R Scott Turner

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein
    Gwendalyn D King
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48105, USA
    J Neurochem 88:971-82. 2004
  2. ncbi request reprint The pathology of REM sleep behavior disorder with comorbid Lewy body dementia
    R S Turner
    Veterans Administration Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, MI 48105, USA
    Neurology 55:1730-2. 2000
  3. ncbi request reprint Biomarkers of Alzheimer's disease and mild cognitive impairment: are we there yet?
    R Scott Turner
    Department of Neurology, Neuroscience Program, and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48105, USA
    Exp Neurol 183:7-10. 2003
  4. pmc X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice
    Inderjeet Saluja
    Department of Neurology, University of Michigan, USA
    Neurobiol Dis 36:162-8. 2009
  5. ncbi request reprint Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism
    Chi S Ho
    Department of Physiology, Institute of Gerontology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Biol Chem 277:27021-8. 2002
  6. pmc The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement
    S Sakura Minami
    Department of Neurology, Georgetown University, 4000 Reservoir Road NW, Washington, DC 20057, USA
    FASEB J 24:58-69. 2010
  7. pmc Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
    Patricia L Kramer
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurobiol Aging 32:2113-22. 2011
  8. ncbi request reprint ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways
    Michelle L Steinhilb
    Institute of Gerontology and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    J Neurochem 80:1019-28. 2002
  9. pmc Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 9:243-52. 2002
  10. ncbi request reprint Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies
    R Scott Turner
    Department of Neurology, University of Michigan, and Veterans Affairs Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, Michigan 48105, USA
    J Geriatr Psychiatry Neurol 15:195-9. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein
    Gwendalyn D King
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48105, USA
    J Neurochem 88:971-82. 2004
    ..By specifically targeting substrate instead of enzyme X11alpha may function as a relatively specific gamma-secretase inhibitor...
  2. ncbi request reprint The pathology of REM sleep behavior disorder with comorbid Lewy body dementia
    R S Turner
    Veterans Administration Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, MI 48105, USA
    Neurology 55:1730-2. 2000
    ....
  3. ncbi request reprint Biomarkers of Alzheimer's disease and mild cognitive impairment: are we there yet?
    R Scott Turner
    Department of Neurology, Neuroscience Program, and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48105, USA
    Exp Neurol 183:7-10. 2003
  4. pmc X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice
    Inderjeet Saluja
    Department of Neurology, University of Michigan, USA
    Neurobiol Dis 36:162-8. 2009
    ..The increased neuropathological indices of AD in mice expressing reduced X11alpha suggest a normal suppressor role for X11alpha on CNS Abeta/amyloid deposition...
  5. ncbi request reprint Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism
    Chi S Ho
    Department of Physiology, Institute of Gerontology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Biol Chem 277:27021-8. 2002
    ..We conclude that Munc18a acts through direct and indirect interactions with X11 proteins and powerfully regulates APP metabolism and Abeta secretion...
  6. pmc The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement
    S Sakura Minami
    Department of Neurology, Georgetown University, 4000 Reservoir Road NW, Washington, DC 20057, USA
    FASEB J 24:58-69. 2010
    ..05, n=4). In the present study, we are the first to demonstrate that ApoEr2 regulates cell movement, and both X11alpha and Reelin enhance this effect...
  7. pmc Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
    Patricia L Kramer
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurobiol Aging 32:2113-22. 2011
    ..Our findings suggest that up-regulation of reelin may be a compensatory response to tau-related or beta-amyloid stress associated with AD even prior to the onset of dementia...
  8. ncbi request reprint ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways
    Michelle L Steinhilb
    Institute of Gerontology and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    J Neurochem 80:1019-28. 2002
    ..These results suggest that APPsw is cleaved by beta-secretase late in the secretory pathway...
  9. pmc Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    Kevin A Corcoran
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Learn Mem 9:243-52. 2002
    ..Hence, learning and memory deficits in old Tg2576 mice are limited to hippocampus-dependent tasks, despite widespread amyloid deposition in cortex, hippocampus, and amygdala...
  10. ncbi request reprint Idiopathic rapid eye movement sleep behavior disorder is a harbinger of dementia with Lewy bodies
    R Scott Turner
    Department of Neurology, University of Michigan, and Veterans Affairs Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, Michigan 48105, USA
    J Geriatr Psychiatry Neurol 15:195-9. 2002
    ..Inclusion of historical or concurrent idiopathic RBD in the diagnostic criteria for DLB may improve their sensitivity, specificity, and clinical utility...
  11. ncbi request reprint Inherited dementias
    Peter Hedera
    Department of Neurology, Vanderbilt University, Nashville, Tennesse, USA
    Neurol Clin 20:779-808, vii. 2002
    ....
  12. pmc Coexisting adult polyglucosan body disease with frontotemporal lobar degeneration with transactivation response DNA-binding protein-43 (TDP-43)-positive neuronal inclusions
    Jill G Farmer
    Memory Disorders Program, Department of Neurology, Georgetown University, Washington, DC 20057, USA
    Neurocase 19:67-75. 2013
    ..It is unclear if these distinct findings are coincidental in this individual, or if pathogenic pathways may intersect to promote these coexisting pathologies...
  13. pmc Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice
    Jen Tzer Gau
    Department of Medicine, Division of Geriatric Medicine, the Institute of Gerontology, University of Michigan, Ann Arbor, MI 48105, USA
    Am J Pathol 160:731-8. 2002
    ..Homeostatic APPsbetaswe levels with aging suggest that progressive amyloid deposition in brain results not from increased beta-secretase cleavage of APP but from impaired Abeta/amyloid clearance mechanisms...
  14. ncbi request reprint FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
    Norman L Foster
    Center for Alzheimer s Care, Imaging and Research and Department of Neurology, University of Utah, USA
    Brain 130:2616-35. 2007
    ..FDG-PET adds important information that appropriately increases diagnostic confidence, even among experienced dementia specialists...
  15. ncbi request reprint A comparison of classification methods for differentiating fronto-temporal dementia from Alzheimer's disease using FDG-PET imaging
    Roger Higdon
    University of Washington, Seattle, USA
    Stat Med 23:315-26. 2004
    ..Methods using PLS appear to be more successful. Averaging or using VOI data may also be helpful...
  16. ncbi request reprint Alzheimer's disease
    R Scott Turner
    Neurology Service, VA Ann Arbor Healthcare System, Michigan 48105, USA
    Semin Neurol 26:499-506. 2006
    ..Novel potential disease-modifying therapies now in preclinical research or clinical trials may be more effective in preventing or arresting the progressive dementia of AD and will provide a test of the amyloid hypothesis...