Stephen W Tuttle

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007
  2. ncbi request reprint Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
  3. pmc Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells
    Prashanthi Javvadi
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:1941-50. 2010
  4. doi request reprint pO(2)-dependent NO production determines OPPC activity in macrophages
    Mary A Robinson
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Free Radic Biol Med 48:189-95. 2010
  5. ncbi request reprint Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
  6. ncbi request reprint 2-Deoxyglucose and radiosensitization: teaching an old DOG new tricks?
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:824-6. 2006
  7. pmc The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway
    Prashanthi Javvadi
    Department of Radiation Oncology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:1491-501. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007
    ..Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia...
  2. ncbi request reprint Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
    ..We conclude that radiation sensitivity and cell survival are dependent on vicinal thiol and GSH. In the former and latter cases, the protein thiols are also important...
  3. pmc Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells
    Prashanthi Javvadi
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 70:1941-50. 2010
    ..These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy...
  4. doi request reprint pO(2)-dependent NO production determines OPPC activity in macrophages
    Mary A Robinson
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Free Radic Biol Med 48:189-95. 2010
    ..These results are the first to investigate the effect of pO(2) on the relationship between NO production and OPPC activity, and to rule out limitations in OPPC activity as a mechanism by which NO production is decreased under hypoxia...
  5. ncbi request reprint Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
    ..The results also show that protein thiol status is a critical factor in cell survival after irradiation...
  6. ncbi request reprint 2-Deoxyglucose and radiosensitization: teaching an old DOG new tricks?
    Amit Maity
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 5:824-6. 2006
  7. pmc The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway
    Prashanthi Javvadi
    Department of Radiation Oncology, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:1491-501. 2008
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