Research Topics
Genomes and Genes | Terry TurnerSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Acute testicular ischemia results in germ cell-specific apoptosis in the ratT T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA
Biol Reprod 57:1267-74. 1997..These events were contemporaneous with the first appearance of apoptosis and consistent with the hypothesis that post-torsion, germ cell-specific apoptosis is induced by reactive oxygen species...- Sonic hedgehog pathway inhibition alters epididymal function as assessed by the development of sperm motilityTerry T Turner
Department of Urology, University of Virginia School of Medicine, PO Box 800422, Charlottesville, Virginia 22908, USA
J Androl 27:225-32. 2006..These results indicate that an operating Shh pathway is important in the murine epididymis for the development of sperm motility and implies a role for Shh signaling in adult epididymal function... 
Cytokine responses to E. coli-induced epididymitis in the rat: blockade by vasectomyTerry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Urology 77:1507.e9-14. 2011..To determine cytokine responses in rat epididymal tissues after retrograde Escherichia coli inoculation of the cauda epididymidis via the intact and obstructed vas deferens...- Testicular torsion alters the presence of specific proteins in the mouse testis as well as the phosphorylation status of specific proteinsTerry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
J Androl 27:285-93. 2006..Knowing these proteins and the pathways to which they point will aid in the search for new therapies of oxidative stress in the testis... - Differential gene expression among the proximal segments of the rat epididymis is lost after efferent duct ligationTerry T Turner
Department of Urology, University of Virginia Health Science System, Charlottesville, Virginia 22908, USA
Biol Reprod 77:165-71. 2007..These results reveal a higher complexity to the regulation of rat epididymal segments than heretofore appreciated... - Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligationTerry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Asian J Androl 9:565-73. 2007..Such results reveal a higher complexity of the regulation of rat epididymal segments than that is generally appreciated... - De Graaf's thread: the human epididymisTerry T Turner
Department of Urology, University of Virginia School of Medicine, PO Box 800422, Charlottesville, VA 22908, USA
J Androl 29:237-50. 2008..The epididymal functions of transporting, concentrating, maturing, and storing sperm are important to male fertility and their absence or significant impairment can be a factor in male infertility... - Oxidative stress: a common factor in testicular dysfunctionTerry T Turner
Department of Urology, University of Virginia School of Medicine, PO Box 800422, Charlottesville, VA 22908, USA
J Androl 29:488-98. 2008..Testicular oxidative stress appears to be a common feature in much of what underlies male infertility, which suggests that there may be benefits to developing better antioxidant therapies for relevant cases of hypospermatogenesis... - Looking to the future of epididymal research: why this, why now?Terry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, VA 22908 0422, USA
J Androl 32:705-10. 2011.... - Experimental testicular torsion: reperfusion blood flow and subsequent testicular venous plasma testosterone concentrationsTerry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Urology 65:390-4. 2005.... - The study of varicocele through the use of animal modelsT T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA
Hum Reprod Update 7:78-84. 2001..Many questions remain regarding the mechanism by which varicocele induces testicular dysfunction, chief among them being how the unilateral varicocele causes a bilateral testicular response in the first place... - The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repairTerry T Turner
Departments of Urology and Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
J Urol 172:2574-8. 2004..Evidence from animal models is used to discover pathways that might be amenable to manipulation by therapeutic regimens... - Postvasectomy alterations in protein synthesis and secretion in the rat caput epididymidis are not repaired after vasovasostomyT T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA
J Androl 21:276-90. 2000..All 3 of these proteins occur in the epididymides of multiple species and have been associated with sperm fertilizing capacity... - Sonic hedgehog pathway genes are expressed and transcribed in the adult mouse epididymisTerry T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, 22903, USA
J Androl 25:514-22. 2004..This suggests that the genes are capable of being regulated in a manner that is influenced by testicular contribution, and it implies that those genes have a function in the epididymis subject to that regulation... - Physician-scientists in urology and the urology research programs that train themT T Turner
The Residency Research Program, Department of Urology, University of Virginia Health System, Charlottesville, USA
J Urol 171:1979-81. 2004 - On the regulation of Crisp-1 mRNA expression and protein secretion by luminal factors presented in vivo by microperfusion of the rat proximal caput epididymidisT T Turner
Department of Urology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Mol Reprod Dev 61:437-44. 2002..This study demonstrates that intraluminal testicular proteins are not important co-regulators with androgens of Crisp-1gene expression or resulting Crisp-1 secretion into the rat proximal caput tubule lumen in vivo... - 5' hox genes and meis 1, a hox-DNA binding cofactor, are expressed in the adult mouse epididymisDaniela Bomgardner
Department of Urology Cell Biology, University of Virginia Health Science System, Charlottesville, Virginia 22908, USA
Biol Reprod 68:644-50. 2003..Our study provides preliminary data from which we suggest the involvement of homeodomain transcription factors in the maintenance of segmental function of the adult epididymis and vas deferens... - Identification of epididymis-specific transcripts in the mouse and rat by transcriptional profilingDaniel S Johnston
Contraception, Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Rd, N2312 Collegeville, PA 19426, USA
Asian J Androl 9:522-7. 2007..The results of the studies described in this report are available at the Mammalian Reproductive Genetics (MRG) Database (http://mrg.genetics.washington.edu/)... - Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsionJeffrey J Lysiak
Department of Urology, University of Virginia Health Science System, Charlottesville 22908, USA
J Androl 23:400-9. 2002..The mechanism by which ROS modulates neutrophil adhesion to venules is presently under investigation, as are additional therapeutic regimens to block oxidative stress... - Activation of the nuclear factor kappa B pathway following ischemia-reperfusion of the murine testisJeffrey J Lysiak
Department of Urology Box 800422, University of Virginia Health System, Charlottesville, VA 22908, USA
J Androl 26:129-35. 2005..The specific roles of these genes in the testicular response to IR remains to be determined... - Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2Jeffrey J Lysiak
Department of Urology, University of Virginia Health Science System, Charlottesville, VA 22908, USA
Cell Tissue Res 328:411-9. 2007.... - The rat epididymal transcriptome: comparison of segmental gene expression in the rat and mouse epididymidesScott A Jelinsky
Biological Technologies, Molecular Profiling and Biomarker Discovery, Wyeth Research, Cambridge, Massachusetts 02140, USA
Biol Reprod 76:561-70. 2007..Furthermore, these data provide a powerful resource for the research community for future studies of biological factors that mediate sperm maturation and storage... - Growth factor-stimulated mitogen-activated kinase (MAPK) phosphorylation in the rat epididymis is limited by segmental boundariesJose L Tomsig
Department of Urology, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Biol Reprod 75:598-604. 2006..These results suggest that CTS regulate the trophic influences of growth factors and potentially other paracrine molecules, thus creating functionally separate units within the epididymis... - Caspase 2 activity contributes to the initial wave of germ cell apoptosis during the first round of spermatogenesisShuqiu Zheng
Department of Urology, University of Virginia Health Science System, Charlottesville, Virginia 22908, USA
Biol Reprod 74:1026-33. 2006.... - Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expressionJeffrey J Lysiak
Department of Urology, University of Virginia Health Science System, Charlottesville, VA 22908, USA
Biol Reprod 69:202-10. 2003..This provides the first evidence of a cytokine/stress-related kinase signaling pathway to E-selectin expression in vivo... - Growth factors and the epididymisJose L Tomsig
Department of Urology, University of Virginia, 300 Lane Rd, MR-4 Bldg, Rm 6153, Box 800422, Charlottesville, 22908, USA
J Androl 27:348-57. 2006 - The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymisDaniel S Johnston
Contraception, Woman s Health and Bone, Wyeth Research, Collegeville, Pennsylvania 19426, USA
Biol Reprod 73:404-13. 2005.... - Identification of rat cysteine-rich secretory protein 4 (Crisp4) as the ortholog to human CRISP1 and mouse Crisp4Michael A Nolan
Contraception, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
Biol Reprod 74:984-91. 2006..Our data identify rat Crisp4 as the true ortholog to human CRISP1 and mouse Crisp4, and demonstrate its interaction with spermatozoa in the epididymis... - In vivo detection of apoptotic cells in the testis using fluorescence labeled annexin V in a mouse model of testicular torsionSang-Kuk Yang
Department of Urology, Konkuk University School of Medicine, Chungju Hospital, Korea
J Urol 176:830-5. 2006..It shows important confounding factors that must be considered as this new imaging technique is developed for detecting apoptotic cells in vivo in testes or in any other organ...
Research Grants
- TESTICULAR TORSION--MECHANISMS AND TREATMENTTerry Turner; Fiscal Year: 2001..Our studies of both ROS and apoptotic pathway proteins have potential to lead to improved therapies for human patients. ..
- Testicular Torsion: Mechanisms and TreatmentTerry Turner; Fiscal Year: 2005..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
- Advanced Training for Leadership in Urology and Urological ResearchTerry Turner; Fiscal Year: 2007..It is the goal of this program to train both physicians and basic scientists for careers in urogenital investigation that will match or exceed those of their mentors. ..