Research Topics
| Todd TuttleSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Contralateral prophylactic mastectomy for patients with unilateral breast cancerTodd Tuttle
University of Minnesota, Department of Surgery, Division of Surgical Oncology, 420 Delaware St SE, Minneapolis, MN, USA
Expert Rev Anticancer Ther 7:1117-22. 2007..The decision to undergo CPM is complex and many factors likely contribute to its use. Future prospective studies are critically needed to evaluate the decision-making processes leading to CPM...
The increasing use of prophylactic mastectomy in the prevention of breast cancerTodd M Tuttle
Department of Surgery, Division of Surgical Oncology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55424, USA
Curr Oncol Rep 12:16-21. 2010..Endocrine therapy with tamoxifen or aromatase inhibitors significantly reduces the risk of contralateral breast cancer and may be more acceptable than CPM for some patients...
Sentinel lymph node biopsy. Preferred method of axillary staging for breast cancerT M Tuttle
Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Minerva Ginecol 57:293-303. 2005..Although minimally invasive internal mammary SLN biopsy is feasible, the usefulness of this procedure is not established...
Toxicity and quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapyTodd M Tuttle
Division of Surgical Oncology, University of Minnesota Medical Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Ann Surg Oncol 13:1627-32. 2006..The purpose of our study was to determine the toxicity and quality of life for patients with peritoneal metastases after cytoreductive surgery (CS) plus hyperthermic intraperitoneal chemotherapy (HIPC)...
Increasing use of contralateral prophylactic mastectomy for breast cancer patients: a trend toward more aggressive surgical treatmentTodd M Tuttle
University of Minnesota, Department of Surgery, Division of Surgical Oncology, 420 Delaware St SE, Minneapolis, MN, USA
J Clin Oncol 25:5203-9. 2007..The purpose of our study was to determine the use and trends of contralateral prophylactic mastectomy in the United States...
Increasing rates of contralateral prophylactic mastectomy among patients with ductal carcinoma in situTodd M Tuttle
Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, MN, USA
J Clin Oncol 27:1362-7. 2009..The use and trends of CPM for DCIS in the United States have not previously been reported...
Trends in the local treatment of breast cancer: should we be worried?Todd M Tuttle
Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
J Surg Oncol 103:313-6. 2011..These trends have important potential untoward consequences. Strategies are being developed to ensure adequate local therapy for breast cancer patients...
The impact of sentinel lymph node biopsy and magnetic resonance imaging on important outcomes among patients with ductal carcinoma in situTodd M Tuttle
Department of Surgery, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
J Natl Cancer Inst Monogr 2010:117-20. 2010..Although MRI may identify occult multicentric or contralateral breast cancer in some patients, it may also lead to unnecessary biopsies and overtreatment...
Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsyAnees Chagpar
Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY, USA
Arch Surg 139:614-8; discussion 618-20. 2004..Subareolar or periareolar injection of radioactive technetium sulfur colloid is equivalent to other injection techniques for breast cancer sentinel lymph node (SLN) biopsy...
Perceptions of contralateral breast cancer: an overestimation of riskAndrea Abbott
Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Ann Surg Oncol 18:3129-36. 2011..The aim of this study is to assess perceptions of contralateral breast cancer (CBC) risk among breast cancer patients and to evaluate tumor and patient factors associated with risk perception...
Technical advances in sentinel lymph node biopsy for breast cancerTodd M Tuttle
Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am Surg 70:407-13. 2004..Routine preoperative lymphoscintigraphy can be avoided, thus facilitating operating room scheduling. Surgeons can use minimally invasive techniques to identify and remove internal mammary SLNs...
Surgeon and community factors affecting breast cancer sentinel lymph node biopsyJulie R Hutchinson
Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KY 40292, USA
Am J Surg 190:903-6. 2005..79, P = .0073) was surgeon experience (>20 SLN cases). CONCLUSIONS: Surgeon experience is the major factor that contributes to improved SLN biopsy results. SLN biopsy can be performed equally well by community and academic surgeons...
Biopsy type does not influence sentinel lymph node statusAnees B Chagpar
Department of Surgery, University of Louisville, 315 E Broadway, Suite 312, Louisville, KY 40202, USA
Am J Surg 190:551-6. 2005..This study sought to determine whether the type of biopsy examination independently affects sentinel lymph node (SLN) status in breast cancer patients...
Inadequacy of lymph node staging in gastric cancer patients: a population-based studyNancy N Baxter
Department of Surgery, Division of Surgical Oncology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Ann Surg Oncol 12:981-7. 2005..e., had the recommended minimum of 15 nodes examined for gastric cancer staging. Better results at one registry (Hawaii) indicate that substantial improvements could be made...
Effect of lymphoscintigraphy drainage patterns on sentinel lymph node biopsy in patients with breast cancerAnees B Chagpar
Department of Surgery, University of Louisville, 315 E Broadway, Suite 312, Louisville, KY 40202, USA
Am J Surg 190:557-62. 2005..Sentinel lymph node (SLN) biopsy examination is an accepted method of staging breast cancer patients. SLN biopsy examination in patients with drainage to the internal mammary chain (IMC) nodes is controversial...
Axillary disease recurrence after sentinel lymph node dissection for breast carcinomaKaren K Swenson
Oncology Research, Park Nicollet Health Services, Minneapolis, Minnesota 55416, USA
Cancer 104:1834-9. 2005..The purpose of the current study was to review data collected on 700 consecutive patients with early-stage breast carcinoma who underwent SLND without concomitant ALND...
Comparison of side effects between sentinel lymph node and axillary lymph node dissection for breast cancerKaren K Swenson
Park Nicollet Institute, Minneapolis, Minnesota 55416, USA
Ann Surg Oncol 9:745-53. 2002..Axillary lymph node dissection (ALND) is often associated with permanent arm side effects. Side effects after sentinel lymph node dissection (SLND) should be less common, because the surgery is less extensive...
A review of technical aspects of sentinel lymph node identification for breast cancerTodd M Tuttle
Department of Surgery, University of Minnesota, Minneapolis 55455, USA
J Am Coll Surg 195:261-8. 2002
Staged laparoscopic infusion of hyperthermic intraperitoneal chemotherapy after cytoreductive surgeryAmy Knutsen
Division of Surgical Oncology, University of Minnesota Medical Center, Minneapolis, Minnesota 55454, USA
J Gastrointest Surg 10:1038-43. 2006..Although the results of this pilot study are encouraging, additional studies are required to determine long-term survival and quality of life...
Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypesSandra L Wong
Department of Surgery, Division of Surgical Oncology, 315 E. Broadway, Suite 309, Louisville, KY 40202, USA
Am J Surg 184:492-8; discussion 498. 2002..Axillary nodal staging remains important in such patients; SLN biopsy is an ideal method to obtain this staging information...
Major cancer surgery in the elderly: results from the American College of Surgeons National Surgical Quality Improvement ProgramWaddah B Al-Refaie
Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Ann Surg 251:311-8. 2010..To examine the association between older age and short-term outcomes after major oncologic resections...
Lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancerEric H Jensen
Division of Surgical Oncology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA
Surgery 146:706-11; discussion 711-3. 2009..We sought to determine the survival benefit conferred by adequate LN evaluation...
Variations in gastric cancer care: a trend beyond racial disparitiesWaddah B Al-Refaie
Department of Surgery, University of Minnesota and Minneapolis Veterans Affairs Medical Center, 420 Delaware Street SE, Mayo Mail Code 195, Minneapolis, MN 55455, USA
Cancer 116:465-75. 2010..By using current recommendations, the authors examined the association between race and guideline-recommended treatments and identified factors that are predictive of variations in gastric cancer care...
Are mastectomy rates really increasing in the United States?Elizabeth B Habermann
University of Minnesota andVeterans Affairs Medical Center, Minneapolis, MN, USA
J Clin Oncol 28:3437-41. 2010..We conducted a population-based study to evaluate national trends in the surgical treatment of breast cancer from 2000 through 2006...
The impact of surgery, radiation, and systemic treatment on outcomes in patients with ductal carcinoma in situRobert L Kane
Division of Health Policy and Management, University of Minnesota School of Public Health, D351 Mayo MMC 729, 420 Delaware St SE, Minneapolis, MN 55455, USA
J Natl Cancer Inst Monogr 2010:130-3. 2010..Ductal carcinoma in situ (DCIS) is associated with low rates of mortality. Outcomes are generally assessed in terms of recurrence...
Association between patient and tumor characteristics with clinical outcomes in women with ductal carcinoma in situTatyana Shamliyan
Division of Health Policy and Management, University of Minnesota School of Public Health, D330 5 Mayo MMC 729, 420 Delaware St SE, Minneapolis, MN 55455, USA
J Natl Cancer Inst Monogr 2010:121-9. 2010..Future research should address composite prediction indices among race groups for all outcomes...
Ductal carcinoma in situ: risk factors and impact of screeningBeth A Virnig
Division of Health Policy and Management, School of Public Health, University of Minnesota, A365 Mayo MMC 729, 420 Delaware St SE, Minneapolis, MN 55455, USA
J Natl Cancer Inst Monogr 2010:113-6. 2010....
Body mass index and major cancer surgery outcomes: lack of association or need for alternative measurements of obesity?Waddah B Al-Refaie
Department of Surgery, University of Minnesota and Minneapolis VAMC, Minneapolis, MN, USA
Ann Surg Oncol 17:2264-73. 2010..Simultaneously, BMI has known comorbidities, which may mediate the effect of BMI if included in multivariable models. We sought to examine the effect of BMI on operative outcomes after adjusting for preoperative factors...
Extremity soft tissue sarcoma care in the elderly: insights into the generalizability of NCI Cancer TrialsWaddah B Al-Refaie
Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Ann Surg Oncol 17:1732-8. 2010..We explored the extent of older age (> or =65 years) on patterns of ESTS care in NCI-sponsored population-based dataset...
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomesBeth A Virnig
Division of Health Policy and Management, University of Minnesota School of Public Health, A365 Mayo MMC 729, Minneapolis, MN 55455, USA
J Natl Cancer Inst 102:170-8. 2010....
Exposure-response relationships for oxaliplatin-treated colon cancer cellsMark N Kirstein
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis 55455, USA
Anticancer Drugs 19:37-44. 2008..5 h. Cell kill effects are reliant on treatment length; hence, the choice of time exposure must be made with a view to maintaining a balance between the cell kill effects and the clinical feasibility of treating the patient...
Factors influencing the number of sentinel lymph nodes identified in patients with breast cancerAnees B Chagpar
Division of Surgical Oncology, Department of Surgery, University of Louisville, 315 East Broadway, Suite 312, Louisville, KY, USA
Am J Surg 194:860-4; discussion 864-5. 2007..Few SLNs are required for adequate staging; removal of more may be unnecessary. The objective of this study was to determine factors influencing the number of SLN identified...
Trends in the treatment of ductal carcinoma in situ of the breastNancy N Baxter
Division of Surgical Oncology and School of Public Health, University of Minnesota, Minneapolis 55455, USA
J Natl Cancer Inst 96:443-8. 2004..This study was designed to evaluate the use of surgery and radiation therapy in treating DCIS...
A critical analysis of the surgical management of early-stage gallbladder cancer in the United StatesEric H Jensen
Division of Surgical Oncology, University of Minnesota Medical Center, 420 Delaware Street SE, MMC 195, Minneapolis, MN 55455, USA
J Gastrointest Surg 13:722-7. 2009..We sought to determine whether radical resection improves survival for patients with early-stage cancer and to evaluate surgeon compliance with current treatment recommendations...
The effect of prior breast biopsy method and concurrent definitive breast procedure on success and accuracy of sentinel lymph node biopsySandra L Wong
Division of Surgical Oncology, Department of Surgery, J. Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Ann Surg Oncol 9:272-7. 2002..CONCLUSIONS: Excisional biopsy does not significantly affect the accuracy of SLN biopsy, nor does the type of definitive surgical procedure...
Subareolar injection of 99mTc facilitates sentinel lymph node identificationTodd M Tuttle
Department of Surgery, Park Nicollet Clinic, Minneapolis, Minnesota, USA
Ann Surg Oncol 9:77-81. 2002..However, the identification and false-negative rates with this method can vary widely from surgeon to surgeon. The subareolar location contains a rich lymphatic network and represents a potential site of injection for SLN identification...
Counseling breast cancer patients on contralateral prophylactic mastectomy: the physician's roleTodd M Tuttle
University of Minnesota, Department of Surgery, Division of Surgical Oncology, Minneapolis, Minnesota, USA
Oncology (Williston Park) 22:545-8. 2008
Conditional survival after surgical treatment of melanoma: an analysis of the Surveillance, Epidemiology, and End Results databaseNatasha M Rueth
Division of Surgical Oncology, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Ann Surg Oncol 17:1662-8. 2010..Therefore, survival estimates may be misleading for long-term cancer survivors. We examined whether conditional survival (CS) is more accurate in predicting long-term melanoma survival...
Factors predicting failure to identify a sentinel lymph node in breast cancerAnees B Chagpar
Division of Surgical Oncology, Department of Surgery, University of Louisville, KY, USA
Surgery 138:56-63. 2005..The purpose of this study was to elucidate factors that independently predict failure to identify an SLN...
Trends in the incidence and treatment of parathyroid cancer in the United StatesPeter K Lee
Department of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer 109:1736-41. 2007..The objectives of this study were to determine the patterns of disease, treatment trends, and outcomes among patients with parathyroid cancer by using a population-based data source...
Determination of the minimum number of lymph nodes to examine to maximize survival in patients with esophageal carcinoma: data from the Surveillance Epidemiology and End Results databaseShawn S Groth
University of Minnesota Department of Surgery, Division of Thoracic Foregut Surgery, Minneapolis, MN 55455, USA
J Thorac Cardiovasc Surg 139:612-20. 2010..We used a population-based cancer registry to examine the association between lymph node counts and mortality to determine the minimum number of lymph nodes that should be examined as part of esophageal resection...
Patient and surgeon characteristics associated with increased use of contralateral prophylactic mastectomy in patients with breast cancerAmanda K Arrington
Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Ann Surg Oncol 16:2697-704. 2009..The current study evaluated patients who underwent breast cancer surgery in a metropolitan-based hospital system to determine factors associated with CPM...
Owen H Wangensteen, Jerome A Urban, and the pursuit of extraaxillary lymph node metastases from breast cancerTodd M Tuttle
Division of Surgical Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Am Coll Surg 199:636-43. 2004
Preoperative staging and postoperative surveillance for gastric cancerEric H Jensen
Division of Surgical Oncology, University of Minnesota Medical Center, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Surg Oncol Clin N Am 16:329-42. 2007..Imaging studies and endoscopy should be selectively performed in symptomatic patients...
Prognosis for primary retroperitoneal sarcoma survivors: a conditional survival analysisAndrea M Abbott
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer 118:3321-9. 2012..We hypothesized that the variables evaluated in the current staging system and post-operative nomograms would have limited ability to predict conditional survival in patients surgically treated for RPS...
Incorporating margin status information in treatment decisions for women with ductal carcinoma in situ: a decision analysisShi Yi Wang
Department of Health Policy and Management, University of Minnesota School of Public Health, 420 Delaware Street S E MMC 729, Minneapolis, MN 55455, USA
Breast Cancer Res Treat 124:393-402. 2010..Our analyses also highlight the importance of patients' preferences in decision making. Our findings suggest that RT is not necessary for all patients with DCIS undergoing BCS...
Surgical therapy for anorectal melanomaKelli M Bullard
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
J Am Coll Surg 196:206-11. 2003..Local resection does not increase the risk of local or regional recurrence. APR offers no survival advantage over local excision. We advocate wide local excision as primary therapy for anorectal melanoma when technically feasible...
Adding in vivo quantitative 1H MR spectroscopy to improve diagnostic accuracy of breast MR imaging: preliminary results of observer performance study at 4.0 TSina Meisamy
Department of Radiology, Center for Magnetic Resonance Research Medical School, 2021 Sixth St SE, Minneapolis, MN 55455, USA
Radiology 236:465-75. 2005..001). CONCLUSION: Current study results suggest that the addition of quantitative 1H MR spectroscopy to the breast MR imaging examination may help to improve the radiologist's ability to distinguish benign from malignant breast lesions...
Neoadjuvant chemotherapy of locally advanced breast cancer: predicting response with in vivo (1)H MR spectroscopy--a pilot study at 4 TSina Meisamy
Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 Sixth St SE, Minneapolis, MN 55455, USA
Radiology 233:424-31. 2004....
Sentinel lymph node biopsy for breast cancer: improvement in results over timeCelia Chao
University of Texas Medical Branch, Galveston, Texas 77555, USA
Breast J 10:337-44. 2004..The improved ID rate may be related to improved technical details, while the FN rate has not changed significantly. This highlights the ongoing need for surgeons to perform backup axillary dissection during their initial learning phase...
Intraoperative subareolar injection of 99mTc-labeled sulfur colloid results in consistent sentinel lymph node identificationTheresa G Zogakis
John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, California 90404, USA
Ann Surg Oncol 12:167-72. 2005..The radioactive SLN is easily and quickly identified after an intraoperative SA TcSC injection. The simplicity of this method eliminates the inherent problems associated with standard PT injection...
Trends in the treatment and outcome of pancreatic cancer in the United StatesNancy N Baxter
Division of General Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
Ann Surg Oncol 14:1320-6. 2007..Although pancreatic cancer is the fourth leading cause of cancer death, few studies have evaluated population-based trends in diagnosis, management, and outcome...
Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastasesGeorges Vlastos
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, TX 77030, USA
Ann Surg Oncol 11:869-74. 2004..Hepatic resection should be considered a component of multimodality treatment of breast cancer in these patients...
