Bruce I Turetsky

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Olfactory physiological impairment in first-degree relatives of schizophrenia patients
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Schizophr Res 102:220-9. 2008
  2. ncbi request reprint Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
  3. pmc Reduced posterior nasal cavity volume: a gender-specific neurodevelopmental abnormality in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 93:237-44. 2007
  4. ncbi request reprint Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatomical, and neurophysiological measures
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Neuropsychology 16:481-90. 2002
  5. ncbi request reprint Alpha2-noradrenergic effects on ERP and behavioral indices of auditory information processing
    Bruce I Turetsky
    Department of Cognitive Science, University of California, San Diego, La Jolla 92093 0515, USA
    Psychophysiology 39:147-57. 2002
  6. pmc Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 33:69-94. 2007
  7. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
  8. ncbi request reprint Low olfactory bulb volume in first-degree relatives of patients with schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
    Am J Psychiatry 160:703-8. 2003
  9. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
  10. doi request reprint Not pitch perfect: sensory contributions to affective communication impairment in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Biol Psychiatry 70:611-8. 2011

Detail Information

Publications64

  1. pmc Olfactory physiological impairment in first-degree relatives of schizophrenia patients
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Schizophr Res 102:220-9. 2008
    ..It is unclear, however, whether these behavioral abnormalities reflect basic olfactory sensory processing deficits or nonspecific disruptions of attention and cognition...
  2. ncbi request reprint Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  3. pmc Reduced posterior nasal cavity volume: a gender-specific neurodevelopmental abnormality in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 93:237-44. 2007
    ....
  4. ncbi request reprint Memory-delineated subtypes of schizophrenia: relationship to clinical, neuroanatomical, and neurophysiological measures
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Neuropsychology 16:481-90. 2002
    ..Unimpaired patients had fewer negative symptoms and dorsal medial prefrontal hypermetabolism. The authors conclude that categorizing patients on the basis of memory deficits may yield neurobiologically meaningful disease subtypes...
  5. ncbi request reprint Alpha2-noradrenergic effects on ERP and behavioral indices of auditory information processing
    Bruce I Turetsky
    Department of Cognitive Science, University of California, San Diego, La Jolla 92093 0515, USA
    Psychophysiology 39:147-57. 2002
    ..Our results offer a possible link between these two sets of findings, suggesting that some patients with schizophrenia may have dysfunctional noradrenergic systems...
  6. pmc Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 33:69-94. 2007
    ..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates...
  7. pmc Olfactory receptor neuron dysfunction in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:767-74. 2009
    ..It unambiguously demonstrates that neurophysiological disturbances in schizophrenia are not limited to cortical and subcortical structures, but rather include even the most peripheral sensory neurons...
  8. ncbi request reprint Low olfactory bulb volume in first-degree relatives of patients with schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, USA
    Am J Psychiatry 160:703-8. 2003
    ..This study examined olfactory bulbs in patients' relatives to determine whether low bulb volume represents an endophenotypic marker of genetic vulnerability...
  9. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  10. doi request reprint Not pitch perfect: sensory contributions to affective communication impairment in schizophrenia
    David I Leitman
    Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Biol Psychiatry 70:611-8. 2011
    ..The neural correlates of this dysfunction are unclear. Prior study has suggested that schizophrenia vocal affect perception deficits stem from an inability to use acoustic cues, notably pitch, in decoding emotion...
  11. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  12. ncbi request reprint Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging
    Raquel E Gur
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Psychiatry 164:442-9. 2007
    ..Cerebral activity underlying abnormal attention can be examined with event-related functional magnetic resonance imaging...
  13. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
    ..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles...
  14. pmc Profile of auditory information-processing deficits in schizophrenia
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychiatry Res 165:27-37. 2009
    ..Such multidimensional profiling of ERP abnormalities may help to clarify the clinical and genetic heterogeneity of schizophrenia...
  15. pmc Scents and nonsense: olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 35:1117-31. 2009
    ..This could help to clarify underlying brain mechanisms and facilitate identification of clinically relevant biomarkers...
  16. pmc Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophrenia
    David I Leitman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Soc Cogn Affect Neurosci 6:66-73. 2011
    ..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
  17. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  18. pmc Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  19. pmc An odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Schizophr Res 138:280-4. 2012
    ..Odor-detection thresholds to two odorants that differ in the degree to which they activate intracellular cAMP were assessed in clinical risk and low-risk participants...
  20. ncbi request reprint Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:1004-15. 2004
    ..Neuropsychological studies have demonstrated verbal episodic memory deficits in schizophrenia during word encoding and retrieval. This study examined neural substrates of memory in an analysis that controlled for successful retrieval...
  21. ncbi request reprint Impairment of odor hedonics in men with schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, the Smell and Taste Center, PA 1914, USA
    Am J Psychiatry 160:1784-9. 2003
    ..This study examined intensity and hedonic judgments in patients with schizophrenia to determine whether these functions were differentially impaired...
  22. doi request reprint Sex differences in familiality effects on neurocognitive performance in schizophrenia
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Psychiatry 73:976-84. 2013
    ..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
  23. ncbi request reprint Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  24. ncbi request reprint Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  25. ncbi request reprint Whole-brain morphometric study of schizophrenia revealing a spatially complex set of focal abnormalities
    Christos Davatzikos
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania Medical Center, 3600 Market Street, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 62:1218-27. 2005
    ..Frontotemporal abnormalities have been documented by using predetermined region-of-interest approaches, but deformation-based morphometry permits examination of the entire brain...
  26. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  27. ncbi request reprint Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential
    Christina R Maxwell
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics in Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:739-46. 2004
    ..This study suggests that olanzapine may help improve N100 impairments seen in schizophrenia, while haloperidol does not...
  28. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  29. ncbi request reprint Hemodynamic responses in neural circuitries for detection of visual target and novelty: An event-related fMRI study
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:263-74. 2007
    ..Age was associated with reduced peak HRF in left frontal region. Thus, indices of the HRF can be used to better understand the relationship between hemodynamic changes and performance and can be sensitive to individual differences...
  30. ncbi request reprint The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics, Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Neurochem Res 29:1179-88. 2004
    ..Future studies could use transcription profiling to clarify such interactions between genetic background, specific neuronal circuits, and transmitter systems...
  31. pmc Odor hedonic capacity and anhedonia in schizophrenia and unaffected first-degree relatives of schizophrenia patients
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Schizophr Bull 39:59-67. 2013
    ..We also examine odor valence processing unirhinally, rather than birhinally, to probe possible lateralized differences in patients' hedonic processing deficits...
  32. ncbi request reprint A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia
    Raquel E Gur
    Department of Psychiatry, Schizophrenia Research Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 55:512-7. 2004
    ..Although gender differences in schizophrenia are evident clinically and correlate with neuroanatomic measures, their relationship to OAR has not been examined...
  33. ncbi request reprint Physiologic impairment of olfactory stimulus processing in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 53:403-11. 2003
    ..Only limited efforts have been made to investigate the neurophysiologic substrate of these olfactory abnormalities. This article reports the first examination of olfactory electrophysiologic responses in patients with schizophrenia...
  34. ncbi request reprint An fMRI study of facial emotion processing in patients with schizophrenia
    Raquel E Gur
    Section of Neuropsychiatry, Department of Psychiatry, Gates Bldg 10th Floor, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Psychiatry 159:1992-9. 2002
    ..The authors evaluated cerebral blood flow response in schizophrenia patients during facial emotion processing to test the hypothesis of diminished limbic activation related to emotional relevance of facial stimuli...
  35. ncbi request reprint Association between facial emotion recognition and odor identification in schizophrenia
    Christian G Kohler
    Schizophrenia Research Center, University of Pennsylvania, Department of Psychiatry, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 19:128-31. 2007
    ..Olfactory and emotion recognition abilities appear significantly linked in schizophrenia...
  36. ncbi request reprint Age-related differences in brain activation during emotional face processing
    Faith M Gunning-Dixon
    Department of Psychiatry and Radiology, Section of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Aging 24:285-95. 2003
    ..The results of this study suggest that older adults may rely on different cortical networks to perceive emotional facial expressions than do their younger counterparts...
  37. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  38. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  39. pmc Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis
    Paul J Moberg
    To whom correspondence should be addressed 10 Gates, HUP, 3400 Spruce Street, Philadelphia, PA 19104, US tel 215 615 3608, fax 215 662 7903, E mail
    Schizophr Bull 40:50-9. 2014
    ..In schizophrenia, several variables had significant impact on these deficits and warrant consideration in prospective studies. Our findings also indicate that olfactory measures may be a useful marker of schizophrenia risk status. ..
  40. doi request reprint The effect of odor valence on olfactory performance in schizophrenia patients, unaffected relatives and at-risk youth
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, Philadelphia, PA, USA Smell and Taste Center, Department of Otorhinolaryngology Head and Neck Surgery, Perelman School of Medicine, Philadelphia, PA, USA Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA Electronic address
    J Psychiatr Res 47:1636-41. 2013
    ..Further research examining the utility of odor valence measures as markers for psychosis risk is warranted. ..
  41. pmc An odor-specific threshold deficit implicates abnormal intracellular cyclic AMP signaling in schizophrenia
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, 10th Floor, Gates Building, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 166:226-33. 2009
    ..This study was designed to test this hypothesis by determining odor detection threshold sensitivities to two odorants that differ in their relative activations of this intracellular cAMP signaling cascade...
  42. pmc Facial emotion recognition in schizophrenia: when and why does it go awry?
    Bruce I Turetsky
    Neurophysiology and Brain Imaging Laboratory, Department of Psychiatry 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Res 94:253-63. 2007
    ..This study examined event-related potential (ERP) responses to emotional faces in schizophrenia patients and controls to determine when, in the temporal processing stream, patient abnormalities occur...
  43. ncbi request reprint Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:788-90. 2005
    ..The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker...
  44. ncbi request reprint Behavioral and physiological findings of gender differences in global-local visual processing
    David Roalf
    University of Pennsylvania School of Medicine, Department of Psychiatry, Neuropsychiatry Section, 10 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain Cogn 60:32-42. 2006
    ..Findings are discussed in the context of existing literature regarding gender differences, hemispheric specialization, and the role of stimulus characteristics...
  45. ncbi request reprint Inhibition of auditory evoked potentials and prepulse inhibition of startle in DBA/2J and DBA/2Hsd inbred mouse substrains
    Patrick M Connolly
    Stanley Center for Experimental Therapeutics in Psychiatry, Division of Neuropsychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Res 992:85-95. 2003
    ..Future studies will attempt to determine the cause of these differences in sensory and sensorimotor processing between these two closely related inbred mouse strains...
  46. pmc Depth of the olfactory sulcus: a marker of early embryonic disruption in schizophrenia?
    Bruce I Turetsky
    Neuropsychiatry Division, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA
    Schizophr Res 115:8-11. 2009
    ..Olfactory and orbital sulcal depths were correlated in controls, but not in patients. Olfactory sulcal depth may therefore be a biomarker denoting an early embryonic disruption in individuals at risk for schizophrenia...
  47. ncbi request reprint Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia
    Paul J Moberg
    Brain Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:2314-6. 2004
    ....
  48. ncbi request reprint Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine
    Farzin Irani
    Division of Neuropsychiatry, Department of Psychiatry, Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 29:960-8. 2004
    ..Thus, the study provides impetus for future work in this area...
  49. doi request reprint Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q
    Paul J Moberg
    Neuropsychiatry Section, Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Psychiatr Genet 22:286-9. 2012
    ..The PTC nontaster haplotype is a genetic marker that may be used to identify subsets of schizophrenia patients who potentially harbor vulnerability genes in this region of chromosome 7q...
  50. pmc Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia
    Vidyulata Kamath
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Behav Neurosci 126:209-15. 2012
    ..Future studies that examine the olfactory processing deficit in schizophrenia with respect to other olfactory measures and COMT haplotypes is warranted...
  51. pmc Identification of pleasant, neutral, and unpleasant odors in schizophrenia
    Vidyulata Kamath
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Psychiatry Res 187:30-5. 2011
    ....
  52. ncbi request reprint Global-local visual processing in schizophrenia: evidence for an early visual processing deficit
    Sarah C Johnson
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 58:937-46. 2005
    ....
  53. doi request reprint P50 amplitude reduction: a nicotinic receptor-mediated deficit in first-degree relatives of schizophrenia patients
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, 10th Floor, Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 221:39-52. 2012
    ..Impaired P50 gating is a putative index of genetically mediated nicotinic dysfunction in schizophrenia. However, assessment is confounded, in patients, by differential effects of smoking, symptoms, and treatment...
  54. pmc Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia
    Daniel H Wolf
    Department of Psychiatry, University of Pennsylvania Philadelphia, PA, USA
    Front Behav Neurosci 5:81. 2011
    ..These findings highlight the importance of accounting for intrinsic motivation and reward when studying cognitive tasks, and add to growing evidence of reward circuit dysfunction in schizophrenia that may impact cognition and function...
  55. ncbi request reprint Brain activation during facial emotion processing
    Ruben C Gur
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuroimage 16:651-62. 2002
    ..These results support the central role of the amygdala in emotion processing, and indicate its sensitivity to the task relevance of the emotional display...
  56. ncbi request reprint Scent of a disorder: olfactory functioning in schizophrenia
    Paul J Moberg
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, 10th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 5:311-9. 2003
    ..Because the olfactory system continuously regenerates throughout life, it allows for a unique view of an ongoing neurodevelopmental process...
  57. ncbi request reprint Working memory for complex figures: an fMRI comparison of letter and fractal n-back tasks
    J Daniel Ragland
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychology 16:370-9. 2002
    ..Results support fractal n-back validity and indicate substantial overlap in working memory functions of dorsal and ventral PFC...
  58. ncbi request reprint Effects of strain, novelty, and NMDA blockade on auditory-evoked potentials in mice
    Steven J Siegel
    Stanley Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychopharmacology 28:675-82. 2003
    ..The ability to model novelty detection deficits in mice will aid in identifying genetic contributions to abnormal neuronal organization in people with schizophrenia...
  59. ncbi request reprint Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults
    Ruben C Gur
    Department of Psychiatry, Brain Behavior Laboratory, University of Pennsylvania, Medical Center, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 10:72-80. 2002
    ..Thus, the biological changes commonly attributed to "aging" do, in fact, begin much earlier in the life-cycle...
  60. pmc Mouse model predicts effects of smoking and varenicline on event-related potentials in humans
    Noam D Rudnick
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nicotine Tob Res 12:589-97. 2010
    ..Nicotine alters auditory event-related potentials (ERPs) in rodents and humans and is an effective treatment for smoking cessation. Less is known about the effects of the partial nicotine agonist varenicline on ERPs...
  61. pmc The influence of semantic processing on odor identification ability in schizophrenia
    Vidyulata Kamath
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Arch Clin Neuropsychol 28:254-61. 2013
    ..No relationship was observed between olfactory and semantic task performance in patients. These data suggest that odor identification deficits may not be primarily due to semantic processing deficits in schizophrenia...
  62. ncbi request reprint Misdiagnosis of schizophrenia in a patient with psychotic symptoms
    Beau V Duwe
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:252-60. 2002
    ..The purpose of this case study is to illustrate the way in which the appellation of schizophrenia can be misapplied in a patient with a complicated medical history and poor follow-up evaluation and treatment...
  63. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  64. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....