biochem 116:63-72. 2010
    ..However, in decompensatory hearts there was increase in MMP-9, TIMP-3, endostatin, angiostatin and vascular rarefaction...
  28. pmc gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    Endothelium 14:315-23. 2007
    ..The data suggest that Hcy increases EC layer permeability through inhibition of GABA(A) receptor and F-actin formation, in part, by transducing ERK and MMP-9 activation...
  29. ncbi request reprint Hyperhomocysteinemia and sudden cardiac death: potential arrhythmogenic mechanisms
    Claudio Maldonado
    Department of Physiology and Biophysics, and Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Curr Vasc Pharmacol 8:64-74. 2010
    ..Efficacy of B vitamin supplementation in patient populations with HHcy and CHD is also reviewed...
  30. pmc H2S protects against methionine-induced oxidative stress in brain endothelial cells
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Antioxid Redox Signal 11:25-33. 2009
    ..In conclusion, the administration of H2S protected the cells from oxidative stress induced by hyperhomocysteinemia (HHcy), which suggested that NaHS/H2S may have therapeutic potential against Met-induced oxidative stress...
  31. ncbi request reprint Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia
    Harpreet S Sood
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 No State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Lung Cell Mol Physiol 284:L333-41. 2003
    ..2 +/- 1.9, 9.7 +/- 0.2, 16.6 +/- 0.8 (P < 0.05 compared with WT), 13.1 +/- 2.1 dyn/cm(2). The results suggest that Hcy increased aortic wall stress by increasing nitrotyrosine and MMP-9 activity...
  32. pmc Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling
    Thomas P Vacek
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Arch Physiol Biochem 118:31-42. 2012
    ..Moreover, the therapeutic implications of NMDA and PPAR ligands are some promise to patient...
  33. ncbi request reprint Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 96:665-71. 2005
    ..To compensate, the heart increases its load which creates adverse cardiac remodeling in which the elastin/collagen ratio is reduced, causing cardiac stiffness and diastolic heart failure in hyperhomocysteinemia...
  34. pmc Differential expression of Gs in a murine model of homocysteinemic heart failure
    Thomas P Vacek
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Vasc Health Risk Manag 5:79-84. 2009
    ..The results suggested no detectable differential G(s) and G(i) expression. This suggested that Hcy did not act as an agonist in vitro to alter G protein content, but that Hcy produced some other in vivo effects to incur these results...
  35. pmc MicroRNAs are involved in homocysteine-induced cardiac remodeling
    Paras K Mishra
    Department of Physiology and Biophysics, University of Louisville, School of Medicine, A 1215, 500 South Preston Street, Louisville, KY, 40202, USA
    Cell Biochem Biophys 55:153-62. 2009
    ..The miRNA microarray assay revealed differential expression of 11 miRNAs and among them miR-188 show dramatic downregulation. These findings suggest that dicer and miRNAs especially miR-188 are involved in Hcy-induced cardiac remodeling...
  36. pmc Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor
    David Lominadze
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Bldg A, Room 1115, 500 South Preston Street, Louisville, KY 40202, USA
    Mol Cell Biochem 371:89-96. 2012
    ..The results demonstrate a novel mechanism in which brain microvascular permeability changes during HHcy and vascular dementias, and have therapeutic ramifications for microvascular disease in Alzheimer's patients...
  37. pmc Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Center, A 1115, University of Louisville, Louisville, KY 40202, USA
    J Mol Neurosci 47:128-38. 2012
    ..This study suggests a potential therapeutic role of dietary THC in cerebral ischemia...
  38. pmc Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction
    Natia Qipshidze
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 302:H688-96. 2012
    ..Treatment with FA abolished this effect in PAC mice. These results suggest that FA treatment improves MMP/TIMP balance and ameliorates mitochondrial dysfunction that results in protection of RV failure during pulmonary hypertension...
  39. pmc Hyperhomocysteinemia decreases bone blood flow
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY, USA
    Vasc Health Risk Manag 7:31-5. 2011
    ..9 ± 0.1 in the Hcy-treated group. The tibia bone density was unchanged in Hcy-treated rats. These results suggest that Hcy causes a reduction in bone blood flow, which contributes to compromised bone biomechanical properties...
  40. ncbi request reprint Cardiac synchronous and dys-synchronous remodeling in diabetes mellitus
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Antioxid Redox Signal 9:971-8. 2007
    ..The decreased levels of thioredoxin and peroxiredoxin and cardiac tissue inhibitor of metalloproteinase are in response to antagonizing PPARgamma...
  41. pmc Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, School of Medicine University of Louisville, Louisville, Kentucky 40202, USA
    J Cell Physiol 215:771-81. 2008
    ..This occurred, in part, by the inhibition of NF-kappabeta nuclear translocation, NF-kappabeta-DNA binding and activation of IKbetaalpha. The study unequivocally suggested the pivotal role of EETs in the modulation of Hcy/MMP-9 signal...
  42. ncbi request reprint Attenuation of oxidative stress and remodeling by cardiac inhibitor of metalloproteinase protein transfer
    Michael J Cox
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Circulation 109:2123-8. 2004
    ..Although it is known that oxidative stress activates MMP and CIMP inhibits MMP, it is unclear whether CIMP administration attenuates oxidative stress and MMP-mediated cardiac dilatation...
  43. pmc Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia
    Neetu Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 S Preston Street, Louisville, KY 40202, USA
    J Cell Biochem 98:1150-62. 2006
    ..Our data suggested that Hcy-mediated ROS production promotes endothelial cell death in part by disturbing MP, which results in subsequent release of cytochrome-c and activation of caspase-9 and 3, leading to cell death...
  44. doi request reprint Tyrosine kinase receptor alteration of renal vasoconstriction in rats is sex- and age-related
    John C Passmore
    Department of Physiology and Biophysics, Health Sciences Center, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 409292, USA
    Can J Physiol Pharmacol 90:1372-9. 2012
    ..We conclude that maximum contraction of interlobar arteries from adult male rats is reduced when tyrosine kinase receptor activity is reduced. Female rats demonstrated much less inhibitor-related change of contraction...
  45. pmc The role of homocysteine in bone remodeling
    Thomas P Vacek
    Department of Physiology and Biophysics, University of Louisville School of Medicine Louisville, Louisville, KY 40202, USA
    Clin Chem Lab Med 51:579-90. 2013
    ..However, more studies are needed to clarify the mechanistic role of Hcy during bone diseases...
  46. pmc Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability
    Charu Munjal
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biochem 113:1159-69. 2012
    ..These findings contribute to clarification of mechanisms of IBD development...
  47. pmc Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Kentucky 40202, USA
    Curr Neurovasc Res 4:289-94. 2007
    ..The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed...
  48. ncbi request reprint Mitochondrial MMP activation, dysfunction and arrhythmogenesis in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Vasc Pharmacol 6:84-92. 2008
    ....
  49. pmc Homocysteine causes cerebrovascular leakage in mice
    David Lominadze
    Department of Physiology and Biophysics, Health Sciences Center, A 1115, University of Louisville, Louisville, Kentucky 40292, USA
    Am J Physiol Heart Circ Physiol 290:H1206-13. 2006
    ..Treatment with a broad-range MMP inhibitor (GM-6001; 1 microM) ameliorated Hcy-induced F-actin formation. These data suggest that Hcy increases microvascular permeability, in part, through MMP-9 activation...
  50. pmc Fibrinogen induces endothelial cell permeability
    Neetu Tyagi
    Department of Physiology and Biophysics, Health Sciences Center, A 1115, University of Louisville, Louisville, KY 40292, USA
    Mol Cell Biochem 307:13-22. 2008
    ..The present study indicates that elevated un-degraded Fg may be a factor causing microvascular permeability that typically accompanies cardiovascular and cerebrovascular disorders...
  51. pmc Folic acid improves acetylcholine-induced vasoconstriction of coronary vessels isolated from hyperhomocysteinemic mice: an implication to coronary vasospasm
    Natia Qipshidze
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Physiol 226:2712-20. 2011
    ..The mechanisms for the impairment of vascular function and therapeutic effects of FA may be related to the regulation of eNOS expression, NO availability and tissue homocysteine...
  52. ncbi request reprint Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation
    Matthew J Hunt
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Am J Physiol Cell Physiol 283:C1073-9. 2002
    ..These results suggest that Hcy competes with CF and PGJ(2) for binding to PPAR-alpha and -gamma, respectively, indicating a role of PPAR in amelioration of Hcy-mediated EE dysfunction...
  53. ncbi request reprint Generation of nitrotyrosine precedes activation of metalloproteinase in myocardium of hyperhomocysteinemic rats
    Harpreet S Sood
    Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Antioxid Redox Signal 4:799-804. 2002
    ..The results suggest that in the absence of endothelial NO, and in an attempt to reduce LV load, MMP-2 is activated and CIMP is inactivated, by increasing nitrotyrosine...
  54. pmc Homocysteine to hydrogen sulfide or hypertension
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Cell Biochem Biophys 57:49-58. 2010
    ..In light of the present information, this review focuses on the mechanism of hyperhomocysteinemia-associated hypertension and highlights the novel modulatory role of H(2)S to ameliorate hypertension...
  55. ncbi request reprint Homocysteine-induced myofibroblast differentiation in mouse aortic endothelial cells
    Utpal Sen
    Department of Physiology and Biophysics, HSC, University of Louisville School of Medicine, 500 South Preston St, Louisville, KY 40202, USA
    J Cell Physiol 209:767-74. 2006
    ....
  56. doi request reprint Ablation of MMP9 induces survival and differentiation of cardiac stem cells into cardiomyocytes in the heart of diabetics: a role of extracellular matrix
    Paras Kumar Mishra
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40202, USA
    Can J Physiol Pharmacol 90:353-60. 2012
    ..We conclude that inhibition of MMP9 ameliorates stem cell survival and their differentiation into cardiomyocytes in diabetes...
  57. pmc Congenic expression of tissue inhibitor of metalloproteinase in Dahl-salt sensitive hypertensive rats is associated with reduced LV hypertrophy
    Walter E Rodriguez
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Arch Physiol Biochem 114:340-8. 2008
    ..We concluded that the congenic transfer of TIMP ameliorated LV hypertrophy and cardiac dysfunction...
  58. ncbi request reprint Peroxisome proliferator ameliorates endocardial endothelial and muscarinic dysfunction in spontaneously hypertensive rats
    Lane M Smiley
    Department of Physiology and Biophysics, University of Louisville Health Sciences Center, Louisville, KY, USA
    Antioxid Redox Signal 6:367-74. 2004
    ....
  59. pmc MMP-9 gene ablation and TIMP-4 mitigate PAR-1-mediated cardiomyocyte dysfunction: a plausible role of dicer and miRNA
    Paras Kumar Mishra
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, HSC A 1215, 500S Preston Street, Louisville, KY 40202, USA
    Cell Biochem Biophys 57:67-76. 2010
    ..There is selective inhibition of miR-376b and over-expression of miR-1, miR-26a, miR-30d, and miR-181c in MMP-9KO that are implicated in regulation of G-PCR and calcium handling...
  60. ncbi request reprint Regulation of homocysteine-induced MMP-9 by ERK1/2 pathway
    Karni S Moshal
    Department of Physiology and Biophysics, University of Louisville School of Medicine, A 1115, 500 S Preston St, Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 290:C883-91. 2006
    ..Our results provide evidence that Hcy triggers the PTX-sensitive ERK1/2 signaling pathway, which is involved in the regulation of MMP-9 in MVECs...
  61. ncbi request reprint Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus
    Walter E Rodriguez
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 291:H81-7. 2006
    ..These results suggest that E-M uncoupling in the myocardium, in part, is due to increased MMP activities secondary to suppressing PPARgamma activity in high-fat, calorie-induced Type 2 diabetes mellitus...
  62. pmc Differential expression of gamma-aminobutyric acid receptor A (GABA(A)) and effects of homocysteine
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Clin Chem Lab Med 45:1777-84. 2007
    ..The aim of the present study was to examine the expression of GABA(A) receptor and its subunits in non-neural tissue...
  63. ncbi request reprint Homocysteine-induced biochemical stress predisposes to cytoskeletal remodeling in stretched endothelial cells
    Utpal Sen
    Department of Physiology and Biophysics, HSC, University of Louisville School of Medicine, A 1215, 500 South Preston Street, Louisville, KY 40202, USA
    Mol Cell Biochem 302:133-43. 2007
    ..Together our results suggest that CS- and HHcy-induced oxidative stress synergistically contribute to small GTPase membrane translocation and focal adhesion protein redistribution leading to endothelial remodeling...
  64. pmc Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure
    Srikanth Givvimani
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Appl Physiol (1985) 110:1093-100. 2011
    ....
  65. pmc Fibrinogen-induced increased pial venular permeability in mice
    Nino Muradashvili
    Department of Physiology and Biophysics, University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA
    J Cereb Blood Flow Metab 32:150-63. 2012
    ..Our results suggest that elevated blood level of Fg could have a significant role in cerebrovascular dysfunction and remodeling...
  66. ncbi request reprint Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure
    Matthew J Hunt
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Lung Cell Mol Physiol 283:L239-45. 2002
    ..In vitro, treatment of CIMP abrogated the DMP activity. The treatment with CIMP may prevent degradation of integrin and connexin and ameliorate heart failure...
  67. ncbi request reprint Early induction of matrix metalloproteinase-9 transduces signaling in human heart end stage failure
    Karni S Moshal
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Cell Mol Med 9:704-13. 2005
    ..This early mechanism for the initiation of LV remodeling appears to have a role in end-stage human heart failure...
  68. pmc Hydrogen sulfide mitigates matrix metalloproteinase-9 activity and neurovascular permeability in hyperhomocysteinemic mice
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Neurochem Int 56:301-7. 2010
    ....
  69. pmc Mechanisms of cardiovascular remodeling in hyperhomocysteinemia
    Mesia M Steed
    Department of Physiology and Biophysics, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Antioxid Redox Signal 15:1927-43. 2011
    ....
  70. ncbi request reprint Matrix metalloproteinase in left ventricular remodeling and heart failure
    Suresh Shastry
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Curr Cardiol Rep 5:200-4. 2003
    ..Identification of major players involved in the control of oxidative and proteolytic stresses that ameliorate matrix deposition by integrin shading will help to develop strategies to prevent congestive heart failure...
  71. pmc Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 300:C155-63. 2011
    ..We conclude that H₂S plays a regulatory role in Hcy-induced mesangial inflammation and that ERK1/2 and JNK1/2 are two signaling pathways involved this process...
  72. ncbi request reprint Synergism between AT1 receptor and hyperhomocysteinemia during vascular remodeling
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Clin Chem Lab Med 45:1771-6. 2007
    ..Therefore, we hypothesized that Hcy activates AT1 receptor that potentiates STAT3 via ERK-1/2 phosphorylation. STAT3 modulates target MMP-9 and collagen, resulting in vascular remodeling...
  73. ncbi request reprint Homocysteine induces metalloproteinase and shedding of beta-1 integrin in microvessel endothelial cells
    Suresh Shastry
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 93:207-13. 2004
    ..We have shown that purified TIMP-4 blocked the increase of beta-1 integrin shedding in Hcy-treated cells. Interestingly, our results suggest that TIMP-1 and TIMP-4 function antagonistically in Hcy-induced signaling pathways...
  74. ncbi request reprint Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR
    Vibhas S Mujumdar
    Department of Physiology and Biophysics, School of Medicine, The University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Cell Physiol 282:C1009-15. 2002
    ..However, CIMP inhibits only homocysteine-mediated contraction. The results suggest that homocysteine may enhance vascular constrictive remodeling by inactivating PPAR-alpha and -gamma in ECs and PPAR-gamma in SMCs...
  75. ncbi request reprint Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats
    Amanda Miller
    Department of Physiology and Biophysics, School of Medicine, The University of Mississippi Medical Center, Jackson 39216 4505, USA
    Am J Hypertens 15:157-63. 2002
    ..These results may suggest a differential role of L- and D-isomers in vascular versus cardiac remodeling...
  76. ncbi request reprint Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: role of insulin and C-peptide
    Irving G Joshua
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Biochem 96:1149-56. 2005
    ..These results suggest a synergistic action between insulin and C-peptide that facilitates increase NO availability and may suggest new clinical treatment modalities for type-1 diabetes mellitus...
  77. ncbi request reprint Homocysteine in microvascular endothelial cell barrier permeability
    Suresh C Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, A 1115, 500 South Preston Street, Louisville, KY 40202, USA
    Cell Biochem Biophys 43:37-44. 2005
    ....
  78. ncbi request reprint Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit
    Joan F Carroll
    Department of Physiology and Biophysics, University of North Texas Health Science Center, Fort Worth, Texas, USA
    Am J Hypertens 18:692-8. 2005
    ..The accumulation of cardiac collagen was associated with induction of Hcy and TGF-beta1 and with suppression of decorin...
  79. ncbi request reprint Apoptosis in the left ventricle of chronic volume overload causes endocardial endothelial dysfunction in rats
    Michael J Cox
    Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Heart Circ Physiol 282:H1197-205. 2002
    ..The results suggest that an increase in the oxidative stress and generation of nitrotyrosine are, in part, responsible for the activation of metalloproteinase and decreased endocardial endothelial function in chronic LV volume overload...
  80. ncbi request reprint Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling
    Suresh C Tyagi
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cardiovasc Pharmacol Ther 10:1-10. 2005
    ....
  81. ncbi request reprint GABA receptors and nitric oxide ameliorate constrictive collagen remodeling in hyperhomocysteinemia
    Suresh Shastry
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Physiol 205:422-7. 2005
    ..The results of this study indicated amelioration of Hcy-induced MVEC collagen gel constriction by induction of nitric oxide through GABA-A and -B receptors...
  82. ncbi request reprint Metalloproteinase in myocardial adaptation and maladaptation
    Suresh C Tyagi
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Cardiovasc Pharmacol Ther 7:241-6. 2002
    ..The cell-extracellular matrix connections are important in maintaining and synchronizing muscle function. However, a complete extracellular matrix-cell disconnect leads to a decrease in muscle cell strength, apoptosis, and hypertrophy...
  83. ncbi request reprint Homocysteine, hydrogen sulfide (H2S) and NMDA-receptor in heart failure
    Neetu Tyagi
    Department of Physiology and Biophysics, School of Medicine University of Louisville Louisville, KY 40202, USA
    Indian J Biochem Biophys 46:441-6. 2009
    ..This scenario is possible, if the activities of both the enzymes (CBS and CGL) are increased in tissues by gene therapy...
  84. pmc Stem cells as a therapeutic target for diabetes
    Paras Kumar Mishra
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Front Biosci (Landmark Ed) 15:461-77. 2010
    ..In this review we discussed stem cells as a potential future therapeutic target for the treatment of diabetes and associated diseases...
  85. ncbi request reprint Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failure
    Melvin R Hayden
    Department of Family and Community Medicine University of Missouri Columbia, Missouri 65020, USA
    Med Sci Monit 9:SR35-52. 2003
    ..Appropriately, we need to examine the mechanisms that result in the development and transition from diastolic and systolic dysfunction to the clinical syndrome of overt CHF with its inherent increase in morbidity and mortality...
  86. ncbi request reprint Mechanisms of homocysteine-induced oxidative stress
    Neetu Tyagi
    Dept of Physiology and Biophysics, School of Medicine, 500 S Preston St, 1115 A, Univ of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 289:H2649-56. 2005
    ....
  87. pmc The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri School of Medicine Columbia, PO BOX 1140 Lk, Rd, 5 87 Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:9. 2005
    ....
  88. ncbi request reprint Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC
    Karni S Moshal
    Dept of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 291:H2825-35. 2006
    ..Taken together, these findings determine the novel role of mitochondrial translocation of calpain-1 in MMP-9 activation during HHcy, in part, by increasing mitochondrial oxidative stress...
  89. ncbi request reprint Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review
    Wolfgang Herrmann
    Department of Clinical Chemistry and Laboratory Medicine Central Laboratory, University Hospital, Saarland University, Homburg Saar, Germany
    Clin Chem Lab Med 45:1633-44. 2007
    ..Future studies need to explore the pathomechanisms of HHCY in CHF. Moreover, larger intervention trials are needed to clarify whether modification of plasma HCY by B-vitamin supplementation improves the clinical outcome in CHF patients...
  90. ncbi request reprint Remodeling of the left atrium in pacing-induced atrial cardiomyopathy
    Brian D Hoit
    University Hospitals of Cleveland and Case Western Reserve University, OH, USA
    Mol Cell Biochem 238:145-50. 2002
    ..Thus, rapid pacing-induced atrial failure is associated with differential changes in MMP activity, an unchanged number of calcium pumps, and compensatory changes in the level of phospholamban...
  91. ncbi request reprint Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats
    Teresa M Camp
    Departmen tof Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
    J Hypertens 21:1719-27. 2003
    ..However, the mechanism of matrix accumulation is unclear. Spontaneously hypertensive rats (SHR) develop hypertension at between 2 and 6 weeks of age...
  92. ncbi request reprint Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice
    Alexander V Ovechkin
    Dept of Physiology and Biophysics, School of Medicine, University of Louisville, KY 40202, USA
    J Appl Physiol (1985) 99:2398-405. 2005
    ..The results suggest that impaired cardiac function in volume overload is associated with EE apoptosis, cardiac remodeling, and endothelium-myocytes uncoupling in response to MMP-9 activation...
  93. ncbi request reprint Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: a marker of cardiac dilatation
    Hanumanth K Reddy
    Division of Cardiology, Department of Internal Medicine, University of Missouri Columbia, MO, USA
    Mol Cell Biochem 264:183-91. 2004
    ..Accordingly, we have sought to correlate (a) collagen degradation with MMP elevations and, (b) assay the neutralizing potential of a known inhibitor of MMP, tetracycline on MMPs in DCM...
  94. ncbi request reprint Oxidative mechanism and homeostasis of proteinase/antiproteinase in congestive heart failure
    Brooke C Henderson
    J Mol Cell Cardiol 41:959-62. 2006
    ..The treatment with ARB mitigates this disruption in cardiac synchrony...
  95. ncbi request reprint Type 2 diabetes mellitus as a conformational disease
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri, Columbia, USA
    JOP 6:287-302. 2005
    ....
  96. ncbi request reprint Oxidative remodeling in pressure overload induced chronic heart failure
    Brooke C Henderson
    Department of Physiology and Biophysics University of Louisville, Louisville, KY 40202, USA
    Eur J Heart Fail 9:450-7. 2007
    ..In conclusion, our results suggest that AS leads to increased oxidative stress, expression/activity of MMP-2/9 and a decrease in antioxidant expression producing collagen degradation and heart failure...
  97. pmc Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions
    Alexander V Ovechkin
    Department of Physiology, School of Medicine University of Louisville, Louisville, Kentucky 40202, USA
    Arch Physiol Biochem 113:1-12. 2007
    ..This review discusses the relationship between ROS, RNS, P-selectin, and platelet-arteriolar wall interactions and proposes a hypothesis for their role in microvascular responses during pulmonary IR...
  98. ncbi request reprint Neural redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic neuropathy
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri, Columbia, MO 65020, USA
    Med Sci Monit 10:RA291-307. 2004
    ..The pain, foot ulceration, limb loss, organ dysfunction, and the associated morbidity and financial burden all contribute to the need for a better understanding of DPN and the role of redox stress and global risk reduction...
  99. ncbi request reprint Protease-activated receptor and endothelial-myocyte uncoupling in chronic heart failure
    Karni S Moshal
    Univ of Louisville School of Medicine, A 1115, Dept of Physiology and Biophysics, 500 S Preston St, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 288:H2770-7. 2005
    ..CIMP treatment normalized PAR-1 expression and ameliorated endothelial-myocyte uncoupling by decreasing oxidant-mediated proteolytic stress in CHF...
  100. pmc Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazone
    Brooke C Henderson
    Department of Physiology, Biophysics, University of Louisville, Louisville, KY 40202, USA
    Int J Biol Sci 3:385-92. 2007
    ....
  101. pmc Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:4. 2005
    ..The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall...