JERROLD TURNER

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier
    Olga Zaborina
    Department of Surgery, University of Chicago, Chicago, USA
    Ann Clin Microbiol Antimicrob 5:14. 2006
  2. ncbi NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 281:C1533-41. 2001
  3. ncbi Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application
    Jerrold R Turner
    Department of Pathology, The University of Chicago, 5841 South Maryland Ave, MC 1089, Chicago, IL 60637, USA
    Am J Pathol 169:1901-9. 2006
  4. ncbi Intestinal mucosal barrier function in health and disease
    Jerrold R Turner
    Department of Pathology, The University of Chicago, 5841 South Maryland, MC 1089, Chicago, Illinois 60637, USA
    Nat Rev Immunol 9:799-809. 2009
  5. ncbi A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    Yevgeny Zolotarevsky
    Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Gastroenterology 123:163-72. 2002
  6. ncbi No static at all
    W Vallen Graham
    Department of Pathology, The University of Chicago, Chicago, Illiniois 60637, USA
    Ann N Y Acad Sci 1165:314-22. 2009
  7. ncbi Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    Daniel R Clayburgh
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:2682-94. 2006
  8. ncbi Tight junction pore and leak pathways: a dynamic duo
    Le Shen
    Department of Pathology, The University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 73:283-309. 2011
  9. ncbi Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    Christopher R Weber
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:12037-46. 2010
  10. ncbi Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership
    David T Rubin
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1309-13. 2006

Research Grants

  1. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    Jerrold R Turner; Fiscal Year: 2010
  2. Physiological Regulation of Intestinal Permeability
    JERROLD TURNER; Fiscal Year: 2005
  3. Regulation of Paracellular Permeability by IFNgamma and TNFa
    JERROLD TURNER; Fiscal Year: 2007
  4. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    JERROLD TURNER; Fiscal Year: 2007
  5. Regulation of Paracellular Permeability by IFNgamma and TNFalpha
    Jerrold R Turner; Fiscal Year: 2010
  6. Mechanisms and consequences of cytokine-induced tight junction barrier regulation
    Jerrold R Turner; Fiscal Year: 2010
  7. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    Jerrold R Turner; Fiscal Year: 2010

Collaborators

Detail Information

Publications81

  1. ncbi Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier
    Olga Zaborina
    Department of Surgery, University of Chicago, Chicago, USA
    Ann Clin Microbiol Antimicrob 5:14. 2006
    ..aeruginosa can cause lethal sepsis from within the intestinal tract of critically ill and immuno-compromised patients via mechanisms involving disruption of epithelial barrier function...
  2. ncbi NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia
    J R Turner
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Am J Physiol Cell Physiol 281:C1533-41. 2001
    ..This coordinated regulation of glucose (SGLT1) and Na(+) (NHE3) absorptive processes may represent a functional activation of absorptive enterocytes by luminal nutrients...
  3. ncbi Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application
    Jerrold R Turner
    Department of Pathology, The University of Chicago, 5841 South Maryland Ave, MC 1089, Chicago, IL 60637, USA
    Am J Pathol 169:1901-9. 2006
    ....
  4. ncbi Intestinal mucosal barrier function in health and disease
    Jerrold R Turner
    Department of Pathology, The University of Chicago, 5841 South Maryland, MC 1089, Chicago, Illinois 60637, USA
    Nat Rev Immunol 9:799-809. 2009
    ..Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease...
  5. ncbi A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    Yevgeny Zolotarevsky
    Department of Pathology, Wayne State University, Detroit, Michigan, USA
    Gastroenterology 123:163-72. 2002
    ..Thus, PIK may be the prototype for a new class of targeted therapeutic agents that can restore barrier function in intestinal disease states...
  6. ncbi No static at all
    W Vallen Graham
    Department of Pathology, The University of Chicago, Chicago, Illiniois 60637, USA
    Ann N Y Acad Sci 1165:314-22. 2009
    ..While the molecular intermediates in this reorganization are not defined, the new discovery that individual tight junction-associated proteins are highly dynamic at steady state may provide insight into the mechanisms of regulation...
  7. ncbi Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo
    Daniel R Clayburgh
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 116:2682-94. 2006
    ..These data demonstrate the necessity of coordinated Na+ malabsorption and barrier dysfunction in TNF-induced diarrhea and provide insight into mechanisms of intestinal water transport...
  8. ncbi Tight junction pore and leak pathways: a dynamic duo
    Le Shen
    Department of Pathology, The University of Chicago, Illinois 60637, USA
    Annu Rev Physiol 73:283-309. 2011
    ..This review presents these data in a historical context and proposes an integrated model in which dynamic regulation of tight junction protein interactions determines barrier function...
  9. ncbi Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    Christopher R Weber
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:12037-46. 2010
    ..Interactions between these otherwise distinct tight junction regulatory pathways may contribute to IBD pathogenesis...
  10. ncbi Surveillance of dysplasia in inflammatory bowel disease: The gastroenterologist-pathologist partnership
    David T Rubin
    Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 4:1309-13. 2006
    ..We address the challenge of management of polypoid lesions and incorporate new information about degree of inflammation as an additional risk of neoplasia in these patients...
  11. ncbi Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
    Le Shen
    Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    J Cell Sci 119:2095-106. 2006
    ..We conclude that myosin light chain phosphorylation alone is sufficient to induce tight junction regulation and provide new insights into the molecular mechanisms that mediate this regulation...
  12. ncbi LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms
    Brad T Schwarz
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    Gastroenterology 132:2383-94. 2007
    ..The aim of this study was to determine if LIGHT is capable of signaling directly to intestinal epithelia and to define the mechanisms and consequences of such signaling...
  13. ncbi Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis
    Liping Su
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    Gastroenterology 136:551-63. 2009
    ..Our aim was to determine whether, in an intact epithelium, primary dysregulation of the intestinal epithelial barrier by pathophysiologically relevant mechanisms can contribute to development of colitis...
  14. ncbi Epithelial barriers in homeostasis and disease
    Amanda M Marchiando
    Department of Pathology, Graduate Program in Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, Illinois, 60637, USA
    Annu Rev Pathol 5:119-44. 2010
    ..In this review, we discuss the critical roles of the tight junction in health and explore the contributions of barrier dysfunction to disease pathogenesis...
  15. ncbi Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease
    Aytekin Oto
    Department of Radiology, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Acad Radiol 16:597-603. 2009
    ....
  16. ncbi MMR vaccination, ileal lymphoid nodular hyperplasia, and pervasive develop-mental disorder
    Barbara A Hendrickson
    Section of Pediatric Infectious Diseases, University of Chicago, Chicago, IL 60637, USA
    Lancet 359:2051-2. 2002
  17. ncbi The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 174:8173-82. 2005
    ..Furthermore, we demonstrated that up-regulation of LIGHT is associated with active CD. These data establish a new mouse model resembling CD and suggest that up-regulation of LIGHT may be an important mediator of CD pathogenesis...
  18. ncbi Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation
    Yueming Tang
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Pathol 176:158-67. 2010
    ..Epithelial NF-kappaB activation induced by mucosal T cells, therefore, actively plays a role in opening paracellular spaces to promote transmucosal fluid effux into the intestinal lumen...
  19. ncbi Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    Fengjun Wang
    Department of Pathology, The University of Chicago, 5841 South Maryland Ave, MC 1089, Chicago, IL 60637, USA
    Am J Pathol 166:409-19. 2005
    ..These TNF-alpha-induced events can be prevented by the clinically relevant drug sulfasalazine...
  20. ncbi Mechanisms and functional implications of intestinal barrier defects
    Le Shen
    Department of Pathology, The University of Chicago, Chicago, Ill 60637, USA
    Dig Dis 27:443-9. 2009
    ..Barrier restoration may, therefore, represent a non-immunosuppressive approach to achieving or maintaining disease remission...
  21. ncbi Differing roles of protein kinase C-zeta in disruption of tight junction barrier by enteropathogenic and enterohemorrhagic Escherichia coli
    Farol L Tomson
    Department of Medicine, Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, USA
    Gastroenterology 127:859-69. 2004
    ..The aim of this study was to compare the role of protein kinase C-zeta in the disruption of tight junctions after infection with enteropathogenic E. coli and enterohemorrhagic E. coli...
  22. ncbi Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis
    Goo Lee
    Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Gastroenterology 139:869-81, 881.e1-9. 2010
    ..We investigated whether phosphoinositide 3-kinase (PI3K) is required for Akt-mediated activation of beta-catenin during intestinal inflammation...
  23. ncbi Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
    Christopher R Weber
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Lab Invest 88:1110-20. 2008
    ..We speculate that increased claudin-1 and claudin-2 expression may be involved at early stages of transformation in IBD-associated neoplasia...
  24. ncbi The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
    Le Shen
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 181:683-95. 2008
    ..These data demonstrate that the tight junction undergoes constant remodeling and suggest that this dynamic behavior may contribute to tight junction assembly and regulation...
  25. ncbi A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability
    Daniel R Clayburgh
    Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 279:55506-13. 2004
    ..These results demonstrate unique physiologically relevant patterns of expression and subcellular localization for long MLCK isoforms and show that MLCK1 is the isoform responsible for tight junction regulation in absorptive enterocytes...
  26. ncbi Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo
    Daniel R Clayburgh
    Department of Pathology, The University of Chicago, Chicago, Illinois, USA
    J Clin Invest 115:2702-15. 2005
    ..The data also indicate that inhibition of epithelial MLCK may be an effective non-immunosuppressive therapy for treatment of immune-mediated intestinal disease...
  27. ncbi MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties
    Qing Sun
    Department of Pathology and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    J Biol Chem 282:21998-2010. 2007
    ..0 nm), because of a slower association rate. These results show that MT6-MMP may play a role in colon cancer and exhibit unique biochemical and structural properties that may regulate proteolytic function at the cell surface...
  28. ncbi MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
    Dan Yu
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:8237-41. 2010
    ..These data demonstrate a critical role for the ZO-1 ABR in barrier function and suggest that MLCK-dependent ZO-1 exchange is essential to this mechanism of barrier regulation...
  29. ncbi Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo
    Donnie E Shifflett
    Department of Medicine, Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA
    Lab Invest 85:1308-24. 2005
    ....
  30. ncbi Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo
    Amanda M Marchiando
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 189:111-26. 2010
    ..These data demonstrate that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional tight junction regulation...
  31. ncbi Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure
    John M Russo
    Department of Pathology, University of Chicago, IL 60637, USA
    Gastroenterology 128:987-1001. 2005
    ..These studies aimed to define the roles of these kinases in purse-string wound closure...
  32. ncbi Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis
    Le Shen
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 16:3919-36. 2005
    ..Thus, LatA-induced actin depolymerization causes TJ structural and functional disruption by mechanisms that include caveolae-mediated endocytosis of TJ components...
  33. ncbi Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 113:826-35. 2004
    ..These observations indicate the critical contributions of dysregulated LIGHT expression and intestinal inflammation to the pathogenesis of IgAN...
  34. ncbi The tight junction in inflammatory disease: communication breakdown
    Karen L Edelblum
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Curr Opin Pharmacol 9:715-20. 2009
    ....
  35. ncbi A porous defense: the leaky epithelial barrier in intestinal disease
    Daniel R Clayburgh
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Lab Invest 84:282-91. 2004
    ..The overarching hypothesis is that modulation of the mucosal epithelial barrier plays a critical role in the initiation and propogation of inflammatory intestinal diseases...
  36. ncbi Outcome after surveillance of low-grade and indefinite dysplasia in patients with ulcerative colitis
    Joel R Pekow
    University of Chicago, Section of Gastroenterology, Hepatology, and Nutrition, Chicago, Illinois, USA
    Inflamm Bowel Dis 16:1352-6. 2010
    ..The management of low-grade (LGD) and indefinite dysplasia (IND) in patients with ulcerative colitis (UC) remains controversial, as outcomes after a diagnosis of LGD or IND in previous studies vary widely...
  37. ncbi Recognition of host immune activation by Pseudomonas aeruginosa
    Licheng Wu
    Department of Surgery, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    Science 309:774-7. 2005
    ..These observations provide details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host...
  38. ncbi Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed
    Le Shen
    Department of Pathology, The University of Chicago, Illnois, USA
    Am J Physiol Gastrointest Liver Physiol 290:G577-82. 2006
    ..Recent advances in understanding the role of tight junction dynamics in response to such stimuli are the focus of this review...
  39. ncbi Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells
    Ravinder K Gill
    Dept of Medicine, Univ of Illinois at Chicago, Medical Research Service, Jesse Brown VA Medical Center, 820 S Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Gastrointest Liver Physiol 295:G700-8. 2008
    ....
  40. ncbi Cell death in the colonic epithelium during inflammatory bowel diseases: CD95/Fas and beyond
    Lina Chen
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 16:1071-6. 2010
    ..This review critically discusses the data on the possible function of CD95 as an apoptosis-inducing receptor in IBD and discusses alternative mechanisms for epithelial cell loss in IBD...
  41. ncbi Mouse model of enteropathogenic Escherichia coli infection
    Suzana D Savkovic
    Section of Digestive and Liver Diseases, Department of Medicine, University of Illinois, 840 South Wood St, CSB Room 706 m c 716, Chicago, IL 60612, USA
    Infect Immun 73:1161-70. 2005
    ..Altogether, these data suggest that the C57BL/6J mouse is susceptible to infection by EPEC and will provide a suitable in vivo model for studying the consequences of EPEC infection...
  42. ncbi Stimulus-induced reorganization of tight junction structure: the role of membrane traffic
    Dan Yu
    Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    Biochim Biophys Acta 1778:709-16. 2008
    ..This review summarizes recent progress in understanding mechanisms and pathways of tight junction protein internalization and the relevance of these to tight junction regulation...
  43. ncbi Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions
    David R Raleigh
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 21:1200-13. 2010
    ..The data further suggest that these proteins are best considered as a group with both redundant and unique contributions to epithelial function and tight junction regulation...
  44. ncbi Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport
    Huiren Zhao
    Departments of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 101:9485-90. 2004
    ..Intact ezrin function is necessary for NHE3 recruitment to the apical membrane and NHE3-dependent pH(i) increases triggered by Na(+)-glucose cotransport. The data also define a pathway of p38 MAP kinase-dependent ezrin activation...
  45. ncbi High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa
    Licheng Wu
    Department of Surgery, University of Chicago, IL 60637, USA
    Gastroenterology 126:488-98. 2004
    ....
  46. ncbi Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa
    Nachiket J Patel
    Department of Surgery, University of Chicago, Chicago, Illinois, USA
    Am J Physiol Gastrointest Liver Physiol 292:G134-42. 2007
    ..The ability of P. aeruginosa to metabolize adenosine to inosine may represent a subversive microbial virulence strategy that deprives the epithelium of the cytoprotective actions of adenosine...
  47. ncbi Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter
    W Vallen Graham
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:26205-15. 2006
    ..Thus either AP-1 or NFkappaB can up-regulate long MLCK transcription, but the mechanisms by which TNF up-regulates intestinal epithelial long MLCK transcription from exon 1A are differentiation-dependent...
  48. ncbi Components of intestinal epithelial hypoxia activate the virulence circuitry of Pseudomonas
    Jonathan E Kohler
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1048-54. 2005
    ..We conclude that the virulence circuitry of P. aeruginosa is activated by both soluble and contact-mediated elements of the intestinal epithelium during hypoxia and normoxic recovery...
  49. ncbi Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells
    Lian-Zhi Gu
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, 835 South Wolcott Ave, Chicago, IL 60612-7342, USA
    Eur J Cancer 42:948-57. 2006
    ..These results provide evidence for the efficacy of ML-7 as an adjuvant to etoposide in these models and warrants further development...
  50. ncbi Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
    Stephanie A Blair
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Lab Invest 86:191-201. 2006
    ..Therefore, these data show that MLCK expression and enzymatic activity are increased in IBD. Moreover, the correlation with disease activity suggests that MLCK upregulation may contribute to barrier dysfunction and IBD pathogenesis...
  51. ncbi Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
    Donna L Arvans
    Martin Boyer Professor of Medicine, The Univ of Chicago, 5841 S Maryland Ave Rm G705, MC 6084, Chicago, IL, 60637, USA
    Am J Physiol Gastrointest Liver Physiol 288:G696-704. 2005
    ..In conclusion, luminal microflora and their metabolic byproducts direct expression of HSPs in gut epithelial cells, an effect that contributes to preservation of epithelial cell viability under conditions of stress...
  52. ncbi Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum
    Keri A Kles
    Martin Boyer Laboratories, The University of Chicago IBD Research Center, Chicago, IL, USA
    Inflamm Bowel Dis 11:253-7. 2005
    ..Physicians should use caution when providing higher doses of the pro-drug forms of 5-ASA to their patients, as this could lead to increased diarrhea...
  53. ncbi Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa
    Licheng R Wu
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    Surg Infect (Larchmt) 6:185-95. 2005
    ..CONCLUSIONS: The intestinal environment of a stressed host contains soluble factors capable of inducing lethal virulence traits in human opportunistic pathogen P. aeruginosa...
  54. ncbi CD95 promotes tumour growth
    Lina Chen
    The Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Nature 465:492-6. 2010
    ..These results demonstrate that CD95 has a growth-promoting role during tumorigenesis and indicate that efforts to inhibit its activity rather than to enhance it should be considered during cancer therapy...
  55. ncbi MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransport
    Zhihong Hu
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:24247-53. 2006
    ..MAPKAPK-2 knockdown also blocked NHE3 translocation. Thus, MAP-KAPK-2 controls Akt2 phosphorylation. In so doing, MAP-KAPK-2 links p38 MAPK to Akt2, ezrin, and NHE3 activation after SGLT1-mediated transport...
  56. ncbi Alternative promoter and GATA5 transcripts in mouse
    Bohao Chen
    Departments of Medicine, Univ of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1214-22. 2009
    ..These findings extend current understanding of the tissue distribution of GATA5 expression and suggests that GATA5 expression and function are more complex than previously appreciated...
  57. ncbi Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells
    Harsha E Rajapakse
    Department of Chemistry, University of Illinois, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 107:13582-7. 2010
    ....
  58. ncbi Glucose-induced ERM protein activation and translocation regulates insulin secretion
    James P Lopez
    Dept of Medicine, The Univ of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 299:E772-85. 2010
    ....
  59. ncbi Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression
    Ali Esmaili
    Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Gastroenterology 137:2074-83. 2009
    ..The present studies examined the effects of EPEC infection on SERT activity and expression in intestinal epithelial cells and elucidated the underlying mechanisms...
  60. ncbi Intercellular junctions: actin the PARt
    Le Shen
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Curr Biol 18:R1014-7. 2008
    ....
  61. ncbi Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis
    Alessandro Fichera
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 67:827-35. 2007
    ..Our findings suggest, moreover, that inhibitors of EGFR might be useful in chemopreventive strategies in individuals at increased risk for colonic malignancies...
  62. ncbi The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent
    Jianhu Zhang
    Department of Surgery, John D. Dingell VA Medical Center, 4646 John R. Street, Detroit, MI 48301, USA
    Gastroenterology 131:1179-89. 2006
    ..Deformation may exert matrix-dependent effects on intestinal epithelial cells, promoting epithelial restitution in fibronectin-rich tissue and proliferation in fibronectin-poor mucosa...
  63. ncbi Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa
    Olga Zaborina
    Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 4:e43. 2008
    ....
  64. ncbi Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane
    Markus Utech
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5040-52. 2005
    ..These results, for the first time, suggest that IFN-gamma induces endocytosis of epithelial TJ proteins via RhoA/ROCK-mediated, myosin II-dependent formation of VACs...
  65. ncbi IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction
    Fengjun Wang
    State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, China
    Gastroenterology 131:1153-63. 2006
    ..The aim of this study was to determine the signaling pathways by which TNF causes intestinal epithelial barrier loss...
  66. ncbi Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia
    Rebecca A Moyer
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Lab Invest 87:807-17. 2007
    ....
  67. ncbi Function, expression, and characterization of the serotonin transporter in the native human intestine
    Ravinder K Gill
    Research Assistant Professor, Univ of Illinois at Chicago, Jesse Brown V A Medical Center, Medical Research Service 600 151 820 South Damen Ave, Chicago, IL 60612
    Am J Physiol Gastrointest Liver Physiol 294:G254-62. 2008
    ....
  68. ncbi Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
    Olga Zaborina
    Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 3:e35. 2007
    ..Taken together, these data demonstrate that P. aeruginosa can intercept opioid compounds released during host stress and integrate them into core elements of quorum sensing circuitry leading to enhanced virulence...
  69. ncbi Anti-inflammatory effects of phosphatidylcholine
    Irina Treede
    Department of Gastroenterology, University Hospital Heidelberg, INF 345, Heidelberg 69120, Germany
    J Biol Chem 282:27155-64. 2007
    ..Collectively, these results provide a molecular foundation for the clinical studies showing a beneficial effect of PC therapy in ulcerative colitis...
  70. ncbi Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells
    Katherine L Schaefer
    Section of Gastroenterology, Boston Medical Center, Boston, MA 02118, USA
    Cancer Res 65:2251-9. 2005
    ..Inhibition of PPARgamma function causes HCC cell death by preventing adhesion and inducing anoikis-mediated apoptosis. PPARgamma inhibitors represent a potential novel treatment approach to HCC...
  71. ncbi Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptors and activation of PKC alpha in human intestinal epithelial cells
    Ravinder K Gill
    Section of Digestive Diseases and Nutrition, University of Illinois at Chicago, Jesse Brown VA Medical Center, IL 60612, USA
    Gastroenterology 128:962-74. 2005
    ..The present studies examined the acute effects of 5-hydroxytryptamine (5-HT) on NHE activity using Caco-2 cells as an in vitro model...
  72. ncbi Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration
    Heather A Edens
    Division of Gastrointestinal Pathology, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 169:476-86. 2002
    ..We propose that regulation of PMN transepithelial migration is mediated, in part, by sequential signaling events between migrating PMN and the epithelium...
  73. ncbi A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase
    Sian Eleri Owens
    Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales, UK
    Pharm Res 22:703-9. 2005
    ..The current study describes a strategy to identify stable analogues of PIK required for future in vivo studies that has resulted in the identification of two promising candidates...
  74. ncbi Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5
    Carolyn B Coyne
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Cell Host Microbe 2:181-92. 2007
    ..Thus, CVB entry depends on occludin and occurs by a process that combines aspects of caveolar endocytosis with features characteristic of macropinocytosis...
  75. ncbi A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age
    Jaideep Moitra
    Department of Medicine, University of Chicago, Chicago, IL 60637 1470, USA
    Transl Res 151:141-53. 2008
    ..These data reveal that nmMLCK2 overexpression in the endothelium exacerbates lung injury in vivo in a sexually dimorphic and age-dependent manner...
  76. ncbi SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis
    Linda C H Yu
    Department of Biological Sciences, University of Calgary, Calgary, AB, Canada T2N 1N4
    Int J Parasitol 38:923-34. 2008
    ..Together, the findings indicate that SGLT-1-dependent glucose uptake may represent a novel epithelial cell rescue mechanism against G. duodenalis-induced apoptosis...
  77. ncbi Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...
  78. ncbi Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells
    Lobke Snoeks
    Department of Medicine, Division of Gastroenterology, Evanston Northwestern Research Institute, Evanston, Illinois 60201, USA
    Infect Immun 76:4677-85. 2008
    ..In conclusion, LPS and bacterial infection inactivate Foxo3a in intestinal epithelia via the PI3K pathway and inactivated Foxo3a leads to the upregulation of IL-8 by suppressing inhibitory IkappaBalpha...
  79. ncbi Characterization of epithelial cell shedding from human small intestine
    Tim F Bullen
    Division of Gastroenterology, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Lab Invest 86:1052-63. 2006
    ..In conclusion, cell shedding is associated with apoptosis though it remains unclear whether apoptosis initiates shedding. It is also associated with phosphorylation of MLCs; a process associated previously with wound healing...
  80. ncbi Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease
    Dario Siccardi
    Welsh School of Pharmacy, University of Wales, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, Wales, UK
    Adv Drug Deliv Rev 57:219-35. 2005
    ....
  81. ncbi Got guts? Need nerve!
    Liping Su
    Gastroenterology 132:1615-8. 2007

Research Grants20

  1. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    Jerrold R Turner; Fiscal Year: 2010
    ....
  2. Physiological Regulation of Intestinal Permeability
    JERROLD TURNER; Fiscal Year: 2005
    ..abstract_text> ..
  3. Regulation of Paracellular Permeability by IFNgamma and TNFa
    JERROLD TURNER; Fiscal Year: 2007
    ..abstract_text> ..
  4. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    JERROLD TURNER; Fiscal Year: 2007
    ..The proposed studies will advance mechanistic understanding of this coordinate regulation and may therefore lead to the development of novel approaches for treatment of intestinal disease. ..
  5. Regulation of Paracellular Permeability by IFNgamma and TNFalpha
    Jerrold R Turner; Fiscal Year: 2010
    ..abstract_text> ..
  6. Mechanisms and consequences of cytokine-induced tight junction barrier regulation
    Jerrold R Turner; Fiscal Year: 2010
    ..The proposed studies will advance mechanistic understanding of barrier regulation and dysregulation and, therefore, lead to development of novel therapeutic approaches to improve human health. ..
  7. Physiological Regulation of Intestinal Epithelial Transport and Barrier Function
    Jerrold R Turner; Fiscal Year: 2010
    ....