Mark Tuszynski

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Concepts and methods for the study of axonal regeneration in the CNS
    Mark H Tuszynski
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0662, USA
    Neuron 74:777-91. 2012
  2. ncbi request reprint Gene therapy for neurological disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Expert Opin Biol Ther 3:815-28. 2003
  3. ncbi request reprint Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093, USA
    Prog Brain Res 146:441-9. 2004
  4. ncbi request reprint NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection
    Mark H Tuszynski
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 181:47-56. 2003
  5. ncbi request reprint Nerve growth factor gene therapy in Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California San Diego, La Jolla 92161, and Veterans Affairs Medical Center, San Diego, CA, USA
    Alzheimer Dis Assoc Disord 21:179-89. 2007
  6. ncbi request reprint Growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, Division of Neurosurgery, University of California at San Diego, La Jolla, California 92093, USA
    Neurosurg Focus 13:e5. 2002
  7. ncbi request reprint Nerve growth factor gene delivery: animal models to clinical trials
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Dev Neurobiol 67:1204-15. 2007
  8. ncbi request reprint New strategies in neural repair
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Prog Brain Res 138:401-9. 2002
  9. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
  10. ncbi request reprint Nerve growth factor gene therapy for Alzheimer's disease
    Mark H Tuszynski
    La Jolla, University of California San Diego, USA
    J Mol Neurosci 19:207. 2002

Research Grants

  1. Netrins and Gene Therapy After Spinal Cord Injury
    Mark Tuszynski; Fiscal Year: 2003
  2. Plasticity and Regeneration in the Primate Spinal Cord
    Mark Tuszynski; Fiscal Year: 2005
  3. Plasticity and Regeneration in the Primate Spinal Cord
    Mark Tuszynski; Fiscal Year: 2007
  4. Combinatorial Approaches to SCI
    Mark Tuszynski; Fiscal Year: 2007
  5. NEUROBIOLOGICAL ASPECTS OF AGING
    Mark Tuszynski; Fiscal Year: 2007
  6. Plasticity and Regeneration in the Primate Spinal Cord
    Mark H Tuszynski; Fiscal Year: 2010

Collaborators

Detail Information

Publications67

  1. pmc Concepts and methods for the study of axonal regeneration in the CNS
    Mark H Tuszynski
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0662, USA
    Neuron 74:777-91. 2012
    ..We address definitions of axonal growth, sprouting and regeneration after injury, and the research tools to assess growth...
  2. ncbi request reprint Gene therapy for neurological disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Expert Opin Biol Ther 3:815-28. 2003
    ..We have thereby begun the transition to molecular-based medicine which has the potential to alter the landscape and prognosis of neurological disease...
  3. ncbi request reprint Nerve growth factor: from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093, USA
    Prog Brain Res 146:441-9. 2004
    ....
  4. ncbi request reprint NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection
    Mark H Tuszynski
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 181:47-56. 2003
    ..Thus, growth factor gene delivery can elicit growth of corticospinal axons in chronic stages of injury and improves functional outcomes compared to non-growth-factor-treated animals...
  5. ncbi request reprint Nerve growth factor gene therapy in Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California San Diego, La Jolla 92161, and Veterans Affairs Medical Center, San Diego, CA, USA
    Alzheimer Dis Assoc Disord 21:179-89. 2007
    ..Gene therapy is one of a limited number of potential methods for achieving these requirements...
  6. ncbi request reprint Growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, Division of Neurosurgery, University of California at San Diego, La Jolla, California 92093, USA
    Neurosurg Focus 13:e5. 2002
    ..In this article the authors summarize the development and implementation of nerve growth factor gene delivery as a potential means of reducing cell loss in AD...
  7. ncbi request reprint Nerve growth factor gene delivery: animal models to clinical trials
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Dev Neurobiol 67:1204-15. 2007
    ..This article reviews progress in evaluating the therapeutic potential of growth factors, from early animal models to human clinical trials currently underway in AD...
  8. ncbi request reprint New strategies in neural repair
    Mark H Tuszynski
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Prog Brain Res 138:401-9. 2002
  9. ncbi request reprint A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, La Jolla 92093, USA
    Nat Med 11:551-5. 2005
    ..05) increases in cortical 18-fluorodeoxyglucose after treatment. Brain autopsy from one subject suggested robust growth responses to NGF. Additional clinical trials of NGF for Alzheimer disease are warranted...
  10. ncbi request reprint Nerve growth factor gene therapy for Alzheimer's disease
    Mark H Tuszynski
    La Jolla, University of California San Diego, USA
    J Mol Neurosci 19:207. 2002
  11. ncbi request reprint Spontaneous and augmented growth of axons in the primate spinal cord: effects of local injury and nerve growth factor-secreting cell grafts
    Mark H Tuszynski
    Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0626, USA
    J Comp Neurol 449:88-101. 2002
    ..Furthermore, as in rodent studies, cellular delivery of a trophic factor significantly augments axonal plasticity in the primate spinal cord...
  12. ncbi request reprint Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition
    Leonard L Jones
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 23:9276-88. 2003
    ..Thus, axons grow along substrates coexpressing both inhibitory and permissive molecules, suggesting that regeneration is successful when local permissive signals balance and exceed inhibitory signals...
  13. ncbi request reprint Axon regeneration through scars and into sites of chronic spinal cord injury
    Paul Lu
    Department of Neurosciences 0626, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 203:8-21. 2007
    ....
  14. pmc Local and remote growth factor effects after primate spinal cord injury
    John H Brock
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:9728-37. 2010
    ..Remote cortical effects of spinally administered growth factors could "prime" the neuron to respond to experimental therapies that promote axonal plasticity or regeneration...
  15. ncbi request reprint Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury
    Hong Yang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 26:2157-66. 2006
    ..Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement...
  16. pmc IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury
    Edmund R Hollis
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 215:53-9. 2009
    ..We conclude that developmental patterns of growth factor responsiveness are not simply recapitulated after adult injury, potentially due to post-natal shifts in patterns of IGF-I receptor expression...
  17. ncbi request reprint Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord
    Laura Taylor
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 26:9713-21. 2006
    ..These findings indicate that a localized and continuous gradient of NT-3 can achieve axonal bridging beyond the glial scar, but growth for longer distances is not sustainable simply with a trophic stimulus...
  18. ncbi request reprint Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury
    Shula Stokols
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Biomaterials 27:443-51. 2006
    ..These findings clearly demonstrate that axonal regeneration can be organized and guided across a site of injury...
  19. doi request reprint Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum
    Christopher D Herzog
    Ceregene, Inc, San Diego, California 92121, USA
    Mol Ther 16:1737-44. 2008
    ..Collectively, these data provide substantial novel evidence for the potential utility of CERE-120 as a novel treatment for PD and support ongoing clinical trials testing CERE-120 in PD patients...
  20. pmc Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
    Alan H Nagahara
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Exp Neurol 215:153-9. 2009
    ..These findings also support the safety and feasibility of lentiviral NGF gene transfer for potential testing in human clinical trials to protect degenerating cholinergic neurons in Alzheimer's disease...
  21. ncbi request reprint Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury
    Paul Lu
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093, USA
    J Neurosci 26:11120-30. 2006
    ....
  22. pmc Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury
    Ken Kadoya
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 64:165-72. 2009
    ..Collectively, these findings provide evidence that regeneration is achievable at unprecedented postinjury time points...
  23. pmc Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    Laura Taylor Alto
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:1106-13. 2009
    ..Thus, we report for the first time, to the best of our knowledge, the reinnervation of brainstem targets after SCI and an essential role for chemotropic axon guidance in target selection...
  24. doi request reprint The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity
    Dhakshin Ramanathan
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 29:5992-6000. 2009
    ....
  25. ncbi request reprint Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury
    Paul Lu
    Department of Neurosciences, University of California at San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 24:6402-9. 2004
    ..Thus, clear axonal regeneration beyond spinal cord injury sites can be achieved by combinatorial approaches that stimulate both the neuronal soma and the axon, representing a major advance in strategies to enhance spinal cord repair...
  26. ncbi request reprint Issues regarding gene therapy products for Parkinson's disease: the development of CERE-120 (AAV-NTN) as one reference point
    Raymond T Bartus
    Ceregene, Inc, San Diego, CA 92121, USA
    Parkinsonism Relat Disord 13:S469-77. 2007
    ..To develop CERE-120 (AAV-NTN) as a novel therapy for Parkinson's disease (PD) that might restore function of degenerating dopamine neurons and prevent further degeneration...
  27. pmc A form of motor cortical plasticity that correlates with recovery of function after brain injury
    Dhakshin Ramanathan
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 103:11370-5. 2006
    ..This evidence suggests the existence of complex movement representations in the rat motor cortex that exhibit plasticity after injury and rehabilitation, serving as a relevant predictor of functional recovery...
  28. ncbi request reprint Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors
    Leonard L Jones
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 22:4611-24. 2002
    ..This is the first demonstration that KSPGs are expressed after SCI in a temporal and spatial relationship that could exert an early and important role in modulating axonal growth after SCI...
  29. ncbi request reprint The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury
    Shula Stokols
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 25:5839-46. 2004
    ....
  30. pmc Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys
    Ephron S Rosenzweig
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 513:151-63. 2009
    ..Thus, augmentation of sprouting of these extensive bilateral CST projections may provide a novel target for enhancing recovery after spinal cord injury...
  31. pmc Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons
    Kathie M Bishop
    Ceregene, Inc, 9381 Judicial Drive, Suite 130, San Diego, CA 92121, USA
    Exp Neurol 211:574-84. 2008
    ....
  32. ncbi request reprint Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys
    Christopher D Herzog
    Ceregene Inc, San Diego, CA 92121, USA
    Mov Disord 22:1124-32. 2007
    ....
  33. doi request reprint Netrin-1 is a novel myelin-associated inhibitor to axon growth
    Karin Löw
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 28:1099-108. 2008
    ..We conclude that netrin-1 is a novel oligodendrocyte-associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury...
  34. doi request reprint Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds
    Thomas Gros
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 31:6719-29. 2010
    ..Further development must reduce reactive cellular interfaces to support effective axonal penetration of host parenchyma...
  35. pmc Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation
    Edmund R Hollis
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 106:7215-20. 2009
    ....
  36. ncbi request reprint Transient growth factor delivery sustains regenerated axons after spinal cord injury
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:10535-45. 2007
    ..Thus, the adult CNS appears capable of sustaining axons that have extended after transient growth factor delivery, an effect potentially attributable to the persistence of Schwann cells in lesion/graft sites...
  37. ncbi request reprint Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth
    Steve Lacroix
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Comp Neurol 454:213-28. 2002
    ..01) at the lesion site. Thus, potential neurotrophic properties of this cytokine family of growth factors must be balanced against their inflammatory properties when considering therapeutic application to CNS injury...
  38. ncbi request reprint NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors
    Leonard L Jones
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 22:2792-803. 2002
    ..Thus, NG2 is a major component of this putatively inhibitory class of ECM molecules expressed at sites of SCI and may restrict axonal regeneration...
  39. ncbi request reprint Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair
    Armin Blesch
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Brain Res Bull 57:833-8. 2002
    ..In this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury...
  40. ncbi request reprint Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons
    Armin Blesch
    Department of Neurosciences 0626, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Ther 11:916-25. 2005
    ..These data demonstrate for the first time that NGF delivery by lentiviral gene transfer using tetracycline-regulated promoters can completely regulate neuronal rescue and protein production in the brain...
  41. ncbi request reprint The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury
    James M Conner
    Department of Neurosciences, Unviersity of California, La Jolla, California 92093, USA
    Neuron 46:173-9. 2005
    ..These findings raise the intriguing possibility that deficits in cholinergic function may limit functional outcomes following nervous system injury...
  42. ncbi request reprint Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination
    Armin Blesch
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 467:403-17. 2003
    ..Thus, GDNF exerts tropic effects on adult spinal axons and Schwann cells that contribute to axon growth after injury...
  43. ncbi request reprint Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 38:819-29. 2003
    ..These results support the hypothesis that the basal forebrain cholinergic system may be specifically implicated in forms of learning requiring plasticity of cortical representations...
  44. ncbi request reprint Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury
    Armin Blesch
    Department of Neurosciences Center for Neural Repair, University of California, San Diego, La Jolla, CA 92093 0626, USA
    Yonsei Med J 45:28-31. 2004
    ..Thus, strategies have evolved for the delivery of potentially neuroprotective molecules, such as neurotrophic factors, and the replacement of cells and tissue lost due to CNS injury and degeneration...
  45. doi request reprint Spinal cord injury: plasticity, regeneration and the challenge of translational drug development
    Armin Blesch
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, CA 92093, USA
    Trends Neurosci 32:41-7. 2009
    ..Therapeutic candidates are most likely to have a detectable effect in human trials if they elicit benefits in severe contusion and larger animal models and pass the test of independent replication...
  46. pmc Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    Alan H Nagahara
    Department of Neurosciences 0626, 9500 Gilman Drive, University of California San Diego, La Jolla, California 92093, USA
    Nat Med 15:331-7. 2009
    ..BDNF therapeutic delivery merits exploration as a potential therapy for Alzheimer's disease...
  47. ncbi request reprint Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury
    Armin Blesch
    Department of Neurosciences 0626, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093 0626, USA
    Prog Brain Res 137:415-23. 2002
  48. pmc NGF is essential for hippocampal plasticity and learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 29:10883-9. 2009
    ..These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain...
  49. pmc Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery
    Alan H Nagahara
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA
    Neurobiol Aging 31:1020-31. 2010
    ....
  50. ncbi request reprint Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study
    Steve Lacroix
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    J Comp Neurol 473:147-61. 2004
    ..Furthermore, bilateral CST projections from a single motor cortex could represent a potential source of plasticity after injury, as well as a target of therapeutic effort in neural regeneration strategies...
  51. doi request reprint Efficient retrograde neuronal transduction utilizing self-complementary AAV1
    Edmund R Hollis
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    Mol Ther 16:296-301. 2008
    ..91 +/- 0.24% of lumbar MNs were transduced. Our data provide the basis for increased retrograde transduction efficiency using peripheral injections of scAAV1 vectors for therapeutic gene delivery to the spinal cord...
  52. ncbi request reprint Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta)
    Gregoire Courtine
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    Brain 128:2338-58. 2005
    ....
  53. pmc Growth factors and combinatorial therapies for CNS regeneration
    Paul Lu
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 209:313-20. 2008
    ..The search for combination therapies that optimize axonal growth after SCI continues...
  54. ncbi request reprint Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons
    David E Smith
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 24:4373-81. 2004
    ..These findings demonstrate extensive but highly localized loss of neocortical neurons in aged, cognitively impaired monkeys that likely contributes to cognitive decline. Cell degeneration, when present, extends transneuronally...
  55. ncbi request reprint Templated agarose scaffolds support linear axonal regeneration
    Shula Stokols
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA
    Tissue Eng 12:2777-87. 2006
    ..The templating process can be useful in fabricating nerve guidance scaffolds for both central and peripheral nerve injuries, or any materials application requiring a precise array of linearly oriented channels...
  56. ncbi request reprint The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
    Leonard L Jones
    Department of Neurosciences 0626, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 182:399-411. 2003
    ..Optimization of strategies to reduce CSPG expression to enhance regeneration may need to target several different family members over an extended period following injury...
  57. ncbi request reprint Growth-factor gene therapy for neurodegenerative disorders
    Mark H Tuszynski
    Department of Neurosciences, University of California at San Diego, and the Veterans Administration Medical Center San Diego, La Jolla 92093, USA
    Lancet Neurol 1:51-7. 2002
    ..The progress of gene-therapy clinical trials is aiding the transition to molecular and gene-targeted therapeutic approaches which have the potential to improve dramatically the prognosis of neurological disease...
  58. ncbi request reprint Hippocampal cell genesis does not correlate with spatial learning ability in aged rats
    David A Merrill
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Comp Neurol 459:201-7. 2003
    ..In the context of aging, these finding do not support a direct relationship of adult hippocampal neurogenesis with learning and memory capability...
  59. pmc Transient demyelination increases the efficiency of retrograde AAV transduction
    Edmund R Hollis
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA
    Mol Ther 18:1496-500. 2010
    ..These findings identify a means of significantly enhancing retrograde vector transport for use in experimental paradigms requiring either retrograde neuronal identification and gene expression, or translational treatment paradigms...
  60. pmc A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth
    Ronald W Alfa
    Department of Neurosciences 0626, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci Res 87:2624-31. 2009
    ..These results demonstrate that small ligand-induced dimerization of the intracellular domain of trkA can efficiently simulate the biological activity of NGF and provide a means to regulate intracellular neurotrophin receptor signaling...
  61. ncbi request reprint Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact?
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci Res 77:174-91. 2004
    ....
  62. ncbi request reprint Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats
    Mathew Blurton-Jones
    Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0626, USA
    J Comp Neurol 452:276-87. 2002
    ..Thus, ER-beta exhibits extensive colocalization with a subclass of inhibitory neurons, suggesting a potential mechanism whereby estrogen can regulate neuronal excitability in diverse and broad brain regions by modulating inhibitory tone...
  63. ncbi request reprint Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus)
    Gregoire Courtine
    Dept of Physiological Science, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, CA 90095 1527, USA
    J Neurophysiol 93:3127-45. 2005
    ..We suggest that such adaptive changes may have facilitated evolution toward bipedal locomotion...
  64. ncbi request reprint Clinical trials in spinal cord injury
    Andrew R Blight
    Acorda Therapeutics, Hawthorne, New York, USA
    J Neurotrauma 23:586-93. 2006
    ....
  65. ncbi request reprint Rebuilding the brain: resurgence of fetal grafting
    Mark H Tuszynski
    Nat Neurosci 10:1229-30. 2007
  66. ncbi request reprint Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF
    Mathew Blurton-Jones
    Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697 4540, USA
    J Comp Neurol 499:603-12. 2006
    ..This identifies a putative two-step transsynaptic mechanism whereby estrogen availability modulates expression of inhibitory transmitters, resulting in increased BDNF expression...
  67. ncbi request reprint Nucleus hears axon's pain
    Armin Blesch
    Nat Med 10:236-7. 2004

Research Grants19

  1. Netrins and Gene Therapy After Spinal Cord Injury
    Mark Tuszynski; Fiscal Year: 2003
    ..Specific Aim 2: Determine whether netrin over-expression in the injured adult spinal cord influences the extent or direction of axonal growth. ..
  2. Plasticity and Regeneration in the Primate Spinal Cord
    Mark Tuszynski; Fiscal Year: 2005
    ..B) Synergy Between Motor Activity and Growth Factor Gene Therapy in Promoting Recovery After Primate SCI. ..
  3. Plasticity and Regeneration in the Primate Spinal Cord
    Mark Tuszynski; Fiscal Year: 2007
    ..Specific Aim 3: Determine Whether BDNF Delivery Into and Below a C5-6 Hemisection Lesion, + cAMP Augmentation, Will Promote Axonal Sprouting or Regeneration, and Functional Recovery. ..
  4. Combinatorial Approaches to SCI
    Mark Tuszynski; Fiscal Year: 2007
    ..We further have a track record of responsibly translating promising therapies from the bench to bedside. ..
  5. NEUROBIOLOGICAL ASPECTS OF AGING
    Mark Tuszynski; Fiscal Year: 2007
    ..Individual trainees will then choose a discipline within which to focus and foster a career research topic. ..
  6. Plasticity and Regeneration in the Primate Spinal Cord
    Mark H Tuszynski; Fiscal Year: 2010
    ..Specific Aim 3: Determine Whether BDNF Delivery Into and Below a C5-6 Hemisection Lesion, + cAMP Augmentation, Will PromoteAxonal Sprouting or Regeneration, and FunctionalRecovery. ..